ATP-dependent chromatin remodeling complexes in Drosophila
We are investigating dMi-2 containing ATP-dependent chromatin remodeling complexes in gene regulation and development. Preliminary results suggest that these complexes are involved in the differentiation of the nervous system, are recruited to their target genes by interactions with SUMOylated factors and with RNA and can both repress and activate transcription. We will determine the role played by these complexes in development, characterize their recruitment to chromatin and identify the molecular mechanisms leading to gene repression and activation.
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