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Background

Inflammation and cytokines
Acute and chronic inflammatory conditions such as rheumatoid arthritis (RA) are of major relevance from a therapeutic but also economical perspective.
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Importance of anti cytokine therapies
The history of relatively specific anti-inflammatory drugs comprises only a few major milestones:
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Drugs targeting IL-1 or TNF
Today the importance of IL-1 and TNF for the pathogenesis of chronic inflammatory diseases is well established and undisputed
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Limitations of current anti cytokine therapies
As for today there are no drugs that are specific for individual inflammatory conditions. Moreover, there is no drug that can cure inflammatory diseases.
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