Inhaltspezifische Aktionen


Pleuger C, Ai D, Hoppe ML, Winter LT, Bohnert D, Karl D, Guenther S, Epelman S, Kantores C, Fijak M, Ravens S, Middendorff R, Mayer JU, Loveland KL, Hedger M, Bhushan S, Meinhardt A.
The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis
Elife. 2022 Dec 14;11:e82193. doi: 10.7554/eLife.82193. PMID: 36515584

Schneider, L Dansranjav T, Neumann E, Yan H, Pilatz A, Schuppe HC, Wagenlehner F, Schagdarsurengin, U
Post-prostatic-massage urine exosomes of men with chronic prostatic/chronic pelvic pain syndome carry prostate cancer-typical micro RNAs and activate proto-oncogenes.
Mol. Oncol. 2023 Mar; 17(3):445-468. doi: 10.1002/1878-0261.13329. PMID: 36321189

Seidensticker M, Tasch S, Mietens A, Exintaris B, Middendorff R.
Treatment of benign prostatic hyperplasia and abnormal ejaculation: live imaging reveals tamsulosin - but not tadalafil - induced dysfunction of prostate, seminal vesicles and epididymis
Reproduction. 2022 Nov 7;164(6):291-301. doi: 10.1530/REP-22-0197. Print 2022 Dec 1. PMID: 36173812

Hosseini S, Moody SC, Fietz D, Indumathy S, Schuppe HC, Hedger MP, Loveland KL.
The changing landscape of immune cells in the fetal mouse testis
Histochem Cell Biol. 2022 Oct;158(4):345-368. doi: 10.1007/s00418-022-02129-6. Epub 2022 Jul 12. PMID: 35829816

Kabbesh H, Bulldan A, Konrad L, Scheiner-Bobis G.
The Role of ZIP9 and Androgen Receptor in the Establishment of Tight Junctions between Adult Rat Sertoli Cells
Biology (Basel). 2022 Apr 26;11(5):668. doi: 10.3390/biology11050668. PMID: 35625396

Kabbesh H, Riaz MA, Jensen AD, Scheiner-Bobis G, Konrad L
Transmigration of macrophages through adult rat Sertoli cells.
Tissue Barriers. 2022 Apr 20:2064179. doi: 10.1080/21688370.2022.2064179. Epub ahead of print. PMID: 35442143.

Hasan H, Bhushan S, Fijak M, Meinhardt A
Mechanisms of inflammatory associated impairment of sperm function, spermatogenesis and steroidogenesis
Front Endocrinol (Lausanne). 2022 Apr 28;13:897029. doi: 10.3389/fendo.2022.897029. PMID: 35574022

Biniwale S, Wijayarathna R, Pleuger C, Bhushan S, Loveland KL, Meinhardt A, Hedger MP
Regulation of macrophage number and gene transcript levels by activin A and its binding protein, follistatin, in the testes of adult mice.
J Reprod Immunol. 2022 Jun;151:103618. doi: 10.1016/j.jri.2022.103618. Epub 2022 Mar 26.   PMID: 35378491

Kabbesh H, Riaz MA, Jensen AD, Scheiner-Bobis G, Konrad L.
Long-Term Maintenance of Viable Adult Rat Sertoli Cells Able to Establish Testis Barrier Components and Function in Response to Androgens
Cells. 2021 Sep 13;10(9):2405. doi: 10.3390/cells10092405. PMID: 34572053

Berg E, Houska P, Nesheim N, Schuppe HC, Pilatz A, Fijak M, Manthey M, Steger K, Wagenlehner F, Schagdarsurengin U.
Chronic Prostatitis/Chronic Pelvic Pain Syndrome Leads to Impaired Semen Parameters, Increased Sperm DNA Fragmentation and Unfavorable Changes of Sperm Protamine mRNA Ratio
Int J Mol Sci. 2021 Jul 23;22(15):7854. doi: 10.3390/ijms22157854. PMID: 34360620

Stadler B, Nowell CJ, Whittaker MR, Arnhold S, Pilatz A, Wagenlehner FM, Exintaris B, Middendorff R.
Physiological and pharmacological impact of oxytocin on epididymal propulsion during the ejaculatory process in rodents and men.
FASEB J. 2021 Jun;35(6):e21639. doi: 10.1096/fj.202100435R. PMID: 34041782

Lee SN, Kraska J, Papargiris M, Teng L, Niranjan B, Hammar J, Ryan A, Frydenberg M, Lawrentschuk N, Middendorff R, Ellem SJ, Whittaker M, Risbridger GP, Exintaris B
Oxytocin receptor antagonists as a novel pharmacological agent for reducing smooth muscle tone in the human prostate.
Sci Rep. 2021 Mar 18;11(1):6352. doi: 10.1038/s41598-021-85439-4. PMID: 33737570

O'Donnell L, Rebourcet D, Dagley LF, Sgaier R, Infusini G, O'Shaughnessy PJ, Chalmel F, Fietz D, Weidner W, Legrand JMD, Hobbs RM, McLachlan RI, Webb AI, Pilatz A, Diemer T, Smith LB, Stanton PG
Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men.
FASEB J. 2021 Mar; 35(3):e21397. doi: 10.1096/fj.202002484R. PMID: 33565176

Pleuger C, Silva EJR , Pilatz A, Bhushan S, Meinhardt A
Differential Immune Response to Infection and Acute Inflammation along the Epididymis
Front Immunol. 2020 Nov 27. doi: 10.3389/fimmu.2020.599594.   Pubmed PMID: 33329594

Indumathy S, Pueschl D, Klein B, Fietz D, Bergmann M, Schuppe HC, Da Silva N, Loveland BE, Hickey MJ, Hedger MP, Loveland KL
Testicular immune cell populations and macrophage polarisation in adult male mice and the influence of altered activin A levels.
J Reprod Immunol. 2020 Nov;142:103204. doi: 10.1016/j.jri.2020.103204. Epub 2020 Sep 14. PMID: 33130539

Stadler B, Whittaker MR, Exintaris B, Middendorff R
Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and -Antagonists.
Front. Endocrinol., 22 October 2020.

Weiser D, Mietens A, Stadler BJežek D, Schuler G, Middendorff R.
Contractions transport exfoliated epithelial cells through the neonatal epididymis.

Reproduction. 2020 Jul 160 (1): doi: 109-116:10.1530/REP-19-0617. Pubmed PMID: 32442962

Yan H, Dittmar F, Schagdarsurengin U, Wagenlehner F.
The clinical application and potential roles of circulating tumor cells in bladder cancer and prostate cancer.

Urology. 2020 Jul 4: 50090-4295(20)30799-8.doi: 10.1016/j.urology.2020.06.039. Online ahead of print. Pubmed PMID: 32634447

Wijayarathna R, Pasalic, A, Nicolas N, Biniwale S, Ravinthiran R, Genovese R, Muir JA, Loveland KL, Meinhardt A, Fijak M, Hedger MP.
Region-specific immune responses to autoimmune epididymitis in the murine reproductive tract.
Cell Tissue Res. 2020 May 8. doi: 10.1007/s00441-020-03215-8. [Epub ahead of print] Pubmed PMID: 32383098

Pleuger C, Lehti MS, Dunleavy JE, Fietz D, O'Bryan MK
Haploid male germ cells-the Grand Central Station of protein transport.
Hum Reprod Update. 2020 Apr 21. pii: dmaa004. doi: 10.1093/humupd/dmaa004. [Epub ahead of print] Pubmed PMID: 32318721

Klein B, Bhushan S, Günther S, Middendorff R, Loveland KL, Hedger MP, Meinhardt A
Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse.
Mol Hum Reprod. 2020 Feb 3. pii: gaaa011. doi: 10.1093/molehr/gaaa011 Pubmed PMID: 32011693

Kudipudi PK, Galuska SP, Dietze R, Scheiner-Bobis G, Loveland KL, Konrad L
Betaglycan (TβRIII) is a Key Factor in TGF-β2 Signaling in Prepubertal Rat Sertoli Cells.

Int J Mol Sci. 2019 Dec 9;20(24). pii: E6214. doi: 10.3390/ijms20246214 Pubmed PMID: 31835434

Pleuger C, Lehti MS, Cooper M, O'Connor AE, Merriner DJ, Smyth IM, Cottle DL, Fietz D, Bergmann M, O'Bryan MK
CBE1 Is a Manchette- and Mitochondria-Associated Protein With a Potential Role in Somatic Cell Proliferation.
Endocrinology. 2019 Nov 1;160(11):2573-2586. doi: 10.1210/en.2019-00468 Pubmed PMID: 31504408

Wijayarathna R, Hedger MP.
Activins, follistatin and immunoregulation in the epididymis.
Andrology. 2019 Sep;7(5):703-711. doi: 10.1111/andr.12682. Epub 2019 Jul 19. Pubmed PMID:31322318

Maresch CC, Stute DC, Fleming T, Lin J, Hammes HP, Linn T
Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis.
Sci Rep. 2019 Sep 10;9(1):13074. doi: 10.1038/s41598-019-49600-4. Pubmed PMID: 31506549

Kauerhof AC, Nicolas N, Bhushan S, Wahle E, Loveland KA, Fietz D, Bergmann M, Groome NP, Kliesch S, Schuppe HC, Pilatz A, Meinhardt A, Hedger MP, Fijak M
Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis.
Hum Reprod. 2019 Aug 1;34(8):1536-1550. doi: 10.1093/humrep/dez109. Pubmed PMID: 31340036

Klein B, Pant S, Bhushan S, Kautz J, Rudat C, Kispert A, Pilatz A, Wijayarathna R, Middendorff R, Loveland KL, Hedger MP, Meinhardt A.
Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model.

Hum Reprod.
2019 Jul 8;34(7):1195-1205. doi: 10.1093/humrep/dez073. Pubmed PMID: 31211847

Szarek M, Bergmann M, Konrad L, Schuppe HC, Kliesch S, Hedger MP, Loveland KL
Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Andrology, 2018 Oct 13. doi:10.1111/andr.12553. Epub ahead of print. Pubmed PMID: 30315637

Wijayarathna R, de Kretser DM, Meinhardt A, Middendorff R, Ludlow H, Groome NP, Loveland KA, Hedger MP
Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.
<br/br> Mol Cell Endocrinol. 2018 Jul 15;470:188-198. doi: 10.1016/j.mce.2017.10.013. [Epub 2017 Oct 28]. Pubmed PMID: 29111388

Fijak M, Pilatz A, Hedger MP, Nicolas N, Bhushan S, Michel V, Tung K SK, Schuppe HC, Meinhardt A
Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice?
Hum Reprod Update, 2018 Apr 10. doi: 10.1093/humupd/dmy009. Epub ahead of print. Pubmed PMID: 29648649

Nesheim N, Ellem S, Dansranjavin T, Hagenkötter C, Berg E, Schambeck R, Schuppe H-C, Pilatz A, Risbridger G, Weidner W, Wagenlehner F, Schagdarsurengin U
Elevated seminal plasma estradiol and epigenetic inactivation of ESR1 and ESR2 is associated with CP/CPPS
Oncotarget, 2018 Feb 24. Pubmed PMID: 29731970

Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T
Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review
Hum Reprod Update, 2017 Nov 10: 1-20. doi:10.1093/humupd/dmx033. Epub ahead of print. Pubmed PMID:29136166

Loveland KL, Klein B, Pueschl D, Indumathy S, Bergmann M, Loveland BE, Hedger MP, Schuppe HC
Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond
Front Endocrinol, 2017 Nov;8:307; doi: 10.3389/fendo.2017.00307 Pubmed PMID: 29250030

Kügler R, Mietens A, Seidensticker M, Tasch S, Wagenlehner FM, Kaschtanow A, Tjahjono Y, Tomczyk CU, Beyer D, Risbridger GP, Exintaris B, Ellem SJ, Middendorff R
Novel imaging of the prostate reveals spontaneous gland contraction and excretory duct quiescence together with different drug effects

Faseb J, 2017 Oct 31; pii: fj.201700430R. PubMed PMID: 29089445

Wijayarathna R, de Kretser D, Sreenivasan R, Ludlow H, Middendorff R, Meinhardt A, Loveland KL, Hedger MP
Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens
Reproduction, 2017 Oct; pii: REP-17-0485. PubMed
PMID: 29030492

Hempfling AL, Lim SL, Adelson DL, Evans J, O'Connor AE, Qu ZP, Kliesch S, Weidner W, O'Bryan MK, Bergmann M
Expression patterns of HENMT1 and PIWIL1 in human testis: Implications for transposon expression
Reproduction, 2017 Oct; 154(4):363-374. PubMed
PMID: 28676534

Nicolas N, Muir JA, Hayward S, Chen JL, Stanton PG, Gregorevic P, de Kretser DM, Loveland KL, Bhushan S, Meinhardt A, Fijak M, Hedger MP
of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin
Reproduction, 2017 Sept; 154(3):193-205. PubMed
PMID: 28667125

Lee SN, Chakrabarty B, Wittmer B, Papargiris M, Ryan A, Frydenberg M, Lawrentschuk N, Middendorff R, Risbridger GP, Ellem SJ, Exintaris B
Related Differences in Responsiveness to Sildenafil and Tamsulosin are due to Myogenic Smooth Muscle Tone in the Human Prostate
Sci Rep, 2017 Aug; 7(1):10150. PubMed
PMID: 28860509

Pleuger C, Fietz D, Hartmann K, Schuppe HC, Weidner W, Kliesch S, Baker M, O'Bryan MK, Bergmann M
Expression of ciliated bronchial epithelium 1 during human spermatogensis
Fertil Steril, 2017 Jul; 108(1):47-54. PubMed
PMID: 28601408

Klein B, Schuppe HC, Bergmann M, Hedger MP, Loveland BE, Loveland KL
An in vitro model demonstrates the potential of neoplastic human germ cells to influence the tumour microenvironment
Andrology, 2017 Jul; 5(4):763-770. PubMed
PMID: 28544640

Maresch CC, Stute DC, Ludlow H, Hammes HP, de Kretser DM, Hedger MP, Linn T
Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes
Mol Cell Endocrinol; 2017 May; 446:91-101. PubMed
PMID: 28214591

Wijayarathna R, Sarraj MA, Genovese R, Girling JE, Michel V, Ludlow H, Loveland KL, Meinhardt A, de Kretser DM, Hedger MP
Activin and follistatin interactions in the male reproductive tract: activing expression and morphological abnormalities in mice lacking follistatin 288
Andrology; 2017 May; 5(3):578-588. PubMed
PMID: 28235253

Maresch CC, Petry SF, Theis S, Bosy-Westphal A, Linn T
Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials
Nutrients, 2017 Apr; 9(4). pii: E38. PubMed
PMID: 28406437

Chan KH, Galuska S, Kudipudi PK, Riaz MA, Loveland KL, Konrad L
Signaling by TGF-betas in tubule cultures of adult rat testis
Am J Trans Res, 2017 Mar; 9(3):1173-1182. PubMed
PMID: 28386343

Nicolas N, Michel V, Bhushan S, Wahle E, Hayward S, Ludlow H, de Kretser DM, Loveland KL, Schuppe HC, Meinhardt A, Hedger MP, Fijak M
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice
Sci Rep; 2017 Feb; 7:42391. PubMed
PMID: 28205525

Pilatz A, Hudemann C, Wolf J, Halefeld I, Paradowska-Dogan A, Schuppe HC, Hossain H, Jiang Q, Schultheiss D, Renz H, Weidner W, Wagenlehner F, Linn T
Metabolic syndrome and the seminal cytokine network in morbidly obese males
Andrology 2017 Jan; 5(1):23-30. PubMed PMID: 27813377

Pleuger C, Fietz D, Hartmann K, Weidner W, Kliesch S, O’Bryan MK, Dorresteijn A, Bergmann M
The expression of Katanin p80 in human spermatogenesis
Fertil Steril, 2016 Dec; 106(7): 1683-1690. PubMed PMID: 27717557

Schagdarsurengin U, Western P, Steger K, Meinhardt A
origins of male subfertility: role of infection, inflammation, and environmental factors
Semin Immunopathol, 2016 Nov; 38(6):765-781. PubMed PMID: 27315198

Schagdarsurengin U, Teuchert LM, Hagenkötter C, Nesheim N, Dansranjavin T, Schuppe HC, Gies S, Pilatz A, Weidner W, Wagenlehner FM
Chronic Prostatitis Affects Male Reproductive Health and Is Associated with Systemic and Local Epigenetic Inactivation of C-X-C Motif Chemokine 12 Receptor C-X-C Chemokine Receptor Type 4
Urol Int, 2017; 98(1):89-101. PubMed PMID: 27760433

Klein B, Haggeney T, Fietz D, Indumathy S, Loveland KL, Hedger MP, Kliesch S, Weidner W, Bergmann M, Schuppe HC
Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia
Hum Reprod; 2016 Oct; 31(10):2192-202. PubMed PMID: 27609978

Stanton PG, Foo CF, Rainczuk A, Stephens AN, Condina M, O'Donnell L, Weidner W, Ishikawa T, Cruickshanks L, Smith LB, McLachlan RI
the testicular interstitial fluid proteome from normal rats
Proteomics, 2016 Sep; 16(17):2391-402. PubMed PMID: 27324652

Michel V, Duan Y, Stoschek E, Bhushan S, Middendorff R, Young JL, Loveland KL, de Kretser DM, Hedger MP, Meinhardt A
Uropathogenic Escherichia coli cause fibrotic remodelling of the epididymis.

J Pathol; 2016 Sep; 240(1):15-24. PubMed PMID:

Koshravi F, Michel V, Galuska CE, Bhushan S, Christian P, Schuppe HC, Pilatz A, Galuska SP, Meinhardt A
Desialylation of spermatozoa and epithelial cell glycocalyx is a consequence of bacterial infection of the epididymis
J Biol Chem; 2016 Aug; 291(34):17717-26. PubMed PMID: 27339898

Wijayarathna R, de Kretser DM
Activins in reproductive biology and beyond
Hum Reprod Update; 2016 Apr; 22(3). PubMed PMID: 26884470

Hutmacher DW, Holzapfel BM, De-Juan-Pardo EM, Pereira BA, Ellem SJ, Loessner D, Risbridger GP
Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance
Current Opinion in Biotechnology; 2015 Dec; 35:123-32. PubMed PMID: 26121082

Hosseini S, Shokri F, Tokhmechy R, Savadi-Shiraz E, Jeddi-Tehrani M, Rahbari M, Zarnani AH
Menstrual blood contains immune cells with inflammatory and anti-inflammatory properties
J Obstet Gynaecol Res; 2015 Nov; 41(11):1803-12. PubMed PMID: 26370728

Lim S, Peng Qu Z, Kortschak RD, Lawrence DM, Geoghegan J, Hempfling A-L, Bergmann M, Goodnow CC, Ormandy CJ, Womg L, Mann J, Scott HS, Jamasal D, Adelson D, O´Bryan MK
HENMT1 and piRNA stability are required for adult male germ cell transposon repression and to define the spermatogenic program in the mouse.

PLoS Genet. 2015 Oct 23;11(10): PubMed PMID: 26496356

Shihan M, Chan KH, Konrad L, Scheiner-Bobis G
Non-classical testosterone signaling in spermatogenic cell line GC-2 is mediated through ZIP9, a GPCR interacting with Gnα11
Cell Signal; 2015 Oct; 27(10):2077-86. PubMed PMID: 26208885

Michel V, Pilatz A, Hedger MP, Meinhardt A
Epididymitis: Revelations at the convergence of clinical and basic sciences
Asian J Androl. 2015 Sep-Oct;17(5):756-63. PubMed PMID: 26112484

Bayat B, Tjahjono Y, Berghöfer H, Werth S, Deckmyn H, De Meyer SF, Sachs UJ, Santoso S.
Choline Transporter-Like Protein-2: New von Willebrand Factor-Binding Partner Involved in Antibody-Mediated Neutrophil Activation and Transfusion-Related Acute Lung Injury
Arterioscler Thromb Vasc Biol; 2015 Jul; 35(7):1616-1622. PubMed PMID: 25931511

Kolodziejczyk B, Winther-Jensen O, Pereira BA, Nair SS, Winther-Jensen B
Patterning of conducting layers on breathable substrates using laser engraving for gas sensors
J Applied Polymer Sci; 2015 Sep; 132(35): 42359.

Gikany K, Minai-Tehrani A, Savadi-Shiraz E, Rezadoost H, Lakpour N
Exploring the human seminal plasma proteome: an unexplored gold mine of biomarker for male infertility and male reproduction disorder

J Reprod Infertil; 2015 Apr-Jun; 16(2):61-71. PubMed PMID: 25927022

Jafarzadeh N, Mani-Varnosfaderani A, Minai-Therani A, Savadi-Shiraz E, Sadeghi MR, Gilany K
Metabolomics fingerprinting of seminal plasma from unexplained infertile men: a need for novel diagnostic biomarkers
Mol Reprod Dev; 2015 Mar; 82(3):150. PubMed PMID: 25676838

Savadi Shiraz E, Edalatkhah H, Talebi S, Heidari-Vala H, Zandemami M, Pahlavan S, Modrressi MH, Akhondi MM, Paradowska-Dogan A, Sadeghi MR
Quantification of sperm specific mRNA transcripts (PRM1, PRM2 and TNP2) in teratozoospermia and normozoospermia: new correlation between mRNA content and morphology of sperm
Mol Reprod Dev; 2015 Jan; 82(1):26-35. PubMed PMID: 25536093

Gilany K, Moazeni-Pourasil RS, Jafarzadeh N, Savadi-Shiraz E
Metabolomics fingerprinting of the human seminal plasma of asthenozoospermic patients
Mol Reprod Dev; 2014 Jan; 81(1):84-6. PubMed PMID: 24254375

Su S, Szarek M, Vooght A, Hutson J, Li R
Gonocyte transformation to spermatogonial stem cells occurs earlier in patients with undervirilisation syndromes
J Pediatr Surg; 2014 Feb; 49(2):323-7. PubMed PMID: 24528977

Szarek M, Li R, Vikraman J, Southwell B, Hutson JM
Molecular signals governing cremaster muscle development clues for cryptorchidism
J Pediatr Surg; 2014 Feb; 49(2):312-6. PubMed PMID: 24528975

Lang T, Hudemann C, Thchatalbachev S, Stammler A, Michel V, Aslani F, Bhushan S, Chakraborty T, Renz H, Meinhardt A
Uropathogenic Escherichia coli modulates innate immunity to suppress Th1-mediated inflammatory responses during infectious epididymitis

Infect Immun; 2014 Mar; 82(3): 1104-11. PubMed PMID: 24366252

Wagenlehner F, Pilatz A, Linn T, Diemer T, Schuppe HC, Schagdarsurengin U, Hossain H, Meinhardt A, Ellem S, Risbridger G, Weidner W
Prostatitis and andrological implications

Minerva Urol Nefrol, 2013 Jun; 65(2):117-23. PubMed PMID: 23703099