Inhaltspezifische Aktionen

Publikationsliste Prof. C. Heiß




  • Biehl C, Biehl L, Tarner IH, Müller-Ladner U, Heiss C, Heinrich M (2022). Microangiopathy in Inflammatory Diseases—Strategies in Surgery of the Lower Extremity. Life (Basel). 2022 Jan 28;12(2):200. doi: 10.3390/life12020200.
  • Biehl C, Szötzel S, Schock L, Szalay G, Heiss C (2022). Treatment of hand and finger fractures with the Stryker Hand Plating System. Ger Med Sci. 2022 Mar 31;20:Doc03. doi: 10.3205/000305. eCollection 2022.
  • Muschol J, Heinrich M, Heiss C, Knapp G, Repp H, Schneider H, Thormann U, Uhlar J, Unzeitig K, Gissel C (2022). Assessing Telemedicine Efficiency in Follow-up Care With Video Consultations for Patients in Orthopedic and Trauma Surgery in Germany: Randomized Controlled Trial. J Med Internet Res. 2022;24(7):e36996. doi: 10.2196/36996.
  • Timm K, Walter N, Heinrich M, Knapp G, Thormann U, El Khassawna T, Alt V, Heiss C, Rupp M (2022). Influence of Thoracic Trauma on Fracture Healing in Long Bones—A Retrospective Analysis. J Clin Med. 2022 Jan 28;11(3):717. doi: 10.3390/jcm11030717.




  • Alkhasawnah Q, Elmas S, Sohrabi K, Attia S, Heinemann S, El Khassawna T, Heiss C (2021). Confirmation of Calcium Phosphate Cement Biodegradation after Jawbone Augmentation around Dental Implants Using Three-Dimensional Visualization and Segmentation Software. Materials. 2021; 14(22):7084. doi: 10.3390/ma14227084.
  • Biehl C, Schmitt J, Stoetzel S, Malhan D, Hassan F, Knapp G, Heiss C, El Khassawna T (2021). DXA reference values of the humanoid sheep model in preclinical studies. PeerJ. 2021 Apr 30;9:e11183. doi: 10.7717/peerj.11183. eCollection 2021. 
  • Biehl C, Stoll M, Heinrich M, Biehl L, Jung J, Heiss C, Szalay G (2021). Long-Term Results of the Modular Physiological Wrist Prosthesis (MPW®) in Patients with Inflammatory Diseases. Life (Basel). 2021 Apr 18;11(4):355. doi: 10.3390/life11040355.
  • Bosbach WA, Heinrich M, Kolisch R, Heiss C (2021). Maximisation of open hospital capacity under shortage of SARS-CoV-2 vaccines. Vaccines (Basel). 2021 May 22;9(6):546. doi: 10.3390/vaccines9060546. 
  • Deering J, Presas A, Yu B, Valentín D, Heiss C, Bosbach WA, Granfield K (2021). Implant Resonance and the Mechanostat Theory: Applications of Therapeutic Ultrasound for Porous Metallic Scaffolds. Mater Sci Eng C Mater Biol Appl. 2021 Jun;125:112070. doi: 10.1016/j.msec.2021.112070. Epub 2021 Mar 27. 
  • El Khassawna T, Knapp G, Scheibler N, Malhan D, Walter N, Biehl C, Alt V, Heiss C, Rupp M (2021). Mortality, Risk Factors and Risk Assessment after Periprosthetic Femoral Fractures—A Retrospective Cohort Study. J Clin Med. 2021; 10(19):4324. doi: 10.3390/jcm10194324.
  • Hemm F, Fijak M, Belikan J, Kampschulte M, El Khassawna T, Pilatz A, Heiss C, Lips KS (2021). Bone Status in a Mouse Model of Experimental Autoimmune-Orchitis. Int J Mol Sci. 2021 Jul 23;22(15):7858. doi: 10.3390/ijms22157858.
  • Knapp G, Möller F, Heiß C, Mülke M, Szalay G (2021). Operative Versorgung des Processus styloideus ulnae mittels winkelstabiler Hakenplatte bei Frakturen und symptomatischen Pseudarthrosen. Oper Orthop Traumatol. 2021 Oct;33(5):430-435. doi: 10.1007/s00064-021-00709-8.
  • Presas A, Valentin D, Deering J, Kampschulte M, Yu B, Grandfield K, Mele E, Biehl C, Krombach GA, Heiss C, Bosbach WA (2021). Resonance vibration interventions in the femur: Experimental-numerical modelling approaches. J Mech Behav Biomed Mater. 2021 Dec;124:104850. doi: 10.1016/j.jmbbm.2021.104850. Epub 2021 Sep 20.
  • Rupp M, Biehl C, Malhan D, Hassan F, Attia S, Rosch S, Schäfer AB, McMahon E, Kampschulte M, Heiss C, El Khassawna T (2021). Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model. Life (Basel). 2021 Mar 19;11(3):254. doi: 10.3390/life11030254. 
  • Rupp M, Kern S, Walter N, Anastasopoulou L, Schnettler R, Heiss C, Alt V (2021). Surgical treatment outcome after serial debridement of infected nonunion-A retrospective cohort study. Eur J Orthop Surg Traumatol. 2021 Mar 27. doi: 10.1007/s00590-021-02930-4. Online ahead of print. 
  • Schlosshauer T, Heiss C, von Hollen AK, Spennato S, Rieger UM (2021). Liposuction treatment improves disease-specific quality of life in lipoedema patients. Int Wound J 2021 May 5.  doi: 10.1111/iwj.13608.  Online ahead of print.
  • Schlosshauer T, Rothenberger J, Heiss C, Rieger UM (2021). The role of near-infrared fluorescence imaging with indocyanine green dye in pedicle division with the paramedian forehead flap. Int Wound J. 2021:1–8. doi: 10.1111/iwj.13590.
  • Stoetzel S, Malhan D, Wild U, Helbing C, Hassan F, Attia S, Jandt KD, Heiss C, El Khassawna T (2021). Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae. Int J Mol Sci. 2021 Dec 29;23(1):374. doi: 10.3390/ijms23010374.
  • Valentin D, Presas A, Roehr C, Mele E, Biehl C, Heiss C, Bosbach WA (2021). On the quantification of local power densities in a new vibration bioreactor. PLoS One 2021 Jan 22;16(1):e0245768. doi: 10.1371/journal.pone.0245768. eCollection 2021.
  • Walter D, Deneke T, Hochbrückner A, Heiß C, Selig S, Griewing B (2021). Standardisierung und Digitalisierung in der Medizin. Innovative Prozessnavigation bei der RHÖN-KLINIKUM AG. KU Gesundheitsmanagement 2021; 90(4):25-27.


Buchbeiträge und Monographien:

  • Heinrich M, Heiß C. Muskuloskelettale Verletzungen. In: Intensivmedizin compact. Weigand MA, Hecker A, Mayer K, Michalski D (Hrsg.). Kapitel 21.5; S. 643-651, Thieme (Verlag), 2021; 740 S., ISBN 978-3-13-241853-0; eISBN (PDF) 978-3-13-241854-7; eISBN (epub) 978-3-13-241855-4.



  • Attia S, Diefenbach J, Schmermund D, Böttger S, Pons-Kühnemann J, Scheibelhut C, Heiss C, Howaldt HP (2020). Donor-Site Morbidity after Fibula Transplantation in Head and Neck Tumor Patients: A Split-Leg Retrospective Study with Focus on Leg Stability and Quality of Life. Cancers (Basel). 2020 Aug 8;12(8):E2217. doi: 10.3390/cancers12082217.
  • Biehl C, Heinrich M, Biehl L, Knapp G, Heiss C, Thormann U (2020). Biomechanical Particularities in the Therapy of the Rheumatic Knee. Appl Sci. 2020, 10(23), 8600;
  • Biehl C, Rupp M, Kern S, Heiss C, ElKhassawna T, Szalay G (2020). Extensor tendon ruptures in rheumatoid wrists. Eur J Orthop Surg Traumatol. 2020 Dec;30(8):1499-1504. doi: 10.1007/s00590-020-02731-1. Epub 2020 Jul 3.
  • Biehl C, Schäfer C, Heiss C, Brobeil A, Dreyer T, Gattenlöhner S, Szalay G (2020). Neurofibroma in Children hand – Case Report an Literature Review. Handchir Mikrochir Plast Chir. 2020 Feb;52(1):29-32.
  • Deering J, Presas A, Lee BEJ, Valentin D, Yu B, Heiss C, Grandfield K, Bosbach WA (2020). Response of Saos-2 Osteoblast-like Cells to Kilohertz-Resonance Excitation in Porous Metallic Scaffolds. Journal of Mechanical Behavior of Biomedical Materials 2020 Jun;106:103726; doi: 10.1016/j.jmbbm.2020.103726. Epub 2020 Mar 24.
  • Heinrich M, Lany M, Anastasopoulou L, Biehl C, Szalay G, Brenck F, Heiss C (2020). Evidence of Prolonged Monitoring of Trauma Patients Admitted via Trauma Resuscitation Unit without Primary Proof of Severe Injuries.  J Clin Med. 2020 Aug 4;9(8):E2516. doi: 10.3390/jcm9082516.
  • Ismat A, Rupp M, Knapp G, Heiss C, Szalay G, Biehl C (2020). Treatment of proximal fifth metatarsal fractures with an ulna hook plate. Foot (Edinb). 2020 Mar;42:101653. doi: 10.1016/j.foot.2019.101653.
  • Kruppke B, Ray S, Alt V, Rohnke M, Kern C, Kampschulte M, Heinemann C, Budak M, Adam J, Döhner N, Franz-Forsthoffer L, El Khassawna T, Heiss C, Hanke T, Thormann U (2020). Gelatin-Modified Calcium/Strontium Hydrogen Phosphates Stimulate Bone Regeneration in Osteoblast/Osteoclast Co-Culture and in Osteoporotic Rat Femur Defects—In Vitro to In Vivo Translation. Molecules. 2020, 25(21), 5103;
  • Loy TL, Vehlow D, Kauschke V, Müller M, Heiss C, Lips KS (2020). Effects of BDNF and PEC Nanoparticles on Osteocytes. Molecules. 2020, 25(18), 4151;
  • Rupp M, Kern S, Weber T, Menges TD, Schnettler R, Heiß C, Alt V (2020). Polymicrobial infections and microbial patterns in infected nonunions - a descriptive analysis of 42 cases. BMC Infect Dis. 2020 Sep 10;20(1):667. doi: 10.1186/s12879-020-05386-9. 
  • Sommer U, Laurich S, de Azevedo L, Viehoff K, Wenisch S, Thormann U, Alt V, Heiss C, Schnettler R (2020). In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy. Molecules 2020, 25(15), 3399;


Buchbeiträge und Monographien:

  • Heinrich M, Lany M, Anastasopoulou L, Biehl C, Szalay G, Brenck F, Heiss C. (2020) Evidence of Prolonged Monitoring of Trauma Patients Admitted via Trauma Resuscitation Unit without Primary Proof of Severe Injuries. In: New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient. Frank Hildebrand and Klemens Horst (Eds.). Seiten: 73-85. Printed Edition of the Special Issue Published in Journal of Clinical Medicin. Pages: 318, Published: December 2020. MDPI, St. Alban-Anlage 664052, Basel, Switzerland. ISBN 978-3-03943-777-1 (Hbk); ISBN 978-3-03943-778-8 (PDF).




  • Alagboso FI, Budak M, Sommer U, Ray S, Kaiser A, Kampschulte M, Henss A, Dürselen L, Biehl C, Lips KS, Heiss C, Thormann U, Alt V (2019). Establishment of a clinically relevant large animal model to assess the healing of metaphyseal bone. Eur Cell Mater. 2019 Jun 20;37:444-466. doi: 10.22203/eCM.v037a27.
  • Alt V, Heiss C, Rupp M (2019). Treatment of a Recurrent Periprosthetic Joint Infection with an Intramedullary Knee Arthrodesis System with Low-Amount Metallic Silver Coating. J Bone Jt Infect. 2019 Apr 20;4(3):111-114. doi: 10.7150/jbji.34484. eCollection 2019.
  • Biehl C, Hiob A, Thormann U, Heiss C (2019). Konservative und operative Behandlung der rheumatischen Gonarthritis. Orthopädische und Unfallchirurgische Praxis (OUP) 2019; 8(3):139-143.
  • Biehl C, Maxeiner H, Rupp M, Heiß C (2019). Perioperatives Management des traumatisierten „Rheumatikers“ – Medikation. Akt Rheumatol 2019; 44(01):39-44. DOI: 10.1055/s-0043-119414.
  • Biehl C, Rupp M, Alt V, Heiss C, El Khassawna T, Szalay G (2019). Peri-Prosthetic Joint Infection after Finger Joint Arthroplasty. Surg Infect (Larchmt). 2019 Dec 18. doi: 10.1089/sur.2019.145. [Epub ahead of print]
  • Biehl C, Rupp M, Schiefer U, El Khassawna T, Heiß C (2019). Rheumatoid arthritis and trauma assessment. Arthritis und Rheuma 2019; 39(05): 327-33. DOI: 10.1055/a-0994-8896
  • Brunotte M, Rupp M, Stötzel S, Sommer U, Mohamed W, Thormann U, Heiss C, Lips KS, Domann E, Alt V (2019). A new small animal model for simulating a two-stage-revision procedure in implant-related methicillin-resistant Staphylococcus aureus bone infection. Injury Nov. 2019; 50(11):1921-28. DOI:
  • Heiss C (2019). Gelenkerhaltende Frakturversorgung. OUP – Orthopädische und Unfallchirurgische Praxis 8(4):185.
  • Heiss C, Rupp M, Knapp G (2019). Knochenersatz und Knochenaufbau. Z Orthop Unfall 2019; 157(6):715-728. doi: 10.1055/a-0756-2768.
  • Hemm F, Anastasopoulou L, Thormann U, Heiss C, Rupp M (2019). Heterotope Ossifikationen nach gelenknahen Frakturen – Klinische Bedeutung, aktueller Stand und Ausblick der Therapie. Orthopädische und Unfallchirurgische Praxis (OUP) 2019; 8(4):220-228.
  • Ivo M, Rupp M, Biehl C, Oberrück S, Heiss C (2019). Pilon tibiale Frakturen – Wann, welche Platte? – Übersicht über aktuelle Behandlungsstrategien zur Optimierung operativer Ergebnisse. Orthopädische und Unfallchirurgische Praxis (OUP) 2019; 8(4):199-205.
  • Kauschke V, Hessland FM, Vehlow D, Müller M, Heiss C, Lips KS (2019). High Concentrations of Polyelectrolyte Complex Nanoparticles Decrease Activity of Osteoclasts. Molecules. 2019 Jun 25;24(12). pii: E2346. doi: 10.3390/molecules24122346.
  • Lany M, Mülke M, Knapp G, Szalay G, Heiss C (2019). Versorgung von Trümmerfrakturen des distalen Humerus beim Erwachsenen – im Alter wie beim jungen Patienten? Orthopädische und Unfallchirurgische Praxis (OUP) 2019; 8(4):188-197.
  • Mülke M, Ivo M, Biehl C, Rupp M, Heiss C (2019). Osteosynthetische Versorgung von Schenkelhalsfrakturen – Risikoanalyse von Pseudarthrosen mittels prä- und postoperativer Bildgebung. Orthopädische Nachrichten 04/2019:16.
  • Müller R, Henss A, Kampschulte M, Rohnke M, Langheinrich AC, Heiss C, Janek J, Voigt A, Wilke HJ, Ignatius A, Herfurth J, El Khassawna T, Deutsch A (2019). Analysis of microscopic bone properties in an osteoporotic sheep model: a combined biomechanics, FE and ToF-SIMS study. Journal of the Royal Society Interface 16: 20180793.
  • Rupp M, Anastasopoulou L, Wintermeyer E, Malhaan D, El Khassawna T, Heiss C (2019). Predatory journals: a major threat in orthopaedic research. Int Orthop. 2019 Mar;43(3):509-517. doi: 10.1007/s00264-018-4179-1. Epub 2018 Oct 4.
  • Rupp M, Kern S, Ismat A, El Khassawna T, Knapp G, Szalay G, Heiss C, Biehl C (2019). Computed tomography for managing periprosthetic femoral fractures. A retrospective analysis. BMC Musculoskelet Disord. 2019 May 29;20(1):258. doi: 10.1186/s12891-019-2632-y.
  • Rupp M, Kern S, El Khassawna T, Ismat A, Malhan D, Alt V, Heiss C, Raschke MJ (2019). Do Systemic Factors Influence the Fate of Nonunions to Become Atrophic? A Retrospective Analysis of 162 Cases. Biomed Res Int. 2019 Feb 19;2019:6407098. doi: 10.1155/2019/6407098. eCollection 2019.
  • Rupp M, Merboth F, Daghma DE, Biehl C, El Khassawna T, Heiß C (2019). Osteocytes - Osteocytes in Bone Remodeling - Conductors and Active Players. Z Orthop Unfall. 2019 Apr;157(2):154-163. doi: 10.1055/a-0658-5922. Epub 2018 Oct 26.
  • Rupp M, Schäfer C, Heiss C, Alt V (2019). Pinning of supracondylar fractures in children - Strategies to avoid complications. Injury. 2019 Jun;50 Suppl 1:S2-S9. doi: 10.1016/j.injury.2019.03.042. Epub 2019 Mar 29.
  • Valentin D, Roehr C, Presas A, Heiss C, Egusquiza E, Bosbach WA (2019). Experimental-Numerical Design and Evaluationstudy of a Vibration Bioreactor Using Piezoelectric Patches. Sensors (Basel). 2019 Jan 21;19(2). pii: E436. doi: 10.3390/s19020436
  • Weisweiler D, Rupp M, Budak M, Alt V, Heiss C (2019). Therapieoptionen bei implantatassoziierter Infektion nach distaler Humerusfraktur – Ein Fallbeispiel und aktuelle Literaturübersicht. Orthopädische und Unfallchirurgische Praxis (OUP) 2019; 8(4):230-235.




  • Al Khasawnah Q, Hassan F, Malhan D, Engelhardt M, Daghma DES, Obidat D, Lips KS, El Khassawna T, Heiss C (2018). Nonsurgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-Oil  Paste.Biomed Res Int. 2018 Feb 12;2018:8198795. doi: 10.1155/2018/8198795. eCollection 2018
  • Baumann L, Kauschke V, Vikman A, Dürselen L, Krasteva-Christ G, Kampschulte M, Heiss C, Yee KT, Vetter DE, Lips KS (2018). Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure. Bone. 2018 Nov 7;120:285-296. doi: 10.1016/j.bone.2018.11.003. [Epub ahead of print]
  • Daghma DES, Malhan D, Simon P, Stötzel S, Kern S, Hassan F, Lips KS, Heiss C, El Khassawna T (2018). Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine. J Bone Miner Metab. 2018 May;36(3):297-306. doi: 10.1007/s00774-017-0844-5. Epub 2017 Jun 6.
  • Biehl C, Ismat A, Kostuj T, Rupp M, Heiß C (2018). Den einen richtigen Op.-Zeitpunkt gibt es nicht. Rheuma der unteren Extremität: Wann gelenkerhaltend operieren? Orthopädie & Rheuma 2018; 21 (4): 40-44.
  • Biehl C, Thormann U, Heiß C (2018). Komplikationen in der Kniechirurgie des Rheumatikers. Aktuelle Rheumatologie 2018; 43: 73–81. doi: 10.1055/s-0042-108724.
  • Bosbach WA, Wilkinson C, Mieczakowski AK, Bagherifard S, Ismat A, López CD, Mele E, Muelke M, Weisweiler D, Boecker W, Lips K, El Khassawna T, Biehl C, Valentin D, Roehr C, Presas A, Rupp M, Heiss C (2018). 2018 Proceedings of the International Conference on Trauma Surgery Technology in Giessen. 2018 Proceedings of the International Conference on Trauma Surgery Technology in Giessen, 1-31.
  • Hessmann M, Heiß C (2018). 1. AOTD-Seminar in Fulda. OP-JOURNAL 2018; 34(03): 342-343. DOI 10.1055/a-0749-4690.
  • Kauschke V, Gebert A, Calin M, Eckert J, Scheich S, Heiss C, Lips KS (2018). Effects of new beta-type Ti-40Nb implant materials, brain-derived neurotrophic factor, acetylcholine and nicotine on human mesenchymal stem cells of osteoporotic and non osteoporotic donors. PLoS 2018 One Feb 28;13(2):e0193468. doi: 10.1371/journal.pone.0193468. eCollection 2018.
  • Kauschke V, Schneider M, Jauch A, Schumacher M, Kampschulte M, Rohnke M, Henss A, Bamberg C, Trinkaus K, Gelinsky M, Heiss C, Lips KS (2018). Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model. Int J Mol Sci. 2018 Nov 9;19(11). pii: E3531. doi: 10.3390/ijms19113531.
  • Lode A, Heiss C, Knapp G, Thomas J, Nies B, Gelinsky M, Schumacher M (2018). Strontium-modified premixed calcium phosphate cements for the therapy of osteoporotic bone defects. Acta Biomater. 2018 Jan;65:475-485. doi: 10.1016/j.actbio.2017.10.036. Epub 2017 Nov 1.
  • Malhan D, Muelke M, Rosch S, Schaefer AB, Merboth F, Weisweiler D, Heiss C, Arganda-Carreras I, El Khassawna T (2018). An Optimized Approach to Perform Bone Histomorphometry. Front Endocrinol (Lausanne). 2018 Nov 21;9:666. doi: 10.3389/fendo.2018.00666. eCollection 2018.
  • Mannala GK, Koettnitz J, Mohamed W, Sommer U, Lips KS, Spröer C, Bunk B, Overmann J, Hain T, Heiss C, Domann E, Alt V (2018). Whole-genome comparison of high and low virulent Staphylococcus aureus isolates inducing implant-associated bone infections. Int J Med Microbiol. 2018 Jul;308(5):505-513. doi: 10.1016/j.ijmm.2018.04.005. Epub 2018 Apr 25.
  • Nachlinger RJ, Kauschke V, Trinkaus K, El Khassawna T, Heiss C, Lips KS (2018). Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model. J Musculoskelet Neuronal Interact. 2018 Sep 1;18(3):354-365.
  • Ray S, Thormann U, Eichelroth M, Budak M, Biehl C, Rupp M, Sommer U, El Khassawna T, Alagboso FI, Kampschulte M, Rohnke M, Henß A, Peppler K, Linke V, Quadbeck P, Voigt A, Stenger F, Karl D, Schnettler R, Heiss C, Lips KS, Alt V (2018). Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing. Biomaterials. 2018 Mar;157:1-16. doi: 10.1016/j.biomaterials.2017.11.049. Epub 2017 Dec 1.
  • Roth A, Beckmann J, Bohndorf K, Heiß C, Jäger M, Landgraeber S, Maus U, Nöth U, Peters KM, Rader C, Reppenhagen S, Smolenski U, Kopp I, Tingart M (2018). Update of the German S3 guideline on atraumatic femoral head necrosis in adults. Orthopade. 2018 Sep;47(9):757-769. doi: 10.1007/s00132-018-3620-x.
  • Rupp M, Biehl C, Budak M, Heiss C, Thormann U, Alt V (2018). Diaphyseal Long Bone Nonunions – Types, Aetiology, Economics and Treatment Recommendations. Int Orthop. 2018 Feb;42(2):247-258. doi: 10.1007/s00264-017-3734-5. Epub 2017 Dec 22. Review
  • Rupp M, Heiss C, Alt V (2018). Septic nonunion in the left femoral shaft of a 22-year-old asylum seeker. Dtsch Arztebl Int 2018; 115(4): 58; DOI: 10.3238/arztebl.2018.058a.
  • Rupp M, Knapp G, Weisweiler D, Heiss C, Alt V (2018). Intestinal Perforation by a Toothpick as Reason for Necrotizing Fasciitis. J Bone Jt Infect. 2018 Oct 4;3(4):226-229. doi: 10.7150/jbji.29065. eCollection 2018.
  • Rupp M, Kockmann S, El Khassawna T, Raschke MJ, Heiss C, Ochman S (2018). Better is the foe of good: Outcome of operatively treated ankle fractures in the elderly. Foot (Edinb). 2018 Sep;36:15-20. doi: 10.1016/j.foot.2018.04.002. Epub 2018 Apr 24.
  • Rupp M, Mika J, Biehl C, Heiss C, Alt V (2018). Successful Total Elbow Replacement after Septic Arthritis with Staphylococcus aureus- a Case Report and Review of the Literature. Acta Chir Orthop Traumatol Cech. 2018;85(1):70-74. 
  • Sandriesser S, Rupp M, Greinwald M, Heiss C, Augat P, Alt V (2018). Locking design affects the jamming of screws in locking plates. Injury. 2018 Jun;49 Suppl 1:S61-S65. doi: 10.1016/S0020-1383(18)30306-1.
  • Simon P, Grüner D, Worch H, Pompe W, Lichte H, El Khassawna T, Heiss C, Wenisch S, Kniep R (2018). First evidence of octacalcium phosphate@osteocalcin nanocomplex as skeletal bone component directing collagen triple-helix nanofibril mineralization. Sci Rep. 2018 Sep 12;8(1):13696. doi: 10.1038/s41598-018-31983-5.




  • Heiss C, Kern S, Malhan D, Böcker W, Engelhardt M, Daghma DES, Stoetzel S, Schmitt J, Ivo M, Kauschke V, Lips KS, Tushtev K, Rezwan K, El Khassawna T (2017).  A New Clinically Relevant T-Score Standard to Interpret Bone Status in a Sheep Model. Med Sci Monit Basic Res 2017 Oct 2;23:326-335.
  • Khassawna TE, Daghma DE, Stoetzel S, Ray S, Kern S, Malhan D, Alt V, Thormann U, Henß A, Rohnke M, Stengel A, Hassan F, Maenz S, Jandt KD, Diefenbeck M, Schumacher M, Gelinsky M, Lips KS, Heiss C (2017). Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals. BioMed Research International, Article ID 2023853, doi:10.1155/2017/2023853. 
  • Schäfer C, Tilp S, Oltenau C, Szalay G, Heiß C (2017). Operative Möglichkeiten zur Behandlung von fehlverheilten distalen Unterarmfrakturen im Kindesalter. Trauma Berufskrankh 2017;19 (Suppl 2):S135-S139. doi: 10.1007/s10039-017-0245-y
  • El Khassawna T, Merboth F, Malhan D, Böcker W, Daghma DES, Stoetzel S, Kern S, Hassan F, Rosenbaum D, Langenstein J, Bauer N, Schlagenhauf A, Rösen-Wolff A, Schulze F, Rupp M, Hose D, Secklinger A, Ignatius A, Wilke HJ, Lips KS, Heiss C (2017). Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis. Am J Pathol. 2017 Jun 12. pii: S0002-9440(17)30132-3. doi: 10.1016/j.ajpath.2017.04.005
  • Ray S, Khassawna TE, Sommer U, Thormann U, Wijekoon ND, Heiss C, Alt V (2017). Differences in expression of Wnt antagonist Dkk1 in healthy versus pathological bone samples.J Microsc 265(1):111.129. doi: 10.1111/jmi.12469.
  • Schneck E, Koch C, Borgards M, Reichert M, Hecker A, Heiss C, Padberg W, Alejandre-Lafont E, Röhrig R, Krombach GA, Weigand M, Bernhard M, Roller FC (2017). Impact of Abdominal Follow-Up Sonography in Trauma Patients Without Abdominal Parenchymal Organ Lesion or Free Intraabdominal Fluid in Whole-Body Computed Tomography. RöFo Fortschr Röntgenstr 189(2):128-136. doi: 10.1055/s-0042-120844. Epub 2017 Jan 31.
  • Heß U, Shahabi S, Treccani L, Streckbein P, Heiss C, Rezwan K (2017). Co-delivery of cisplatin and doxorubicin from calcium phosphate beads/matrix scaffolds for osteosarcoma therapy. Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:427-435. doi: 10.1016/j.msec.2017.03.164. Epub 2017 Mar 21.
  • Daghma DES, Malhan D, Simon P, Stötzel S, Kern S, Hassan F, Lips KS, Heiss C, El Khassawna T (2017).
    Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine. J Bone Miner Metab. 2017 Jun 6. doi: 10.1007/s00774-017-0844-5. [Epub ahead of print]
  • Schumacher TC, Tushtev K, Wagner U, Becker C, Große Holthaus M, Hein SB, Haack J, Heiss C, Engelhardt M, El Khassawna T, Rezwan K (2017). A novel, hydroxyapatite-based screw-like device for anterior cruciate ligament (ACL) reconstructions. Knee 2017 Jul 22; pii: S0968-0160(17)30188-6.
    doi: 10.1016/j.knee.2017.07.005.
  • Schulze F, Malhan D, El Khassawna T, Heiss C, Seckinger A, Hose D, Rösen-Wolff A (2017). A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model. BMC Genomics. 2017 Dec 19;18(1):975. doi: 10.1186/s12864-017-4356-4.




  • Heiß C (2016). Plattensystem LOQTEQ®: Neue Ideen in der winkelstabilen Plattenosteosynthese. Jatros Orthopädie & Traumatologie Rheumatologie 5:50-53.
  • Augat P, Robioneck PB, Abdulazim A, Wipf F, Lips KS, Alt V, Schnettler R, Heiss C (2016). Fixation performance of an ultrasonically fused, bioresorbable osteosynthesis implant: A biomechanical and biocompatibility study. J Biomed Mater Res B Appl Biomater. 104(1):170-9.
  • Biehl C, Thormann U, Heiß C (2016). Komplikationen in der Kniechirurgie des Rheumatikers
    Aktuelle Rheumatologie, doi: 10.1055/s-0042-108724.
  • Biehl C, Eckhard M, Szalay G, Heiß C (2016). Minor-Amputationen beim diabetischen Fußsyndrom. Oper Orthop Traumatol 28(5):365-72.
  • Biehl C, Thormann U, Madera N, Heiss C (2016). Joint Involvement in Ochronosis. Surgery Curr Res 6:279. doi:10.4172/2161-1076.1000279. 
  • Charyeva O, Dakischew O, Sommer U, Heiss C, Schnettler R, Lips KS (2016). Biocompatibility of magnesium implants in primary human reaming debris-derived cells stem cells in vitro.  J Orthop Traumatol 17(1):63-73.
  • Ray S, Thormann U, Sommer U, Khassawna TE, Hundgeburth M, Henß A, Rohnke M, Lips KS, Heiss C, Heinemann S, Hanke T, Dürselen L, Schnettler R, Alt V (2016). Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats. Injury 47 Suppl 1:S52-61.
  • Roth A, Beckmann J, Bohndorf K, Fischer A, Heiss C, Kenn W, Jäger M, Maus U, Nöth U, Peters KM, Rader C, Reppenhagen S, Smolenski U, Tingart M, Kopp I, Sirotin I, Breusch SJ (2016). S3-Guideline non-traumatic adult femoral head necrosis. Arch Orthop Trauma Surg 136(2):165-7.
  • Hess U, Mikolajczyk G, Treccani L, Streckbein P, Heiss C, Odenbach S, Rezwan K (2016). Multi-loaded ceramic beads / matrix scaffolds obtained by combining ionotropic and freeze gelation for sustained and tuneable vancomycin release.Mater Sci Eng C Mater Biol Appl 67:542-53, doi:10.1016/j.msec.2016.05.042.
  • Mohamed W, Domann E, Chakraborty T, Mannala G, Lips KS, Heiss C, Schnettler R, Alt V (2016). TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress. BMC Microbiology 16:230, doi: 10.1186/s12866-016-0855-8




  • Heiß C (2015). Defektfüllung bei Osteoporose. Osteologie 2015 Current congress, Berlin, 12.-14.03.2015: 6-7.
  • El Khassawna T, Böcker W, Brodsky K, Weisweiler D, Govindarajan P, Kampschulte M, Thormann U, Henss A, Rohnke M0, Bauer N, Müller R, Deutsch A, Ignatius A, Dürselen L, Langheinrich A, Lips KS, Schnettler R, Heiss C (2015). Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats. Histochem Cell Biol 144(5):491-507.
  • Szalay G, Scheufens T, Alt V, Thormann U, Heiß C (2015). Erfahrungen mit Mini TightRope® bei schmerzhafter Proximalisierung des 1. Mittelhandstrahls nach Trapezektomie bei Rhizarthrose [Primary results Using the Mini TightRope® for Revision Surgery for Painful Proximalisation of the first Metacarpal after Trapezectomy for CMC-1-osteoarthritis]. Handchir Mikrochir Plast Chir 47(1):17-23
  • Kampschulte M, Erdmann G, Sender J, Martels G, Böcker W, ElKhassawna T, Heiss C, Langheinrich AC, Roeb E, Roderfeld M, Krombach GA (2015). The development and validation of micro-CT of large deep frozen specimens. Scanning. 2015 Jan-Feb;37(1):63-72.
  • Hess U, Hill S, Treccani L, Streckbein P, Heiss C, Rezwan K (2015). A mild one-pot process for synthesising hydroxyapatite/biomolecule bone scaffolds for sustained and controlled antibiotic release.
    Biomed Mater 10(1):015013.
  • Pardun K, Treccani L, Volkmann E, Destri GL, Marletta G, Streckbein P, Heiss C, Rezwan K (2015).
    Characterization of Wet Powder-Sprayed Zirconia/Calcium Phosphate Coating for Dental Implants.
    Clin Implant Dent Relat Res 17(1):186-98.
  • Bauer NB, Khassawna TE, Goldmann F, Stirn M, Ledieu D, Schlewitz G, Govindarajan P, Zahner D, Weisweiler D, Schliefke N, Böcker W, Schnettler R, Heiss C, Moritz A (2015). Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis. Exp Toxicol Pathol 67(4):287-96.
  • Haupt M, Kauschke V, Sender J, Kampschulte M, Kovtun A, Dürselen L, Heiss C, Lips KS (2015). Bone status of adult female butyrylcholinesterase gene-deficient mice. Int Immunopharmacol 29(1):208-14.
  • Kauschke V, Kneffel M, Floel W, Hartmann S, Kampschulte M, Dürselen L, Ignatius A, Schnettler R, Heiss C, Lips KS (2015). Bone status of acetylcholinesterase-knockout mice. Int Immunopharmacol 29(1):222-30.
  • Lips KS, Kneffel M, Willscheid F, Mathies FM, Kampschulte M, Hartmann S, Panzer I, Dürselen L, Heiss C, Kauschke V (2015). Altered ultrastructure, density and cathepsin K expression in bone of female muscarinic acetylcholine receptor M3 knockout mice. Int Immunopharmacol 2015 Nov;29(1):201-7.
  • Lips KS, Yanko Ö, Kneffel M, Panzer I, Kauschke V, Madzharova M, Henß A, Schmitz P, Rohnke M, Bäuerle T, Liu Y, Kampschulte M, Langheinrich AC, Dürselen L, Ignatius A, Heiss C, Schnettler R, Kilian O (2015). Small changes in bone structure of female alpha7 nicotinic acetylcholine receptor knockout mice. BMC Musculoskelet Disord 16(1):5. doi: 10.1186/s12891-015-0459-8.
  • Maus U, Roth A, Tingart M, Rader C, Jäger M, Nöth U, Reppenhagen S, Heiss C, Beckmann J (2015).
    S3 Guideline. Part 3: Non-Traumatic Avascular Necrosis in Adults - Surgical Treatment of Atraumatic Avascular Femoral Head Necrosis in Adults. Z Orthop Unfall 153(5):498-507.
  • Pardun K, Treccani L, Volkmann E, Streckbein P, Heiss C, Li Destri G, Marletta G, Rezwan K (2015).
    Mixed zirconia calcium phosphate coatings for dental implants: tailoring coating stability and bioactivity potential. Mater Sci Eng C Mater Biol Appl 48:337-46.
  • Pardun K, Treccani L, Volkmann E, Streckbein P, Heiss C, Gerlach JW, Maendl S, Rezwan K (2015).
    Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior. J Biomater Appl 30(1):104-18.
  • Roth A, Beckmann J, Smolenski U, Fischer A, Jäger M, Tingart M, Rader C, Peters KM, Reppenhagen S, Nöth U, Heiß C, Maus U (2015). S3-Leitlinie. Teil 2: Atraumatische Femurkopfnekrose des Erwachsenen – unbehandelter Verlauf und konservative Behandlung. [S3 guideline. Part 2: Non-Traumatic Avascular Femoral Head Necrosis in Adults - Untreated Course and Conservative Treatment]. Z Orthop Unfall 153(5):488-97.
  • Ternes S, Trinkaus K, Bergen I, Knaack S, Gelinsky M, Kilian O, Heiss C, Lips KS (2015). Impact of acetylcholine and nicotine on human osteoclastogenesis in vitro. Int Immunopharmacol 29(1):215-21.
  • Thormann U, Alt V, Heimann L, Gasquere C, Heiss C, Szalay G, Franke J, Schnettler R, Lips K (2015).
    The biocompatibility of degradable magnesium interference screws - An experimental study with sheep.
    Biomed Res Int 2015:943603. doi: 10.1155/2015/943603.
  • Uhle F, Lichtenstern C, Brenner T, Fleming T, Koch C, Hecker A, Heiss C, Nawroth PP, Hofer S, Weigand MA, Weismüller K (2015). Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study. Mediators of Inflammation Volume 2015, Article ID 691491, 9 pages
  • Zablotni A, Dakischew O, Trinkaus K, Hartmann S, Szalay G, Heiss C, Lips KS (2015). Regulation of acetylcholine receptors during differentiation of bone mesenchymal stem cells harvested from human reaming debris. Int Immunopharmacol 29(1):119-26.
  • Alt V, Borgman B, Eicher A, Heiss C, Kanakaris NK, Giannoudis PV, Song F (2015). Effects of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in grade III open tibia fractures treated with undreamed nails – A clinical and health economic analysis. Injury 46(11):2267-72.
  • Lautenschläger S, Striegler C, Dakischew O, Schütz I, Szalay G, Schnettler R, Heiss C, Appelhans D, Lips KS (2015). Effects of dendritic core-shell glycoarchitectures on primary mesenchymal stem cells and osteoblasts obtained from different human donors. J Nanobiotechnology. 2015 Oct 8;13:65.




  • Böcker W, El Khassawna T, Bauer N, Brodsky K, Weisweiler D, Govindarajan P, Schlewitz G, Kampschulte M, Dürselen L, Thormann U, Szalay G, Schnettler R, Langheinrich AC, Heiss C (2014). Short-term glucocorticoid treatment causes spinal osteoporosis in ovariectomized rats. EUR SPINE J, 23(11): 2437-48.
  • Govindarajan P, Böcker W, El Khassawna T, Kampschulte M, Schlewitz G, Huerter B, Sommer U, Dürselen L, Ignatius A, Bauer N, Szalay G, Wenisch S, Lips KS, Schnettler R, Langheinrich A, Heiss C (2014). Bone matrix, cellularity, and structural changes in a rat model with high-turnover osteoporosis induced by combined ovariectomy and a multiple-deficient diet. AM J PATHOL, 184(3): 765-77.
  • Fehrendt H, Linn T, Hartmann S, Szalay G, Heiss C, Schnettler R, Lips KS (2014). Negative influence of a long-term high-fat diet on murine bone architecture. INT J ENDOCRINOL, 2014: 318924. 
  • Kauschke V, Lips KS, Heiss C, Schnettler R (2014). Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis. MED SCI MONITOR, 20: 869-74.
  • Lips KS, Kauschke V, Hartmann S, Thormann U, Ray S, Schumacher M, Gelinsky M, Heinemann S, Hanke T, Kautz AR, Schnabelrauch M, Szalay G, Heiss C, Schnettler R, Alt V, Kilian O (2014). Cholinergic nerve fibers in bone defects of a rat osteoporosis model and their regulation by implantation of bone substitution materials. J MUSCULOSKEL NEURON, 14(2): 173-88.
  • Müller R, Kampschulte M, Khassawna TE, Schlewitz G, Hürter B, Böcker W, Bobeth M, Langheinrich AC, Heiss C, Deutsch A, Cuniberti G (2014). Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model.
    MED BIOL ENG COMPUT, 52(4): 405-14.
  • Roth P, Heiss C, Koshty A, Niemann B, Boening A (2014). Posttraumatic arteriovenous fistula of the distal posterior tibial artery as cause of delayed wound healing in an unrecognized arterial injury.
    Thorac Cardiovasc Surg Rep, 3(1): 67-70.
  • Thormann U, El Khawassna T, Ray S, Duerselen L, Kampschulte M, Lips KS, von Dewitz H, Heinemann S, Heiss C, Szalay G, Langheinrich AC, Ignatius A, Schnettler R, Alt V (2014). Differences of bone healing in metaphyseal defect fractures between osteoporotic and physiological bone in rats.




  • Heiß C, Maier GS, Gelinsky M, Hose D, Schnettler R (2013). Klinische Verwendung osteologischer Biomaterialien. Osteologie 22(3): 173-178.
  • Elkhassawna T, Böcker W, Govindarajan P, Schliefke N, Hürter B, Kampschulte M, Schlewitz G, Alt V, Lips KS, Faulenbach M, Möllmann H, Zahner D, Dürselen L, Ignatius A, Bauer N, Wenisch S, Langheinrich AC, Schnettler R, Heiss C (2013). Effects of Multi-Deficiencies-Diet on Bone Parameters of Peripheral Bone in Ovariectomized Mature Rat. PLOS ONE 8(8), e71665: 1-12.
  • Govindarajan P, ElKhassawna T, Kampschulte M, Böcker W, Huerter B, Dürselen L, Faulenbach M, Heiss  C (2013). Implications of combined ovariectomy and glucocorticoid (dexamethasone) treatment on mineral, microarchitectureal, biomechanical and matrix properties of rat bone. Int J Exp Pathol 94(6):387-98.
  • Schlewitz G, Govindarajan P, Schliefke N, Böcker W, el Khassawna T,  Alt V, Thormann U,  Lips KS, Hemdan NY,  Zahner D, Schnettler R, Heiss C (2013). Ovariectomy and calcium-/vitamin D2/3-deficient diet as a model of osteoporosis in the spine of sprague-dawley rats. Z Orthop Unfall 151(1):14-9. [German]
  • Govindarajan P, Schlewitz G, Schliefke N, Weisweiler D, Alt V, Thormann U, Lips KS, Wenisch S, Langheinrich AC, Zahner D, Hemdan NYA, Schnettler R, Heiss C (2013). Implications of combined ovariectomy/multi-deficiency diet on rat bone with age related variation in bone parameters and bone loss at multiple skeletal sites by DEXA. Med Sci Monit Basic Res 28;19:76-86.
  • Grüner D, Lips KS, Heiss C, Schnettler R, Kollmann T, Simon P, Kniep R (2013). Irregular shaped, assumably semi-crystalline calciumphosphate platelet deposition at the mineralization front of rabbit femur osteotomy: a HR-TEM study. Scanning 35(3):169-82.
  • Liu Y, Cao L, Hillengass J, Delorme S, Schlewitz G, Govindarajan P, Schnettler R, Heiss C, Bäuerle T (2013). Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI and histology. Acta Radiol 54(2):205-13.
  • Kraus R, Stahl JP, Heiss C, Horas U, Dongowski N, Schnettler R (2013). Fractures of the thoracic and lumbar spine in children and adolescents. Unfallchirurg 116(5):435-41. [German]
  • Alt V, Thormann U, ElKhassawna T, Ray S, Lips KS, Heiss C, Zahner D, Dürselen L, Kampschulte M, Heinemann S, Langheinrich AC, Ignatius A, Schnettler R (2013). A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures. Acta Biomat 9(6): 7035-42.
  • Cheng C, Heiss C, Dimitrakopoulou-Strauss A, Schlewitz G, Govindarajan P, Pan L, Schnettler R, Weber K, Strauss LG (2013). Evaluation of bone remodeling with 18F-Fluoride and correlation with the glucose metabolism as measured with 18FFDG in lumbar spine within time in an experimental nude rat. Am J Nucl Med Mol Imaging 3(2):118-28.
  • Goergen J, Wenisch S, Raabe O, Moritz A, Schlewitz G, Schnettler R, Hempel U, Heiss C, Arnhold S (2013). Characterization of Bone-Marrow-Derived Stem Cells in Osteoporotic Models of the Rat. ISRN Stem Cells Volume 2013, Article ID 262451, 9 pages,
  • Henss A, Rohnke M, ElKhassawna T, Govindarajan P, Schlewitz G, Heiss C, Janek J (2013). Applicability of ToF-SIMS for monitoring compositional changes in bone in a long term animal model. J R Soc Interface 10: 20130332
  • Lips KS, Kauschke V, Hartmann S, Thormann U, Ray S, Kampschulte M, Langheinrich A, Schumacher M, Gelinsky M, Heinemann S, Hanke T, Kautz AR, Schnabelrauch M, Schnettler R, Heiss C, Alt V, Kilian O (2013). Podoplanin immunopositive lymphatic vessels at the implant interface in a rat model of osteoporotic fractures. PLoS One 8(10):e77259. doi: 10.1371/journal.pone.0077259
  • Thormann U, Ray S, Sommer U, Elkhassawna T, Rehling T, Hundgeburth M, Henß A, Rohnke M, Janek J, Lips KS, Heiss C, Schlewitz G, Szalay G, Schumacher M, Gelinsky M, Schnettler R, Alt V (2013). Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats. Biomaterials 34(34):8589-98. doi: 10.1016/j.biomaterials.2013.07.036. Epub 2013 Jul 29.
  • Thormann U, Ray S, Sommer U, El Khassawna T, Heiss C, Schnettler R, Alt V (2013). Biomaterials for enhancement of bone healing in osteoporotic fractures. BioNanoMaterials 14: Heft 3-4: 135-142.


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