SFB 1213 Seminarreihe - Guest speaker Prof. Joachim Fandrey: "When the going gets tough – cellular life and work under hypoxia"
Seminarreihe des Sonderforschungsbereichs Pulmonale Hypertonie und Cor pulmonale - Gastvortrag von Prof. Dr. med. Joachim Fandrey, Universität Duisburg-Essen und Universitätsklinikum Essen
- https://www.uni-giessen.de/de/ueber-uns/veranstaltungen/seminar/seminarsfb1213fandrey
- SFB 1213 Seminarreihe - Guest speaker Prof. Joachim Fandrey: "When the going gets tough – cellular life and work under hypoxia"
- 2017-01-17T18:00:00+01:00
- 2017-01-17T19:00:00+01:00
- Seminarreihe des Sonderforschungsbereichs Pulmonale Hypertonie und Cor pulmonale - Gastvortrag von Prof. Dr. med. Joachim Fandrey, Universität Duisburg-Essen und Universitätsklinikum Essen
17.01.2017 von 18:00 bis 19:00 (Europe/Berlin / UTC100)
Biomedizinisches Forschungszentrum Seltersberg (BFS), Schubertstr. 81, 35392 Gießen, kleiner Hörsaal (EG, Foyer B)
Members of the SFB 1213 and everybody who is interested
Prof. Dr. med. Joachim Fandrey is Director of the Institute of Physiology at the University of Duisburg-Essen. In his talk
"When the going gets tough – cellular life and work under hypoxia"
he will present his and his working group's recent research, which is focused on investigations of an oxygen-dependent gene expression and of a cellular oxygen sensor.
In particular, his research work is focused on three main areas:
a) Oxygen-dependent Gene Expression – Structure and Function of the Cellular Oxygen Sensor
- Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1) – molecular imaging of HIF-1 assembly
- In vivo 2-photon microscopy and three-dimensional localization of intracellular proteins
- Regulation of the oxygen-dependent expression of the erythropoietin gene
- The role of oxygen-dependent expression of the angiogenic protein VEGF for tumor vascularisation
b) Mechanisms of Inflammatory Hypoxia: Role of HIF-1 Complexes in Colitis
- Roles of hypoxia-inducible factor-1 in immune cells during inflammatory bowel disease
- Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
- Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of the adaptive immune system
- Colitis-induced colon carcinogenesis
c) Role of HIF-1 Complexes in Muscle Trauma
- Activation of HIF-1 in traumatised tissue
- Role of HIF-1 activation for the severity of tissue trauma
- Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle
Everybody who is interested is very welcome to join our seminar series.
The seminars are taking place every second Tuesday from 18:00 - 19:00.