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SFB 1213 seminar series - "Regulatory network of histone modifications in human pulmonary arterial hypertension"

Seminar series of the Collaborative Research Center "Pulmonary Hypertension and Cor Pulmonale" - presentation of project A05 by Dr. Prakash Chelladurai from the Max Planck Institute

  • SFB 1213 seminar series - "Regulatory network of histone modifications in human pulmonary arterial hypertension"
  • 2018-03-13T18:00:00+01:00
  • 2018-03-13T19:00:00+01:00
  • Seminar series of the Collaborative Research Center "Pulmonary Hypertension and Cor Pulmonale" - presentation of project A05 by Dr. Prakash Chelladurai from the Max Planck Institute
Wann

13.03.2018 von 18:00 bis 19:00 (Europe/Berlin / UTC100)

Wo

Max Planck Institute, Ludwigstr. 43, 61231 Bad Nauheim, seminar room E3

Name des Kontakts

Telefon des Kontakts

0641 99 42422

Teilnehmer

Members of the SFB 1213 and everybody who is interested

Termin zum Kalender hinzufügen

iCal

The progress of the project "Regulatory network of histone modifications in human pulmonary arterial hypertension" will be presented by Dr. Prakash Chelladurai.

 

Project outline:

Vascular remodeling in pulmonary arterial hypertension (PAH) is characterized by pro-proliferative, pro-migratory, pro-inflammatory, pro-fibrotic and anti-apoptotic vascular cell phenotypes. PH vascular cells maintain this phenotype even when cultured outside their vascular microenvironment. We hypothesize and provide preliminary evidence that alterations in histone modifications linked with further epigenetic changes underlie these key pathological features of PAH vascular cells. These epigenetic alterations will be investigated in detail, aiming to decipher the mechanisms driving the PH cell phenotype acquisition and to use this knowledge to "reprogram" the PAH phenotype.

 


Everybody who is interested is very welcome to join our seminar series.SFB 1213 Logo
The seminars are taking place every second Tuesday from 18:00 - 19:00.