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Kerstin Wendt
Does cohesin regulate genes by organizing higher order chromatin structure?
The activity of genes depends on regulatory elements such as promoters and enhancers, but also on the conformation of the chromatin fibre. Recent studies showed that the cohesin complex, well characterized for its role during cell division and DNA damage repair, is also important for gene activity and it might cooperate with the chromatin insulator protein CTCF (CCCTC binding factor) to organize higher order chromatin structure. We will investigate whether chromatin loop formation by cohesin is a general mechanism by which the complex influences gene activity, and address the molecular mechanism of loop formation.
07.07.2010 13:34
