The Projects
IRTG1062 consists of 15 projects, each of which is conducted by MBML Faculty in association with a participating laboratory at one of the two participating centres in the USA. Here you can find detailed information about each project and the scientists involved.
There are 15 research projects associated with the IRTG1062 programme second funding period. Project consist of a senior principal investigator and a junior co-principal investigator based in Giessen, together with a senior co-principal investigator based at one of the two participating centres in the United States of America, being Columbia University (CU), and Northwestern University (NU). The current projects are:
| Principal investigator structure | Project title | |||
| Senior PI (Germany) |
Junior co-PI (Germany) |
USA-based partner | ||
| 1 | Seeger | Vadász | Sznajder (NU) | CO2 signalling in the alveolar epithelium: Role of ENaC in the hypercapnia-induced alveolar epithelial dysfunction |
| 2 | Morty | Königshoff | Sznajder (NU) | Impaired alveolar fluid reabsorption in acute lung injury: a role for dysregulated TGF-beta signalling? |
| 3 | Fink | Kwapiszewska | Ridge (NU) | Cytoskeletal proteins in pulmonary vascular remodelling |
| 4 | Ghofrani | Pullamsetti | Steinhorn (NU) | Growth factor signalling in persistent pulmonary hypertension of the newborn |
| 5 | Grimminger | Savai | Powell (CU) | Analysis and manipulation of tumour stroma in lung cancer |
| 6 | Günther | Markart | Bhattacharya (CU) | Role of defective surfactant processing and transport in the induction of chronic endoplasmic reticulum stress and apoptosis of alveolar type II cells: impact on the development of lung fibrosis |
| 7 | Kummer | Grau | Bhattacharya (CU) | Para- and autocrine intermedin signalling by alveolar macrophages |
| 8 | Lohmeyer | Herold | Budinger (NU) | Pathogenesis of IV-induced acute lung injury: impact of viral and host factors on alveolar fluid clearance |
| 9 | Mayer | Hecker | Mutlu (NU) | The Spatiotemporal impact of vascular endothelial growth factor (VEGF) in acute lung injury |
| 10 | Pleschka | Silverstein (CU) | Effect of influenza virus-induced signalling on post-translational NP-processing: relevance for influenza virus RNP-function and localisation | |
| 11 | Preissner | Wygrecka | Kwaan (NU) | The role of enolase-1 in lung inflammation, remodelling and tumorigenesis |
| 12 | Sauer | Sedding | Wedgwood (NU) | Reactive oxygen species and calcium-signalling pathways in the PDGF-BB/FGF-2/VEGF axis regulating vascularisation and vascular remodelling during pulmonary hypertension |
| 13 | Schermuly | Dumitrascu | Emala (CU) | Growth factor signalling in pulmonary hypertension |
| 14 | Voswinckel | Braun | d’Armiento (CU) | Impact of cigarette smoke on lung structural maintenance programmes |
| 15 | Weissmann | Krick | Schumacker (NU) | Cross talk between mitochondria and NADPH oxidases in pulmonary oxygen sensing and vascular remodelling |