SFB 1213 Seminarreihe - Guest speaker Prof. Joachim Fandrey: "When the going gets tough – cellular life and work under hypoxia"
von 18:00 bis 19:00
|Wo||Biomedizinisches Forschungszentrum Seltersberg (BFS), Schubertstr. 81, 35392 Gießen, kleiner Hörsaal (EG, Foyer B)|
|Kontakttelefon||0641 99 42422|
Members of the SFB 1213 and everybody who is interested
Prof. Dr. med. Joachim Fandrey is Director of the Institute of Physiology at the University of Duisburg-Essen. In his talk
"When the going gets tough – cellular life and work under hypoxia"
he will present his and his working group's recent research, which is focused on investigations of an oxygen-dependent gene expression and of a cellular oxygen sensor.
In particular, his research work is focused on three main areas:
a) Oxygen-dependent Gene Expression – Structure and Function of the Cellular Oxygen Sensor
- Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1) – molecular imaging of HIF-1 assembly
- In vivo 2-photon microscopy and three-dimensional localization of intracellular proteins
- Regulation of the oxygen-dependent expression of the erythropoietin gene
- The role of oxygen-dependent expression of the angiogenic protein VEGF for tumor vascularisation
b) Mechanisms of Inflammatory Hypoxia: Role of HIF-1 Complexes in Colitis
- Roles of hypoxia-inducible factor-1 in immune cells during inflammatory bowel disease
- Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
- Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of the adaptive immune system
- Colitis-induced colon carcinogenesis
c) Role of HIF-1 Complexes in Muscle Trauma
- Activation of HIF-1 in traumatised tissue
- Role of HIF-1 activation for the severity of tissue trauma
- Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle