Inhaltspezifische Aktionen

SFB 1213 seminar series - "Elucidating the contribution of SIAH2 to the development of cor pulmonale"

Seminar series of the Collaborative Research Center "Pulmonary Hypertension and Cor Pulmonale" - presentation of project B06 by Prof. Lienhard Schmitz and Prof. Susanne Rohrbach from Justus Liebig University

  • SFB 1213 seminar series - "Elucidating the contribution of SIAH2 to the development of cor pulmonale"
  • 2017-08-29T18:00:00+02:00
  • 2017-08-29T19:00:00+02:00
  • Seminar series of the Collaborative Research Center "Pulmonary Hypertension and Cor Pulmonale" - presentation of project B06 by Prof. Lienhard Schmitz and Prof. Susanne Rohrbach from Justus Liebig University
Wann

29.08.2017 von 18:00 bis 19:00 (Europe/Berlin / UTC200)

Wo

Biomedical Research Center Seltersberg, Schubertstr. 81, 35392 Giessen, small lecture hall, ground floor

Name des Kontakts

Telefon des Kontakts

0641 99 42422

Teilnehmer

Members of the SFB 1213 and everybody who is interested

Termin zum Kalender hinzufügen

iCal

Prof. Lienhard Schmitz, Institute of Biochemistry, and Prof. Susanne Rohrbach, Institute of Physiology, will present the progress of the project


"Elucidating the contribution of SIAH2 to the development of cor pulmonale."


Project description:

We have found that mice lacking the ubiquitin E3 ligase SIAH2 are largely protected from hypoxia-induced right heart hypertrophy. Against this background we will now investigate whether a time- and cardiomyocyte-specific deletion of Siah2 protects against right ventricular (RV) hypertrophy. We will also assess whether ongoing RVH can be inhibited or even reversed by inducible ablation of Siah2. The molecular targets, signaling pathways and metabolic changes regulated by SIAH2 in the right ventricle will be identified and further characterized. Additionally, we will test the applicability of SIAH2 inhibitors for the prevention and treatment of RV hypertrophy and failure.


Everybody who is interested is very welcome to join our seminar series.
The seminars are taking place every second Tuesday from 18:00 s.t. - 19:00.