Publikationen
Giaimo B.D., Ferrante F., Vallejo D.M., Hein K., Gutierrez-Perez I., Nist A., Stiewe T., Mittler G., Herold S., Zimmermann T., Bartkuhn M., Schwarz P., Oswald F., Dominguez M. and Borggrefe T. Histone Variant H2A.Z Deposition and Acetylation directs the canonical Notch signaling response. Nucleic Acids Res. doi: 10.1093/nar/gky551. (in press)
Xu, T., Park, S.S., Giaimo, B.D., Hall, D. Ferrante, F., Ho, D., Hori, K., Anhezini, L., Ertl, I., Bartkuhn, M., Zhang, H., Milon, E., Ha, K., Conlon, K.P., Kuick, R., Govindarajoo, B., Zhang, Y., Basrur, V., Elenitoba-Johnson, K., Nesvizhskii, A., Ceron, J., Lee, C., Borggrefe, T., Kovall, R. Rual, J.F. (2017). The RBP-J/L3MBTL3 axis promotes the repression of Notch signaling by the histone demethylase KDM1A. EMBO J. 36(21):3232-3249. doi: 10.15252/embj.201796525.
Pitulescu, M.E., Schmidt, I., Giaimo, B.D., Antoine, T., Berkenfeld, F., Ferrante, F., Park, H., Ehling, M., Biljes, D., Rocha, S.F., Langen, U.H., Stehling, M., Nagasawa, T., Ferrara, N., Borggrefe, T., Adams, R.H. (2017) Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nature Cell Biology doi: 10.1038/ncb3555.
Thiel, V., Giaimo, B.D., Schwarz, P., Sollner, K., Vas, V., Bartkuhn, M., Blätte, T., Döhner, K., Bullinger, L., Borggrefe, T., Geiger, H., Franz Oswald (2017) Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation. Leukemia doi: 10.1038/leu.2017.105.
Oswald, F., Rodriguez, P., Giaimo, B., Antonello, Z., Mira, L., Mittler, G. Thiel, V., Collins, K., Tabaja, N., Cizelsky, W., Radenz, M., Kühl, S., Kühl, M., Ferrante, F., Hein, K., Kovall, R., Dominguez, M. and Borggrefe, T. (2016) A phospho-dependent mechanism involving NCoR and KMT2D controls a committed chromatin state at Notch target genes. Nucleic Acids Research 44(10):4703-20. doi: 10.1093/nar/gkw105.
Thomas-Claudepierre, A., Robert, I., Rocha, P., Raviram, R., Schiavo, E., Heyer, V., Bonneau, R., Luo, V., Reddy, JK, Borggrefe, T., Skok, J. and Reina-San-Martin, B. (2016) Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus durch class switch recombination. Journal of Experimental Medicine
Hein, K. Mittler, G. W. Cizelsky, W., Kühl, M., Liefke, R., Berger, I.M., Just, S., Sträng, J., Kestler, H., Oswald, F., T. Borggrefe, T. (2015) Site-specific methylation of Notch1 controls amplitude and duration of the Notch1 response. Science Signaling 8(369):ra30, selected for cover illustration.
Tariki M, Dhanyamraju PK, Fendrich V, Borggrefe T, Feldmann G, Lauth M. The Yes-associated protein controls the cell density regulation of Hedgehog signaling. (2014) Oncogenesis 3:e112.
Geimer Le Lay AS, Oravecz A, Mastio J, Jung C, Marchal P, Ebel C, Dembélé D, Jost B, Le Gras S, Thibault C, Borggrefe T, Kastner P and Chan S. The tumor suppressor Ikaros shapes the repertoire of Notch target genes in T-cells (2014) Science Signaling 7:(317)
Jung C, Mittler G, Oswald F, Borggrefe T. RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway (2013). Biochim Biophys Acta 1833(5):1180-9.
Yue, X., Izcue, A. und Borggrefe, T. An essential role of the Mediator subunit Med1 in invariant natural killer T cell development (2011). P.N.A.S., 108(41):17105-10.
Wacker, S., Alvarado, C, von Wichert, G., Knippschild, U., Wiedenmann, J., Claus, K., Nienhaus, G, Hameister, H., Baumann, B., Borggrefe, T., Knöchel, W. und Oswald, F. (2011) RITA, a novel modulator of Notch signaling, acts via nuclear export of RBP-J. EMBO J., 30(1):43-56.
Stumpf, M., Yue, X., Schmitz, S., Luche, H., Fehling, H. Reddy, J. und Borggrefe, T. (2010) Specific erythroid-lineage defect in mice deficient for Mediator subunit Med1. P.N.A.S., 107 (50): 21541-21546
Liefke, R., Oswald, F., Alvarado, C., Ferres-Marco, D., Mittler, G., Rodriguez, P., Dominguez, M. and Borggrefe, T. (2010): Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes&Development, 24(6):590-601.
Borggrefe, T. and Oswald, F. (2009): The Notch signaling pathway: Transcriptional regulation at Notch target genes. Cellular and Molecular Life Sciences 66(10):1631-46. selected for cover illustration