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Klebe, Gerhard

Klebe, Gerhard

Expertise: The lab of Gerhard Klebe is internationally recognized in the field of structure-based drug development. In the search for and optimization of small molecules that bind disease-related target proteins and modulate their function, his lab uses both self-developed computer-assisted methods and experimental ones (e.g. crystallization of the protein in complex with the ligand, isothermal titration calorimetry (ITC), surface plasmon resonance spectroscopy (SPR), microscale thermophoresis (MST), various enzyme assays). The lab runs two in-house x-ray diffractometers and regularly books time at synchrotrons, especially the one in Berlin named BESSY.