Die Verbundprojekte bilden das Herzstück des Innovations- und Forschungsprogramm der EU. Im Zentrum stehen all diejenigen Maßnahmen, welche auf die grenzüberschreitende Zusammenarbeit der Teilnehmer innerhalb Europas bzw. auf ihre internationale Kooperation mit Drittstaaten abzielen.
Natural epidemics and outbreaks of emerging viral epidemics are growing problems internationally. The General aim of the CCHFVaccine project is to develop and deliver a vaccine, which can significantly increase our capacity to control the situation of Crimean Congo Haemorrhagic fever (CCHF) disease on a global basis. The proposed work program on CCHF virus aims to build a multidisciplinary research network, able to deliver vaccine candidates, methods and procedures eligible for clinical trials, with a special focus on prevention. Thanks to the background, unique facilities and tools available among the consortium participants, CCHFVaccine will deliver tools for countering the threat of this infection in Europe and endemic areas of the world. This work program will attempt to fill gaps in CCHFV virus research on immunology and vaccinology. To achieve this overall aim, an intensive work plan will be put in place with the following specific objectives: i) to produce vaccine candidates, ii) to bring several unique animal models into front line vaccine research, iii) to validate and bring the most promising vaccine candidates to clinical trials, iv) to ensure that an immune mediated protection is adequately understood, v) to perform clinical trials at Phase I and ensure a strategy for the effective deployment and utilization in resource-poor countries, and vi) to link this project to public health bodies, NGOs and vaccine companies.
The proposed CCHFVaccine project will succeed in bringing together selected competitive advantages such as: operating capacity with appropriate facilities (state-of-the-art BSL-4s) and the only animal BSL-4 -with capacity to challenge domestic animals in Europe, highly experienced researchers in the development and evaluation of vaccine candidates, authorities and entities of human and animal health, clinical samples from endemic countries, and an international network proven to be functional by the previous EU-funded CCHFever and EDENext.
Thematische Ausrichtung: Health
Laufzeit: 01/2017 - 12/2022
Projektpartner: Prof. Dr. Friedemann Weber, Fb10
MINOTOR’s strategic objective is to demonstrate the feasibility of the ECRA technology as a disruptive game-changer in electric propulsion, and to prepare roadmaps paving the way for the 2nd EPIC call, in close alignment with the overall SRCEPIC strategy.
Based on electron cyclotron resonance (ECR) as the sole ionization and acceleration process, ECRA is a cathodeless thruster with magnetic nozzle, allowing thrust vectoring. It has a considerable advantage in terms of global system cost, where a reduction of at least a factor of 2 is expected, and reliability compared to mature technologies. It is also scalable and can potentially be considered for all electric propulsion applications, from microsatellites to space tugs.
Although the first results obtained with ECRA have been encouraging, the complexity of the physics at play has been an obstacle for the understanding and development of the technology. Thus an in-depth numerical and experimental investigation plan has been devised for the project, in order to bring the technology from TRL3 to TRL5. The strong consortium is composed of academic experts to perform the research activities on ECRA, including alternative propellants, along with experienced industrial partners to quantify its disruptive advantages on the propulsion subsystem and its market positioning.
ECRA’s advantages as an electric thruster technology can be a disruptive force in a mostly cost-driven satellite market. It would increase European competitiveness, help develop low-cost satellite missions such as constellations, provide end-oflife propulsion, and pave the way for future emerging electric propulsion technologies.
The 36 months MINOTOR project requests a total EC grant of 1 485 809 M€ for an experienced consortium of 7 partners from 4 countries: ONERA (FR, Coordinator), industries Thales Alenia Space (BE), Thales Microelectronics (FR), SNECMA (FR), Universities Carlos III (ES) and Giessen (GE), and SME L-up (FR).
Thematische Ausrichtung: Space
Laufzeit: 01/2017 - 12/2019
Projektpartner: Dr. Kristof Holste, Fb07
The current approach to diagnosis and management of the rare disease systemic sclerosis (SSc) is based on American College of Rheumatology criteria with low sensitivity and few validated recommendations for the therapy of the disease and its manifold organ manifestations. To overcome these shortcomings, the DeSScipher project will use the multinational, prospective and open EUSTAR (Scleroderma Trials and Research group of the European League Against Rheumatism) SSc cohort based on the established MEDSonline database which covers >30 data items and will evolve into a multimodular tool to answer step-by-step all immanent questions in a long-term setting according to the nature of the disease. The resulting progress will address functionally disabling manifestations affecting the hands (digital ulcers and arthritis), and compare the efficacy and safety of off-label drugs in the treatment of vital organ manifestations. Specifically, the DeSScipher project will evaluate (i) the utility of a combination of easy-to-perform clinical and laboratory investigations in combination with capillaroscopy for identifying SSc patients at risk for the development of digital ulcers at an early stage (ii) the prevention and treatment of digital ulcers and hand arthritis in order to improve long-term disability and quality of life, (iii) the efficacy of different immunosuppressive agents in attenuating or inhibiting pulmonary fibrosis, (iv) the optimal treatment options for reducing morbidity and mortality of pulmonary hypertension and severe heart disease in SSc. Based on the results of these observational trials, the DeSScipher project will develop evidence-based clinical guidelines for the future management of adult and juvenile SSc to be disseminated widely and rapidly to physicians and patients. Novel outcome measures will also be provided as a basis for future clinical trials.
Thematische Ausrichtung: Health
Laufzeit: 12/2012 - 11/2015
Koordinator: Prof. Dr. Ulf Müller-Ladner, Fb11
IACOBUS: Diagnosis and Monitoring of Inflammatory and Arthritic diseases using a COmbined approach Based on Ultrasound, optoacoustic and hyperSpectral imaging
Rheumatoid arthritis (RA) and psoriasis arthritis (PSA) are destructive polyarthritic diseases having high incidence rates worldwide of about 1,5% and 0,5% respectively. Arthritis-related joint destruction leads to disabilities which result in a loss of patient’s quality of life, often include an inability to work and significant costs for healthcare systems. The functional outcome is strongly dependent on the time lag between the onset of the disease and the treatment beginning (ideally < 3-6 months). For early diagnosis allowing to improve the course of this devastating disease, sensitive and accurate diagnostic tools are required. Further, excellent image quality is needed for differentiated diagnosis (osteoarthritis vs RA or PSA) permitting the stratification of patient groups required for enabling a personalized therapeutical approach. Therefore, tools for early, precise and reliable diagnosis being affordable for screenings are of highest importance. Within IACOBUS, we suggest a new multimodal approach combining hyperspectral imaging with ultrasound (US) and optoacoustic (OA) techniques for diagnosis of arthritic diseases in finger joints. The proposed concept will allow the diagnosis and monitoring of arthritis based on imaging of early inflammation-induced hyperperfusion. Hyperspectral overview imaging for identification of suspicious joints will be combined with detailed high-resolution 3D imaging of affected joints (OA/US). Osteochondral information will be provided by high-frequency US while OA imaging will allow the high-sensitivity imaging of microvasculature in inflamed tissue. The consortium consisting of 4 SMEs and 3 academic partners will develop a novel non-invasive image-based diagnostic tool with significantly enhanced sensitivity for early arthritis symptoms and thereby allow to make use of the therapeutical window of opportunities. 50% of the overall project budget will go to SMEs which will ensure the exploitation of the developed platform.
Thematische Ausrichtung: Health
Laufzeit: 01/2013 - 12/2015
Projektpartner: Prof. Dr. Ulf Müller-Ladner, Fb11
Orama is on the development of new high performance multifunctional oxide based electronic materials, processable at low temperatures, including flexible substrates that have the potential to catapult the electronics industry into a new era of growth. Orama will develop, analyze and utilize these new materials and techniques to investigate into device concepts highlighting the potential of oxides as electronic materials in the automotive industry – a highly competitive environment being of high importance for Europe’s industry with challenging demands on information, sensor and resource efficient energy technology to provide sustainable mobility for the European society. It will achieve this by addressing the four key elements being essential for building up the new era of oxide based electronic industry: 1st principle material modelling, synthesis of new materials, development of low temperature and damage free deposition and patterning techniques and novel characterization methods.
Thematische Ausrichtung: Nanosciences, Nanotechnologies, Materials and new Production Technologies/NMP
Laufzeit: 10/2010 - 09/2014
Projektpartner: Prof. Dr. Bruno Meyer, Fb07
The effort to strengthen social cohesion and lower social inequalities is among Europe’s main policy challenges. It means that local welfare systems are at the forefront of the struggle to address this challenge – and they are far from winning. While the statistics show some positive signs, the overall picture still shows sharp and sometimes rising inequalities, a loss of social cohesion and failing policies of integration. But, contrary to what is sometimes thought, a lack of bottom-up innovation is not the issue in itself. European cities are teeming with new ideas, initiated by citizens, professionals and policymakers. The problem is, rather, that innovations taking place in the city are not effectively disseminated because they are not sufficiently understood. Many innovations are not picked up, because their relevance is not recognised or they fail after they have been introduced, because they were not suitable to the different conditions in another city in another country. In this project, we will look into this missing link between innovations at the local level and their successful transfer and implementation to other settings. We will examine innovation in cities, not as a disconnected phenomenon, but as an element in a tradition of welfare that is part of particular socio-economic models and the result of specific national and local cultures. By contextualising innovations in local welfare, will be more effective in understanding how they could work in other cities, for the benefit of other citizens. In short, the aim of the project is to examine, through cross-national comparative research, how local welfare systems affect social inequalities and how they favour social cohesion and sustainability. The results will be used, through strong interaction with stakeholders and urban policy recommendations, to link immediately to the needs of practitioners.
Thematische Ausrichtung: Socio-economic Sciences and Humanities/SSH
Laufzeit: 12/2010 - 11/2013
Projektpartner: Prof. Dr. Adalbert Evers, Fb09
mismatch2model: Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance
Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability. In both bacteria and eukaryotes, the loss of mismatch repair gives rise to a mutator phenotype. In hereditary non-polyposis colon cancer (HNPCC) families, germline mutations in one MSH2, MSH6 or MLH1 allele predispose to cancer of the colon, endometrium, ovary and other organs. HNPCC is the most frequent form of familiar cancer. In the mismatch2model project we adopt and exploit a systems biology approach in which we combine Europe’s expertise in DNA mismatch repair with sophisticated multidisciplinary technology and expertise in quantitative modeling in order to describe this DNA repair process at different levels of complexity. The multidisciplinary consortium will have the following tasks that relate directly to the topics raised in Call HEALTH 126.96.36.199: - Gather quantitative and structural data sets describing the principal steps of DNA mismatch repair - Integrate and analyze structural and functional data obtained from single molecule and bulk studies - Develop mathematical models for single and/or multiple steps of the MMR pathway - Perform analyses at different levels of complexity: from recognition of the mismatch through repairosome assembly to in vivo function - Combine the well-understood MMR E.coli model system with the cancer-protective human system The combination of the individual strengths of the multidisciplinary groups involved in this program ensures that significant progress will be made towards the understanding of this complex process.
Thematische Ausrichtung: Health
Laufzeit: 11/2008 - 10/2012
Projektpartner: Prof. Dr. Peter Friedhoff, Fb08
Cattle farming is one of the most important agricultural activities in the EU. This project will address issues of the health and welfare of cattle and the safety of cattle products, focussing on diseases that are on the increase in European cattle population and are of growing concern elsewhere. Two related diseases will be targeted, bovine tuberculosis (TB) and bovine paratuberculosis (Para-TB or Johnes disease). The objective of the proposed project is to use a combined functional and classical genomics and system biology approaches (systems genetics) to investigate host-pathogen interactions and the host immune response to myco-bacterium infection. The outcomes will be 1) increased knowledge of macrophage function the application of this knowledge will be to develop tests to identify infected animals, and 2) the identification of genes that regulate the response of an individual to infection: information that could be applied in selective breeding programmes. Specifically the project will use functional, comparative genomics and in silico analysis to understand the genetic control of variation in the outcomes of disease challenge to develop molecular diagnostic tools to improve disease surveillance and to assist in selective improvement of breeding of cattle to control these diseases. Hence the project will impact directly on improved animal health. ealthy livestock are more productive and so the improvements achieved will contribute to improved efficiency and profitability of animal production and competitiveness of animal production and hence the sustainability of farming systems. The work will contribute both to improved animal health and welfare and also to the improved safety of animal products and to safeguarding human health. The project involves an SME partner who will assess the market requirements and lead the development of project outcomes to commercially vial products to ensure that the research is appropriately and efficiently exploited.
Thematische Ausrichtung: Food, Agriculture, Fisheries and Biotechnology/KBBE
Laufzeit: 11/2008 - 10/2012
Projektpartner: Prof. Dr. Georg Erhardt, Fb09
SOILSERVICE: Conflicting demands of land use, soil biodiversity and the sustainable delivery of ecosystem goods and services in Europe
European soil biodiversity is pivotal for delivering food, fiber and biofuels and carbon storage. However, the demand is greater than the amount of soil available, as production of biofuels competes with areas for food production and nature. Moreover, intensified land use reduces soil biodiversity and the resulting ecosystem services. SOILSERVICE will value soil biodiversity through the impact on ecosystem services and propose how these values can be granted through payments. SOILSERVICE will combine interdisciplinary empirical studies and soil biodiversity surveys to construct soil food web models and determine effects of changing soil biodiversity on stability and resilience of carbon, nitrogen and phosphorus cycling, as well as assess consequences for outbreaks of pests or invasive species. SOILSERVICE will link ecological and economic models to develop a system for valuing soil biodiversity in relation to ecosystem services. Objectives: • Develop methods to value soil ecosystem services during different pressure of land use and changes in soil biodiversity. • Field and modelling studies will determine to what spatial and temporal scales soil biodiversity and soil ecosystem services are vulnerable to disturbance. • Detecting processes that indicate when ecosystems are approaching the limits of their natural functioning or productive capacity. • Establishing methods to determine and predict sustainability of ecosystem services at different types of land use • Building scenarios to identify economical and social drivers of how land use such as biofuel production and land abandonment can influence soil biodiversity and ecosystem services over European scale. • Interacting with EU policies and strategies with results on which services are at threat and mitigating changes in soil biodiversity to achieve a sustainable use of soils. Our results contribute to a European knowledge-based competitive economy and to a future EU directive on soils.
Thematische Ausrichtung: Environment (including Climate Change)
Laufzeit: 09/2008 - 04/2012
Projektpartner: Prof. Dr. Volkmar Wolters, Fb08
eurIPFnet: European IPF Network: Natural course, Pathomechanisms and Novel Treatment Options in Idiopathic Pulmonary Fibrosis
In the eurIPFnet consortium, leading European basic and clinical scientists in the field of interstitial lung diseases associate to jointly decipher the natural course and molecular pathomechanisms of Idiopathic Pulmonary Fibrosis (IPF) and to develop new therapeutic strategies for patients with IPF. This devastating disease affects about 360.000 patients in the EU and causes a substantial socioeconomic burden. IPF patients experience a gradual decrease in quality of life due to progressive dyspnoe and coughing, and usually die within 3-5 years upon diagnosis. There is currently no approved treatment available. Our translational research programme includes implementation of a European IPF registry (eurIPFreg), in which data with regard to natural course, familiar background and susceptibility factors of IPF will be collected, and of a European IPF biobank (eurIPFbank) of blood, bronchoalveolar lavage fluid, cells and tissue specimen of IPF. In these samples, we will perform transcriptome, proteome, phosphoproteome and lipidome analysis, cellular studies and genetic analysis to unravel the molecular pathways underlying IPF and to identify and establish new diagnostic and prognostic markers. Candidate gene verification will be performed in cell culture and animal studies, including siRNA and gene transfection technologies and development of genetically altered mice and will result in the development of new animal models of IPF. Identification of new therapeutic targets in these models will be followed by rapid commercial exploitation and early preclinical and early clinical evaluation. Ultimately, we wish to establish a unique, sustainable and internationally unrivalled European infrastructure for investigation and treatment of IPF. Our mission statement is straight-forward and clear: “Fighting for improved survival in Idiopathic Pulmonary Fibrosis”.
Thematische Ausrichtung: Health
Laufzeit: 01/2008 - 12/2011
Koordinator: Prof. Dr. Andreas Günther, Fb11
PRIV-WAR: Regulating privatisation of “war”: the role of the EU in assuring the compliance with international humanitarian law and human rights
The goal of the research project is to assess the impact of the extensive use of private military and security companies in situations of armed conflict and to discuss the regulatory framework at national, European and international levels, to assure compliance with international humanitarian law and human rights. Though this is not a new phenomenon, the fear motivating commentators and activists was that private companies operate in a legal vacuum. Although there is growing consensus now in the literature that the situation actually resembles more a complex patchwork of norms, the key question still remains whether and how these existing norms can be effectively applied and whether they need to be supplemented with new norms. Specific objectives are: to promote a better understanding of the phenomenon of the privatisation of war; to clarify the legal status of PMCs/PSCs employees under international humanitarian law; to foster knowledge on the impact of private military activities on the enjoyment of human rights; to analyse international responsibility and accountability of the corporations; to examine the existing regulation at national and EU levels, to explore the ways the EU could regulate PMCs/PSCs. The current proposal seeks to highlight the crucial role of the EU in three respects, which to date have not received much attention in the literature. First, the proposal will seek to offer insights into how the EU can and should develop a unified position on the international regulation of PMCs/PSCs. Second, the work to be undertaken will assess the need for and potential of harmonization of the EU member states’ domestic approaches towards PMCs/PSCs. Lastly, the present proposal will offer advice to policymakers on the development of a regulation scheme at the supranational level. To date, the existing literature on such schemes has largely neglected the role of the EU could and should play in this regard.
Thematische Ausrichtung: Socio-economic Sciences and Humanities/SSH
Laufzeit: 01/2008 - 06/2011
Projektpartner: Prof. Dr. Thilo Marauhn, Fb01
The objective of DOTSENSE is the application of III-nitride (InxGa1-xN) quantum dots (QDs) and nanodisks (NDs) as opto-chemical transducers for the detection of hydrogen, hydrocarbons and the pH-value in gaseous and liquid environments. The characteristics of intense room-temperature luminescence from III-nitride nanostructures can be altered by chemically induced variations of the surface potential. The transparency of the substrate material and the involved buffer layers allow optical excitation and detection of the changes in QD or ND luminescence from the substrate backside. These transducers are hence capable of operating in harsh environments (high pressure, explosive media), as neither electrical feedthroughs nor a deterministic current are necessary for the sensor signal read-out. Furthermore, spatially-resolved detection of variations in the surface potential is possible, since the spatial extension of excited nanostructures is determined by the diameter of the incident light beam. In the first part of the project, the work is focused on the optimization of the structural properties of QD and ND ensembles (size, alloy composition, number of layers, crystallographic orientation) with the aim of attaining a maximum sensitivity of the emission properties (intensity and energetic distribution) upon variations in the surface potential. In a second stage, the opto-chemical transducers will be integrated with commercially available light emitters and detectors, to implement different kinds of sensor systems, which demonstrate and exploit the advantages of this innovative transducer concept. This prototypes find application in the field of aeronautics, with a the potential to increase the safety and/or the economy of flying.
Thematische Ausrichtung: Information and Communication Technologies/ICT
Laufzeit: 05/2008 - 04/2011
Koordinator: Prof. Dr. Martin Eickhoff, Fb07