Publications Ross G. Douglas

(^*Authors contributed equally, ^†Corresponding author)

1. Prazak, V., Vasishtan, D., Grunewald, K., Douglas, R.G. and Ferreira, J. (2025) Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum. EMBO Reports. Accepted.
   
   
2. Douglas, R.G., Moon, R.W. and Frischknecht, F. (2024) Cytoskeleton Organization in Formation and Motility of Apicomplexan Parasites. Annual Review of Microbiology. 78(1):311. (Review)
   
   
3. Yee, M., Walther, T., Frischknecht, F.^† and Douglas, R.G.^† (2022) Divergent Plasmodium actin residues are essential for filament localization, mosquito salivary gland invasion and malaria transmission. PLoS Pathogens. 18(8):e1010779.
   
   
4. Douglas, R.G., Nandekar, P., Aktories, J., Kumar, H., Weber, R., Sattler, J.M., Singer, M., Lepper, S., Sadiq, S.K., Wade, R.C. and Frischknecht, F. (2018) Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments. PLoS Biology. 16(7):e2005345.
   
   
5. Douglas, R.G.^†, Reinig, M., Neale, M. and Frischknecht, F^†. (2018) Screening for prophylactics of sporozoite motility through the skin. Malaria Journal. 17(1):319. IF: 2.8
   
   
6. Klug, D.^†, Mair, G.R., Frischknecht, F. and Douglas, R.G.^† (2016) A small mitochondrial protein present in myzozoans is essential for malaria transmission. Open Biology. 6:160034.
   
   
7. Sharma, R.K., Espinoza-Moraga, M., Poblete, H., Douglas, R.G., Sturrock, E.D., Caballero, J., Chibale, K. (2016) The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. Journal of Chemical Information and Modeling. 56(12):2486-2494.
   
   
8. Larmuth, K.M., Masuyer, G., Douglas, R.G., Schwager, S.L., Acharya, K.R. and Sturrock, E.D. (2016) Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme. FEBS Journal. 283(6):1060-1076.
   
   
9. Douglas, R.G., Amino, R., Sinnis, P. and Frischknecht, F. (2015) Active migration and passive transport of malaria parasites. Trends in Parasitology. 31(8):357-362. (Review)
   
   
10. Masuyer, G.*, Douglas, R.G.*, Sturrock, E.D. and Acharya, K.R. (2015) Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme. Scientific Reports. 25(5):13742.
    
    
11. Douglas, R.G.*, Sharma, R.K.*, Masuyer, G., Lubbe, L., Acharya, K.R., Chibale, K. and Sturrock, E.D. (2014) Fragment-based design for the development of N-domain selective angiotensin-1 converting enzyme inhibitors. Clinical Science (London). 126(4):305-314.
    
    
12. Danilov, S.M., Wade, M.S., Schwager S.L., Douglas, R.G., Nesterovitch, A.B., Popova, I.A., Hogarth K.D., Bhardwaj, N., Schwartz, D.E., Sturrock, E.D. and Garcia, J.G. (2014) A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP. PLoS One. 9(2):e88001.
    
    
13. Douglas, R.G., Ehlers, M.R. and Sturrock, E.D. (2013) Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): opportunities for angiotensin-converting enzyme inhibitor design. Clinical and Experimental Pharmacology and Physiology. 40(8):535-41. (Review)
    
    
14. Douglas, R.G. and Sturrock, E.D. (2012) Angiotensin-Converting Enzyme. Encyclopedia of Metalloproteins (book title). Editors-in-chief: Uversky, V., Kretsinger, R.H. and Permyakov, E.A. Publisher: Springer Media. (Book chapter)
    
    
15. Bersanetti, P.A., Sabatini, R.A., Matos, B.S., Douglas, R.G., Nchinda, A., Juliano, M.A., Pesquero, J.B., Sturrock, E.D. and Carmona, A.K. (2012) Characterization of Angiotensin I-Converting Enzyme N-domain Selectivity using Positional-Scanning Combinatorial Libraries of Fluorescence Resonance Energy Transfer Peptides. Biological Chemistry. 393:1547-1554.
    
    
16. Sharma, R.K.*, Douglas, R.G.*, Chibale, K. and Sturrock, E.D. (2012) New Ketomethylene Inhibitor Analogues: Synthesis and Assessment of Structural Determinants for N-domain Selective Inhibition of Angiotensin-Converting Enzyme. Biological Chemistry. 393:485-493.
    
    
17. Douglas, R.G. and Sturrock, E.D. (2012) Structure-Based Design of Domain-Selective Angiotensin-Converting Enzyme Inhibitors. Drug Discovery in Africa (book title). Chibale, K., Davies-Coleman, M. and Masimirembwa (eds). Publisher: Springer Media. Chapter 15: 355-377. (Book chapter)
    
    
18. Douglas, R.G., Ehlers, M.R.W., and Sturrock, E.D. (2011) Vasopeptidase inhibition- solving the cardiovascular puzzle? Drugs of the Future. 36:33-43. (Review)
    
    
19. Kröger, W.L., Douglas, R.G., O’Neill, H.G., Dive, V., and Sturrock, E.D. (2009) Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme. Biochemistry 48:8405-8412.