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Publications

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EU Research Deckblatt  Download EU Resarch PDF
Research into underlying reasons for infertility in men.
Steger K, Gromoll J

EU Research, 7:101-103 (2011)

Project Target 2020   Download Project PDF
Research into underlying reasons for infertility in men.
Steger K, Gromoll J

British Publishers, Project - Target 2020:55-58 (2010)

Spitzenforschung Urologie_StegerDownload Spitzenforschung Urologie
Der Histon-Protamin-Austausch während der Spermiogenese : Mögliche Funktionen von Resthistonen.
Steger K, Paradowska A, Weidner W

Lebendige Wissenschaft / Spitzenforschung i. d. Urologie 2:176-183 (2009)

Reviews

Impact of father's diet on sperm quality and offspring's health
Schgadrsurengin U, Steger K
Nat Rev Urol [online] August 2016

Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells - Its relevance for CNP degradation

Thong A, Müller D, Feuerstacke C, Mietens A, Stammler A, Middendorff R

Mol Cell Endocrinol 25:234-243 (2014)

Analysing the sperm epigenome: roles in early embryogenesis and assisted reproduction
Schagdarsurengin U, Paradowska A, Steger K

Nat Rev Urol 9:609-619 (2012)

Prognostic markers for competent human spermatozoa: fertilizing capacity and contribution to the embryo
Steger K, Cavalcanti M, Schuppe HC

Int J Androl 34:513-527 (2011)

Testicular innate immune defense against bacteria
Bhushan S, Schuppe HC, Tchtatalbachev S, Fijak M, Weidner W, Chakraborty T, Meinhardt A

Mol Cell Endocrinol 306:37-44 (2009)

The Neuroendocrine Leydig cells and their stem cell progenitors, the pericytes
Davidoff MS, Middendorff R, Müller D, Holstein AF

Adv Anat Embryol Cell Biol 205:1-107 (2009)

Testicular sperm retrieval in azoospermic men
Pantke P, Diemer T, Marconi M, Bergmann M, Steger K, Schuppe HC, Weidner W

Eur Urol Suppl 7:703-714 (2008)

Publications 2015-2016

  • Kai N, Dansranjavin T, Rogenhofer N, Deuker J, Bergmann M, Schuppe HC, Wagenlehner FM, Weidner W, Steger K, Schagdarsurengin U: Ten-Eleven-Translocation (TET) enzymes are successively activated during human spermatogenesis and their expression level is pivotal for male fertility. Human Reproduction [Epub ahead of print] (2016)

  • Ni K, Spiess AN, Schuppe HC, Steger K: The impact of sperm protamine deficiency and sperm DNA damage on human male fertility: a systematic review and meta-analysis. Andrology [ahead of print] 2016

  • Biswas B, Bhushan S, Rajesh A, Suraj SK, Lu Y, Meinhardt A, Yenugu S. Uropathogenic Escherichia coli (UPEC) induced antimicrobial gene expression in the male reproductive tract of rat: evaluation of the potential of Defensin 21 to limit infection. Andrology 368-375 (2015)
  • Dietze R, Shihan M, Stammler A, Konrad L, Scheiner-Bobis G. Cardiotonic steroid ouabain stimulates expression of blood-testis barrier proteins claudin-1 and -11 and formation of tight junctions in Sertoli cells. Mol Cell Endocrinol 405:1-13 (2015)
  • Silva JV, Korrodi-Gregório L, Lüers G, Cardoso MJ, Patrício A, Maia N, da Cruz E, Silva EF, Fardilha M. Characterisation of several ankyrin repeat protein variant 2, a phosphoprotein phosphatase 1-interacting protein, in testis and spermatozoa. Reprod Fertil Dev.  [Epub ahead of print] (2015).
  • Simon P, Feuerstacke C, Kaese M, Saboor F, Middendorff R, Galuska SP. Polysialylation of NCAM characterizes the proliferation period of contractile elements during postnatal development of the epididymis. PLOS One 10(3):e0123960 (2015)
  • Sokurenko Yu V, Zelenikhin PV, Ulyanova VV, Kolpakov AI, Müller D, Ilinskaya ON. Identification of 2', 3'-cGMP as an intermediate of RNA catalytic cleavage by binase and evaluation of its biological action. Russ J of Bioorganic Chemistry 41(1):31-36 (2015)
  • Stammler A, Hau T, Bhushan S, Meinhardt A, Jonigk D, Lippmann T, Pilatz A, Schneider-Hüther I, Middendorff R. Epidi-dymitis: ascending infection restricted by segmental boundaries. Human Reprod 30(7):1557-1565 (2015)
  • Vieweg M, Dvorakova-Hortova K, Dudkova B, Waliszewski P, Otte M, Oels B, Hajimohammad A, Turley H, Schorsch M, Schuppe HC, Weidner W, Steger K, Paradowska-Dogan A. Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients. Clin Epigenetics 19;7(1):31 (2015)
  • Expression of sperm-specific protamines impairs eukaryotic and bacterial cell proliferation

    Günther K, Paradowska-Dogan A, Klein H, Eichel-Streiber C, Bärmann B, Hertley R, Weidner W, Behr R, Steger K. Histochem & Cell Biol 143:599-609 (2015)

Publications 2014

  • Bartel J, Feuerstacke C, Galuska CE, Weinhold B, Gerardy-Schahn R, Geyer R, Münster-Kühnel A, Middendorff R, Galuska SP: Laser microdissection of paraffin embedded tissue as a tool to estimate the sialylation status of selected cell populations. Anal Chem 86:2326-2331(2014)
  • Borgers M, Wolter M, Hentrich A, Bergmann M, Kliesch S, Stammler A, Konrad L. Role of compensatory mechanisms in impaired spermatogenesis. Reproduction, 148:315-320 (2014)
  • Dottermusch-Heidel C, Klaus ES, Gonzalez NH, Bhushan S, Meinhardt A, Bergmann M, Renkawitz-Pohl R, Rathke C, Steger K:  H3K79 methylation directly precedes the histone-to-protamine transition in mammalian spermatids and is sensitive to bacterial infections. Andrology 5: 655-665 (2014)
  • Mietens A, Tasch S, Stammler A, Konrad L, Feuerstacke C, Middendorff R: Time-lapse imaging as a tool to investigate contractility of the epididymal duct-effects of cgmp signaling. PLoS One. 9:e92603 (2014)
  • Ni K, Steger K, Yang H, Wang H, Hu K, Chen B: Sperm protamine mRNA ratio and DNA fragmentation index represent reliable clinical biomarkers for men with varicocele after microsurgical varicocele liguation. J Urol 2:521-530  (2014)
  • Paradowska-Dogan A, Fernandez A, Bergmann M, Kretzer K, Mallidis C, Vieweg M, Waliszewski P, Zitzmann M, Weidner W, Steger K, Kliesch S: Protamine mRNA ratio stallion spermatozoa correlates with mare fecundity. Andrology 2:521-530 (2014)
  • Pilatz A, Lochnit G, Karnati S, Paradowska-Dogan A, Lang T, Schultheiss D, Schuppe HC, Hossain H, Baumgart-Vogt E, Weidner W, Wagenlehner F. Acute epididymitis induces alterations in sperm protein composition. Fertil Steril. 101:1609-1617 (2014).
  • Samans B, Yang Y, Krebs St, Gaurav S, Blum H, Reichenbach M, Wolf E, Steger K, Dansranjavin T, Schagdarsurengin U: Uniformity of nucleosome preservation pattern in mammalian sperm and its connection to repetitive DNA elements. Dev Cell 30:23-35 (2014)
  • Thong A, Müller D, Feuerstacke C, Mietens A, Stammler A, Middendorff R: Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells - Its relevance for CNP degradation. Mol Cell Endocrinol 25:234-243 (2014)
  • Weidner W, Schuppe HC, Pilatz A, Altinkilic B, Diemer T: Sperm cells for artificial reproduction and germ cell transplantation. Eir Urol Suppl 13:83-88 (2014)

Publications 2013

  • The sperm protamine ratio as a clinical parameter to estimate the fertilizing potential of subfertile men taking part in an ART program.
    Rogenhofer N, Dansranjavin T, Schorsch M, Spiess A, Wang H, Schönfeldt V, Vapallo-Obermann H, Baukloh V, Yang H, Paradowska A, Chen B, Thaler C, Weidner W, Schuppe HC, Steger K. Hum Repord 28:969-978 (2013)
  • Evaluating the localization and DNA binding complexity of histones in mature sperm.
    Miller D, Paradowska A. Methods Mol Biol 927:459-475 (2013)
  • Grant P, Ahlemeyer B, Karnati S, Berg T, Stelzig I, Nenicu A, Kuchelmeister K,Crane DI, Baumgart-Vogt E. The biogen-esis protein PEX14 is an optimal marker for the identification and localization of peroxisomes in different cell types, tissues, and species in morphological studies. Histochem Cell Biol 140:423-442 (2013)

  • Günther S, Fietz D, Weider K, Bergmann M, Brehm R: Effects of a murine germ cell-specific knockout of Connexin 43 on Connexin expression in testis and fertility. Transgenic Res 22:631-641 (2013)

  • Karnati S, Lüers G, Pfreimer S, Baumgart-Vogt E. Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes. Histochem Cell Biol 140:105-117 (2013).

  • Bacterial prostatitis Wagenlehner FM, Pilatz A, Bschleipfer T, Diemer T, Linn T, Meinhardt A, Schagdarsurengin U, Dansranjavin T, Schuppe HC, Weidner W. World J Urol 31:711-716 (2013)
  • Prostatitis and andrological implications Wagenlehner F, Pilatz A, Linn T, Diemer T, Schuppe HC, Schagdarsurengin U, Hossain H, Meinhardt A, Ellem S, Risbridger G, Weidner W.Minerva Urol Nefrol 65:117-23 (2013)

Transgenic Res 22:631-641 (2013)

Budnik LT, Brunswig-Spickenheier B, Müller D

Signaling and Biochemistry. New Jersey: John Wiley & Sons; p. 569-586 (2013)

Publications 2012

Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M

J Biol Chem 287:17930-17941 (2012)

Mietens A, Tasch S, Feuerstacke C, Eichner G, Volkmann J, Schermuly RT, Grimminger F, Müller D, Middendorff R

Mol Cell Endocrinol 349:145-153 (2012)

Marconi M, Keudel A, Diemer T, Bergmann M, Steger K, Schuppe H, Weidner W

Eur Urol 62:713-719 (2012)

Paradowska A, Miller D, Spiess AN, Vieweg M, Cerna M, Dvorakova-Hortova K, Bartkuhn M, Schuppe HC, Weidner W, Steger K

Epigenetics 7:1057-1070 (2012)

Konrad L, Kuhnert S, Nayudu P, Einspanier R, Hinsch KD, Hinsch E

Andrologia 44: 349-353 (2012)

Cavalcanti MCO, Failing K, Schuppe HC, Bergmann M, Stalf T, Weidner W, Steger K

Andrologia 43:78-83 (2012)

Asmarinah T, Nuraini T, Sumarsih T, Paramita R, Saleh M, Narita V, Moelek N, Steger K, Hinsch KD, Hinsch E

Andrologia 44: 46-52 ( 2012)

Giese S, Hossain H, Markmann M, Chakraborty T, Tchatalbachev S, Guillou F, Bergmann M, Failing K, Weider K, Brehm R

Disease Model & Mechanisms 5:895-913 (2012)

Publications 2011

Uropathogenic E.coli induce different immune response in testicular and peritoneal macrophages: implications for testicular privilege
Bhushan S, Hossain H, Lu Y, geisler A, Tchatalbachev S, Mikulski Z, Schuler G, Klug J, Pilatz A, Wagenlehner FME, Chakraborty T, Meinhardt A

PLos One 6:e28452 (2011)

Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa
Steilmann C, Paradowska A, Bartkuhn M, Vieweg M, Schuppe HC, Bergmann M, Kliesch S, Weidner W, Steger K

Reprod Fertil Dev 23:997-1011 (2011)

Germ cells of male mice express genes for peroxisomal metabolic pathways implicated in the regulation of spermatogenesis and the protection against oxidative stress
Dastig S, Nenicu A, Otte DM, Zimmer A, Seitz J, Baumgart-Vogt E, Lüers GH

Histochem Cell Biol 136:413-425 (2011)

Mixed Testicular Atrophy Related to Atherosclerosis: First Lessons from the ApoE-/-/LDL Receptor-/- Double Knockout Mouse Model
Langheinrich A, Paradowska A, Kilinski R, Kampschulte M, Steinfeld K, Altinkilic B, Steger K, Stieger Philipp, Bergmann M, Weidner W

Int J Androl 35:562-571 (2011)

Evaluation of CAG repeat length of androgen receptor expressing cells in human testes showing different pictures of spermatogenic impairment
Fietz D, Geyer J, Kliesch S, Gromoll J, Bergmann M

Histochem Cell Biol 136:689-697 (2011)

Cardiotonic steroids trigger nonclassical testosterone signaling Sertoli cells via the a4 isoform of the sodium pump
Konrad L, Dietze R, Kirch U, Eva A, Scheiner-Bobis G

BBA Mol Cell Res 1813:21118-2124 (2011)

Male Fertility Depends on Ca2+ Absorption by TRPV6 in Epididymal Epithelia
Wiessgerber P. Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M

Science Signaling Vol 4 Issue 171:ra27 (2011)

Cyclic GMP signaling in rat urinary bladder, prostate and epididymis: Tissue-specific changes with aging and in response to Leydig cell depletion
Müller D, Mukhopadhyay AK, Davidoff MS, Middendorff R

Reproduction 142:333-343 (2011)

Reduced numbers of Sertoli, germ, and spermatogonial stem cells in impaired spermatogenesis
Hentrich A, Wolter M, Szardening-Kirchner C, Lüers GH, Bergmann M, Kliesch S, Konrad L

Modern Pathol 24:1380-1389 (2011)

Apoptotic gene expression in potentially fertile and subfertile men
Cavalcanti MCO, Steilmann C, Failing K, Bergmann M, Kliesch S, Weidner W, Steger K

Mol Hum Reprod 17:451-420 (2011)

Overexpression of peroxisomal testis-specific1 protein induces germ cell apoptosis and leads to infertility in male mice
Kaczmarek K, Studencka M, Meinhardt A, Wieczerak K, Thoms S, Engel W, Grzmil P

Mol Cell Biol 22:1766-1779 (2011)

Recognising the Sertoli-cell-only (SCO) syndrome: a case study
Anniballo R, Brehm R, Steger K

Andrologia 43:78-83 (2011)

Disturbed spermatogenesis associated with thickened lamina propria of seminiferous tubules is not caused by dedifferentiation of myofibroblasts
Volkmann J, Müller D, Feuerstacke C, Kliesch S, Bergmann M, Mühlfeld C, Middendorff R

Hum Reprod 26:1450-1461 (2011)

Publications 2010

Protamine-1 represents a sperm specific gene transcript: a study in Callithrix jacchus and Bos taurus
Hecht N, Cavalcanti MC, Nayudu P, Behr R, Reichenbach M, Weidner W, Steger K

Andrologia 43:167-173 (2010)

Role of Glycerol-3-phosphate dehydrogenase 2 in mouse sperm capacitation
Kota V, Rai P, Weitzel J, Middendorff R, Bhande S, Shivaji S

Mol Reprod Dev 77:773-783 (2010)

Temporal patterns of blood flow and nitric oxide synthase expression affect macrophage accumulation and proliferation during collateral growth
Sager H, Middendorff R, Rauche K, Weil J, Lieb W, Schunkert H, Ito WD

J Angiogenesis Res 2:18 (2010)

Aberrant mRNA expression of chromatin remodelling factors in round spermatid maturation arrest compared with normal human spermatogenesis
Steilmann C, Cavalcanti MCO, Bergmann M, Kliesch S, Weidner W, Steger K

Mol Hum Reprod 16:726-733 (2010)

The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men
Steilmann C, Cavalcanti MC; Bartkuhn M, Pons-Kühnemann J, Schuppe HC, Weidner W, Steger K, Paradowska A

Reproduction 140: 435-43 (2010)

Major involment of connexin 43 in seminiferous epithelial junction dynamics and male fertility
Carrette D, Weider K, Gilleron J, Giese S, Dompierre J, Bergmann M, Brehm R, Denizot JP, Segretain D, Pointis G

Dev Biol 346:54-67 (2010)

Publications 2009

The common marmoset (Callithrix jacchus) as a model for histone and protamine expression during human spermatogenesis
Hecht N, Behr R, Hild A, Bergmann M, Weidner W, Steger K

Hum Reprod 24:536-45 (2009)

A novel sequence variation in the transactivation regulation domain of the human androgen receptor
Hose K, Häffner K, Fietz D, Gromoll J, Eckert T, Kliesch K, Siebert HC, Bergmann M

Fertil Steril 92:390.e9-390.e11 (2009)

Molecular pathogenesis of male infertility due to peroxisome dysfunction in sertoli cells
Nenicu A, Okun JG, Hartmann M, Wudy St, Guillou F, Crane DI, Baumgart-Vogt E

Biol Reprod 81:682 (2009)

Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences
Arpanahi A, Brinkworth M, Iles D, Krawetz SA, Paradowska A, Platts AE, Saida M, Steger K, Tedder P, Miller D

Genome Res 19:1338-49 (2009)

Bhushan S, Schuppe HC, Tchtatalbachev S, Fijak M, Weidner W, Chakraborty T, Meinhardt A: Testicular innate immune defense against bacteria. Mol Cell Endocrinol 306:37-44 (2009)


Davidoff MS, Middendorff R, Müller D, Holstein AF: The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes. Adv Anat Embryol Cell Biol 205:1-107 (2009)

 

Publications 2008

Both protamine-1 to protamine-2 mRNA ratio and Bel2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between ferile and infertile men
Steger K, Wilhelm J, Konrad L, Stalf T, Greb R, Diemer T, Kliesch S, Bergmann M, Weidner W

Hum Reprod 23:112-116 (2008)

In-vivo application of histone deacetylase inhibitor trichostatin-A impairs murine male meiosis
Fenic I, Hossain HM, Sonnack V, Tchatalbachev S, Thierer F, Trapp J, Failing K, Edler KS, Bergmann M, Jung M, Chakraborty T, Steger K

J Androl 29:172-185 (2008)

Identification of a new Smad6 splice variant
Konrad L, Scheiber JA, Bergmann M, Eickelberg O, Hofmann R

Andrologia 40:358-363 (2008)

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Schermuly RT, Stasch JP, Pullamsetti SS, Middendorff R, Müller D, Schlüter KD, Dingendorf A, Kolosionek E, Hackemack S, Kaulen C, Medebach T, Dumitrascu R, Weissmann N, Mittendorf J, Klepetko W, Seeger W, Ghofrani HA, Grimminger F

Eur Respir J 32:881-891 (2008)

Erg K+ channels modulate contractile activity in the bovine epididymal duct
Mewe M, Wulfsen I, Schuster A, Middendorff R, Glassmeier G, Schwarz JR, Bauer CK

Am J Physiol Reg I 294: R895-R904 (2008)

Uropathogenic Escherichia coli block MyD88-dependent and activate MyD88-independent signaling pathways in rat testicular cells
Bhushan S, Tchatalbachev S, Klug J, Fijak M, Pineau C, Chakraborty T, Meinhardt A.

J Immunol 180:5537-47 (2008)

TESE and mTESE. Therapeutic options in male infertility due to testicular azoospermia
Weidner W, Steger K, Paradowska A, Marconi M, Pantke KH, Diemer T

Urologe 47:1106-1108-11 (2008)

Pantke P, Diemer T, Marconi M, Bergmann M, Steger K, Schuppe HC, Weidner W: Testicular sperm retrieval in azoospermic men. Eur Urol Suppl 7:703-714 (2008)

Other Publications

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