GenDBE
GenDBE was developed based on the GenDB genome annotation system that was originally designed for prokaryotic genomes only. The system has been adapted to facilitate the creation and functional annotation of sequence features that are specific for eukaryotic genomes, e.g. intron and exon gene structures.

GenDBE offers user interfaces that allow expert annotation with large, geo-graphically dispersed teams of experts. Genes to be annotated can be categorized by functional class or gene location. A number of naming schemes (aka ontologies or functional classification schemes) are supported: EC numbers, GO, COG. In addition to its use as a production genome annotation system, it can be employed as a flexible framework for the large-scale evaluation of different annotation strategies. The software currently is in use several eukaryotic genome annotation projects.