SFB 1213 seminar series - "Deciphering the role of BMP9 and BMP10 in pulmonary hypertension and right ventricular hypertrophy"
von 18:00 bis 19:00
|Wo||Biomedizinisches Forschungszentrum Seltersberg (BFS), Schubertstr. 81, 35392 Gießen, kleiner Hörsaal (EG, Foyer B)|
|Kontakttelefon||0641 99 42422|
Members of the SFB 1213 and everybody who is interested
The progress of the project "Deciphering the role of BMP9 and BMP10 in pulmonary hypertension and right ventricular hypertrophy" will be presented by project leader Prof. Thomas Braun.
BMP9 and BMP10 bind to ALK1, a TGF-β superfamily receptor that is causally linked to pulmonary hypertension (PH). We found that genetic inactivation of both BMP9 and BMP10 drastically impacts lung vascular integrity and tone and cardiac function. We will elucidate how ALK1/BMP9/BMP10 signaling functions in the maintenance of pulmonary and cardiac vascular homeostasis and during PH and right heart failure. We propose that BMP9/BMP10/ALK1 signaling is important for vascular development as well as for the pathogenesis of PH and RVH. We will explore whether modulation of BMP9/10 signaling provides novel therapeutic strategies for the treatment of PH and RHV.
Everybody who is interested is very welcome to join our seminar series.
The seminars are taking place every second Tuesday from 18:00 - 19:00.