Picture of the Month - March 2019
Here you see current insights into the research of the LaMa groups. A collection of the former pictures can be found in the Gallery.
Compounds which alkylate and split DNA are common reagents in cancer therapy as well as antibiotics. In our group we developed an efficient synthetic approach to bis-3-chloropiperidines as such artificial DNA-alkylants. In cooperation with the groups of Barbara Gatto (pharmacy in Padova/Italy) and Daniele Fabris (mass-spectrometry in Albany) we analyse the reactivity and selectivity of these compounds.
- I. Zuravka, A. Sosic, B. Gatto, R. Göttlich, Synthesis and evaluation of a bis-3-chloropiperidine derivative incorporating an anthraquinone pharmacophore, Bioorg. Med. Chem.Lett. 2015, 25, 4606-4609, doi:
- A. Sosic, I. Zuravka, N.-K. Schmitt, A. Miola, R. Göttlich, D. Fabris, B. Gatto, Direct and Topoisomerase II mediated DNA damage by Bis-3-chloropiperidines: the importance of being an earnest G, ChemMedChem 2017, 12, 1471 – 1479, doi:
- C. Carraro, A. Francke, A. Sosic, F. Kohl, T. Helbing, M. De Franco, D. Fabris, R. Göttlich B. Gatto, Behind the mirror: chirality tunes the reactivity and cytotoxicity of chloropiperidines as potential anticancer agents, Med.Chem.Lett. 2019, 10, doi:
This picture was submitted by Tim Helbing, group of Prof. Dr. Richard Göttlich.