Dr. Irina Häcker
Office: TIG / 2.41
Tel.: +49 641/99-39502
Institute for Insect Biotechnology
Department of Insect Biotechnology in Plant Protection
Winchester Str. 2
|2013 - present||Postdoctoral Associate Emmy Noether Group. Justus-Liebig University Giessen|
|2009 - 2013||
Postdoctoral Associate, Dept. of Molecular Genetics and Microbiology University
of Florida, Gainesville, Florida, USA
|2008 - 2009||
Postdoctoral Associate at the Max-Planck-Institute for Biophysical Chemistry,
|2004 - 2008||
Ph.D. at the Max-Planck-Institute for Biophysical Chemistry,
|1999 - 2004||Diploma in Biochemistry at the University Bayreuth, Germany|
Irina Häcker graduated from the University of Bayreuth with a diploma degree in Biochemistry. For her Ph.D. she moved to the laboratory of Prof. Dr. Reinhard Lührmann at the Max-Planck-Institute for Biophysical Chemistry in Göttingen where she applied biochemical and structural biology techniques to solve questions about the mechanism of pre-mRNA splicing. Her research was supported by scholarships of the „Verband der Chemischen Industrie“ and the Max-Planck Society. She then spent four years in the laboratory of Prof. Dr. Rolf Renne to detect new cellular pathways regulated by the microRNAs of Kaposis sarcoma-associated herpesvirus (KSHV). Moreover, she collaborated with the group of Prof. Dr. Michael Kladde to provide new insights into the epigenetic regulation of viral reactivation. Since May 2013 Irina Häcker is working as Postdoc in the Emmy Noether group of Dr. Marc F. Schetelig. Her research interests are the development of new genetic systems to use in SIT (Sterile Insect Technique) programs for mosquito control and the risk assessment of transgenic systems for environment-friendly pest control.
Häcker I, Schetelig MF (2019). Genome editing and its applications for insect pest control: Curse or Blessing (IAEA Conference Book); submitted
Häcker I, Schetelig MF (2018). Molecular tools to create new strains for mosquito sexing and vector control. Parasites & Vectors 11 (Suppl 2):645
Aumann RA, Schetelig MF, Häcker I (2018). Highly efficient genome editing by homology-directed repair using Cas9 protein in Ceratitis capitata. Insect Biochemistry and Molecular Biology 101: 85-93.
Häcker I, Bourtzis K, Schetelig MF (2018). Applications of modern molecular technologies in support of the sterile insect technique. Sterile Insect Technique, 2nd Edition, Editors Arnold Dyck, Jorge Hendrichs, under review
Häcker I, Aumann R, Schetelig MF (2017). Vector control strategies for mosquitoes. Zeitschrift für Naturforschung C 72 (9-10): e11.
Häcker I, Harrell II RA, Eichner G, Pilitt KL, O’Brochta DA, Handler AM, Schetelig MF (2017). Cre/lox-Recombinase-Mediated Cassette Exchange for Reversible Site-Specific Genomic Targeting of the Disease Vector, Aedes aegypti. Scientific Reports, 7: 43883
Vaibhav Jain V, Plaisance-Bonstaff K, Sangani R, Lanier C, Dolce A, Hu J, Brulois K, Haecker I, Turner P, Renne R, Krueger B (2016). A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants. Viruses 8 (2): 1–12.
Haecker I, Renne R (2014). HITS-CLIP and PAR-CLIP advance viral miRNA targetome analysis. Critical Reviews in Eukaryotic Gene Expression, 24 (2): 101–116.
Plaisance-Bonstaff K, Choi HS, Beals T, Krueger BJ, Boss IW, Gay LA, Haecker I, Hu J, Renne R (2014). KSHV miRNAs decrease expression of lytic genes in latently infected PEL and endothelial cells by targeting host transcription factors. Viruses 6 (10): 4005–4023.
Yang Y, Fear J, Hu J, Haecker I, Zhou L, Renne R, Bloom D, McIntyre LM (2014). Leveraging biological replicates to improve analysis in ChIP-seq experiments. Computational and Structural Biotechnology Journal 9 (13): 1–10.
Darst RP, Haecker I, Pardo CE, Renne R, Kladde MP (2013). Epigenetic diversity of Kaposi's sarcoma-associated herpes virus. Nucleic Acids Research 41 (5): 2993–3009.
Zhu Y, Haecker I, Yang Y, Gao SJ, Renne R (2013). γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis. Current Opinion in Virology 3 (3): 266–275.
Haecker I, Gay LA, Yang Y, Hu J, Morse AM, McIntyre LM, Renne R (2012). Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas. PLoS Pathogens 8 (8) e1002884
Häcker I, Sander B, Golas MM, Wolf E, Karagöz E, Kastner B, Stark H, Fabrizio P, Lührmann R (2008). Localization of Prp8, Brr2, Snu1 14 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nature Structural and Molecular Biology 15 (11): 1206–1212.
- 2012: Trainee Award, UF Shands Cancer Center, University of Florida, USA
- 2008 – 2009: Max-Planck Postdoc fellowship
- 2005 – 2007: Kekule PhD fellowship, Fonds der Chemischen Industrie
- 2005: Otto Braun fellowship, University of Kassel, Germany
- Speaker: 4thRCM by the IAEA on the sex separation in mosquitoes, 2018, Bangkok, Thailand.
- Invited speaker: Göttingen Spirit Summer School, 2017, Göttingen, Germany.
- Invited speaker: Bio-Rad ddPCR Expert Day, 2017.
- Speaker: 3rdRCM by the IAEA on the sex separation in mosquitoes, 2016, Tapachula, Mexico.
- Speaker: 1stRCM by the IAEA on the rearing efficiency and competitiveness of sterile males, 2015, Vienna, Austria.
- Speaker: 2ndRCM by the IAEA on the sex separation in mosquitoes, 2015, Juazeiro, Brazil.
- Invited speaker: Gametocyte meeting, 2014, Fraunhofer IME, Aachen, Germany.
Professional Societies and Engagement
- 2017 – present: Project manager for biological lab safety, Fraunhofer IME-BR
- 2017 – present: Fraunhofer Society
- 2005 – 2009: Max-Planck Society
- 2004 – present: Verband Biologie, Biowissenschaften & Biomedizin in Deutschland
- MP 090 – Biotechnology in pest control
- MP 149 – Molecular Techniques
- MP 156 – Laboratory Course I
- MP 157 – Laboratory Course II
- BP 038 – Agrarökologie und integrierter Pflanzenschutz
- Bachelor, Master, and PhD theses