Possible structure of PTPIP51 as predicted by I-TASSER
These functions are carried out by interaction with different proteins. So far, interaction with Protein Tyrosine Phosphatase 1B, T-cell Protein Tyrosine Phosphatase, 14-3-3β, Insulin Receptor, Protein Kinases A and C, Lyn and c-src have been described. One of the main pathways influenced is the MAPK pathway. Thus, PTPIP51 is able to control essential cell functions, namely proliferation, differentiation and apoptosis.
The working group found PTPIP51 to be expressed in some types of cancer, including squamous cell carcinoma, leukemia, malignant melanoma, glioblastoma and ependymoma. Additionally, it plays a role in important organs (pancreas, liver, adipose tissue) during the development of metabolic disorders.