Inhaltspezifische Aktionen


2020 | 2019 | 2018 | 2017



1.     Chen S, Cooper N, Müller M, Bein G, Sachs UJ (2020) Piperacillin-dependent anti-platelet antibodies are a relevant, easy to confirm differential diagnosis in patients with rapid-onset thrombocytopenia. British journal of haematology 190 (5): e320-e321.

2.     Cooper N, Li Y-T, Möller A, Schulz-Weidner N, Sachs UJ, Wagner F, Hackstein H, Wienzek-Lischka S, Grüneberg M, Wild MK, Bein G, Marquardt T (2020) Incidental diagnosis of leukocyte adhesion deficiency type II following ABO typing. Clinical immunology (Orlando, Fla.): 108599.

3.     Holzwarth ST, Strobel J, Cooper N, Leyh J, Bayat B, Bein G, Zingsem J, Sachs UJ (2020) A point mutation c.473A G of ITGB3 is responsible for the formation of the Woa human platelet alloantigen. Transfusion 60 (1): E5-E6.

4.     Holzwarth ST, Bayat B, Zhu J, Phuangtham R, Fischer L, Boeckelmann D, Röder L, Berghöfer H, Schmidt S, Bein G, Santoso S (2020) Naturally occurring point mutation Cys460Trp located in the I-EGF1 domain of integrin β3 alters the binding of some anti-HPA-1a antibodies. Transfusion.

5.     Kjær M, Geisen C, Akkök ÇA, Wikman A, Sachs U, Bussel JB, Nielsen K, Walles K, Curtis BR, Vidarsson G, Järås K, Skogen B (2020) Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 59 (1): 102712.

6.     Liu J, Shao Y, Ding H, Deng J, Xu X, Wang J, Xia W, Santoso S, Ye X, Fu Y (2020) Distribution of CD36 deficiency in different Chinese ethnic groups. Human immunology 81 (7): 366–371.

7.     Norris PAA, Segel GB, Burack WR, Sachs UJ, Lissenberg-Thunnissen SN, Vidarsson G, Bayat B, Cserti-Gazdewich CM, Callum J, Lin Y, Branch D, Kapur R, Semple JW, Lazarus AH (2020) FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia. Haematologica.

8.     Phuangtham R, Santoso S, Leelayuwat C, Komvilaisak P, Ding H, Romphruk AV (2020) Frequency of CD36 deficiency in Thais analyzed by quantification of CD36 on cell surfaces and in plasma. Transfusion 60 (4): 847–854.

9.     Runkel B, Bein G, Sieben W, Sow D, Polus S, Fleer D (2020) Targeted antenatal anti-D prophylaxis for RhD-negative pregnant women: a systematic review. BMC pregnancy and childbirth 20 (1): 83.

10.   Sachs UJ (2020) Prospects for risk stratification of anti-HPA-1a alloimmunized pregnant women. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 59 (1): 102709.

11.   Sachs UJ, Radke C, Bein G, Grabowski C, Simtong P, Bux J, Bayat B, Reil A (2020) Primary structure of human neutrophil antigens 1a and 1b. Transfusion 60 (4): 815–821.

12.   Sachs UJ, Wienzek-Lischka S, Duong Y, Qiu D, Hinrichs W, Cooper N, Santoso S, Bayat B, Bein G (2020) Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia. British journal of haematology 189 (4): 751–759.

13.   Schwab L, Michel G, Bein G, Hackstein H (2020) CD71 surface analysis of T cells: a simple alternative for extracorporeal photopheresis quality control. Vox sanguinis 115 (1): 81–93.

14.   Sommer N, Noack S, Hecker A, Hackstein H, Bein G, Weissmann N, Seeger W, Mayer K, Hecker M (2020) Decreased Thymic Output Contributes to Immune Defects in Septic Patients. Journal of clinical medicine 9 (9).

15.   Wienzek-Lischka S, Bachmann S, Froehner V, Bein G (2020) Potential of Next-Generation Sequencing in Noninvasive Fetal Molecular Blood Group Genotyping. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 47 (1): 14–22.

16.   Wienzek-Lischka S, Sawazki A, Ehrhardt H, Sachs UJ, Axt-Fliedner R, Bein G (2020) Non-invasive risk-assessment and bleeding prophylaxis with IVIG in pregnant women with a history of fetal and neonatal alloimmune thrombocytopenia: management to minimize adverse events. Archives of gynecology and obstetrics 302 (2): 355–363.

17.   Wu Y, Chen D, Xu X, Mai M, Ye X, Li C, Santoso S, Xia W, Fu Y (2020) Hydrops fetalis associated with anti-CD36 antibodies in fetal and neonatal alloimmune thrombocytopenia: Possible underlying mechanism. Transfusion medicine (Oxford, England).



1.     Albesa R, Sachs U, Infantino M, Manfredi M, Benucci M, Baus Y, Lutterbeck S, Andrade L, Morris K, Friedenberg A, Casas S, Bossuyt X, Mahler M (2019) Increased prevalence of anti-DFS70 antibodies in young females: experience from a large international multi-center study on blood donors. Clinical chemistry and laboratory medicine 57 (7): 999–1005.

2.     Baal N, Cunningham S, Obermann H-L, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H (2019) ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function. Journal of immunology (Baltimore, Md. : 1950) 202 (4): 1099–1111.

3.     Bayat B, Traum A, Berghöfer H, Werth S, Zhu J, Bein G, Sachs UJ, Santoso S (2019) Current Anti-HPA-1a Standard Antibodies React with the β3 Integrin Subunit but not with αIIbβ3 and αvβ3 Complexes. Thrombosis and haemostasis 119 (11): 1807–1815.

4.     Bux J, Sachs UJ (2019) Be alert to leukocyte antibodies when prescribing granulocyte transfusions. Transfusion 59 (6): 2174.

5.     Dabrowski AN, Conrad C, Behrendt U, Shrivastav A, Baal N, Wienhold SM, Hackstein H, N'Guessan PD, Aly S, Reppe K, Suttorp N, Zahlten J (2019) Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection. Frontiers in microbiology 10: 199.

6.     Eekels JJM, Althaus K, Bakchoul T, Kroll H, Kiefel V, Nazy I, Lee LS, Sachs U, Warkentin TE, Greinacher A (2019) An international external quality assessment for laboratory diagnosis of heparin-induced thrombocytopenia. Journal of thrombosis and haemostasis : JTH 17 (3): 525–531.

7.     Elsemüller A-K, Tomalla V, Gärtner U, Troidl K, Jeratsch S, Graumann J, Baal N, Hackstein H, Lasch M, Deindl E, Preissner KT, Fischer S (2019) Characterization of mast cell-derived rRNA-containing microvesicles and their inflammatory impact on endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 (4): 5457–5467.

8.     Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A (2019) Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases. Scientific reports 9 (1): 8333.

9.     Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H (2019) Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice. Journal of leukocyte biology 106 (4): 977–985.

10.   Penter L, Dietze K, Ritter J, Lammoglia Cobo MF, Garmshausen J, Aigner F, Bullinger L, Hackstein H, Wienzek-Lischka S, Blankenstein T, Hummel M, Dornmair K, Hansmann L (2019) Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer. Oncoimmunology 8 (6): e1586409.

11.   Sachs UJ (2019) Diagnosing Immune Thrombocytopenia. Hamostaseologie 39 (3): 250–258.

12.   Singh VK, Werner S, Schwalm S, Lennerz V, Ruf S, Stadler S, Hackstein H, Reiter A, Wölfel T, Damm-Welk C, Woessmann W (2019) NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma. Oncoimmunology 8 (9): e1625688.

13.   Vollenberg R, Jouni R, Norris PAA, Burg-Roderfeld M, Cooper N, Rummel MJ, Bein G, Marini I, Bayat B, Burack R, Lazarus AH, Bakchoul T, Sachs UJ (2019) Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia. Haematologica 104 (6): 1237–1243.

14.   Wu J, Li Y, Schuller RM, Li L, Litmeyer A-S, Bein G, Sachs UJ, Bayat B (2019) The nonconservative CD177 single-nucleotide polymorphism c.1291GA is a genetic determinant for human neutrophil antigen-2 atypical/low expression and deficiency. Transfusion 59 (5): 1836–1842.

15.   Zhang N, Santoso S, Aster RH, Curtis BR, Newman PJ (2019) Bioengineered iPSC-derived megakaryocytes for the detection of platelet-specific patient alloantibodies. Blood 134 (22): e1-e8.



1.     Flommersfeld S, Mand C, Kühne CA, Bein G, Ruchholtz S, Sachs UJ (2018) Unmatched Type O RhD+ Red Blood Cells in Multiple Injured Patients. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 45 (3): 158–161.

2.     Hecker M, Sommer N, Foch S, Hecker A, Hackstein H, Witzenrath M, Weissmann N, Seeger W, Mayer K (2018) Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation. Biochimica et biophysica acta. Molecular and cell biology of lipids 1863 (9): 1016–1028.

3.     Lin M, Xu X, Lee H-L, Liang D-C, Santoso S (2018) Fetal/neonatal alloimmune thrombocytopenia due to anti-CD36 antibodies: antibody evaluations by CD36-transfected cell lines. Transfusion 58 (1): 189–195.

4.     Preußer C, Hung L-H, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A (2018) Selective release of circRNAs in platelet-derived extracellular vesicles. Journal of extracellular vesicles 7 (1): 1424473.

5.     Shrivastav A, Dabrowski AN, Conrad C, Baal N, Hackstein H, Plog S, Dietert K, Gruber AD, N'Guessan PD, Aly S, Suttorp N, Zahlten J (2018) Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice. Frontiers in microbiology 9: 103.

6.     Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V (2018) Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1β via CD36 and Nicotinic Acetylcholine Receptors. Frontiers in immunology 9: 877.

7.     Simtong P, Puapairoj C, Leelayuwat C, Santoso S, Romphruk AV (2018) Assessment of HNA alloimmunisation risk in Northeastern Thais, Burmese and Karen. Transfusion medicine (Oxford, England) 28 (1): 47–55.

8.     Simtong P, Romphruk AV, Hofmann C, Reil A, Sachs UJ, Santoso S (2018) Improvement of monoclonal antibody-immobilized granulocyte antigen assay for the detection of anti-HNA-1 alloantibodies. Transfusion 58 (1): 200–207.

9.     Simtong P, Romphruk AV, Traum A, Burg-Roderfeld M, Bein G, Jakubowski K, Dominik A, Theisen M, Kana IH, Sachs UJ, Santoso S (2018) Molecular and Functional Characterization of Fcγ Receptor IIIb-Ligand Interaction: Implications for Neutrophil-Mediated Immune Mechanisms in Malaria. Infection and immunity 86 (8).

10.   Verdú-Amorós J, Woessmann W, Maecker-Kolhoff B, Schulz A, Strauss G, Bein G, Hackstein H (2018) Mini photopheresis for refractory chronic graft-versus-host disease in children and adolescents. Transfusion 58 (11): 2495–2500.

11.   Wang J, Xia W, Deng J, Xu X, Shao Y, Ding H, Chen Y, Liu J, Chen D, Ye X, Santoso S (2018) Analysis of platelet-reactive alloantibodies and evaluation of cross-match-compatible platelets for the management of patients with transfusion refractoriness. Transfusion medicine (Oxford, England) 28 (1): 40–46.

12.   Xu X, Li L, Xia W, Ding H, Chen D, Liu J, Deng J, Chen Y, He Z, Wang J, Shao Y, Santoso S, Ye X, Fang Q (2018) Successful management of a hydropic fetus with severe anemia and thrombocytopenia caused by anti-CD36 antibody. International journal of hematology 107 (2): 251–256.



1.    Boeckelmann D, Hengartner H, Greinacher A, Nowak-Göttl U, Sachs UJ, Peter K, Sandrock-Lang K, Zieger B (2017) Patients with Bernard-Soulier syndrome and different severity of the bleeding phenotype. Blood cells, molecules & diseases 67: 69–74.

2.     Denomme GA, Anani WQ, Avent ND, Bein G, Briggs LB, Lapadat RC, Montemayor C, Rios M, St-Louis M, Uhl L, Wendel S, Flegel WA (2017) Red cell genotyping precision medicine: a conference summary. Therapeutic advances in hematology 8 (10): 277–291.

3.     Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, Lachner C von, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD (2017) Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia. PloS one 12 (11): e0188251.

4.     Gündüz D, Tanislav C, Sedding D, Parahuleva M, Santoso S, Troidl C, Hamm CW, Aslam M (2017) Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation. International journal of molecular sciences 18 (2).

5.     Hackstein H, Möller A, Gerlach M, Sachs U, Bein G (2017) Prospective quality control study of a novel gravity-driven whole blood separation system suitable for humanitarian crises. Vox sanguinis 112 (8): 806–809.

6.     Killer MC, Nold P, Henkenius K, Fritz L, Riedlinger T, Barckhausen C, Frech M, Hackstein H, Neubauer A, Brendel C (2017) Immunosuppressive capacity of mesenchymal stem cells correlates with metabolic activity and can be enhanced by valproic acid. Stem cell research & therapy 8 (1): 100.

7.     Lippitsch A, Chukovetskyi Y, Baal N, Bein G, Hackstein H (2017) Unique high and homogenous surface expression of the transferrin receptor CD71 on murine plasmacytoid dendritic cells in different tissues. Cellular immunology 316: 41–52.

8.     Nold P, Hartmann R, Feliu N, Kantner K, Gamal M, Pelaz B, Hühn J, Sun X, Jungebluth P, Del Pino P, Hackstein H, Macchiarini P, Parak WJ, Brendel C (2017) Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles: a prerequisite for in vivo tracking of MSCs. Journal of nanobiotechnology 15 (1): 24.

9.     Sluzalska KD, Liebisch G, Lochnit G, Ishaque B, Hackstein H, Schmitz G, Rickert M, Steinmeyer J (2017) Interleukin-1β affects the phospholipid biosynthesis of fibroblast-like synoviocytes from human osteoarthritic knee joints. Osteoarthritis and cartilage 25 (11): 1890–1899.

10.   Sluzalska KD, Liebisch G, Wilhelm J, Ishaque B, Hackstein H, Schmitz G, Rickert M, Steinmeyer J (2017) Growth factors regulate phospholipid biosynthesis in human fibroblast-like synoviocytes obtained from osteoarthritic knees. Scientific reports 7 (1): 13469.

11.   Türkmen T, Qiu D, Cooper N, Sachs UJ, Wößmann W, Schranz D, Zimmer K-P, Ehrhardt H, Hackstein H, Bein G (2017) Red blood cell alloimmunization in neonates and children up to 3 years of age. Transfusion 57 (11): 2720–2726.

12.   Wienzek-Lischka S, König IR, Papenkort E-M, Hackstein H, Santoso S, Sachs UJ, Bein G (2017) HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia. Transfusion 57 (3): 533–540.

13.   Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, Maat S de, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P (2017) Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury. American journal of respiratory and critical care medicine 196 (2): 186–199.



1.    V. Kiefel, Santoso S. Nachweis von thrombozytären Antigenen und Antikörpern. In: Kiefel V (Hrsg.) Transfusionsmedizin und Immunhämatologie. 4. Auflage. Berlin, Heidelberg, New York: Springer-Verlag, 2010, S. 223-243

2.    V. Kiefel, Santoso S. Alloantigene von Thrombozyten. . In: Kiefel V (Hrsg.) Transfusionsmedizin und Immunhämatologie. 4. Auflage. Berlin, Heidelberg, New York: Springer-Verlag, 2010, S. 223-243.

3.    Sachs UJ, Bux J. Gewinnung, Herstellung und Lagerung von Blut und Blutkomponenten. In: Kiefel V (Hrsg.) Transfusionsmedizin und Immunhämatologie. 4. Auflage. Berlin, Heidelberg, New York: Springer-Verlag, 2010, S. 223-243.

4.    Bux J, Sachs UJ. Therapie mit Granulozyten. In: Kiefel V (Hrsg.) Transfusionsmedizin und Immunhämatologie. 4. Auflage. Berlin, Heidelberg, New York: Springer-Verlag, 2010, S. 321-326

5.    Wallis JP, Sachs UJ. Transfusion-related acute lung injury. In: Simon TL, Snyder EL, Solheim BG, Stowell CP, Strauss RG, Petrides M (ed.) Rossi’s Principles of Transfusion Medicine. 4th edition. Bethesda: American Association of Blood Bank Press, 2009, S. 870-884.

6.    Bein G, Sachs UJ. Unerwünschte Wirkungen. In: Vorstand und Wissenschaftlicher Beirat der Bundesärztekammer (Hrsg.) Querschnitts-Leitlinien zur Therapie mit Blutkomponenten und Plasmaderivaten. 4. überarbeitete Auflage. Köln: Deutscher Ärzte-Verlag, 2009, S. 233-264.

7.    Bux J, Sachs UJ. Pathophysiology of TRALI. In: Popovsky MA, Kleinman SH (Hrsg.) TRALI: Mechanisms, Management, and Prevention. Bethesda: American Association of Blood Bank Press, 2008, S. 43-69.



1.    Herrman A, Klaus G, Höfle G, Irschik H, Kemmer T, Werner K, Kunze B, Reichenbach H, Santoso S, Steinmetz H, Trowitzsch W. Culture Medium, Extract, Active Mixture, Active Compounds as well as the microbiological preparation thereof, and microorganism used therein (MX v48). European Patent Nr. 81100183; US Patent PCT/EP81/00183.


2.    Newman PJ, Santoso S. Molecular basis of the human platelet alloantigen Bra/Brb alloantigen system and applications thereof. US Patent 5,516,634.