Inhaltspezifische Aktionen

Publikationen des Instituts

2022

  • Carlsson MJ, Vollmer AS, Demuth P, Heylmann D, Reich D, Quarz C, Rasenberger B, Nikolova T, Hofmann TG, Christmann M, Fuhlbrueck JA, Stegmüller S, Richling E, Cartus AT, Fahrer J. p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol. Cell Death & Disease 2022, 13 (11): 1009.
  • Petersen L, Stroh S, Schottelndreier D, Grassl GA, Rottner K, Brakebusch C, Fahrer J and Genth H. The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition. Front. Microbiol. 2022 13, 846215.

2021

  • Arnold C, Demuth P, Seiwert N, Wittmann S, Boengler K, Rasenberger B, Christmann M, Huber M, Brunner T, Linnebacher M, Fahrer J. The mitochondrial disruptor devimistat (CPI-613) synergizes with genotoxic anticancer drugs in colorectal cancer therapy in a Bim-dependent manner. Mol Cancer Ther. 2021, 21 (1): 100–112.
  • Jiso A, Demuth P, Bachowsky M, Haas M, Seiwert N, Heylmann D, Rasenberger B, Christmann M, Dietrich L, Brunner T, Riyanti, Schäberle TF, Plubrukarn A, Fahrer J. Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-type and Mutant Colorectal Cancer. Cancers (Basel). 2021 Jun 30;13(13):3282.
  • Seiwert N, Adam J, Steinberg P, Wirtz S, Schwerdtle T, Adams-Quack P, Hövelmeyer N, Kaina B, Foersch S, Fahrer J. Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo. Arch Toxicol. 2021 Jul;95(7):2507-2522.
  • Heylmann D, Ponath V, Kindler T, Kaina B. Comparison of DNA repair and radiosensitivity of different blood cell populations. Sci Rep. 2021 Jan 28;11(1):2478.

2020

  • Seiwert N, Wecklein S, Demuth P, Hasselwander S, Kemper TA, Schwerdtle T, Brunner T, Fahrer J. Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron. Cell Death Dis.; 2020 Sep 23; 11(9):787.

2019

  • Kivivirta K, Herbert D, Lange M, Beuerlein K, Altmüller J, Becker A. A protocol for laser microdissection (LMD) followed by transcriptome analysis of plant reproductive tissue in phylogenetically distant angiosperms. Plant Methods . 2019 Dec 16;15:151.
  • Neitzel C, Seiwert N, Göder A, Diehl E, Weber C, Nagel G, Stroh S, Rasenberger B, Christmann M, Fahrer J. Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation. Cells. 2019 Jul 30;8(830;8(8).
  • Rund KM, Heylmann D, Seiwert N, Wecklein S, Oger C, Galano JM, Durand T, Chen R, Gueler F, Fahrer J, Bornhorst J, Schebb NH. Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress. Prostaglandins Other Lipid Mediat. 2019 Oct;144:106334.
  • Gogiraju R, Hubert A, Fahrer J, Straub BK, Brandt M, Wenzel P, Münzel T, Konstantinides S, Hasenfuss G and Schäfer K. Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling.

2018

  • Zelenikhin PV, Gorbunova AS, Beuerlein K, Makeeva AV and Ilinskaya ON. Binase-Induced Changes of Tumor Cell Membranes. Cell Biology. 2018 Vol 73, No. 1, pp. 10-15.
  • Kraus A, McKeague M, Seiwert N, Nagel G, Geisen SM, Ziegler N, Trantakis IA, Kaina B, Thomas AD, Sturla SJ and Fahrer J. Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo. Arch Toxicol. 2018, Feb;93(2):559-572.
  • Heylmann D, Badura J, Becker H, Fahrer J, Kaina B. Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response. Cell Death Dis. 2018, 9(11):1053.
  • Dörsam B, Seiwert N, Försch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M., Stier A, Mangerich M, Dantzer F, Kaina B and Fahrer J. PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. Proc Natl Acad Sci U S A. 2018, 115(17):E4061-E4070.

2015

  • Trenkwalder C, Chaudhuri KR, Martinez-Martin P, Rascol O, Ehret R, Vališ M, Sátori M, Krygowska-Wajs A, Marti MJ, Reimer K, Oksche A, Lomax M, DeCesare J, Hopp M; PANDA study group. Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinson's disease (PANDA): a double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2015 Dec;14(12):1161-70.

2013

  • Gissel C, Repp, H. Cost per responder of TNF-α therapies in Germany. Clin Rheumatol. 2013 Dec;32(12):1805-9.

2011

  • Burger S, Döring B, Hardt M, Beuerlein K, Gerstberger R, Geyer J. Co-expression studies of the orphan carrier protein SLC10A4 and the vesicular carriers vesicular acetylcholine transporter and vesicular monoamine transporter 2 in the rat central and peripheral nervous system. Neuroscience. 2011 193(1):109-121.

2010

  • Al-Anati L, Essid E, Stenius U, Beuerlein K, Schuh K, Petzinger E. Differential cell sinsitivity between OTA and LPS upon releasing TNF-alpha. Toxins. 2010 2(6), 1279-1299.
  • Wind S, Beuerlein K, Armitage ME, Taye A, Kumar AHS, Janowitz D, Neff C, Shah AM, Wingler K, Schmidt HHHW. Oxidative stress and endothelial dysfunktion in aortas of aged spontaneously hypertensive rats by NOX 1/2 is reversed by NADPH oxidase inhibitions. Hypertension. 2010,56(3), 490-497.
  • Wind S, Beuerlein K, Eucker T, Müller H, Scheurer P, Armitage ME, Ho H, Schmidt HHHW, Wingler K. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. British Journal of Pharmacology. 2010 161(4), 885-898.
  • Lehr T, Frank S, Natsuka S, Geyer H, Beuerlein K, Doenhoff MJ, Hase S, Geyer R. N-glycosylation patterns of hemolymph glycoproteins from Biomphalaria glabrata strains expressing different susceptibility to Schistosoma mansoni infection. Experimental Parasitolog. 2010 126(4), 592-602.

2008

  • Nedvetsky PI, Meurer S, Opitz N, Nedvetskaya TY, Müller H, Schmidt HHHW. Heat shock protein 90 regulates stabilization rather than activation of soluble guanylate cyclase. FEBS Letters. 2008 582: 327-331.
  • Heumüller S, Wind S, Barbosa-Sicard E, Schmidt HHHW, Busse R, Schröder K, Brandes RP. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension. 2008 51(2):211-7. Epub 2007 Dec 17.
  • Lehr T, Beuerlein K, Doenhoff MJ, Grevelding CG, Geyer R. Localization of carbohydrate determinants common to Biomphalaria glabrata as well as to sporocysts and miracidia ofSchistosoma mansoni. Parasitology. 2008 135(8):931-42.
  • Ilinskaya ON, Koschinski A, Repp H, Mitkevich VA, Dreyer F, Scholtz JM, Pace CN, Makarov AA. RNase-induced apoptosis: fate of calcium-activated potassium channels. Biochimie. 2008 May; 90(5):717-25.

2007

  • Reineke J, Tenzer S, Rupnik M, Koschinski A, Hasselmayer O, Schrattenholz A, Schild H, von Eichel-Steiber C. Autocatalytic cleavage of Clostridium difficile toxin B. Nature. 2007 446(7134):415-9.
  • Schnizler MK, Bogdan R, Bennert A, Bury NR, Fronius M, Clauss W. Short-term exposure to waterborne free silver has acute effects on membrane current of Xenopus oocytes.
    Biochim Biophys Acta. 2007 768(2):317-23.
  • Godoy JR, Fernandes C, Döring B, Beuerlein K, Petzinger E, Geyer J. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertrebrates and bacteria. Eur J Cell Biol. 2007 86(8):445-60.

2006

  • Dumitrascu R, Weissmann N, Ghofrani HA, Dony E, Beuerlein K, Schmidt H, Stasch JP, Gnoth MJ, Seeger W, Grimminger F, Schermuly RT. Activation of soluble guanylate cyclase reverses experimental pulmonary hyptertension and vascular remodeling. Circulation. 2006 113(2):286-95): 286-95.
  • Langenickel TH, Buttgereit J, Pagel-Langenickel I, Lindner M, Monti J, Beuerlein K, Al-Saadi N, Plehm R, Popova E, Tank J, Dietz R, Willenbrock R, Bader M. Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B.
    Proc Natl Acad Sci U S A. 2006 103(12):4735-4740.
  • Stasch JP, Schmidt PM, Nedvetsky PI, Nedvetskaya TY, Arun Kumar HS, Meurer S, Deile M, Taye A, Knorr A, Lapp H, Müller H, Turgay Y, Rothkegel C, Tersteegen A, Kemp-Harper B, Müller-Esterl W, Schmidt HHHW. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest. 2006 116(9):2330-2.
  • Koschinski A, Repp H, Ünver B, Dreyer F, Brockmeier D, Valeva A, Bhakdi S, Walev I. Why Escherichia coli α-hemolysin induces calcium oscillations in mammalian cells -the pore is on its own. FASEB J. 2006 20(7):973-52006 May;20(7):973-5.

2005

  • Kumar S, Arun KH, Kaul CL, Sharma SS (2005). Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy. Neurol Res 27(1):60-6.
  • Arun KH, Kaul CL, Ramarao P. AT1 receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats. Cardiovasc Res. 2005 65(2):374-86.
  • Arun KH, Kaul CL, Ramarao P. Green fluorescent proteins in receptor research: An emerging tool for drug discovery. J Pharmacol Toxicol Methods. 2005 51(1):1-23. Review.
  • Arun Kumar HS. A meeting inspiring the young minds: Yet another noble venture from the Nobel laureates. Pharmacognosy Magazine. 2005 1(4):121-122.
  • Arun Kumar HS. Preclinical safety studies on medicinal plants: Part I.
    Pharmacognosy Magazine. 2005 1(1):10-12.
  • Arun Kumar HS. Preclinical safety studies on medicinal plants: Part II.
    Pharmacognosy Magazine. 2005 1(2):32-38.
  • Arun Kumar HS, Manjunath HS, Reddy KS, Ressy R. Zeetress (a polyherbal formulation of W. somnifera, O. sanctum and E. officinalis) prevents salinomycin toxicity in broiler chicks.
    Pharmacognosy Magazine. 2005 1(3):109-113.
  • Rothkegel C, Schmidt PM, Arun Kumar HS, Stoll F, Lapp H, Wunder F, Schröder H, Rinke M, Schmidt HH, Stasch JP. Beyond NO and heme: biochemical and pharmacological opportunities. BMC Pharmacology. 2005 5(1):18.
  • Springer J, Ruth P, Beuerlein K, Palus S, Schipp R, Westermann B. Distribution and function of biogenic amines in the heart of Nautilus pompilius L. (Cephalopoda, Tetrabranchiata).
    J Mol Histol. 2005 Oct21:1-9.
  • Westermann B, Schmidtberg H, Beuerlein K. Functional morphology of the mantle of Nautilus pompilius (Mollusca, Cephalodopa). J Morphol. 2005 Jun;264(3):277-85.
  • Westermann B, Beuerlein K. Y-maze experiments on the chemotactic behaviour of the tetrabranchiate cephalopod Nautilus Pompilius (Mollusca). Marine Biology. 2005 147(1), 145-151.
  • Dimpfel W.Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG). Eur Neuropsychopharmacol. 2005 15(6):673-82.
  • Matter H, Kumar HS, Fedorov R, Frey A, Kotsonis P, Hartmann E, Frohlich LG, Reif A, Pfleiderer W, Scheurer P, Ghosh DK, Schlichting I, Schmidt HH (2005). Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
    J Med Chem 48(15):4783-92.
  • Kumar AH, Ramarao P. Saga of renin-angiotensin system and calcium channels in hypertensive diabetics: does it have a therapeutic edge? Cardiovasc Drug Rev. 2005 23(2):99-114.
  • Zelmer A, Krusch S, Koschinski A, Rohde M, Repp H, Chakraborty T, Weiss S. Functional transfer of eukaryotic expression plasmids to mammalian cells by Listeria monocytogenes: a mechanistic approach. J Gene Med. 2005 Aug;7(8):1097-112.
  • Koschinski A, Wengler G, Wengler G, Repp H. Rare earth ions block the ion pores generated by the class II fusion proteins of alphaviruses and allow analysis of the biological functions of these pores. J Gen Virol. 2005 86(12):3311-20.
  • Matejic R, Schulz A, Muhling J, Uhlich H, Bodeker RH, Hempelmann G, Teschemacher H. Preoperative concentration of beta-lipotropin immunoreactive material in cerebrospinal fluid: A predictor of postoperative pain? Neuropeptides. 2005 Nov 10.
  • Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy S, Gamez G, Griendling KK, Harrison DG. Hemodynamic and biochemical adapations to vascular smooth muscle overexpression of p22phox in mice. Am J Physiol. 2005 288(1):H7-12. Epub 2004 Oct 7. Erratum in: Am J Physiol Heart Circ Physiol 288(4):H2021.
  • Schulz A, Teschemacher H. Inter- and Intracellular Signaling: Opioid Peptide Precursor Derivatives. In: F.C. Mooren and K. Völker (Eds): Molecular and Cellular Exercise Physiology; Human Kinetics: Leeds (UK) 2005 :117-124. Review.
  • Wind S, Arun Kumar HS. Apocynin: Mothers Nature's gift to combat oxidative stress.
    Pharmacognosy Magazine. 2005 1(4):136-139.

2004

  • Saini AK, Arun KHS, Kaul CL, Sharma SS. Acute hyperglycaemia attenuates nerve conduction velocity and nerve blood flow in male Sprague-Dawley rats: Reversal by adenosine.
    Pharmacological Research. 2004 50:593-599.
  • Shilpi M, Alpeshkumar M, Selvam C, Arun KHS, Johar PS, Sanjay MJ, Ramarao P, Bharatam PV, Chawla HPS. Synthesis and Evaluation of S-4-(3-thienyl)phenyl-methylacetic acid. Bioorganic and Medicinal Chemistry Letters. 2004 14(4):979-982.
  • Ratan Kumar M, Kala Kumar B, Arun Kumar HS, Reddy KS. Effect of "Zeetress" on aflatoxin depressed growth and immunity in broilers. Indian Veterinary Journal. 2004 81(8):903-905.
  • Arun KHS, Kaul CL, Ramarao P. In vitro high glucose concentration augments angiotensin II mediated contraction via AT1 receptors in control but not diabetic rat thoracic aorta.
    Pharmacol Res. 2004 50:561-568.
  • Arun KHS, Kaul CL , Poduri R. Tempol augments angiotensin II induced AT2 receptor-mediated relaxation in diabetic rat thoracic aorta. J Hypertens. 2004 22:2143-2152.
  • Westermann B, Beck-Schildwachter I, Beuerlein K, Kaleta EF, Schipp R (2004). Shell growth and chamber formation of aquarium-reared Nautilus pompilius (Mollusca, Cephalopoda) by X-ray analysis. J Exp Zoolog A Comp Exp Biol 301:930-937.
  • Springer J, Ruth P, Beuerlein K, Westermann B, Schipp R (2004). Immunohistochemical localization of cardio-active neuropeptides in the heart of a living fossil, Nautilus pompilius L. (Cephalopoda, Tetrabranchiata). J Mol Histol 35:21-28.
  • Beuerlein K, Ruth P, Scholz FR, Springer J, Lieb B, Gebauer W, Westermann B, Schmidtberg H, von Boletzky S, Markl J, Schipp R. Blood cells and the biosynthesis of hemocyanin in Sepia embryos. Micron. 2004 35:115-116.
  • Schaeffeler E, Fischer C, Brockmeier D, Wernet D, Moerike K, Eichelbaum M, Zanger UM, Schwab M. Comprehensive analysis of thoiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants.
    Pharmacogenetics. 2004 14: 407-417.
  • Christ B, Brockmeier D, Hauck EEW, Kamali-Ernst S. Investigation on interaction between tacrolimus and sildenafil in kidney-transplanted patients with erectile dysfunction. Int J Clin Pharmacol Ther. 2004 42:149-156.
  • Dimpfel W, Pischel I, Lehnfeld R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers. Eur J Med Res. 2004 9:423-431.
  • Wengler G, Koschinski A, Wengler G, Repp H. During entry of alphaviruses, the E1 glycoprotein molecules probably form two separate populations that generate either a fusion pore or ion-permeable pores. J Gen Virol. 2004 85:1695-1701.
  • Ilinskaya ON, Koschinski A, Mitkevich VA, Repp H, Dreyer F, Pace CN, Makarov AA (2004). Cytotoxicity of RNases is increased by cationization and counteracted by KCa channels. Biochem Biophys Res Commun 314:550-554.
  • Melichar VO, Behr-Roussel D, Zabel U, Uttenthal LO, Rodrigo J, Rupin A, Verbeuren TJ, Kumar HSA, Schmidt HH (2004). Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. ProcNatlAcad Sci USA 101:16671-16676.
  • Matejec R, Schulz A, Harbach HW, Uhlich H, Hempelmann G, Teschemacher H. Effects of tourniquet-induced ischemia on the release of proopiomelanocortin derivatives determined in peripheral blood plasma. J Appl Physiol. 2004 97:1040-1045.
  • Müller FU, Loser K, Kleideiter U, Neumann J, von Wallbrunn C, Dobner T, Scheld HH, Bantel H, Engels IH, Schulze-Osthoff K, Schmitz W. Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Cell Death Differ. 2004 11:485-493.
  • Muller MJ, Rossbach W, Mann K, Roschke J, Muller-Siecheneder F, Blumler M, Wetzel H, Russ H, Dittmann RW, Benkert O. Subchronic effects of olanzapine on sleep EEG in schizophrenic patients with predominantly negative symptoms. Pharmacopsychiatry. 2004 37:157-162.
  • Olanow CW, Damier P, Goeth CG, Mueller T, Nutt J, Rascol O, Serbanescu A, Deckers F, Russ H. Multicenter, open-label, trial of sarizotan in Parkinson desease patients with levodopa-induced dyskinesias (the SPLENDID Study). Clin. Neuropharmacol. 2004 27:58-62.
  • Bartoszyk GD, Van Amsterdam C, Greiner HE, Rautenberg W, Russ H. Sarizotan, a serotonin 5-HT1A receptor agonist and domapine receptor ligand. 1. Neurochemical profile. J Neural Transm. 2004 111: 113-126.
  • Reif A, Shutenko ZV, Feelisch M, Schmidt HH. Superoxide dismutase and catalase are required to detect NO from both coupled and uncoupled neuronal no synthase. Free Radic Biol Med. 2004 37:988-997.
  • Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R, Brandes RP. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem. 2004 279:45935-45941.
  • Goyal P, Weissmann N, Grimminger F, Hegel C, Bader L, Röse F, Fink L, Ghofrani HA, Schermuly RT, Schmidt HH, Seeger W, Hänze J. Upregulation of Nox 1 in hypoxia activates HIF-1a via increase in reactive oxygen species. Free Radic Biol Med. 2004 36:1279-1288.
  • Chamulitrat W, Stremmel W, Kawahara T, Rokutan K, Fujii H, Wingler K, Schmidt HH, Schmidt R. A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. J Invest Dermatol. 2004 122:1000-1009.
  • Ding JD, Burette A, Nedvetsky PI, Schmidt HH, Weinberg RJ. Distribution of soluble guanylyl cyclase in the rat brain. J Comp Neurol. 2004 472:437-448.
  • Kahl, KG, Schmidt HH, Jung S, Huang P, Sherman P, Toyka KV, Zielasek J. Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: Increased T-helper 1 response. Neurosci Lett. 2004 358:58-62.
  • Ilinskaya ON, Koschinski A, Mitkevich VA, Repp H, Dreyer F, Pace CN, Makarov AA. Cytotoxicity of RNases is increased by cationization and counteracted by K(Ca). Biochem Biophys Res Commun. 2004 Feb 6;314(2):550-4.

2003

  • Dimpfel W, Wedekind W, Keplinger I. Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states.
    Med Res. 2003 8(5):183-91.
  • Dimpfel W, Wedekind W, Keplinger I. Gender difference in electrical brain activity during presentation of various film excerpts with different emotional contentr. J Med Res. 2003 8(5):192-8.
  • Dimpfel W. Preclinical data base of pharmaco-specific rat EEG fingerprints (tele-stereo-EEG). Eur J Med Res. 2003 8(5):199-207.
  • Mayser P, Dreyer F, Repp H. Persistent skin reaction and Raynaud phenomenon after a sting by Echiichthys draco (great weever fish). Hautarzt. 2003 54:633-637.
  • Koschinski A, Wengler G, Wengler G, Repp H. The membrane proteins of flaviviruses form ion-permeable pores in the target membrane after fusion: Identification of the pores and analyssis of their possible role in virus infection. J Gen Virol.2003 84(7):1711-21.
  • Wengler G, Koschinski A, Wengler G, Dreyer F. Entry of alphaviruses at the plasma membrane converts the viral surface proteins into an ion-permeable pore that can be detected by electrophysiological analyses of whole-cell membrane currents. J Gen Virol. 2003 84(1):173-81.
  • Matejec R, Ruwoldt R, Bödeker R-H, Hempelmann G, Teschemacher H. Release of ß-endorphin immunoreactive material under perioperative conditions into blood or cerebrospinal fluid: Significance for postoperative pain? Anesth Analg. 2003 96:481-486.
  • Kahl KG, Zielasek J, Uttenthal LO, Rodrigo J, Toyka KV, Schmidt HH. Protective role of the cytokine-inducible isoform of nitric oxide synthase induciton and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat. J Neurosc Re. 2003 s 73:198-205.
  • Schneider R, Zielasek J, Uttenthal LO, Rodrigo J, Toyka KV, Schmidt HH. L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats. Kidney Int. 2003 64:216-225.
  • Teschemacher H. Opioid receptor ligand derived from food proteins. Curr Pharm Des. 2003 9:1331-1344.
  • Teschemacher H. Lactoferrin elicits opioid-mediated antinociception without development of tolerance: Central nNOS-1 set off duty? Am J Physiol Regul Integr Comp Physiol. 2003 285:R302-R305.
  • Teschemacher H. Proopiomelanocortin: Welche Rolle spielt dieser ACTH- und Endorphin-Präkursor für die Streß-Adaptation? Arzneim.- Therapie-Kritik. 2003 35:233-242.

2002

  • Dreyer F, Bigalke H, Repp H. Obituary: Ernst Richard Habermann (1926-2001).
    Naunyn-Schmidberg's Arch Pharmacol. 2002 365:R3-R5.
  • Ilinskaya ON, Dreyer F, Mitkevich VA, Shaw KL, Pace CN, Makarov AA. Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic. Protein Sci. 2002 11:2522-2525.
  • Zabel U, Kleinschnitz C, Oh P, Smolenski A, Müller H, Kronich P, Nedvetsky P, Kugler P, Walter U, Schnitzer JE, Schmidt HH. Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol. 2002 4:307-311.
  • Nedvetsky PI, Kleinschnitz C, Schmidt HH. Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation. Brain Res. 2002 950:148-154.
  • Nedvetsky PI, Sessa WC, Schmidt HH. There's NO binding like NOS binding: protein-protein interactions in NO/cGMP signaling. Proc Natl Acad Sci U S A. 2002 99:16510-16512.
  • Repp H, Pamukci Z, Koschinski A, Domann E, Darji A, Birringer J, Brockmeier D, Chakraborty T, Dreyer F. Listeriolysin of Listeria monocytogenes forms Ca2+ - permeable pores leading to intracellular Ca2+ oscillations. Cell Microbiol. 2002 4:482-491.
  • Bigalke H, Ebritsch A, Ladilova L, Repp H, Dreyer F. Analysis of fusion events and clostridial neurotoxin-treated endplates. Naunyn-Schmidberg's Arch Pharmacol. 2002 365:R23.
  • Schilling T, Repp H, Richter H, Koschinski A, Heinemann U, Dreyer F, Eder C. Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCal Ca2+ -dependent K+ channels. Neuroscience. 2002 109:827-835.
  • Ibarra C, Galle JC, Melichar VO, Mameghani A, Schmidt HH. Phosphorylation of blood vessel VASP at Serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling. 2002
  • Beer S, Reincke M, Kral M, Lie SZ, Steinhauer S, Schmidt HH, Allolio B, Neubauer S. Susceptibility to cardiac ischemia/reperfusion injury is modulated by chronic estrogen status. J Cardiovasc Pharmacol. 2002 40:420-428.
  • Burette A, Zabel U, Weinberg RJ, Schmidt HH, Valtschanoff JG. Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. J Neurosci. 2002 Oct 15;22(20):8961-70.
  • Lührs H, Papadopoulos T, Schmidt HH, Menzel T. Type I nitric oxide synthase in the human lung is predominantly expressed in capillary endothelial cells. Respir Physiol. 2002 129:367-374.
  • Schramm L, La M, Hecker M, Beckman JS, Lopau K, Zimmermann J, Rendl J, Reiners C, Winderl S, Wanner C, Schmidt HH (2002). L-Arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Intern 4:1423-1432.
  • Matter H, Kotsonis P, Klingler O, Strobel H, Frohlich LG, Frey A, Pfleiderer W, Schmidt HH (2002). Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors. J Med Chem 45(14):2923-41.

2001

  • Christ B, Brockmeier D, Hauck EW, Friemann S. Interactions of sildenafil and tacrolismus in men with erectile dysfunction after kidney transplantation. Urology. 2001 58:589-593.
  • Ilinskaya O, Decker K, Koschinski A, Dreyer F, Repp H. Bacillus intermedius ribonuclease as inhibitor of cell proliferation and membrane current. Toxicology. 2001 156:101-107.
  • Ibarra C, Nedvetsky PI, Gerlach M, Riederer P, Schmidt HH. Regional and age-dependent expression of the nitric oxide receptor, soluble guanylyl cyclase, in the human brain.
    Brain Res. 2001 907:54-60
  • Repp H, Birringer J, Koschinski A, Dreyer F (2001). Activation of CA2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src. Naunyn-Schmiedeberg's Arch Pharmacol 363:295-301.
  • Wenzlaff H, Repp H, Schmidt HH (2001). Wegweiser zum Internet. DGPT-Forum 28:50-51.
  • Kotsonis P, Fröhlich LG, Berg M, Gerwig R, Groehn V, Kang Y, Al-Masoudi N, Taghavi-Moghadam S, Mohr D, Münch U, Schnabel J, Strobel H, Matter H, Pfleiderer W, Schmidt HH. Structural basis for pterin antagonism in Nitric-oxide synthase: development of novel 4-oxo pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin. J Biol Chem. 2001 276(52):49133-41.
  • Pantke MM, Reif A, Valtschanoff JG, Shutenko Z, Frey A, Weinberg RJ, Pfleiderer W, Schmidt HH. Pterin interactions with distinct reductase activities of NO synthase. Biochem J. 2001 356:43-51.
  • Reif A, Zecca L, Riederer P, Feelisch M, Schmidt HH. Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable manner. Free Rad Biol Med. 2001 30:803-808.
  • Burette A, Petrusz P, Schmidt HH, Weinberg RJ. Immunohistochemical localization of nitric oxide synthase and soluble guanylyl cyclase in the ventral cochlear nucleus of the rat. J Comp Neurol. 2001 431:1-10.
  • Vruwink M, Schmidt HH, Weinberg RJ, Burette A (2001). Substance P and nitric oxide signaling in cerebral cortex: Anatomical evidence for reciprocal signaling between two classes of interneurons. J Comp Neurol 441:288-301.
  • Wingler K, Wünsch S, Kreutz R, Rothermung L, Paul M, Schmidt HH. Upregulation of the vascular NAD(P)H-oxidase isoforms Nox-1 and Nox-4 by the renin-angiotensin system in vitro and in vivo. Free Rad Biol Med. 2001 31:1456-1464.

2000

  • Brockmeier D, Hattingberg von HM. Friedrich Hartmung Dost. Die frühen Jahre der Pharmakokinetik. DGPT-Forum. 2000 26:43-4.
  • Brockmeier D. The correlation of in vitro and in vivo dissolution. In: Oral Drug Absorption (Eds. Dressmann, Lennernäs). Marcel Decker, New York, Basel 2000 281-30.
  • Ilinskaya ON, Kolpakov AI, Mulyukin AL, Dreyer F, El-Registan GI. Effect of membrane-active microbial autoregulators on the growth of cultured ras-transformed fibroblasts.
    Prikl Biokhim Mikrobiol. 2000 36(5):449-454.
  • Habermann E, Lasch H, Gödicke P. Therapeutische Prüfungen an Nicht-Einwilligungsfähigen im Eilfall - ethisch geboten und rechtlich zulässig? NJW. 2000 46:3389-3395
  • Habermann E. Abbildung eines Nocebo-Phänomens im menschlichen Gehirn durch fMRi. DGPT-Forum. 2000 26:63.
  • Habermann E. Buchbesprechung: Handbuch der unterwünschten Arzneimittelwirkungen. DGPT-Forum. 2000 26:25.
  • Habermann E. Buchbesprechung: Handbuch Medikamenten. Über 5000 Arzneimittel für Sie bewertet. Der Arzneimittelbrief. 2000 10:79-80.
  • Habermann E. Buchbesprechung: Mit Schwarzbuch und CD-Rom wider den Arzneiverordnungs-Report. Der Arzneimittelbrief. 2000 1:8.
  • Habermann E, Krämer HJ. Erste Hilfe aus dem Internet.
    Deutsches Ärzteblatt. 2000 41:2692-2694
  • Komarov, AM, Wink DA, Feelisch M, Schmidt HH. Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase. Free Radic Biol Med. 2000 28(5):739-742.
  • Kotsonis P, Fröhlich LG, Shutenko ZV, Horejsi R, Pfleiderer W, Schmidt HH. Allosteric regulation of neuronal nitric-oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide. Biochem J. 2000 346:767-776.
  • Groehn V, Fröhlich L, Schmidt HH, Pfleiderer W (2000). Pteridine-Based Photoaffinity Probes for Nitric Oxide Synthase and Aromatic Amino Acid Hydroxylases. Helv Chim Acta 83:2738-2750.
  • Matejec R, Harbach H, Ruwoldt R, Hempelmann G, Teschemacher H. Beeinflussung hypophysärer und zentralnervöser Proopiomelanocortin-Systeme durch postoperative Schmerzbelastung. Anästhesiologie und Schmerzmedizin. 2000 41:844-845.
  • Harbach H, Hell K, Gramsch C, Katz N, Hempelmann G, Teschemacher H. Beta-endorphin (1-31) in the plasma of male volunteeres undergoing physical exercise. Psychoneuroendocrinology. 2000 25(6):551-562.
  • Mayer P, Tischmeyer H, Jayasinghe M, Bonnekoh B, Gollnick H, Teschemacher H, Höllt V. A delta opioid receptor lacking the third cytoplasmic loop is generated by atypic mRNA processing in human malignomas. FEBS Lett. 2000 1;480(2-3):156-160.
  • Schulz A, Harbach H, Katz N, Geiger L, Teschemacher H. beta-Endorphin immunoreactive material and authentic beta-endorphin in the plasma of males undergoing anaerobic exercise on a rowing ergometer. Int J Sports Med. 2000 21(7):513-517.
  • Schulte-Frohlinde E, Reindl W, Bierling D, Lersch C, Brantl V, Teschemacher H, Schusdziarra V. Effects of oral casokefamide on plasma levels, tolerance and intestinal transit in man. Peptides. 2000 21:439-442
  • Welters ID, Menzebach A, Goumon Y, Langefeld TW, Teschemacher H, Hempelmann G, Stefano GB. Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and mu(3) opiate receptor-dependent mechanism. J Neuroimmunol. 2000 111:139-145.
  • Wingler K, Müller C, Schmehl K, Florian S, Brigelius-Flohé. R. Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells. Gastroenterol. 2000 119(2):420-430.