Inhaltspezifische Aktionen

SFB 1213 seminar series - "Deciphering the role of BMP9 and BMP10 in pulmonary hypertension and right ventricular hypertrophy"

Seminar series of the Collaborative Research Center "Pulmonary Hypertension and Cor Pulmonale" - presentation of project A02 by Prof. Thomas Braun from Max Planck Institute Bad Nauheim/Justus Liebig University

  • SFB 1213 seminar series - "Deciphering the role of BMP9 and BMP10 in pulmonary hypertension and right ventricular hypertrophy"
  • 2018-01-16T18:00:00+01:00
  • 2018-01-16T19:00:00+01:00
  • Seminar series of the Collaborative Research Center "Pulmonary Hypertension and Cor Pulmonale" - presentation of project A02 by Prof. Thomas Braun from Max Planck Institute Bad Nauheim/Justus Liebig University
Wann

16.01.2018 von 18:00 bis 19:00 (Europe/Berlin / UTC100)

Wo

Biomedizinisches Forschungszentrum Seltersberg (BFS), Schubertstr. 81, 35392 Gießen, kleiner Hörsaal (EG, Foyer B)

Name des Kontakts

Telefon des Kontakts

0641 99 42422

Teilnehmer

Members of the SFB 1213 and everybody who is interested

Termin zum Kalender hinzufügen

iCal

The progress of the project "Deciphering the role of BMP9 and BMP10 in pulmonary hypertension and right ventricular hypertrophy" will be presented by project leader Prof. Thomas Braun.

 

Project outline:

BMP9 and BMP10 bind to ALK1, a TGF-β superfamily receptor that is causally linked to pulmonary hypertension (PH). We found that genetic inactivation of both BMP9 and BMP10 drastically impacts lung vascular integrity and tone and cardiac function. We will elucidate how ALK1/BMP9/BMP10 signaling functions in the maintenance of pulmonary and cardiac vascular homeostasis and during PH and right heart failure. We propose that BMP9/BMP10/ALK1 signaling is important for vascular development as well as for the pathogenesis of PH and RVH. We will explore whether modulation of BMP9/10 signaling provides novel therapeutic strategies for the treatment of PH and RHV.

 

 


Everybody who is interested is very welcome to join our seminar series.
The seminars are taking place every second Tuesday from 18:00 - 19:00.