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Titel

Artikelaktionen

Publikationen

Ausgewählte Publikationen

Tvarogová, J., R. Madhugiri, G. Bylapudi, L. J. Ferguson, N. Karl, and J. Ziebuhr. 2019. Identification and characterization of a human coronavirus 229E nonstructural protein 8-associated RNA 3'-terminal adenylyltransferase activity. J. Virol. 93:e00291-19.

Kanitz, M., S. Blanck, A. Heine, A. A. Gulyaeva, A. E. Gorbalenya, J. Ziebuhr, and W. E. Diederich. 2019. Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus. Virology 533:21-33.

Melior, H., S. Li, R. Madhugiri, M. Stötzel, S. Azarderakhsh, S. Barth-Weber, K. Baumgardt, J. Ziebuhr, and E. Evguenieva-Hackenberg. 2019. Transcription attenuation-derived small RNA rnTrpL regulates tryptophan biosynthesis gene expression in trans. Nucleic Acids Res. 47:6396-6410.

Durzynska, I., M. Sauerwald, N. Karl, R. Madhugiri, and J. Ziebuhr. 2018. Characterization of a bafinivirus exoribonuclease activity. J. Gen. Virol. 99:1253-1260.

Ehmann, R., C. Kristen-Burmann, B. Bank-Wolf, M. König, C. Herden, T. Hain, H. J. Thiel, J. Ziebuhr, and G. Tekes. 2018. Reverse genetics for type I feline coronavirus field isolate to study the molecular pathogenesis of feline infectious peritonitis. MBio 9:e01422-18.

Madhugiri, R., N. Karl, D. Petersen, K. Lamkiewicz, M. Fricke, U. Wend, R. Scheuer, M. Marz, and J. Ziebuhr. 2018. Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions. Virology 517:44-55.

Müller, C., M. Hardt, D. Schwudke, B. W. Neuman, S. Pleschka, and J. Ziebuhr. 2018. Inhibition of cytosolic phospholipase A2alpha impairs an early step of coronavirus replication in cell culture. J. Virol. 92:e01463-17.

Müller, C., F. W. Schulte, K. Lange-Grünweller, W. Obermann, R. Madhugiri, S. Pleschka, J. Ziebuhr, R. K. Hartmann, and A. Grünweller. 2018. Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Res. 150:123-129.

Florek, D., R. Ehmann, C. Kristen-Burmann, T. Lemmermeyer, G. Lochnit, J. Ziebuhr, H. J. Thiel, G. Tekes. 2017. Identification and characterization of a Golgi retention signal in feline coronavirus accessory protein 7b. J. Gen. Virol. 98:2017-2029.

Kindler, E., C. Gil-Cruz, J. Spanier, Y. Li, J. Wilhelm, H. H. Rabouw, R. Züst, M. Hwang, P. V'Kovski, H. Stalder, S. Marti, M. Habjan, L. Cervantes-Barragan, R. Elliot, N. Karl, C. Gaughan, F. J. van Kuppeveld, R. H. Silverman, M. Keller, B. Ludewig, C. C. Bergmann, J. Ziebuhr, S. R. Weiss, U. Kalinke, and V. Thiel. 2017. Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS Pathog. 13:e1006195.

Mejdrová, I., D. Chalupská, P. Plačková, C. Müller, M. Šála, M. Klíma, A. Baumlová, H. Hřebabecký, E. Procházková, M. Dejmek, D. Strunin, J. Weber, G. Lee, M. Matoušová, H. Mertlíková-Kaiserová, J. Ziebuhr, G. Birkus, E. Boura, and R. Nencka. 2017. Rational design of novel highly potent and selective phosphatidylinositol 4-kinase IIIbeta (PI4KB) inhibitors as broad-spectrum antiviral agents and tools for chemical biology. J. Med. Chem. 60:100-118.

Poppe, M., S. Wittig, L. Jurida, M. Bartkuhn, J. Wilhelm, H. Müller, K. Beuerlein, N. Karl, S. Bhuju, J. Ziebuhr, M. L. Schmitz, and M. Kracht. 2017. The NF-kappaB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog. 13:e1006286.

Snijder, E. J., E. Decroly, and J. Ziebuhr. 2016. The nonstructural proteins directing coronavirus RNA synthesis and processing. Adv. Virus Res. 96:59-126.

Blanck, S. and J. Ziebuhr. 2016. Proteolytic processing of mesonivirus replicase polyproteins by the viral 3C-like protease. J. Gen. Virol. 97:1439-1445.

Lemmermeyer, T., B. Lamp, R. Schneider, J. Ziebuhr, G. Tekes, and H. J. Thiel. 2016. Characterization of monoclonal antibodies against feline coronavirus accessory protein 7b. Vet. Microbiol. 184:11-19.

Madhugiri, R., M. Fricke, M. Marz, and J. Ziebuhr. 2016. Coronavirus cis-acting RNA elements. Adv. Virus Res. 96:127-163

Mühlbauer, D., J. Dzieciolowski, M. Hardt, A. Hocke, K. L. Schierhorn, A. Mostafa, C. Müller, C. Wisskirchen, S. Herold, T. Wolff, J. Ziebuhr, and S. Pleschka. 2015. Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes. J. Virol. 89:6009-6021.

Blanck, S., A. Stinn, L. Tsiklauri, F. Zirkel, S. Junglen, and J. Ziebuhr. 2014. Characterization of an alphamesonivirus 3C-like protease defines a special group of nidovirus main proteases. J. Virol. 88:13747-13758.

Madhugiri, R., M. Fricke, M. Marz, and J. Ziebuhr. 2014. RNA structure analysis of alphacoronavirus terminal genome regions. Virus Res. 194:76-89.

Paasche, A., A. Zipper, S. Schäfer, J. Ziebuhr, T. Schirmeister, and B. Engels. 2014. Evidence for substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the SARS-CoV main protease. Biochemistry 53:5930-5946.

Habjan, M., P. Hubel, L. Lacerda, C. Benda, C. Holze, C. H. Eberl, A. Mann, E. Kindler, C. Gil-Cruz, J. Ziebuhr, V. Thiel, and A. Pichlmair. 2013. Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA. PLoS Pathog. 9:e1003663.

de Groot, R. J., S. C. Baker, R. S. Baric, C. S. Brown, C. Drosten, L. Enjuanes, R. A. Fouchier, M. Galiano, A. E. Gorbalenya, Z. A. Memish, S. Perlman, L. L. Poon, E. J. Snijder, G. M. Stephens, P. C. Woo, A. M. Zaki, M. Zambon, and J. Ziebuhr. 2013. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J. Virol. 87:7790-7792.

Zirkel, F., H. Roth, A. Kurth, C. Drosten, J. Ziebuhr, and S. Junglen. 2013. Identification and characterization of genetically divergent members of the newly established family Mesoniviridae. J. Virol. 87:6346-6358.

 Lauber, C., J. Ziebuhr, S. Junglen, C. Drosten, F. Zirkel, P. T. Nga, K. Morita, E. J. Snijder, and A. E. Gorbalenya. 2012. Mesoniviridae: a proposed new family in the order Nidovirales formed by a single species of mosquito-borne viruses. Arch. Virol. 157:1623-1628.

 Zhao, L., B. K. Jha, A. Wu, R. Elliott, J. Ziebuhr, A. E. Gorbalenya, R. H. Silverman, and S. R. Weiss. 2012. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe 11:607-616.

 Züst, R., L. Cervantes-Barragan, M. Habjan, R. Maier, B. W. Neuman, J. Ziebuhr, K. J. Szretter, S. C. Baker, W. Barchet, M. S. Diamond, S. G. Siddell, B. Ludewig, and V. Thiel. 2011. Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nature Immunol. 12:137-43.

Zirkel, F., A. Kurth, P. L. Quan, T. Briese, H. Ellerbrok, G. Pauli, F. H. Leendertz, W. I. Lipkin, J. Ziebuhr, C. Drosten, and S. Junglen. 2011. An insect nidovirus emerging from a primary tropical rainforest. MBio 2:e00077-11.

Ulferts, R., T. C. Mettenleiter, and J. Ziebuhr. 2011. Characterization of bafinivirus main protease autoprocessing activities. J. Virol. 85:1348-59.

Ulferts, R., and J. Ziebuhr. 2011. Nidovirus ribonucleases: structures and functions in viral replication. RNA. Biol. 8:295-304.

Ulferts, R., I. Imbert, B. Canard, and J. Ziebuhr. 2010. Expression and functions of SARS coronavirus replicative proteins, p. 75-98. In S. K. Lal (ed.), Molecular biology of the SARS-Coronavirus. Springer, Berlin & Heidelberg.

Nedialkova, D. D., R. Ulferts, E. van den Born, C. Lauber, A. E. Gorbalenya, J. Ziebuhr, and E. J. Snijder. 2009. Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease. J. Virol. 83:5671-82.

Ziebuhr, J. 2008. Coronavirus replicative proteins, p. 65-81. In S. Perlman, T. Gallagher, and E. J. Snijder (ed.), Nidoviruses. ASM Press, Washington, DC.

Ziebuhr, J., B. Schelle, N. Karl, E. Minskaia, S. Bayer, S. G. Siddell, A. E. Gorbalenya, and V. Thiel. 2007. Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication. J. Virol. 81:3922-32.

Schütze, H., R. Ulferts, B. Schelle, S. Bayer, H. Granzow, B. Hoffmann, T. C. Mettenleiter, and J. Ziebuhr. 2006. Characterization of White bream virus reveals a novel genetic cluster of nidoviruses. J. Virol. 80:11598-609.

Ricagno, S., M. P. Egloff, R. Ulferts, B. Coutard, D. Nurizzo, V. Campanacci, C. Cambillau, J. Ziebuhr, and B. Canard. 2006. Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Proc. Natl. Acad. Sci. USA 103:11892-7.

Minskaia, E., T. Hertzig, A. E. Gorbalenya, V. Campanacci, C. Cambillau, B. Canard, and J. Ziebuhr. 2006. Discovery of an RNA virus 3'-5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc. Natl. Acad. Sci. USA 103:5108-13.

Putics, A., W. Filipowicz, J. Hall, A. E. Gorbalenya, and J. Ziebuhr. 2005. ADP-ribose-1"-monophosphatase: a conserved coronavirus enzyme that is dispensable for viral replication in tissue culture. J Virol 79:12721-31.

Seybert, A., C. C. Posthuma, L. C. van Dinten, E. J. Snijder, A. E. Gorbalenya, and J. Ziebuhr. 2005. A complex zinc finger controls the enzymatic activities of nidovirus helicases. J. Virol. 79:696-704.

Ziebuhr, J. 2004. Molecular biology of severe acute respiratory syndrome coronavirus. Curr. Opin. Microbiol. 7:412-9.

Ivanov, K. A., V. Thiel, J. C. Dobbe, Y. van der Meer, E. J. Snijder, and J. Ziebuhr. 2004. Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. J. Virol. 78:5619-32.

Ivanov, K. A., T. Hertzig, M. Rozanov, S. Bayer, V. Thiel, A. E. Gorbalenya, and J. Ziebuhr. 2004. Major genetic marker of nidoviruses encodes a replicative endoribonuclease. Proc. Natl. Acad. Sci. USA 101:12694-9.

Thiel, V., K. A. Ivanov, A. Putics, T. Hertzig, B. Schelle, S. Bayer, B. Weissbrich, E. J. Snijder, H. Rabenau, H. W. Doerr, A. E. Gorbalenya, and J. Ziebuhr. 2003. Mechanisms and enzymes involved in SARS coronavirus genome expression. J. Gen. Virol. 84:2305-15.

Anand, K., J. Ziebuhr, P. Wadhwani, J. R. Mesters, and R. Hilgenfeld. 2003. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science 300:1763-7.