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SFB 1213 Seminarreihe - "Regulatory network of histone modifications in human pulmonary arterial hypertension"

Seminarreihe des Sonderforschungsbereichs Pulmonale Hypertonie und Cor pulmonale - Präsentation des Teilprojektes A05 durch Prakash Chelladurai, Max-Planck-Institut

  • SFB 1213 Seminarreihe - "Regulatory network of histone modifications in human pulmonary arterial hypertension"
  • 2017-03-14T18:00:00+01:00
  • 2017-03-14T19:00:00+01:00
  • Seminarreihe des Sonderforschungsbereichs Pulmonale Hypertonie und Cor pulmonale - Präsentation des Teilprojektes A05 durch Prakash Chelladurai, Max-Planck-Institut
Wann

14.03.2017 von 18:00 bis 19:00 (Europe/Berlin / UTC100)

Wo

Max-Planck-Institut, Ludwigstr. 43, 61231 Bad Nauheim, Seminarraum E3 (3.OG)

Name des Kontakts

Telefon des Kontakts

0641 99 42422

Teilnehmer

Members of the SFB 1213 and everybody who is interested

Termin zum Kalender hinzufügen

iCal

Prakash Chelladurai from the Max Planck Institute will present the project


"Regulatory network of histone modifications in human pulmonary arterial hypertension".

 

Vascular remodeling in pulmonary arterial hypertension (PAH) is characterized by pro-proliferative, pro-migratory, pro-inflammatory, pro-fibrotic and anti-apoptotic vascular cell phenotypes. PH vascular cells maintain this phenotype even when cultured outside their vascular microenvironment. We hypothesize and provide preliminary evidence that alterations in histone modifications linked with further epigenetic changes underlie these key pathological features of PAH vascular cells. These epigenetic alterations will be investigated in detail, aiming to decipher the mechanisms driving the PH cell phenotype acquisition and to use this knowledge to "reprogram" the PAH phenotype.

 



Everybody who is interested is very welcome to join our seminar series.
The seminars are taking place every second Tuesday from 18:00 - 19:00.