Mechanisms of epigenetic regulation of tumor suppressor genes
Epigenetic silencing of tumor suppressor genes is one of the most relevant molecular alterations, which occurs during carcinogenesis. It is clear that the inactivation state is maintained by aberrant DNA methylation and a repressive chromatin structure at the promoter. However mechanisms that cause this aberrant gene silencing are enigmatic. In our project we aim to reveal chromatin-associated factors that are important for the epigenetic regulation of tumor suppressor genes and investigate the altered chromatin configuration that occur during this process.