Inhaltspezifische Aktionen

Highlights publications

  • Targeting Wnt-ss-Catenin-FOSL signaling ameliorates right ventricular remodeling (Nayakanti et al., Circ Res 2023, CP02)
  • Identification of molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension by transcriptional profiling (Khassafi et al., Nat Cardiovasc Res 2023, A05)
  • Smoke-induced PH is prevented by fibroblast growth factor (FGF) 10 overexpression (Hadzic et al., Eur Respir J 2023, A04/A07), inducible nitric oxide synthase (iNOS) deletion in myeloid cells (Gredic et al., Eur Respir J 2022, A07), or by NADPH oxidase organizer (NoxO)-1 deletion (Seimetz et al., Nat Metab 2020, A07)
  • Uncovering a role of cellular metabolism for chromatin-dependent gene regulation – inhibition of fatty acid oxidation enables heart regeneration in adult mice (Li et al., Nature 2023, B02)
  • The mammalian Ste20-like kinases (MST) controls pulmonary vascular remodeling and pulmonary hypertension via the mitotic checkpoint protein BUB3 and FOXO (Kudryashova et al., Circ Res 2022, A01)
  • Development of a novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops (Richter et al., Eur Heart J Cardiovasc Imaging 2022, B08)
  • Epigenetic reactivation of transcription factors (TFs) associated with lung development underlies PAH pathogenesis. Pharmacological inhibition of the P300/CREB reversed established PH in three rodent models (Chelladurai et al., Sci Transl Med 2022, A05)
  • Inhaled Iloprost improves right ventricular load-independent contractility in pulmonary hypertension (Tello K et al., Am J Respir Crit Care Med 2022, B08)
  • The matricellular protein secreted protein acidic and rich in cysteine (SPARC) is involved in human PH pathogenesis and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function (Veith et al., Circulation 2022, A06)
  • Definition of a cut-off to predict PH based on 2D echocardiography (Gall et al., EClinicalMedicine 2021, B08) – findings were implemented in the 2022 ESC/ERS guidelines for PH diagnosis and treatment (Humbert et al., Eur Heart J and Eur Respir J 2022)
  • BMP9 and BMP10 act directly on vascular smooth muscle cells for induction and maintenance of their contractile state. Disbalance in this pathway enables vascular smooth muscle cells to escape from control by BMP9 and BMP10 and initiates pathologic processes (Wang et al., Circulation 2021, A02)
  • The presence of PH has a marked impact on the clinical outcome, including survival, of patients with lung cancer (Eul et al., Am J Respir Crit Care Med 2021, A10)
  • In Zebrafish, we observed that IL-11 signaling in endothelial cells antagonizes profibrotic transforming growth factor–β signaling and endothelial-to-mesenchymal transition, limiting scarring and promoting cardiomyocyte repopulation, after injury (Allanki et al., Sci Adv 2021, B01). Transferring those findings to mammals may allow us to develop not only antifibrotic but also regenerative therapies for RV decompensation
  • Loss of the histone-methyl-transferase Suv4-20h1 in cardiopulmonary progenitor cells in mice causes a PH-like phenotype, including RV dilation and premature death (Qi et al., Circulation 2021, B02)
  • CILP1 was identified as a novel and promising biomarker of RV remodeling that is associated with RV maladaptation and RV-PA uncoupling in patients with PH (Keranov et al., Eur Respir 2021, B07)
  • Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing underlying acute hypoxia-induced PH (Sommer et al., Sci Adv 2020, A06)