LOEWE Focus Group NNCS
Prof. Dr. Wolfgang Kummer
Department of Anatomy and Cellular Biology
Tel.: 0641 99-47000
Fax: 0641 99-47009
In the LOEWE focus group "Non-neuronal Cholinergic Systems" (Prof. Dr. Wolfgang Kummer, Department of Anatomy and Cellular Biology) they are working with mechanisms that maintain the body's barrier and integrity, which previously were only understood in parts; acetylcholine (ACh) is a mediator in the nervous system and works as a signal molecule in bacteria, protozoa, plants, and many mammalian cells outside the nervous system, especially on body surfaces and in the immune system ("non-neuronal cholinergic system"). Disturbances in this system lead to diseases. The goal of the LOEWE focus group is unlock the molecular and cellular components of this regulatory system under healthy and diseased conditions and to enable therapeutic uses of them. The span of relevant clinical pictures reaches across several organ systems from the skin (neurodermitis, blister-building diseases) to transplant rejection to sepsis leading frequently to death. The Universities of Marburg and Frankfurt are also participating in this planned focus group being led by JLU.