Mechanisms of gene silencing by the p53 family inhibitor ΔNp73
Transcription factors of the same gene family often bind to similar sequence motifs, yet
can generate opposite chromatin states. One example is the p53 family of tumor
suppressors. Tumors frequently express the transcriptionally repressive p73 isoform
ΔNp73, which inhibits the transactivating p53 family members and contributes to the
establishment of a repressive chromatin structure leading to reduced patient survival.
Here we plan to characterize genome-wide ΔNp73-induced chromatin changes to better
understand how ΔNp73 contributes to epigenetic reprogramming during tumorigenesis.