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March 2021

ProLOEWE News: The LOEWE Center DRUID fighting neglected tropical diseases – within two animated videos the Centers shows why research in this field is so important.

https://www.youtube.com/watch?v=NXgVhyspT2A&t=11s

https://www.youtube.com/watch?v=WnIqLakxqFw&t=3s

22.-24.02.2021 Spring Symposium LOEWE Center DRUID more...
28.01.2021

JLU Expert`s Statement - World NTD Day!

Prof. Grevelding on the subject of NTDs more...

28.05.2020

Note: The topic of NTDs is recognized on a broad political basis in Berlin and was actively discussed as part of the 163rd session of the Bundestag on May 28, 2020.

More...

16.03.2020 Dr. Simone Häberlein received the Karl Asmund Rudolphi Medal of the German Society for Parasitology (DGP) more...
05.02.2020 Talk: Prof. David Rollinson more...
03.02.2020 Spring Symposium of the LOEWE Center DRUID more...
24.01.2020 Talk: Prof. Antonio Jimènez Ruiz more...
29.11.2019 Talk: Prof. Ron Hokke more...
06.11.2019 Talk: Prof. Hans-Guide Wendel more...
14.06.2019 Talk: Prof. Dr. Jaap J. van Hellemond more...
13.06.2019 Minisymposium "Neue Impulse in der parasitologischen Forschung" more...
05.06.2019 Talk: Dr. Annette C. Kuesel more ...
24.05.2019 Talk: Dr. Tah Yves-Nathan Tian Bi more ...
22.05.2019 Talk: Prof. Dr. John Ziebuhr more ...
25.04.2019 Talk: PD Dr. Alexander Mosig more ...
Award Florian Röttgerding received a poster award at „13th International Symposium on Ticks and Tick-borne Diseases“ in Weimar. More ...
26.-29.03.2019

Third Announcement Joint meeting of the 20th Anniversary Drug Design & Development Seminar (DDDS) 2019
of the German Society for Parasitology (DGP) & the LOEWE Center DRUID

Sponsored by Boehringer, Euroimmun, Jung-Stiftung, Sanofi, Merck, TransMIT more

Conference Program

13.03.2019 Minisymposium "Neglected infectious diseases with the focus on imaging techniques" more ...
20.02.2019 Talk: PD Dr. Alexander Mosig more ...
18.-19.02.2019 Spring Symposium of the LOEWE Center DRUID more ...
14.12.2018 Talk: Prof. Christoph Grunau more ...
13.11.2018 Talk: Prof. Christian Münz more ...
08.10.2018 Talk: Rafaela Ferreira
18.09.2018 Talk:Prof. Hans-Georg Breitinger more ...
12.09.2018 Session: DRUID – die hessische Antwort auf vernachlässigte Tropenerkrankungen more...
09.05.2018 Talk: Andreas Stroehlein (PhD) more ...
08.05.2018 Lecture: Dr. Nikolai Windbichler more ...
13.04.2018 Talk: Prof. Paul Brindley more ...
26.02.2018 Inaugural Symposium LOEWE Centre DRUID more ...
Joint publications of DRUID

2022

Dekevic G, Tasto L, Czermak P, Salzig D (2022) Statistical experimental designs to optimize the transient transfection of HEK 293T cells and determine a transfer criterion from adherent cells to larger-scale cell suspension cultures. J Biotechnol, https://doi.org/10.1016/j.jbiotec.2022.01.004.


2021


Kirstgen M, Müller S.F, Lojaga, K.A.A.T, Goldmann N, Lehmann F, Alakurtti S, Yli-Kauhaluoma J, Baringhaus K-H, Krieg R, Glebe D, Geyer J (2021) Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screeing. Viruses13(8), 1489; https://doi.org/10.3390/v13081489 

 

Taroncher-Oldenburg G, Müller C, Obermann W, Ziebuhr J, Hartmann RK, Grünweller A (2021) Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates - A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics. Microorganisms 9, https://doi.org/10.3390/microorganisms9030540. 


Frese N, Schmerer P, Wortmann M, Schürmann M, König M, Westphal M, Weber F, Sudhoff H, Gölzhäuser A (2021) Imaging of SARS-CoV-2 infected Vero E6 cells by helium ion microscopy. Beilstein J Nanotechnology, https://doi.org/10.3762/bjnano.12.13.


Glitscher M, Martín DH, Woytinek K, Schmidt B, Tabari D, Scholl C, Stingl JC, Seelow E, Choi M, Hildt E (2021) Targeting cholesterol metabolism as an efficient antiviral strategy against the hepatitis E virus. Cell Mol Gastroenterhttps://doi.org/10.1016/j.jcmgh.2021.02.002.


Lam van TV, Heindl MR, Schlutt C, Böttcher-Friebertshäuser E, Bartenschlager R, Klebe G, Brandstetter H, Dahms SO, Steinmetzer T (2021) The basicity makes the difference – Improved canavanine-derived inhibitors of the proprotein convertase furin. ACS Med Chem Lett, https://doi.org/10.1021/acsmedchemlett.0c00651.


Slanina H, Madhugiri R, Bylapudi G, Schultheiß K, Karl N, Gulyaeva A, Gorbalenya AE, Linne U, Ziebuhr J (2021) Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.


Glitscher M, Himmelsbach K, Woytinek K, Schollmeier A, Johne R, Praefcke GJK, Hildt E (2021) Identification of the interferon-inducible GTPase GBP1 as major restriction factor for the Hepatitis E virus. J Virol, doi: 10.1128/JVI.01564-20.


Krähling V, Halwe S, Rohde C, Becker D, Berghöfer S, Dahlke C, Eickmann M, Ercanoglu MS, Gieselmann L, Herwig A, Kupke A, Müller H, Neubauer-Rädel P, Klein F, Keller C, Becker S (2021) Development and characterization of an indirect ELISA to detect SARS-CoV-2 spike protein-specific antibodies. J Immunol Methods, 490, 112958.

 

Müller C, Obermann W, Karl N, Wendel HG, Taroncher-Oldenburg G, Pleschka S, Hartmann RK, Grünweller A, Ziebuhr J. (2021) The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo. Antiviral Res, 7:105012. doi: 10.1016/j.antiviral.2021.105012.


2020

Häcker I, Koller R, Eichner G, Martin J, Liapi E, Rühl J, Rehling T, Schetelig MF (2020) Evaluation of Hydrogen Peroxide Fumigation and Heat Treatment for Standard Emergency Arthropod Inactivation in BSL-3 Insectaries. Front Bioeng Biotechnol, https://doi.org/10.3389/fbioe.2020.602937.


Weglage J, Wolters F, Hehr L, Lichtenberger J, Wulz C, Hempel F, Baier A, Quack T, Köhler K, Longerich T, Schramm G, Irungbam K, Mueller H, von Buelow V, Tschuschner A, Odenthal M, Drebber U, El Arousy M, Ramalho LNZ, Bankov K, Wild P, Pons‑Kühnemann J, Tschammer J, Grevelding CG, Roeb E, Roderfeld M (2020) Schistosoma mansoni eggs induce Wnt/β‑catenin signaling and activate the protooncogene c‑Jun in human and hamster colon. Sci Rep, 10:22373, https://doi.org/10.1038/s41598-020-79450-4.


Blum L, Ulshöfer T, Henke M, Krieg R, Berneburg I, Geisslinger G, Becker K, Parnham MJ, Schiffmann S (2020) The immunomodulatory potential of the arylmethylaminosteroid sc1o. JMolMed, https://doi.org/10.1007/s00109-020-02024-4.


Kirstgen M, Lowjaga KAAT, Müller SF, Goldmann N, Lehmann F, Alakurtti S, Yli-Kauhaluoma J, Glebe DGeyer J (2020) Selective Hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids. Sci Rep 10:21772, doi: 10.1038/s41598-020-78618-2.


Kadesch P, Gerbig S, Mokosch A, Häberlein S, Spengler B (2020) Parasiten im Massenspektrometer. NadC, https://doi.org/10.1002/nadc.20204093357.

 

Ghezellou P, Albuquerque W, Garikapati V, Casewell NR, Kazemi SM, Ghassempour A, Spengler B (2020) Integrating top-down and bottom-up mass spectrometric strategies for proteomic profiling of Iranian saw-scaled viper, Echis carinatus sochureki, venom. J Proteome Res, https://dx.doi.org/10.1021/acs.jproteome.0c00687.

 

Morawietz C M, Houhou H, Puckelwaldt O, Hehr L, Dreisbach D, Mokosch A, Roeb E, Roderfeld M, Spengler B*, Haeberlein S* (2020) Targeting kinases in Fasciola hepatica: anthelminthic effects and tissue distribution of selected kinase inhibitors. Front Vet Sci, doi: 10.3389/fvets.2020.611270.

 

Kadesch P, Hollubarsch T, Gerbig S, Schneider L, Silva LMR, Hermosilla C, Taubert A, Spengler B (2020) Intracellular parasites Toxoplasma gondii and Besnoitia besnoiti, Unveiled in single host cells using AP-SMALDI MS imaging. J Am Soc Mass Spectrom 31, 1815 - 1824, https://dx.doi.org/10.1021/jasms.0c00043.

 

Beller M, Herker E, Fullekrug J (2020) Grease on-perspectives in lipid droplet biology. Semin Cell Dev Biol, doi: 10.1016/j.semcdb.2020.06.017.

 

Bley H, Schobel A, Herker E (2020) Whole lotta lipids-from HCV RNA replication to the mature viral particle. Int J Mol Sci 21, http://dx.doi.org/10.3390/ijms21082888.

 

Blum L, Gul S, Ulshöfer T, Henke M, Krieg R, Berneburg I, Thomas D, Trautmann S, Kurz J, Geyer J, Geisslinger G, Becker K, Parnham MJ, Schiffmann S (2020) In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o. Sci Rep. 10:7534, doi: 10.1038/s41598-020-64382-w.

 

Klöss S, Dehmel S, Braun A, Michael JP, Koehl U, Schiffmann S (2020) From cancer to immune-mediated diseases and tolerance induction: Lessons learned from immune oncology and classical anti-cancer treatment. Front Immunol. 11:1423. doi: 10.3389/fimmu.2020.01423.


Peiffer KH, Spengler C, Basic M, Jiang B, Kuhnhenn L, Obermann W,  Zahn T, Glitscher M, Loglio A,  Facchetti F, Carra G, Kubesch A, Vermehren J, Knop V, Graf C, Dietz J,  Finkelmeier F, Herrmann E,  Trebicka J, Grünweller A, Zeuzem S, Sarrazin C, Lampertico P, Hildt E (2020) Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers. JCI Insight. 15:135833; doi: 10.1172/jci.insight.135833.


Tonk M, Vilcinskas A, Grevelding CG, Haeberlein S (2020) Anthelminthic activity of assassin bug venom against the blood fluke Schistosoma mansoni. Antibiotics 9, 664; doi:10.3390/antibiotics9100664. 


Du P, Giri BR, Liu J, Xia T, Grevelding CG, Cheng G. (2020) Proteomic and deep sequencing analysis of extracellular vesicles isolated from adult male and female Schistosoma japonicum. PLoS Negl Trop Dis. 14(9):e0008618. PMID: 3298670.


Harnischfeger J, Käßer L, Zitzmann J, Salzig D, Czermak P (2020) Bioreactor-based antigen production process using the baculovirus expression vector system. Methods Mol Biol, 2183:95-118. doi: 10.1007/978-1-0716-0795-4_8.

 

Pritchard DI, Falcone FH, Mitchell PD (2020) The evolution of IgE-mediated type I hypersensitivity and its immunological value. Allergy, 00: 117. https://doi.org/10.1111/all.14570.

 

Kadesch P, Quack T, Gerbig S, Grevelding CG, Spengler B (2020) Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging. PLoS Negl Trop Dis. 14(5):e0008145.

 

Turoňová B, Sikora M, Schürmann C, Hagen WJH, Welsch S, Blanc FEC, von Bülow S, Gecht M, Bagola K, Hörner C, van Zandbergen G, Mosalaganti S, Schwarz A, Covino R, Mühlebach MD, Hummer G, Krijnse Locker J, Beck M (2020) In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science, doi: 10.1126/science.abd5223.

 

Luu M, Romero R, Bazant J, Abass E, Hartmann S, Leister H, Fischer F, Mahdavi R, Plaza-Sirvent C, Schmitz I, Steinhoff U & Visekruna A (2020) The NF‐κB transcription factor c‐Rel controls host defense against Citrobacter rodentium. Eur J Immunol, 50(2), doi: 10.1002/eji.201948314.

 

Pereira IE, Silva KP, Menegati LM, Pinheiro AC, Assuncao EAO, Araujo MDLP, Abass E, Duthie MS, Steinhoff U, Teixeira HC (2020) Performance of recombinant proteins in diagnosis and differentiation of canine visceral leishmaniasis infected and vaccinated dogs. Eur J Microbiol Immunol, doi: 10.1556/1886.2020.00018.

 

Harbig A, Mernberger M, Bittel L, Pleschka S, Schughart K, Steinmetzer T, Stiewe T, Nist A & Böttcher-Friebertshäuser E (2020) Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways. J Biol Chem, 295(33), doi:10.1074/jbc.RA120.012635.


Röttgerding F & Kraiczy P (2020) Immune evasion strategies of relapsing fever spirochetes. Front Immunol, 11:1560. doi: 10.3389/fimmu.2020.01560.


Bestle D, Heindl MR, Limburg H, Lam van TV, Pilgram O, Moulton H, Stein AD, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk HD, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E (2020) TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance, doi:10.26508/lsa.202000786.


Braun NJ, Quek JP, Huber S, Kouretova J, Rogge D, Lang-Henkel H, Cheong EZK, Chew BLA, Heine A, Luo D, Steinmetzer T (2020) Structure-based macrocyclization of substrate analogue NS2B-NS3 protease inhibitors of Zika, West Nile and Dengue viruses. ChemMedChem, doi:10.1002/cmdc.202000237.

 

Lin YP, Diuk-Wasser M, Stevenson B, Kraiczy P (2020) Complement evasion contributes to Lyme borreliae host association. Trends Parasitol, 16:634-645. doi.org/10.1016/j.pt.2020.04.011.


Blum L, Geisslinger G, Parnham MJ, Grünweller A, Schiffmann S (2020) Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells. J Cell Mol Med, 10.1111/jcmm.15360. doi:10.1111/jcmm.15360.


Frye AM, Hart TM, Tufts DM, Ram S, Diuk-Wasser MA, Kraiczy P, Blom AM, Lin YP (2020) A soft tick Ornithodoros moubata salivary protein OmCI is a potent inhibitor to prevent avian complement activation. Ticks Tick Borne Dis, 11:101354, doi: 10.1016/j.ttbdis.2019.101354.


Moreira BP, Armstrong T, Batista ICA, Clemente Tavares N, Pires CV, de Moraes Mourão M, Falcone FH, Dekker LV (2020) Use of BODIPY-Labeled ATP Analogues in the Development and Validation of a Fluorescence Polarization-Based Assay for Screening of Kinase Inhibitors. ACS Publications. doi.org/10.1021/acsomega.9b03344.s001.


Haberger V, Elgner F, Roos J, Bender D, Hildt E (2020) Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells. Front Cell Dev Biol 8:44. doi: 10.3389/fcell.2020.00044.


Müller C, Obermann W, Schulte FW, Lange-Grünweller K, Oestereich L, Elgner F, Glitscher M, Hildt E, Singh K, Wendel HG, Hartmann RK, Ziebuhr J, Grünweller A (2020) Comparison of Broad-Spectrum Antiviral Activities of the Synthetic Rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol. Antiviral Res 175, 104706, doi: 10.1016/j.antiviral.2020.104706.


Dichter AA, Schultze TG, Becker SA, Tsukayama P, Kempf VAJ (2020) Complete Genome Sequence of Bartonella bacilliformis Strain KC584 (ATCC 35686). Microbiol Resour Announc 2;(9), doi: 10.1128/MRA.01377-19.


2019


Kellershohn J, Thomas L, Hahnel SR, Grünweller A, Hartmann RK, Hardt M, Vilcinskas A, Grevelding CG, Haeberlein S (2019) Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni. PLoS Negl Trop Dis. 13(3):e0007240. doi: 10.1371/journal.pntd.0007240.

 

Walter L, Sürth V, Röttgerding F, Zipfel PF, Fritz-Wolf K, Kraiczy P (2019) Elucidating the immune evasion mechanisms of Borrelia mayonii, the causative agent of Lyme disease. Front Immunol, 10:2722, doi: 10.3389/fimmu.2019.02722.


Barekzai J, Petry F, Zitzmann J, Czermak P, Salzig D (2019) Bioprocess Development for Human Mesenchymal Stem Cell Therapy ProductsNew Advances on Fermentation Processes, R. M. Martínez-Espinosa, Editors. 2019, InTechOpen. doi: 10.5772/intechopen.90029.

Thibau A, Dichter AA, Vaca DJ, Linke D, Goldman A, Kempf VAJ (2019) Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets. Med Microbiol Immunol, doi: 10.1007/s00430-019-00649-y.


Mojtahed Poor S, Ulshöfer T, Gabriel LA, Henke M, Köhm M, Behrens F, Geisslinger G, Parnham MJ, Burkhardt H, Schiffmann S (2019) Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab. Clin Exp Immunol 196: 259–275, doi: 10.1111/cei.13261.


Crauwels P, Bank E, Walber B, Wenzel A, Agerberth B, Chanyalew M, Abebe M, König R, Ritter U, Reiling N, van Zandbergen G (2019) Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages. Front Immunol 10: 2697, doi: 10.3389/fimmu.2019.02697.


Basic M, Elgner F, Bender D, Sabino C, Herrlein ML, Roth H, Glitscher M, Fath A, Kerl T, Schmalz HG, Hildt E (2019) A synthetic derivative of houttuynoid B prevents cell entry of Zika virus. Antiviral Res 172, 104644, doi: 10.1016/j.antiviral.2019.104644.

 

Millies B, von Hammerstein F, Gellert A, Hammerschmidt S, Barthels F, Göppel U, Immerheiser M, Elgner F, Jung N, Basic M, Kersten C, Kiefer W, Bodem J, Hildt E, Windbergs M, Hellmich UA, Schirmeister T (2019) Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases. J Med Chem, 62(24):11359-11382.

 

Houhou H, Puckelwaldt O, Strube C, Haeberlein S (2019) Reference gene analysis and its use for kinase expression profiling in Fasciola hepatica. Sci Rep 9, 15867, doi.org/10.1038/s41598-019-52416-x.

 

Peter Ventura AM, Haeberlein S, Lange-Grünweller K, Grünweller A, Hartmann RK, Grevelding CG, Schlitzer M (2019) Development of biarylalkyl carboxylic acid amides with improved antischistosomal activity. Chem Med Chem, 14(21):1856-1862. doi: 10.1002/cmdc.201900423.


Bender D, Hildt E (2019) Effect of hepatitis viruses on the Nrf2/Keap1-signaling pathway and its impact on viral replication and pathogenesis. Int J Mol Sci 20(18), 4659, doi.org/10.3390/ijms20184659.

 

Akhras S, Herrlein ML, Elgner F, Holzhauser T, Hildt E (2019) ZIKV envelope domain-specific antibodies: Production, purification and characterization. Viruses 11(8), doi: 10.3390/v11080748.


Sabino C, Basic M, Bender D, Elgner F, Himmelsbach K, Hildt E (2019) Bafilomycin A1 and U18666A efficiently impair ZIKV infection. Viruses 11(6), doi: 10.3390/v11060524.

 

Brandstaedter C, Delahunty C, Schipper S, Rahlfs S, Yates JR & Becker K (2019) The interactome of 2-Cys peroxiredoxins in Plasmodium falciparum. Sci Rep 9(1), 13542, doi: 10.1038/s41598-019-49841-3.

 

Caffrey CR, El-Sakkary N, Mäder P, Krieg R, Becker K, Schlitzer M, Drewry DH, Vennerstrom JL & Grevelding CG (2019) Drug discovery and development for Schistosomiasis. Neglected Tropical Diseases: Drug Discovery and Development, Wiley Online Library, doi:10.1002/9783527808656, Online ISBN:9783527808656.

 

Kadesch P, Quack T, Gerbig S, Grevelding CG & Spengler B (2019) Lipid topography in Schistosoma mansoni cryosections, revealed by microembedding and high-resolution atmospheric-pressure matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging. Analytical Chemistry, 91, 4520-4528.

 

Garcia-Quintanilla M, Dichter AA, Guerra H, Kempf VAJ (2019) Carrion's disease: more than a neglected disease. Parasit Vectors 12:141. doi: 10.1186/s13071-019-3390-2.

 

Li X, Haeberlein S, Zhao L, Mughal MN, Zhu T, Liu L, Fang R, Zhou Y, Zhao J, Grevelding CG, Hu M (2019) The ABL kinase inhibitor imatinib causes phenotypic changes and lethality in adult Schistosoma japonicum. Parasitol Res. doi: 10.1007/s00436-019-06224-x.


Haeussler K, Berneburg I, Jortzik E, Hahn J, Rahbari M, Schulz N, Preuss J, Zapol'skii VA, Bode L, Pinkerton AB, Kaufmann DE, Rahlfs S, Becker K (2019) Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies. Malar J 18:22. doi.org/10.1186/s12936-019-2651-z.


Lam van TV, Ivanova T, Hardes K, Heindl MR, Morty RE, Böttcher-Friebertshäuser E, Lindberg I, Than ME, Dahms SO, Steinmetzer T (2019) Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin. Chem Med Chem. doi: 10.1002/cmdc.201800807.


2018

 

Krüger N, Sauder C, Hüttl S, Papies J, Voigt K, Herrler G, Hardes K, Steinmetzer T, Örvell C, Drexler JF, Drosten C, Rubin S, Müller MA, Hoffmann M (2018). Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus. Cell Report 25(2):312-320.e7.

 

Phoo WW, Zhang Z, Wirawan M, Chen ECJ, Liang Alvin CB, Kouretova J, Steinmetzer T, Luo D (2018). Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors. Antiviral Research. doi: 10.1016/j.antiviral.2018.10.006.

 

Glitscher M, Himmelsbach K, Woytinek K, Johne R, Reuter A, Spiric J, Schwaben L, Grünweller A, Hildt E (2018). Inhibition of Hepatitis E Virus Spread by the Natural Compound Silvestrol. Viruses 10(6). pii: E301, doi: 10.3390/v10060301.

 

Müller C, Schulte FW, Lange-Grünweller K, Obermann W, Madhugiri R, Pleschka S, Ziebuhr J, Hartmann RK, Grünweller A (2018). Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Research 150:123-129.

 

Elgner F, Sabino C, Basic M, Ploen D, Grünweller A, Hildt E (2018). Inhibition of Zika Virus Replication by Silvestrol. Viruses. 27;10(4).

 

Hahnel S, Wheeler N, Lu Z, Wangwiwatsin A, McVeigh P, Maule A, Berriman M, Day T, Ribeiro P, Grevelding CG (2018) Tissue-specific transcriptome analyses provide new insights into GPCR signaling in adult Schistosoma mansoni. PLoS Pathogens 14(1): e1006718.

 

Grevelding CG, Langner S, Dissous C (2018) Kinases: Molecular Stage Directors for Schistosome Development and Differentiation. Trends in Parasitology Vol. 34(3), 246-260.

 

Preusser C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A (2018) Selective release of circRNAs in platelet-derived extracellular vesicles. J Extracell Vesicles, 7:1424473.

 

Henss L, Scholz T, Grünweller A, Schnierle B (2018). Silvestrol inhibits Chikungunja Virus Replication. Viruses 10(11), E592. doi: 10.3390/v10110592.

 

Himmelsbach K, Bender D, Hildt E (2018). Viral life cycle and morphogenesis of the Hepatitis E Virus. Emerg Microbes Infect 7(1):196. doi: 10.1038/s41426-018-0198-7.

 

Elgner F, Hildt E, Bender D (2018). Relevance of Rab proteins for the life cycle of Hepatitis C Virus. Front Cell Dev Biol 6: 166. doi: 10.3389/fcell.2018.00166.


Haeussler K, Fritz-Wolf K, Reichmann M, Rahlfs S, Becker K (2018) Characterization of Plasmodium falciparum 6-phosphogluconate dehydrogenase as an antimalarial drug target. J Mol Biol, 430:4049-4067.


Mäder P, Rennar GA, Ventura AMP, Grevelding CG, Schlitzer M (2018) Chemotherapy for fighting Schistosomiasis: Past, present and future. Chem Med Chem, 13(22):2374-238. doi: 10.1002/cmdc.201800572.


Schuh AK, Rahbari M, Heimsch KC, Mohring F, Gabryszewski SJ, Weder S, Buchholz K, Rahlfs S, Fidock DA, Becker K (2018) Stable integration and comparison of hGrx1-roGFP2 and sfroGFP2 redox probes in the malaria parasite Plasmodium falciparum. ACS Infect Dis 4;1601-1612.