Pingoud
|
|
| Site- and strand-specific nicking of DNA by fusion
proteins derived from MutH and I-SceI or TALE repeats |
| Gabsalilow L, Schierling B, Friedhoff P, Pingoud A,
Wende W |
| Nucleic Acids Res. 2013 Feb 13. [Epub ahead of
print] |
Free pdf file
|
|
| High-resolution structures of Thermus thermophilus
enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and
in complex with NAD+ and triclosan |
| Otero JM, Noël AJ, Guardado-Calvo P, Llamas-Saiz
AL, Wende W, Schierling B, Pingoud A, van Raaij MJ. |
| Acta Crystallogr Sect F Struct Biol Cryst Commun.
2012 Oct 1;68(Pt 10):1139-48. Epub 2012 Sep 22. |
pdf download
|
|
| Inhibitors of Streptococcus pneumoniae Surface
Endonuclease EndA Discovered by High-Throughput Screening Using a PicoGreen
Fluorescence Assay |
| Peterson EJ, Kireev D, Moon AF, Midon M, Janzen WP,
Pingoud A, Pedersen LC, Singleton SF. |
| J Biomol Screen. 2012 Sep 26. [Epub ahead of print] |
Free pdf file
|
|
| Identification
of ICAD-derived peptides capable of specifically inhibiting the
caspase-activated DNase |
| Kutscher,
Daniel; Pingoud, Alfred; Jeltsch, Albert; Meiß, Gregor |
| FEBS J. 2012 Aug;279(16):2917-28. |
Free pdf file
|
|
| Redesigning
the single-chain variant of the restriction endonuclease PvuII by circular
permutation |
| Schierling
B, Wende W, Pingoud A. |
| FEBS
Lett. 2012 Jun 12;586(12):1736-41. Epub 2012 May 18. |
Free pdf file
|
|
| Controlling
the DNA Cleavage Activity of Light-Inducible Chimeric Endonucleases by
Bidirectional Photoactivation |
| Schierling B, Pingoud A. |
| Bioconjug
Chem. 2012 May 11. [Epub ahead of print] |
Free pdf file
|
|
Chemical rescue of active site mutants of the S. pneumoniae surface endonuclease EndA and other nucleases of the H-N-H family by imidazole
|
Marika Midon, Oleg Gimadutdinow, Gregor Meiss, Peter Friedhoff, and Alfred Pingoud
|
ChemBioChem 2012, 13,
713-721. (doi: 10.1002/cbic.201100775)
|
Free pdf file
|
|
| The rotation-coupled sliding of EcoRV. |
Dikic J, Menges C, Clarke S, Kokkinidis M, Pingoud A, Wende W, Desbiolles P.
|
Nucl. Acids Res. 2012,
40, 4064-4070. [Epub ahead of print 2012 Jan 12.] doi: 10.1093/nar/gkr1309
|
Free pdf file
|
|
| A
novel zinc-finger nuclease platform with a sequence-specific cleavage module. |
| Schierling B, Dannemann N, Gabsalilow L, Wende W, Cathomen T, Pingoud A.
|
| Nucleic
Acids Res., 2012,
40, 2623-2638. (doi:10.1093/nar/gkr1112) |
Free pdf file
|
|
| Creating highly specific nucleases by fusion of
active restriction endonucleases and catalytically inactive homing
endonucleases. |
| Fonfara
I, Curth U, Pingoud A, Wende W. |
| Nucleic Acids Res. 2012, 40, 847-860. [Epub ahead of print 2011
Sep 29.] |
Free pdf file
|
|
| Restriction endonuclease SsoII with
photoregulated activity - a "molecular gate" approach. |
| Hien
le T, Zatsepin TS, Schierling B, Volkov EM, Wende W, Pingoud A, Kubareva EA, Oretskaya TS. |
| Bioconjug Chem. 2011
Jul 20;22(7):1366-73. Epub 2011 Jul 1. |
Free pdf file
|
|
| Generation of novel nucleases with extended
specificity by rational and combinatorial strategies. |
| Pingoud
A, Wende W. |
| Chembiochem.
2011 Jul 4;12(10):1495-500. doi: 10.1002/cbic.201100055. Epub 2011 May 10. No
abstract available. |
Free pdf file
|
|
| Photocaged Variants of the
MunI and PvuII Restriction Enzymes. |
| Silanskas A, Foss M,
Wende W, Urbanke C, Lagunavicius A, Pingoud A, Siksnys V. |
| Biochemistry. 2011 Apr
12;50(14):2800-7. Epub 2011 Mar 16. |
Free pdf file
|
|
| Structural insights into
catalytic and substrate binding mechanisms of the strategic EndA nuclease
from Streptococcus pneumoniae. |
| Moon AF, Midon M, Meiss
G, Pingoud A, London RE, Pedersen LC. |
| Nucleic Acids Res. 2011
Apr 1;39(7):2943-53. Epub 2010 Nov 26. |
Free pdf file
|
|
| Mutational and biochemical
analysis of the DNA-entry nuclease EndA from Streptococcus pneumoniae. |
| Midon M, Schäfer P,
Pingoud A, Ghosh M, Moon AF, Cuneo MJ, London RE, Meiss G. |
| Nucleic Acids Res. 2011
Jan;39(2):623-34. Epub 2010 Sep 15. |
Free pdf file
|
|
| Controlling the enzymatic
activity of a restriction enzyme by light. |
| Schierling B, Noël AJ,
Wende W, Hien le T, Volkov E, Kubareva E, Oretskaya T, Kokkinidis M, Römpp A,
Spengler B, Pingoud A. |
| Proc Natl Acad Sci U S
A. 2010 Jan 26;107(4):1361-6. Epub 2009 Dec 18. |
Free pdf file
|
|
| [New derivatives of
azobenzene for the directed modification of proteins]. |
| Khien le T, Shirling B,
Riazanova AIu, Zatsepin TS, Volkov EM, Kubareva EA, Velichko TI, Pingoud A,
Oretskaia TS. |
| Bioorg Khim. 2009
Sep-Oct;35(5):610-7. Russian. |
|
| On the divalent metal ion
dependence of DNA cleavage by restriction endonucleases of the EcoRI family. |
| Pingoud V, Wende W,
Friedhoff P, Reuter M, Alves J, Jeltsch A, Mones L, Fuxreiter M, Pingoud A. |
| J Mol Biol. 2009 Oct
16;393(1):140-60. Epub 2009 Aug 13. |
Free pdf file
|
|
| Characterization
of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals
a unique mode of DNA binding, helical distortion, and cleavage compared with
a canonical LAGLIDADG homing endonuclease. |
| Singh P, Tripathi P,
Silva GH, Pingoud A, Muniyappa K. |
| J Biol Chem. 2009 Sep
18;284(38):25912-28. Epub 2009 Jul 15. |
| Free full text |
|
| Endonucleases induced
TRAIL-insensitive apoptosis in ovarian carcinoma cells. |
| Geel TM, Meiss G, van
der Gun BT, Kroesen BJ, de Leij LF, Zaremba M, Silanskas A, Kokkinidis M,
Pingoud A, Ruiters MH, McLaughlin PM, Rots MG. |
| Exp Cell Res. 2009 Sep
10;315(15):2487-95. Epub 2009 Jun 18. |
Free pdf file
|
|
| Tracking of single quantum
dot labeled EcoRV sliding along DNA manipulated by double optical tweezers. |
| Biebricher A, Wende W,
Escudé C, Pingoud A, Desbiolles P. |
| Biophys J. 2009 Apr
22;96(8):L50-2. |
Free pdf file
|
|
| Sliding and jumping of
single EcoRV restriction enzymes on non-cognate DNA. |
| Bonnet I, Biebricher A,
Porté PL, Loverdo C, Bénichou O, Voituriez R, Escudé C, Wende W, Pingoud A,
Desbiolles P. |
| Nucleic Acids Res. 2008
Jul;36(12):4118-27. Epub 2008 Jun 10. |
Free pdf file
|
|
| Precision genome surgery. |
| Pingoud A, Silva GH. |
| Nat Biotechnol. 2007
Jul;25(7):743-4. No abstract available. |
Free pdf file
|
|
| A sliding restriction
enzyme pauses. |
| Pingoud A, Wende W. |
| Structure. 2007
Apr;15(4):391-3. No abstract available. |
Free pdf file
|
|
| Reversible inactivation of
the CG specific SssI DNA (cytosine-C5)-methyltransferase with a
photocleavable protecting group. |
| Rathert P, Raskó T, Roth
M, Slaska-Kiss K, Pingoud A, Kiss A, Jeltsch A. |
| Chembiochem. 2007 Jan
22;8(2):202-7. |
Free pdf file
|
|
| The nuclease a-inhibitor
complex is characterized by a novel metal ion bridge. |
| Ghosh M, Meiss G,
Pingoud AM, London RE, Pedersen LC. |
| J Biol Chem. 2007 Feb
23;282(8):5682-90. Epub 2006 Nov 30. |
Free pdf file
|
|
| Engineering site-specific
endonucleases. |
| Friedhoff P, Pingoud A. |
| Methods Mol Biol.
2007;352:111-23. |
|
| Identification
of base-specific contacts in protein-DNA complexes by photocrosslinking and
mass spectrometry: a case study using the restriction endonuclease SsoII. |
| Pingoud V, Geyer H,
Geyer R, Kubareva E, Bujnicki JM, Pingoud A. |
| Mol Biosyst. 2005
Jul;1(2):135-41. Epub 2005 Jun 9. |
Free pdf file
|
|
| From monomeric to
homodimeric endonucleases and back: engineering novel specificity of
LAGLIDADG enzymes. |
| Silva GH, Belfort M,
Wende W, Pingoud A. |
| J Mol Biol. 2006 Aug
25;361(4):744-54. Epub 2006 Jul 12. |
Free pdf file
|
|
| Developing a programmed
restriction endonuclease for highly specific DNA cleavage. |
| Eisenschmidt K, Lanio T,
Simoncsits A, Jeltsch A, Pingoud V, Wende W, Pingoud A. |
| Nucleic Acids Res. 2005
Dec 14;33(22):7039-47. Print 2005. |
Free pdf file
|
|
| Affinity modification of
the restriction endonuclease SsoII by 2'-aldehyde-containing double stranded
DNAs. |
| Sud'ina AE, Zatsepin TS,
Pingoud V, Pingoud A, Oretskaya TS, Kubareva EA. |
| Biochemistry (Mosc).
2005 Aug;70(8):941-7. |
Free pdf file
|
|
| Structural insights into
the mechanism of nuclease A, a betabeta alpha metal nuclease from Anabaena. |
| Ghosh M, Meiss G,
Pingoud A, London RE, Pedersen LC. |
| J Biol Chem. 2005 Jul
29;280(30):27990-7. Epub 2005 May 15. |
Free pdf file
|
|
| Type II restriction
endonucleases: structure and mechanism. |
| Pingoud A, Fuxreiter M,
Pingoud V, Wende W. |
| Cell Mol Life Sci. 2005
Mar;62(6):685-707. Review. |
Free pdf file
|
|
| Interaction
of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism
for nuclease inhibition and suggests that DFF can be activated in a DNA-bound
state. |
| Korn C, Scholz SR,
Gimadutdinow O, Lurz R, Pingoud A, Meiss G. |
| J Biol Chem. 2005 Feb
18;280(7):6005-15. Epub 2004 Nov 30. |
Free pdf file
|
|
| Specificity
changes in the evolution of type II restriction endonucleases: a biochemical
and bioinformatic analysis of restriction enzymes that recognize unrelated
sequences. |
| Pingoud V, Sudina A,
Geyer H, Bujnicki JM, Lurz R, Lüder G, Morgan R, Kubareva E, Pingoud A. |
| J Biol Chem. 2005 Feb
11;280(6):4289-98. Epub 2004 Nov 24. |
Free pdf file
|
|
Friedhoff
|
|
| Site- and strand-specific nicking of DNA by fusion
proteins derived from MutH and I-SceI or TALE repeats |
| Gabsalilow L, Schierling B, Friedhoff P, Pingoud A,
Wende W |
| Nucleic Acids Res. 2013 Feb 13. [Epub ahead of
print] |
| Free pdf file |
|
| Covalently
trapping MutS on DNA to study DNA mismatch recognition and signaling |
| Heinze
RJ, Sekerina S, Winkler I, Biertümpfel C, Oretskaya TS, Kubareva E, Friedhoff
P |
| Mol
Biosyst. 2012 Jul 6;8(7):1861-4. Epub 2012 May 24. |
Free pdf file
|
|
| Single-molecule
multiparameter fluorescence spectroscopy reveals directional MutS binding to
mismatched bases in DNA |
| Cristóvão
M, Sisamakis E, Hingorani MM, Marx AD, Jung CP, Rothwell PJ, Seidel CA,
Friedhoff P |
| Nucleic
Acids Res. 2012 Jul 1;40(12):5448-5464. Epub 2012 Feb 24. |
Free pdf file
|
|
| Chemical rescue of active site mutants of the S. pneumoniae surface endonuclease EndA and other nucleases of the H-N-H family by imidazole |
Marika Midon, Oleg Gimadutdinow, Gregor Meiss, Peter Friedhoff, and Alfred Pingoud
|
| ChemBioChem 2012, 13,
713-721. (doi: 10.1002/cbic.201100775) |
| Free pdf file |
|
| Generation
of DNA nanocircles containing mismatched bases |
| Xiao
Y, Jung C, Marx AD, Winkler I, Wyman C, Lebbink JH, Friedhoff P, Cristovao M |
| Biotechniques.
2011 Oct;51(4):259-62, 264-5. |
Free pdf file
|
|
| Crosslinking
of (cytosine-5)-DNA methyltransferase SsoII and its complexes with specific DNA
duplexes provides an insight into their structures |
| Ryazanova
AY, Winkler I, Friedhoff P, Viryasov MB, Oretskaya TS, Kubareva EA |
| Nucleosides
Nucleotides Nucleic Acids. 2011 Jul-Aug;30(7-8):632-50. |
|
| Native
mass spectrometry provides direct evidence for DNA mismatch-induced regulation
of asymmetric nucleotide binding in mismatch repair protein MutS |
| Monti
MC, Cohen SX, Fish A, Winterwerp HH, Barendregt A, Friedhoff P, Perrakis A,
Heck AJ, Sixma TK, van den Heuvel RH, Lebbink JH |
| Nucleic
Acids Res. 2011 Oct;39(18):8052-64. Epub 2011 Jul 6. |
Free pdf file
|
|
| Chemical trapping of the
dynamic MUTS-MUTL complex formed in DNA mismatch repair in Escherichia coli. |
| Winkler I, Marx AD,
Lariviere D, Heinze R, Cristovao M, Reumer A, Curth U, Sixma TK, Friedhoff P. |
| J Biol
Chem. 2011 May 13;286(19):17326-37. Epub 2011 Mar 15. |
Free pdf file
|
|
| Changes in cytosolic Mg2+
levels can regulate the activity of the plasma membrane H+-ATPase in maize. |
| Hanstein S, Wang X, Qian
X, Friedhoff P, Fatima A, Shan Y, Feng K, Schubert S. |
| Biochem J. 2011 Apr
1;435(1):93-101. |
Free pdf file
|
|
| [Secondary structure of
SsoII-like (cytosine-5)-DNA methyltransferases N-terminal region determined
by circular dichroism spectroscopy]. |
| Riazanova AIu, Molochkov
NV, Abrosimova LA, Alekseevskiĭ AV, Kariagina AS, Protsenko AS, Friedhoff P,
Oretskaia TS, Kubareva EA. |
| Mol Biol (Mosk). 2010
Sep-Oct;44(5):911-21. Russian. |
|
| The C-terminal domain of
the MutL homolog from Neisseria gonorrhoeae forms an inverted homodimer. |
| Namadurai S, Jain D,
Kulkarni DS, Tabib CR, Friedhoff P, Rao DN, Nair DT. |
| PLoS One. 2010 Oct
28;5(10):e13726. |
Free pdf file
|
|
| Structure of the
endonuclease domain of MutL: unlicensed to cut. |
| Pillon MC, Lorenowicz
JJ, Uckelmann M, Klocko AD, Mitchell RR, Chung YS, Modrich P, Walker GC,
Simmons LA, Friedhoff P, Guarné A. |
| Mol Cell. 2010 Jul
9;39(1):145-51. |
Free pdf file
|
|
| Identification of Lynch
syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and
mismatch repair. |
| Kosinski J, Hinrichsen I, Bujnicki JM,
Friedhoff P, Plotz G. |
| Hum Mutat. 2010
Aug;31(8):975-82. |
Free pdf file
|
|
| Maintaining a sense of
direction during long-range communication on DNA. |
| Szczelkun MD, Friedhoff P, Seidel R. |
| Biochem Soc Trans. 2010
Apr;38(2):404-9. Review. |
Free pdf file
|
|
| On the divalent metal ion
dependence of DNA cleavage by restriction endonucleases of the EcoRI family. |
| Pingoud V, Wende W,
Friedhoff P, Reuter M, Alves J, Jeltsch A, Mones L, Fuxreiter M, Pingoud A. |
| J Mol Biol. 2009 Oct
16;393(1):140-60. Epub 2009 Aug 13. |
| Free pdf file |
|
| The C-terminal domain is
sufficient for endonuclease activity of Neisseria gonorrhoeae MutL. |
| Duppatla V, Bodda C,
Urbanke C, Friedhoff P, Rao DN. |
| Biochem J. 2009 Sep
25;423(2):265-77. |
Free pdf file
|
|
| Physical and functional
interactions between Escherichia coli MutL and the Vsr repair endonuclease. |
| Heinze RJ, Giron-Monzon
L, Solovyova A, Elliot SL, Geisler S, Cupples CG, Connolly BA, Friedhoff P. |
| Nucleic Acids Res. 2009
Jul;37(13):4453-63. Epub 2009 May 27. |
Free pdf file
|
|
| The PMS2 subunit of human
MutLalpha contains a metal ion binding domain of the iron-dependent repressor
protein family. |
| Kosinski J, Plotz G,
Guarné A, Bujnicki JM, Friedhoff P. |
| J Mol Biol. 2008 Oct
10;382(3):610-27. Epub 2008 Jun 28. |
Free pdf file
|
|
| Mutations in the MutSalpha
interaction interface of MLH1 can abolish DNA mismatch repair. |
| Plotz G, Welsch C, Giron-Monzon L,
Friedhoff P, Albrecht M, Piiper A, Biondi RM, Lengauer T, Zeuzem S, Raedle J. |
| Nucleic Acids Res.
2006;34(22):6574-86. Epub 2006 Nov 28. |
Free pdf file
|
|
| Engineering site-specific
endonucleases. |
| Friedhoff P, Pingoud A. |
| Methods Mol Biol.
2007;352:111-23. |
|
| Structural and functional
analysis of the MutS C-terminal tetramerization domain. |
| Manelyte L, Urbanke C,
Giron-Monzon L, Friedhoff P. |
| Nucleic Acids Res.
2006;34(18):5270-9. Epub 2006 Sep 29. |
Free pdf file
|
|
| Identifying
an interaction site between MutH and the C-terminal domain of MutL by
crosslinking, affinity purification, chemical coding and mass spectrometry. |
| Ahrends R, Kosinski J, Kirsch D, Manelyte
L, Giron-Monzon L, Hummerich L, Schulz O, Spengler B, Friedhoff P. |
| Nucleic Acids Res. 2006
Jun 13;34(10):3169-80. Print 2006. |
Free pdf file
|
|
| Analysis of the quaternary
structure of the MutL C-terminal domain. |
| Kosinski J, Steindorf I,
Bujnicki JM, Giron-Monzon L, Friedhoff P. |
| J Mol Biol. 2005 Aug
26;351(4):895-909. |
Free pdf file
|
|
| Mapping protein-protein
interactions by bioinformatics and cross-linking. |
| Friedhoff P. |
| Anal Bioanal Chem. 2005
Jan;381(1):78-80. No abstract available. |
Free pdf file
|
|
Wende
|
|
| Site- and strand-specific nicking of DNA by fusion
proteins derived from MutH and I-SceI or TALE repeats |
| Gabsalilow L, Schierling B, Friedhoff P, Pingoud A,
Wende W |
| Nucleic Acids Res. 2013 Feb 13. [Epub ahead of
print] |
| Free pdf file |
|
| High-resolution structures of Thermus thermophilus
enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and
in complex with NAD+ and triclosan |
| Otero JM, Noël AJ, Guardado-Calvo P, Llamas-Saiz
AL, Wende W, Schierling B, Pingoud A, van Raaij MJ. |
| Acta Crystallogr Sect F Struct Biol Cryst Commun.
2012 Oct 1;68(Pt 10):1139-48. Epub 2012 Sep 22. |
| pdf download |
|
| Redesigning
the single-chain variant of the restriction endonuclease PvuII by circular
permutation |
| Schierling
B, Wende W, Pingoud A. |
| FEBS
Lett. 2012 Jun 12;586(12):1736-41. Epub 2012 May 18. |
| Free pdf file |
|
| The rotation-coupled sliding of EcoRV. |
| Dikic J, Menges C, Clarke S, Kokkinidis M, Pingoud A, Wende W, Desbiolles P. |
| Nucl. Acids Res. |
