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Publications

Selected Publications

Schloer S, Goretzko J, Pleschka S, Ludwig S, Rescher U. Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection. Viruses. 2020 Jun 29;12(7):E703. doi: 10.3390/v12070703. PMID: 32610711

Harbig A, Mernberger M, Bittel L, Pleschka S, Schughart K, Steinmetzer T, Stiewe T, Nist A, Böttcher-Friebertshäuser E. Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airway.J Biol Chem. 2020 Apr 17:jbc.RA120.012635. doi: 10.1074/jbc.RA120.012635. Online ahead of print. PMID: 32303635

Laure M, Hamza H, Koch-Heier J, Quernheim M, Müller C, Schreiber A, Müller G, Pleschka S, Ludwig S, Planz O. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model. Antiviral Res. 2020 Jun;178:104806. doi: 10.1016/j.antiviral.2020.104806. Epub 2020 Apr 15. PMID: 32304723

C, Kuznetsova I, Schulze J, Hardt M, Lecuona E, Sznajder JI, Vadász I, Morty RE, Pleschka S, Wolff T, Herold S. Influenza A Virus Infection Induces Apical Redistribution of Na+, K+-ATPase in Lung Epithelial Cells In Vitro and In Vivo. Peteranderl Am J Respir Cell Mol Biol. 2019 Sep;61(3):395-398. doi: 10.1165/rcmb.2019-0096LE. PMID: 31469298

Weber A, Dam S, Saul VV, Kuznetsova I, Müller C, Fritz-Wolf K, Becker K, Linne U, Gu H, Stokes MP, Pleschka S, Kracht M, Schmitz ML. Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks. J Virol. 2019 Jun 14;93(13):e00528-19. doi: 10.1128/JVI.00528-19. Print 2019 Jul 1. PMID: 30996098

Wiwie C, Kuznetsova I, Mostafa A, Rauch A, Haakonsson A, Barrio-Hernandez I, Blagoev B, Mandrup S, Schmidt HHHW, Pleschka S, Röttger R, Baumbach J. Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets. Syst Med (New Rochelle) 2019; 2(1): 1–9. Published online 2019 Mar 28. doi: 10.1089/sysm.2018.0013

Weber A, Dam S, Saul VV, Kuznetsova I, Müller C, Fritz-Wolf K4, Becker K, Linne U, Gu H, Stokes MP, Pleschka S, Kracht M, Schmitz ML. Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks. J Virol. 2019 Jun 14;93(13). pii: e00528-19. doi: 10.1128/JVI.00528-19. Print 2019 Jul 1.

Mostafa A, Abdelwhab EA, Mettenleiter TC, Pleschka S. Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview.Viruses. 2018 Sep; 10(9): 497. Published online 2018 Sep 13. doi:10.3390/v10090497

Petersen H, Mostafa A, Tantawy MA, Iqbal AA, Hoffmann D, Tallam A, Selvakumar A, Pessler F, Beer M, Rautenschlein S, Pleschka S. NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems. Front Microbiol. 2018; 9: 526. Published online 2018 Mar 22. doi: 10.3389/fmicb.2018.00526

Scheuch G, Canisius S, Nocker K, Hofmann T, Naumann R, Pleschka S, Ludwig S, Welte T, Planz O. Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients. Emerg Microbes Infect. 2018; 7: 21. Published online 2018 Mar 7. doi: 10.1038/s41426-018-0023-3

Kuznetsova I, Arnold T, Aschacher T, Schwager C, Hegedus B, Garay T, Stukova M, Pisareva M, Pleschka S, Bergmann M, Egorov A. Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase. Mol Ther Oncolytics. 2017 Dec 15; 7: 37–44. Published online 2017 Sep 8. doi: 10.1016/j.omto.2017.09.002

Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Mielke M, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T. Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR. J Virol. 2017 May 15; 91(10): e00198-17. Prepublished online 2017 Mar 1. Published online 2017 Apr 28. doi: 10.1128/JVI.00198-17

Kanrai P, Mostafa A, Madhugiri R, Lechner M, Wilk E, Schughart K, Ylösmäki L, Saksela K, Ziebuhr J, Pleschka S Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems. J Gen Virol. 2016 Sep;97(9):2135-48. doi: 10.1099/jgv.0.000542.

Dam S, Kracht M, Pleschka S, Schmitz ML. The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB. J Virol. 2016 Aug 12;90(17):7980-90. doi: 10.1128/JVI.00946-16.

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S. Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest. 2016 Apr 1;126(4):1566-80. doi: 10.1172/JCI83931.

Mostafa A, Kanrai P, Ziebuhr J, Pleschka S. The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs. J Gen Virol. 2016 Mar;97(3):620-31. doi: 10.1099/jgv.0.000390.

Schmier S, Mostafa A, Haarmann T, Bannert N, Ziebuhr J, Veljkovic V, Dietrich U, Pleschka S. In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses. Sci Rep. 2015 Jun 19;5:11434. doi: 10.1038/srep11434.

Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S. Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes. J Virol. 2015 Jun;89(11):6009-21. doi: 10.1128/JVI.03531-14. Epub 2015 Mar 25.

Mostafa A, Kanrai P, Petersen H, Ibrahim S, Rautenschlein S, Pleschka S. Efficient generation of recombinant influenza A viruses employing a new approach to overcome the genetic instability of HA segments. PLoS One. 2015 Jan 23;10(1):e0116917. doi: 10.1371/journal.pone.0116917. eCollection 2015.

Högner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlöhner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S. Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia. PLoS Pathog. 2013 Feb;9(2):e1003188. doi: 10.1371/journal.ppat.1003188. Epub 2013 Feb 28.

Petersen H, Wang Z, Lenz E, Pleschka S, Rautenschlein S. Reassortment of NS segments modifies highly pathogenic avian influenza virus interaction with avian hosts and host cells. J Virol. 2013 May;87(10):5362-71. doi: 10.1128/JVI.02969-12. Epub 2013 Mar 6.

Herold S, Ludwig S, Pleschka S, Wolff T. Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury.J Leukoc Biol. 2012 Jul;92(1):75-82. doi: 10.1189/jlb.1011530. Epub 2012 Feb 17. Review.

Droebner K, Pleschka S, Ludwig S, Planz O. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res. 2011 Aug 11. [Epub ahead of print]

Pinto R, Herold S, Cakarova L, Hoegner K, Lohmeyer J, Planz O, Pleschka S. Inhibition of influenza virus-induced NF-kappaB and Raf-MEK-ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo. Antiviral Res. 2011 May 27. [Epub ahead of print]

Wang Z, Robb NC, Lenz E, Wolff T, Fodor E, Pleschka S. 2010. NS Reassortment of an H7-Type Highly Pathogenic Avian Influenza Virus Affects Its Propagation by Altering the Regulation of Viral RNA Production and Antiviral Host Response. J Virol. Nov;84(21):11323-35

Ma W, Brenner D, Wang Z, Dauber B, Ehrhardt C, Högner K, Herold S, Ludwig S, Wolff T, Yu K, Richt JA, Planz O, Pleschka S. 2010. The NS-segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism and host range of an H7N1 HPAIV. J Virol. Feb;84(4):2122-33.

Herold S., von Wulffen W., Steinmueller M., Pleschka S., Kuziel W.A., Seeger W., Maus U.A. and Lohmeyer J. 2008. Lung epithelial apoptosis in influenza virus pneumonia: The role of macrophage expressed TNF-related apoptosis-inducing ligand. J Exp Med. Dec; 205 (13): 3065-77

Mazur I, Wurzer WJ, Ehrhardt C, Pleschka S, Puthavathana P, Silberzahn T, Wolff T, Planz O, Ludwig S. 2007. Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity. Cell Microbiol. Jul;9(7):1683-94.

Marjuki H., Alam M.I., Ehrhardt C., Wagner R., Planz O., Klenk H.-D., Ludwig, Pleschka S. 2006. Membrane accumulation of Influenza A virus hemagglutinin triggers nuclear export of the viral genome via PKC-alpha mediated activation of ERK signalling. J Biol Chem.;281(24):16707-15.

Ludwig S., Wolff T., Ehrhardt C., Wurzer W.J., Reinhardt J., Planz O., Pleschka S. 2004. MEK inhibition impairs influenza B virus propagation without emergence of resistant variants. FEBS Lett. 561(1-3):37-43.

Pleschka S., Wolff T., Ehrhardt C., Hobom G., Planz O., Rapp U. and Ludwig S. 2001. Influenza virus propagation is impaired upon specific inhibition of the Raf/MEK/ERK signaling cascade, Nat Cell Biol. 3(3):301-305. featured in “Nature Views” and in “Science Now”

Pleschka S., Jaskunas S., R., Engelhardt O., Zürcher T., Palese P. and García-Sastre A., 1996, A plasmid based reversed genetics system for influenza A virus, J. Virol. 70, 4188-4192.