Inhaltspezifische Aktionen

Winter School 2017

Program of the 2017 IRTG Winter School

7th Winter School of the Collaborative Research Centre TRR81
“Chromatin Changes in Differentiation and Malignancies” Marburg-Giessen-Bad Nauheim-Rotterdam
at the Kleinwalsertal, February 26 - March 03, 2017

 

Sunday 26.2.2017

19:15 Dinner
20:15 Ski Rental

Monday 27.2.2017

08:00-09:00 Breakfast

MORNING SESSION
09:00-11:30
Chair: Ruben Boers and Sara Völkel

Welcome at the seminar room - Sjaak Philipsen

  • Mingjing Li (PI Braun BN) Epigenetic regulation of cardiomyocyte proliferation and cardiac regeneration
  • Ilias Boltsis (PIs Grosveld & Gribnau R) The role of non-coding RNAs and transcription factor networks in X-inactivation

  • Peeyush Sahu (PI Bauer M) Effects of PRMT6 deletion on H3R2me2a deposition and transcription in NT2/D1 cells

  • Martijn Vos (PI Grosveld & Delwel R) Targeting G protein coupled receptor 56 using (ant)agonistic antibodies, a potential therapeutic in acute myeloid leukemia

  • Markus Seibert (PI Schmitz G) Characterization of histone H2B serine 6 phosphorylation

  • Lize Meert (PI Poot R) Protein interaction networks of autism chromatin modifiers in human neural stem cells

12:00-17:00 Open Discussions
17:30-18:15 Dinner


EVENING SESSION
18:30-21:30
Chair: Ilona Vuist and Karim Bouazoune


  • Hegias Mira Bontenbal (PI Gribnau R) Generation of an X Chromosome Reactivation mouse model

  • Sandra Hake (new PI) Histone variants in stem cell differentiation and disease
  • Anne Korporaal (PI Philipsen R) The Klf1 Nan variant affects developmental expression patterns of globin genes
  • Katja Sträßer / Wolfgang Wende (new PI) Coupling between nuclear mRNP formation and epigenetic marks

  • Aleksandra Turkiewicz (PI Borggrefe G) Characterization of the RBP-J/SHARP-mediated repression mechanism at Notch target genes

  • Soni Pullamsetti (new PI) JMJD histone demethylases: Role and regulation in the pathogenesis of Pulmonary Hypertension

 

Tuesday 28.2.2017

 

08:00-09:00 Breakfast


MORNING SESSION
09:00-11:30
Chair: Hegias Mira Bontenbal and Parysatis Sachs

  • Valentina Casa (PI Wendt R) Regulation of the cohesin-loading factor NIPBL: role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element

  • Fan Wu (PI Braun BN) Tet3 mediated epigenetic signature affects cell identity and remodeling in lung bronchioles

  • Jeffrey Boeren (PI Gribnau R) Characterization of the Xist promoter protein interactors by CasID

  • Francesca Ferrante (PI Borggrefe G) HDAC3 is a positive regulator of Notch signalling that acts by stabilizing the cleaved Notch protein

  • Judith Birkhoff (PI Huylebroeck R) Transcription factor Zeb2 action mechanisms and regulations in embryonic cell fate decisions

  • Karim Bouazoune (PI Brehm M) Biochemical characterization of the DNA repair protein SHPRH using nucleosome substrates

12:00-17:00 Open Discussions
17:30-18:15 Dinner

EVENING SESSION
18:30-21:30
Chair: Laura Brueckner and Markus Seibert

  • Peter Kolb (new PI) Identifying selective protein ligands in chemical space
  • Ilona Vuist (PI Houtsmuller R) Effects of UV induced DNA damage on mRNA concentration in single genes
  • Wibke Diederich (new PI) Computer-based Design and synthesis of Protein Arginine Methyltransferase 4 inhibitors
  • Ayestha Sijm (PI Verrijzer R) Gene control by USP7/GMPS
  • Debbie van den Berg (new PI) Migration matters: Transcriptional control of forebrain development by Nipbl and Zfp609

PI meeting in the seminar room

Wednesday 1.3.2017

 

08:00-09:00 Breakfast

Morning SESSION
9:00-11:30
Chair: Andrea Conidi and Aleksandra Turkiewicz

  • Joanna Brühl (PI Brehm M) Identification of potential chromatin remodeling factor drug targets in Acute Myeloid Leukemia
  • Lennart van der Wal (PIs Demmers and Verrijzer R) Analyzing changes in ubiquitylation status using quantitative mass spectrometry
  • Ikram Ullah (PI Brehm M) dMi-2 and RNA, EcR/USP
  • Marti Quevedo (PI Poot R) A Mediator-associated transcription factor activates transcription in neural stem cells
  • Parysatis Sachs (PI Mermoud M) Genome-wide mapping of the ATP-dependent chromatin remodeler SMARCAD1 in mouse embryonic stem cells
  • Laura Brueckner (PI Van Steensel A) Studying the interplay between genome organization and gene regulation by thousands of integrated reporters


12:00-17:00 Open Discussions
17:30-18:15 Dinner

EVENING SESSION
18:30-21:30
Chair: Valentina Casa and Peeyush Sahu

  • Ruben Schep (PI Van Steensel A) What are the effects of chromatin on DNA double strand break repair response?
  • Mehrnaz Ghazvini (PI Gribnau R) Study of XCI regulation in development in human
  • Jana Haas (PI Schmitz G) Analysis of HIPK2-mediated chromatin decondensation
  • Esther Sleddens-Linkels (PI Baarends R) Meiotic checkpoint activation in men with non -obstructive azoospermia
  • Tim Hundertmark (PI Renkawitz-Pohl M) The role of Plus3 domain proteins in male germ cell development of Drosophila
  • Andrea Conidi (PI Huylebroeck R) How sweet is Zeb2: O-GlcNAcylation of Zeb2 is necessary for its activity as cell-autonomous E-cadherin (Cdh1) regulator and BMP signalling antagonist

 

Thursday 2.3.2017

 

08:00-09:00 Breakfast



MORNING SESSION
09:00-11:30
Chair: Marti Quevedo and Jana Haas

 

  • Dong Ding (PI Mermoud M) Study of SMARCAD1 Function in Mouse Embryonic Stem Cells by Proteomics and RNAi
  • Joachim Boers (PI Gribnau R) MeD-seq, a novel method to detect genome wide DNA methylation – Bioinformatics
  • Ruben Boers (PI Gribnau R) MeD-seq, a novel method to detect genome wide DNA methylation – Wet lab
  • Sara Völkel (PI Suske M) Zinc finger independent genome-wide binding of Sp2 to CCAAT box promoters
  • Teresa Robert Finestra (PI Gribnau R) Single-cell methylation profiling using MeD-seq
  • Sjaak Philipsen Closing remarks


12:00-16:00 Open Discussions
16:00-17:30 Workshops on Perspectives

17:30-18:30 Farewell Dinner and events:
19:00-20:00 Torch-light procession
20:00-late    Farewell party

Friday 3.3.2017

 

07:30-08:30 Breakfast and departure (Rotterdam participants)

 

Download the program in PDF format here!