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LOEWE-Schwerpunkt iCANx

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Ordner, in dem die Bilder zum LOEWE-Schwerpunkt iCANx gesammelt werden.

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About us

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LOEWE research cluster iCANx

LOEWE-Schwerpunkt iCANx: Cancer – Lung (Disease) Crosstalk: Tumor and Organ Microenvironment

As the second leading cause of death worldwide, cancer is a global health problem. The occurrence of primary and secondary (metastases) lung tumors reduces the quality and expectation of life of patients significantly. Progression and lethality of lung tumors are critically determined by the interaction of tumor cells with the surrounding microenvironment. It is largely unknown how tumors adapt to the organ microenvironment and reprogram their environment for successful metastasis to the lung. Hence, the goal of iCANx is to elucidate mechanisms that allow tumor cells to colonize the lung in a bidirectional crosstalk with the organ microenvironment. Furthermore, we investigate how lung tumor-associated diseases such as COPD, pulmonary hypertension and fibrosis influence this. The deeper understanding of the complex interactions of primary and secondary lung tumors with the lung microenvironment promises, in addition to fundamental insights into the molecular mechanisms of tumor-organ adaptation, innovative therapeutic and curative approaches that target the organ- and tumor-specific microenvironment, e.g. to prevent metastatic colonization of the lung.

Current Events

Interested in latest findings in cancer research?

 

Then the iCANx Cancer Minisymposium is the right event to join for you!

 

The next in-person Minisymposium is scheduled for May 11th 2023 in Gießen:

Find the program and biosketches of our speakers here: Download poster and biosketches

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Slideshow Hauptseite

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Join our 2nd iCANx Cancer Minisymposium TODAY!

Join the talks of the 2nd iCANx Cancer Symposium (from 15:00 on) here:

https://uni-giessen.webex.com/uni-giessen/j.php?MTID=mf0bfbe7f4f61c551012df456220588ba

 

Join the Meet-the-speakers-Sessions (from ~ 17:30 on) here:

https://uni-giessen.webex.com/uni-giessen/j.php?MTID=md3c50602ff57ad005ec7c0caddab8160

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LOEWE-Schwerpunkt iCANx: Cancer – Lung (Disease) Crosstalk: Tumor and Organ Microenvironment

As the second leading cause of death worldwide, cancer is a global health problem. The occurrence of primary and secondary (metastases) lung tumors reduces the quality and expectation of life of patients significantly. Progression and lethality of lung tumors are critically determined by the interaction of tumor cells with the surrounding microenvironment. It is largely unknown how tumors adapt to the organ microenvironment and reprogram their environment for successful metastasis to the lung. Hence, the goal of iCANx is to elucidate mechanisms that allow tumor cells to colonize the lung in a bidirectional crosstalk with the organ microenvironment. Furthermore, we investigate how lung tumor-associated diseases such as COPD, pulmonary hypertension and fibrosis influence this. The deeper understanding of the complex interactions of primary and secondary lung tumors with the lung microenvironment promises, in addition to fundamental insights into the molecular mechanisms of tumor-organ adaptation, innovative therapeutic and curative approaches that target the organ- and tumor-specific microenvironment, e.g. to prevent metastatic colonization of the lung.