Program
Monday, August 28, 2023
- 28. August '23
-
14:00
Registration opens
18:00 - 19:00
Welcome & Opening of the Symposium
Wolfgang Kummer, Giessen
Norbert Suttorp, Berlin, Representative of the Leopoldina
Gabriele Krombach, Giessen, Vice President of the von Behring-Röntgen Foundation
Till Acker, Vice Dean (Research) of the Faculty of Medicine, JLU Giessen
19:00 - 19:45
Opening Keynote Lecture
Chair: Klaus Deckmann
Gingival solitary chemosensory cells serve as immune sentinels to protect against periodontitis
Robert Margolskee, Philadelphia, USA
20:00
Welcome Reception
Tuesday, August 29, 2023
- 29. August '23
-
07:30
Registration opens
08:30 - 10:00
Session I: Development and Cancer
Chair: Yosuke Yamada
08:30 - 09:00
Transcriptional master regulators of the tuft cell lineage
Christopher R. Vakoc, Cold Spring Harbor, USA
09:00 - 09:30
Metaplasia-derived tuft cells inhibit disease progression in the exocrine pancreas
Kathleen E. DelGiorno, Nashville, USA
09:30 - 09:45
O1 - ID2 and TCF7L1 are Novel Regulators of Tuft Cell Differentiation in Mouse Small Intestine
Zinina V, Mainz, Germany
09:45 – 10:00
O2 - The Ras Exchange Factor RasGRP1 Drives Tuft Cell Generation in Mouse Small Intestine
Shechtman L, San Francisco, USA
10:00 - 10:30
Coffee break
10:30 - 12:00
Session II: Type 2 Immunity
Chair: Michael Howitt
10:30 - 11:00
Tuft-cell-derived acetylcholine regulates epithelial fluid secretion
Jakob von Moltke, Seattle, USA
11:00 - 11:20
Tuft cell – ILC2 crosstalk in the intestine
Christoph Schneider, Zurich, Switzerland
11:20 - 11:35
O3 - Co-existing Atoh1+ and Atoh1– progenitors contribute to tuft cell expansion during intestinal helminth infection
Feng X, Zürich, CH
11:35 - 11:50
O4 - Liver X receptor controls Tuft cell-ILC2 circuit impairing anti-helminth immunity
Luo X, Stockholm, Sweden
12:00 - 13:00
Lunch
13:00 - 14:15
Session III: Homeostatic and inflammatory circuits
Chair: Christoph Schneider
13:00 - 13:30
A Paneth cell – tuft cell crosstalk controls microbiota and inflammation states in the gut mucosa
Philippe Jay, Montpellier, France
13:30 – 13:45
O5 - Acute tuft cell depletion alters secretory cell lineages and nutrient absorption in mouse small intestine
Kaji I, Nashville, TN, USA
13:45 – 14:00
O6 - WNT signalling promotes tuft cell specification during inflammation
Soshnikova N, Mainz, Germany
14:00 – 14:15
O7 - Tuft cell expression of IL-17RB controls IL-25 availability in the small intestine and prevents chronic activation of ILC2s
Andersson T, Zürich, CH
14:15 - 15:15 Session IV: Acute Paracrine Regulation
Chair: Jakob von Moltke
14:15 - 14:35
Tuft cells as sentinels within the airways
Alexander Perniss, Giessen, Germany/Boston, USA
14:35 - 14:55
Paracrine regulation by biliary tuft Cell cotransmitters: Cysteinyl leukotrienes and acetylcholine
Maryam Keshavarz, Giessen/Augsburg, Germany
14:55 - 15:10
O8 - Succinate triggers long-range Ca2+ waves via TRPM5-expressing brush cells across the tracheal epithelium
Boonen B, Leuven, Belgium/Homburg, Germany
15:15 -15:45
Coffee Break
15:45 -17:20
Session V: The Neuronal Link
Chair: Frank Zufall
15:45 - 16:15
Epithelial Chemosensory Cells: From Single Cells to Taste Buds
Tom Finger, Philadelphia, USA
16:15 - 16:45
Tracheal brush cells exert antimicrobial host defense via communication to sensory neurons
Gabriela Krasteva-Christ, Homburg, Germany
16:45 - 17:05
Urethral cholinergic chemosensory cells
Klaus Deckmann, Giessen, Germany
17:05 - 17:20
O9 - Activation of tracheal brush cells induces TRPV1-mediated neurogenic inflammation
Elhawy MI, Homburg, Germany
19:00
Open Public Lecture
Bürstenzellen – Wächter des Darms
Christoph Schneider, Zürich, CH
20:00
Congress Dinner
Late breaking abstracts, posters on display in the main lecture hall
P1 – Short-term high fat feeding induces inflammatory responses of tuft cells and mucosal barrier cells in the murine stomach
Widmayer P, Hohenheim, Germany
P2 - Tuft cells mediate lung-gut connection in Aspergillus fumigatus-induced allergic lung inflammation
Boussad R, Orleans, France
P3 - Tas2r expression in the murine tracheal epithelium
Wiegand S, Giessen Germany
Wednesday, August 30, 2023
- 30. August '23
-
7:30
Registration opens
08:30 - 09:45
Session VI: Viral and Protozooan Diseases
Chair: Claire O’Leary
08:30 - 09:00
Tuft cell tropism mediates norovirus immune evasion
Craig Wilen, Yale, USA
09:00 - 09:30
Ectopic tuft cells after viral lung injury: function or dysfunction?
Andrew Vaughan, Philadelphia, USA
09:30 - 09:45
O10 - Characterising the role of the microbiota in mediating parasite-tuft cell crosstalk during Giardia infection
Sosnowski O, Calgary, Canada
09:45 - 10:15
Coffee break
10:15 - 11:20
Session VII: Tuft Cells and Lymphoid Organs
Chair: Burkhard Schütz
10:15 - 10:45
Genetic control of thymic tuft cell development by Ikaros
Mark Anderson, San Francisco, USA
10:45 - 11:05
Transcriptional regulation of thymic tuft cell development: similar but different?
Kristin Rattay, Marburg, Germany
11:05 - 11:20
O11 - Trpm5-dependent immune cell dynamics in lymphoid organs during Pseudomonas aeruginosa pneumonia
Evers S, Homburg, Germany
11:20 - 12:30
General Discussion
“What’s your name?”, Collaborative efforts, further meetings
12:00 - 13:00
Lunch
13:30 - 14:45
Session VIII: New kids on the block
Chair: Kristin Rattay
13:30 – 14:00
Olfactory microvillous cells join the tuft cell family as allergen and danger sensor
Lora G. Bankova, Boston, USA
14:00 - 14:15
O12 - Whether tuft cells are present in the human breast? The potential relevance to triple-negative breast cancer
Yamada Y, Kyoto, Japan
14:15 - 14:30
O13 - Marker refinement in murine lower airways: advillin for tuft cells, villin for a neuroendocrine phenotype
Mahmoud W, Irbid, Jordan/Giessen. Germany
14:30 - 14:45
O14 – LRMP+ chemosensory cells in the human respiratory tract
Hamarsheh D, Giessen, Germany
14:45 - 15:00
O15 - Tuft cells inhibit pancreatic injury through IL-25 synthesis and secretion
Ruelas A, Nashville, USA
15:00 - 15:30
Coffee break
15:30 - 16:45
Session IX: Bacterial Triggers
Chair: Maryam Keshavarz
15:30 - 16:00
Bittersweet Regulation of Tuft Cell Antimicrobial Defenses
Noam Cohen, Philadelphia, US
16:00 - 16:15
O16 – The Role of the Aryl hydrocarbon Receptor (AhR) in Tuft Cell-mediated Intestinal Immunity
Mayer M, Bonn, Germany
16:15 - 16:30
O17 - Tracheal brush cells modulate immune responses during airways inflammation through TRPM5 channel activation
Abdel Wadood N, Homburg, Germany
16:30 - 16:45
O18 - Tracheal brush cells contribute positively to the phagocytosis of Pseudomonas aeruginosa by dendritic cells
Elhawy MI, Homburg, Germany
16:45 - 17:00
Closing remarks and awards
Burkhard Schütz, Marburg, Germany