Open projects
This is an overview of open projects offered for the summer term 2022. Due to the pandemic we are able to offer only one open project this year. You may select the projects in our portal by project ID, name of supervisor and title. We will not be able to consider incomplete applications or applications that are not submitted via the online portal.
| Supervisor | ProjectID |
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Prof. Dr. Martin Berghoff Prof. Dr. Tilman Borggrefe |
1
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Description |
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Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is associated with chronic inflammation and degeneration of the CNS. FGFR-dependent pathways have been shown to modulate disease activity. Our group has applied FGFR inhibitors in EAE, which resulted in beneficial effects of substances on inflammation, myelin and axons. It is known that an altered lipid metabolism is characteristic for chronic inflammatory disorders. Prelimanary data suggest that treatment with such an inhibitor decreases the concentration of lipids associated with neurodegeneration in EAE. The goal of these experiments ist to study the effects of pharmacological FGFR inhibition on cellular functions using a multi-omics approach. The EAE experiments are already completed. Data will have to be analysed in the context of model EAE. Identification of alterations in „-omics“ may lead to a better understanding of the pathology of EAE and eventually multiple sclerosis. For more information go to: https://www.ukgm.de/ugm_2/deu/ugi_neu/50282.html Requirements: The PhD student (biochemist, immunologist, etc.) should be interested in basic science, ideally in lipodomics and metabolomics. Fluency in English and an interest in writing of manuscripts is expected. |
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This project is offered in the GGL research Section - 5
| Supervisor | ProjectID |
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PD Dr. Martin Roderfeld Prof. Dr. Elke Roeb |
2 |
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Description |
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Chronic stages of schistosomiasis and HBV occur disproportionately often as co-infections in endemic areas. A previous infection with S. mansoni is suspected to predispose for infections with hepatitis B virus (HBV) and hepatitis C virus (HCV). Co-infections of HBV and S. mansoni also accelerate liver disease progression, increase mortality through an enhanced incidence of liver cirrhosis and HCC. Molecular mechanisms of endogenous damage to the host parenchyma by e.g. hepatocellular stress, fibrosis, and carcinogenesis during co-infection have not been addressed so far, although they very likely play a role in disease progression, as our preliminary work on HBV- and schistosomiasis-induced liver pathogenesis suggests. Based on clinical studies on S. mansoni/HBV co-infection and our preliminary work, we aim to analyze how immune system-independent mechanisms are involved in hepatic pathogenesis and carcinogenesis. New coworkers will be introduced intensively in required methods like qRT-PCR, western blot, ELISA, immunohistochemistry, mRNA and protein array techniques, cell culture, and others. For further information go to: https://www.uni-giessen.de/en/faculties/f11/departments/gastrolab/team |
| Description of the Team |
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Our offer to you
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Requirements
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A university degree in biology (MSc), biomedicine (MSc), biochemistry (MSc), medicine,
veterinary medicine, or equivalent
• Very good knowledge in molecular biology and cell biology
• Experience with cell cultures, histology, in vivo techniques, physiology
• Knowledge in the field of liver diseases and transgenic mice is an advantage but not required
• Extraordinary level of autonomy, initiative, analytical thinking and ability to work in a team
• The project involves work in a biosafety level 3 laboratory for which a documented protective immunity against hepatitis B virus is required
• A certificate in laboratory animal science (FELASA B) would be advantageoususs
| Funding |
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The salary is in accordance with the collective labour agreement of the State of Hessen (E 13 II-6 TV-H) 65% part-time position, limited to 3 years of funding. Supervision, lab space and personal funding are available. |
this project is offered in the GGL resarch Section - 1
| Supervisor | ProjectID |
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Prof. Dr. Janina Burk, M.SC. Stem Cells and Regeneration Prof. Dr. Katrin Lips |
3 |
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Description |
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For further information go to: https://www.uni-giessen.de/de/fbz/fb10/institute_klinikum/klinikum/klinik-fur-pferde/klinik-fur-pferde-chirurgie/forschung/stammzellforschung |
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Description of the Team
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You will work in a dynamic and supportive team, together with scientists and other PhD candidates with different backgrounds (currently veterinary medicine, medicine, biology, biotechnology).
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| Expected skills |
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| We search for a highly motivated candidate with strong interest in regenerative medicine and related basic research. Applications are particularly welcome from candidates with a degree in veterinary medicine and life science subjects with relevance to cell biology and/ or medicine. Experience with cell culture techniques is not mandatory but can be an advantage. |
| Funding |
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Supervision and lab space available; personal funding opportunities available. Personal funding is to be specified on qualifications and starting date. |
This project is offered in the GGL research Section 10 - Clinical Sciences