News
December
Second Epigenetics lecture at Goethe School in Wetzlar
As in the previous year, the Institute for Genetics aims to spark enthusiasm for biology in general and for epigenetics in particular even before students begin their university studies. For this reason, Sandra Hake once again visited the advanced biology courses at the Goetheschule in Wetzlar and gave a lecture on the topic of “Epigenetics.” The students’ enthusiasm for science and their many exciting and very well-thought-out questions were truly impressive. Warm thanks go to everyone who made this visit possible!
Christmas Party
Due to the relocation of the Hake team to the Carl Vogt House, it was not possible to hold a large institute-wide Christmas party this year. Instead, there was a “lab-warming party” with (lots of) mulled wine, cookies, and Secret Santa gifts for everyone present. Institute members, people involved in the move, staff from the building renovation, and new scientific neighbours celebrated the AG Hake’s move-in together. What a wonderful start. Everyone stopped by and warmly welcomed the Hake team to their new place of work. The AG Hake is already looking forward to many new collaborations in the coming years.
Afterwards, members of the Hake team (who were not ill) and their friends/alumni held a small, fun celebration with music and singing.
The Hake Lab Moves into Newly Renovated Laboratories in the Carl Vogt Building!
After many years of successful work in laboratories that had grown a bit old, the Hake Lab — along with a large practical training room — is moving into newly renovated facilities in the Carl-Vogt-Building (CVH) of the JLU. More than two years of preparation, planning, and organization have finally paid off. After four weeks of packing, moving, and unpacking, the Hake Lab has finally arrived in its new home. And everything fit — even the large equipment has found its place! As soon as all the new instruments have arrived, the technical systems are working, and the cold room is operational, research can resume. Many thanks to all the dedicated participants, the professional moving companies, and the helpful technicians!
To mark the occasion, the Hake team is hosting a welcome celebration on December 15th to meet their new neighbors in the CVH and to say goodbye to the other groups at the Institute for Genetics.
This means that the Institute for Genetics is now separated spatially, but not scientifically: Prof. Braun’s group can be found in the New Chemistry Building (Heinrich-Buff-Ring 17), Prof. Hake’s group in the Carl-Vogt-Building (Heinrich-Buff-Ring 38), and Prof. Dammann’s group remains — at least for the next few months, before they too have to move — in the Old Chemistry Building (Heinrich-Buff-Ring 58).
But the Institute for Genetics remains united in teaching and research!
November
Congratulations to Ghazal Sinjar!
October
Goodbye, Dennis Koch!
With heavy hearts, the Institute for Genetics bids farewell to Dennis Koch, who has been a tremendous asset to the secretariat over the past three years. We wish Dennis all the best for his future career in Marburg and look forward to seeing him again – outside the institute. Dennis, you were a wonderful, helpful, and always cheerful colleague; your departure leaves a big gap in our “Genetics family.”
September
GfG Symposium "Epigenetics & Chromatin"
From September 24 to 26, 2025, the annual meeting of the German Genetics Society (GfG) was held at the Justus-Liebig-University (JLU) in Giessen. This year’s focus was on the topic “Epigenetics & Chromatin.” The GfG organizers – Sandra Hake (President), Sigurd Braun (Vice President), Alexander Brehm, Patrick Heun, and Fides Zenk (all members of the advisory board) – were delighted with the strong participation of around 80 scientists from Germany and abroad (see https://www.gfgenetik.de/ )
Over three days, the program offered a wide range of exciting presentations, including numerous unpublished studies that sparked lively discussions as well as intensive and collegial scientific exchange. Special highlights included the Max-Delbrück-Lecture by Prof. Dr. Peter B. Becker from LMU Munich, the Elisabeth-Gateff-Prize for the best dissertation awarded to Dr. Agata Kalita, and the many excellent flash talks and outstanding poster presentations.
Members of the Hake and Braun research groups were also strongly represented and presented their latest findings. Everyone is especially proud of Lena Paasche from Sandra Hake’s group, who won the €300 prize for the best short talk. We are all thrilled and warmly congratulate Lena on this fantastic achievement!
July
Student Internship No. 6 and “Jugend-forscht”
Once again this year, the school student internship in the Hake lab offered a successful combination of fun and exciting insights into scientific research. Six dedicated students had the opportunity to experience everyday lab work up close and to actively participate in various tasks. In addition, the Hake lab enthusiastically supported another student in developing her own project idea for the “Jugend-forscht” competition.
With such talented young scientists, we look to the future with confidence!
May
Sandra Hake and Sigurd Braun as invited speakers at the final IRTG 1064 “Chromatin Day” Symposium in Munich
Sandra Hake and Sigurd Braun were invited as alumni of the CRC 1064 “Chromatin Dynamics” to give talks at the “Chromatin Day” Symposium. It was a fantastic two days, filled with excellent scientific discussions and lots of fun during the barbecue and game night that followed. It was wonderful to see many friends and former colleagues again, especially the spokesperson of CRC 1064, Prof. Dr. Peter Becker!
Institute Excursion to the Senckenberg Museum in Frankfurt
This year, the Institute for Genetics – including the Braun, Dammann, and Hake research groups – visited the Senckenberg Museum. After a shared morning snack in Giessen, we took the train to Frankfurt to learn more about biodiversity, dinosaurs, extinct animals and plants, and many other fascinating discoveries during a guided tour of this wonderful museum. Afterwards, the day ended with refreshments and lots of fun in beautiful weather. It was a fantastic outing that we will fondly remember for a long time!
Welcome back, Dr. Tim Marius Wunderlich!
We are all absolutely thrilled about Tim Wunderlich’s return. After completing his outstanding doctoral thesis, Tim is rejoining the Hake research group as an
Akademischer Rat a. Z.
, where he has truly been missed. This wonderful moment had to be celebrated with the whole team. Tim will actively support us in teaching, research, and organizational matters—including the upcoming move. Welcome back, Tim! We couldn’t be happier!
Welcome to our new Bachelor Students
We are happy to welcome our new Bachelor students Maja Gärtner, Tyra Grundig, Lea Gude, Alina Jakob and Larissa Probst at the AG Hake from the Institute for Genetics!!! We are sure, we will all have a great and productive time together!
March
Applause for Dr. KCFO!
We warmly congratulate Dr. Karl Christoph Frederic Olsen on the successful defense of his dissertation and an impressive doctoral examination!
Karl impressed both his examiners and all of us with his deep expertise, analytical precision, and passionate presentation of his research on heterochromatin, boundary elements, and the enigmatic demethylase Epe1.
The Braun Lab made the trip to LMU Munich and was there in person to celebrate this important milestone together with Karl’s family and friends.
We’re proud of you, Karl – and wish you all the best for the future!
February
Congratulations to Felix Diegmüller and Dr. Jörg Leers on the publication of their review in JBC!
Finally! The outstanding review article by Felix Diegmüller and Jörg Leers from the Hake research group has been published in the Journal of Biochemistry (JBC) ! This article was written for a special issue in memory of the brilliant scientist and mentor C. David (Dave) Allis, who passed away unexpectedly in early 2023.
The review highlights Dave’s remarkable discoveries in the field of histone variants, with a special focus on the histone variant H2A.Z—a must-read !
As always, this success was celebrated with a "paper-hanging" ceremony together with the entire research group and friends.
Congratulations to everyone involved!
January
Congratulations, Tim Marius Wunderlich, on your excellent doctoral defense!
The Hake Group has welcomed a new Dr. rer. nat. into its ranks! Tim Marius Wunderlich defended his dissertation on ZNF512B with distinction. With his outstanding presentation, thorough answers to all questions, and comprehensive knowledge, he fully convinced the examiners Sandra Hake, Alexander Brehm, Oliver Rossbach, and Marek Bartkuhn. Simply fantastic, Dr. Wunderlich!
This wonderful achievement was, of course, celebrated appropriately with colleagues, friends, and family!
December
Christmas Party at the Institute for Genetics
We conclude the scientific year 2024 with a delightful Christmas celebration. The afternoon and evening were marked by a wonderful atmosphere full of joy, fun, and communal activities and games. Together, we enjoyed a variety of entertaining and sporty challenges, including a "PI contest," "fun facts" about institute members and their baby photos, "Secret Santa" surprises, and karaoke. The grand finale was a shared dinner in the city, accompanied by countless laughs and stories. It was, as always, a beautiful experience!
November
Epigenetics lecture at Goethe School in Wetzlar
The Institute of Genetics aims to inspire enthusiasm for biology in general and epigenetics in particular even before students begin their studies. For this reason, Sandra Hake visited the advanced biology classes at the Goetheschule in Wetzlar and gave a lecture on the topic of "Epigenetics." The students' excitement for science and their many fascinating and thought-through questions were truly impressive. A heartfelt thank you to everyone who made this visit possible!
There is so much to celebrate: publication in NAR, new members in the Hake team and Jörg Leers' 30th anniversary of service
The 'Hake team' is growing and warmly welcomes the new members: Johannes Groos will enrich the group as a PhD student and bioinformatician, Jonas Schauß and Jannik Lörke are working on their master's theses, Evelin Mamro supports the team as a student assistant and Malcolm Wilhelm is helping both AGs Hake and Braun as a technical assistant in their experiments and in teaching.
We warmly congratulate Jörg Leers, who had his 30th service anniversary in the summer of 2024. What a commitment to science!
And Tim Wunderlich and his co-authors celebrate their publication in Nucleic Acids Research (NAR; https://pubmed.ncbi.nlm.nih.gov/39460621/ ) with the tradition of the “paper hanging ceremony”. They show ZNF512B is
Congratulations to everyone involved!
October
Welcome, Johannes!
The 'Hake team' warmly welcomes Johannes Groos as a new doctoral student. Johannes will actively support us as a bioinformatician and bring new ideas into the team with his project(s).We are extremely happy that Johannes joined the team!We wish Johannes a successful and happy time at the Institute!
Study from Tim Marius Wunderlich accepted by Nucleic Acids Research (NAR )
Congratulations Tim!
Tim's exciting work on the zinc finger protein ZNF512B, which aggregates chromatin, interacts with the NuRD complex and represses gene expression, has been accepted in the journal Nucleic Acids Research (NAR). Since almost all members of the Hake group were involved in this research project, we all spontaneously got together and toasted this success! Many thanks also to our collaboration partners Olalla Vazquez (University of Marburg), Joel Mackay (University of Sydney, Australia), Falk Butter (FLI Greifswald) and Marek Bartkuhn (JLU Giessen)! As soon as the study is published, there will - of course - be a ceremonial hanging of the paper. Stay tuned...
September
AG Hake retreat to Wetzlar
This year the Hake team visited Wetzlar. A retreat of reflection but also team spirit strengthening. After an invigorating brunch, Germany's dark history was brought into the present with a tour of an extensive, underground tunnel that was used for the industrial production of weapons material during World War II, reinforcing all of our concerns about the current socio-political situation. We all agree: NEVER AGAIN! After this extremely interesting visit to these oppressive underground facilities, we were able to work through the experience in the beer garden at the river Lahn followed by a refreshment in a restaurant. The day ended sportily with lots of fun in the bowling center. As a team, which stands for diversity and inclusion, we approach new scientific and social challenges thoughtfully and with strengthened views.
1. Mini-Symposium des Instituts für Genetik mit anschließendem Sommergrillfest
Ein Vormittag mit spannenden wissenschaftlichen Vorträgen von Mitgliedern der AGs Dammann (Yufen Thao und Sarah Arroyo y Villora), Braun (Vishnu Sreechakram) und Hake (Jie Lan und Carlotta Kreienbaum) wurde mit einem anschließenden Grillfest bei strahlendem Sonnenschein verbunden. Das Institut für Genetik zeigte sich von seiner besten Seite. Man kann fesselnde Forschung mit gemeinsamen Spaß wunderbar verbinden.
Juli
September
1st mini-symposium of the Institute for Genetics followed by a summer barbecue
A morning with exciting scientific lectures by members of the Dammann (Yufen Thao and Sarah Arroyo y Villora), Braun (Vishnu Sreechakram) and Hake (Jie Lan and Carlotta Kreienbaum) groups was combined with a subsequent barbecue in bright sunshine. The Institute of Genetics showed itself at its best. We demonstrated beautifully: one can wonderfully combine captivating research with shared fun.
July
Award ceremony for the European Championship betting game 2024
The Institute of Genetics shines not only with scientific excellence, but also with sporting knowledge. At this year's European Championship prediction game, Nadine was able to impress with her great football expertise. Jörg came – very narrowly – second and Jonas third. Congratulations to the winners! As always, it was a lot of fun to compete with each other also outside of the academic world.
Summer conclusion to AG Hake's employee discussions
As every year, AG Hake's employee discussions were very well received and provided a lot of new inspiration. Reinforced as a team and “scientific family”, this day ended with a wonderful and very fun dinner next to the Lahn.
School student internship number 5
Once again it was a lot of fun and a lot to learn during the student internship at the AG Hake. Five students learned about everyday laboratory life through experiments: sterile work in cell culture, isolation of histones and subsequent molecular biological and biochemical analyses. All five of them worked extremely well and we are glad that they enriched our everyday laboratory life. With such committed young talents, the future of science is secured!
Sandra Hake and Sigurd Braun as speakers at the first Hessian-Bavarian “Chromatin” minisymposium in Marburg (organizer Prof. Dr. Alexander Brehm)
Prof. Dr. Alexander Brehm from the University of Marburg organized the first Hessian-Bavarian minisymposium on “chromatin”. It was an exciting afternoon with inspiring lectures by Patrick Heun, Axel Imhof, Gernod Langst as well as Sandra Hake and Sigurd Braun. In the evening, the friendships between the scientists from Hesse and Bavaria were further strengthened at a joint dinner! Many thanks to Alexander Brehm for this wonderful symposium. Hopefully there will be more in the future.
June
Excursion of the working group Dammann to Marburg
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April
Symposium "Dynamics in chromatin organization and RNA regulation"
On April 10-12, 2024, a three-day international symposium on chromatin and RNA research took place in the auditorium of the JLU main building, organized by Prof. Dr. Sigurd Braun (Institute of Genetics) in collaboration with Prof. Dr. Katja Sträßer (Institute of Biochemistry). The conference was funded by two EU and DFG-supported graduate programs ( Cell2Cell , RTG2355 ), coordinated by LMU Munich and JLU Giessen. Registration was free, allowing many students and doctoral candidates to participate.
The event was a great success! A total of 130 local and international participants attended. The symposium was opened by the Vice President for Research of the JLU, Prof. Dr. Martin Kramer. Leading researchers from Israel (Prof. Dr. Schraga Schwarz), Switzerland (Prof. Dr. Susan Gasser), and the Netherlands (Prof. Dr. Bas van Steensel) delivered the keynote lectures. Many other presentations followed from guest speakers and local researchers, such as Prof. Dr. Sandra Hake and Vishnu N. Suma Sreechakram from the Institute of Genetics. Among the speakers were also many early stage researchers from the two graduate programs. Another highlight was the awarding of the 300 Euro poster prize by the German Genetics Society to Gertjan Laenen (Institut Curie, Paris), presented by the GfG President, Prof. Dr. Sandra Hake.
The presentations covered a
wide range of different aspects of gene expression
: from genome architecture to epigenetic mechanisms and single-cell level analyses to RNA modifications. Their importance during adaptation to environmental changes and infection with various parasites was also highlighted.
Februar
Dammann Group celebrates
Fasching
January
Sandra Hake and Sigurd Braun: newly elected President and Vice President of the German Society for Genetics (GfG)
At the online general meeting of the Society for Genetics (@GfGenetik), Prof. Dr. Sandra Hake and Prof. Dr. Sigurd Braun were elected as the new President and Vice President of the German Society for Genetics. Both are very honored and look forward to the future tasks and challenges. An interview with Sandra Hake about her new position can be found in the BIOspektrum Edition 1/2024 (https://www.biospektrum.de/ausgabe).
December
Christmas Party at the Institute for Genetics
Epigenetics lecture at Johanneum Gymnasium
The Institute of Genetics would like to arouse enthusiasm for biology in general and epigenetics in particular before University studies begin. That's why Sandra Hake visited school students taking an advanced biology course at the Johanneum Gymnasium in Herborn and gave a lecture on “Epigenetics”. The students’ knowledge and desire to learn were impressive. Many thanks to everyone who made this visit possible.
October
Time to say good-bye!
Many good but also sad events happened in October. We congratulate Sonja Sahner from the AG Hake on an incredible 30 years of service! What would we all do without you, Sonja? You are the best! Congratulations!
Unfortunately we had to say several goodbyes in October. On the one hand, it was with a heavy heart that we had to say goodbye to Melanie Bingel, who will return to her original laboratory after a year-long implementation. Thank you for your tireless help, Melanie. We will miss you and wish you all the best in your new/old job!
On the other hand, Prof. Sigurd Braun's group is leaving Heinrich-Buff-Ring 58. As part of the upcoming renovation, the AG Braun has moved into the laboratories of the Institute of Biochemistry. But: out of sight does not mean out of mind! We will continue to work closely together as an Institute and will not allow ourselves to be segregated by spatial separation. The ties of the Institute for Genetics' scientific family (members of the Braun, Dammann and Hake groups) remain strong!
September/October
Willkommen zurück, Nadine!
Alle im ‚Hake-Team’ sind überglücklich, dass Nadine, nach der Geburt ihres Kindes, wieder zurück im Labor ist. Herzlichen Glückwunsch, Nadine! Wir werden alles tun, damit Du beides, Mutterschaft und Wissenschaftlerin, ohne zu viel Stress kombiniert bekommst! Willkommen zurück!
September
Visit from Agnes Kavira!
We are honored and overjoyed by the visit of Agnes Kavira, an extraordinary young woman who fought her way through very difficult conditions! Agnes was born in the Republic of Congo and through hard work and dedication managed to secure a
“BEBUC” scholarship
to study medicine. She is currently working and studying in Paris and Alexandria (Egypt) and stopped by for a day visit. It's wonderful to finally meet Agnes in person and hear directly about her remarkable career path, which is just beginning and which we all support.
Agnes, you are an impressive role model for so many young people and are now part of the Hake team!
Hake group retreat to Limburg
This year the Hake team went to Limburg. A beautiful city whose history we were all able to explore in more detail with a guided tour of the city. A competition to see who could leave first one of two identical "Escape Rooms" combined teamwork, fun, adventure and adrenaline rushes.... With a good meal this very successful and hot day came to an end.
Welcome Felix!
The 'Hake team' is pleased that Felix Diegmüller is starting as a new doctoral student. Felix has already successfully completed his Bachelor's and Master's theses in the Hake team and will now continue his excellent work. We are sure that he will also shine in his doctoral thesis! Good luck, Felix! We are extremely happy that you stayed with us!
July
A "day to do good" at the Institute of Genetics
The motto of this year's institute excursion was " doing something good ". First, we did something good for nature by collecting rubbish at the river Lahn. Unfortunately, this was urgently necessary. After a picnic lunch on the banks of the Lahn, we continued to the climbing forest. There, we did something good physically and mentally for ourselves. After this top sporting performance, there was extensive feasting, drinking and celebrating. A beautiful day that brought us closer together!
School student internship Number 3
And even more students have visited the Institute of Genetics for an internship. We are very excited about the interest of the next generation in natural sciences, especially biology and epigenetics. Maybe we have a future top researcher " in the making " here!
May
Congratulations, Andreas Herchenröther , on the excellent doctoral examination
A new doctor is in the Hake group! Congratulations to Andreas Herchenröther for an excellent thesis defense. He stunned the thesis defense examiners Sandra Hake, Alexander Brehm, Katja Sträßer and Marek Bartkuhn with a brilliant talk and on-point answers to all questions. Fantastic job, Dr. Herchenröther!
Soon, Andreas will be leaving Germany to rock the USA as PostDoc! We all will miss him and wish him an exciting time with many great discoveries!
March
School student internship Number 2
We are excited about the new generation of students and – hopefully – future researchers to be! During another two-week student internship at the Institute for Genetics, the current participant even managed to make a new discovery that will advance our research projects! Congratulations! We are very happy about her active help and hope that she will decide to study biology at the JLU after her Abitur. The Institute is waiting impatiently!
"Paper-hanging" party of Andreas Herchenröther's Nature Communications publication
Finally, Andreas Herchenröther's work from the team of Prof. Dr. Hake on the chromatin protein HMG20A and its role in controlling important gene expression programs in early embryonic development and stem cell differentiation was published in Nature Communications . These groundbreaking discoveries were also highlighted by the JLU press department ( https://tinyurl.com/2p8ct4mx ) and are also to be selected by the Cardio Pulmonary Institute (CPI; https ://www.cpi-online.de/) as "Paper of the Month".
As is tradition at the Institute of Genetics, the paper was ceremonially hung on the publication wall. Everyone involved and who were on site (Andreas Herchenröther, Felix Diegmüller, Jie Lan, Marek Bartkuhn and Stefanie Gossen (Marburg University)) helped.
Congratulations PROF . Dr. Sigurd Braun!
The Institute of Genetics warmly welcomes Sigurd Braun as a new W2 professor and congratulates him on his appointment to the JLU! Sigurd enriches our chromatin and epigenetics research focus with his excellent and internationally recognized work on the mechanisms of heterochromatin establishment and maintenance. To this end, he introduced a new model system at the institute, the fission yeast S. pombe . This allows conducting large-scale, state-of-the-art screens with genetically modified organisms.Sigurd and his international team of Ph.D. students (Agnisrota, Abubakar, Karl und Vishnu) came from the LMU Munich to the JLU in 2021 via the renowned Heisenberg program funded by the DFG. We are delighted that he and his group are immensely strengthening our team and our research and teaching. Of course, this special moment had to be celebrated with all institute members.
January
School student internship
Everyone at the Institute of Genetics welcome three school students for their two-week internship here on site. Sterile work, cell extractions, gel electrophoresis, western blots, cloning and much more are learned. So much interest and enthusiasm is contagious. We look forward to the next generation of University students at the JLU!
Study from Andreas Herchenroether accepted by Nature Communications
Congratulations Andreas!
Andreas seminal work on HMG20A's chromatin function during early embryonic development and stem cell differentiation was accepted in the journal Nature Communications . This happy occasion was celebrated with everyone involved on site, Jie Lan, Jörg Leers and Felix Diegmüller (Hake Group), our collaboration partners Marek Bartkuhn and Tobias Friedrich (Bartkuhn Group) and the entire Hake team!
Excellent work Andreas!
The study was so sensational that a German television team conducted interviews with all those involved during a subsequent celebration in a Giessen club.
As soon as the publication is published, Andreas' discoveries and the contributed work of our collaborators will be reported here in detail.
December 2022
Christmas-Party at the Institute for Genetics
After a long - and at times lonely - pandemic period, all employees of the Institute of Genetics finally came together for a Christmas party. We spent a wonderful evening together with games, secret Santa gift, lots of laughter and a concluding dinner in a restaurant in the city.
December 2022
Welcome, Franzi!
The 'Hake team' welcomes Franziska Hintermeier as a new doctoral student. Franzi will work on the biological function and chromatin incorporation of a newly discovered histone variant in collaboration with the team of Prof. Kaustuv Sanyal (Jawaharlal Nehru Center for Advanced Scientific Research, India).
We wish Franzi a successful and happy time at the institute!
November 2022
Welcome Melanie Bingel and Dennis Koch: new technician in the Hake group and secretary at the Institute for Genetics
All members of the Institute for Genetics are thrilled to welcome Dennis Koch as new secretary of the Institute as well as Melanie Bingel as new Technician in the Hake group! Welcome, Dennis and Melanie! We are super happy to have you as new team members and are looking forward to a great teamwork!
October 2022
Retreat of the Institute for Genetics to Frankfurt
Finally, members of the Institute for Genetics (Braun, Dammann & Hake teams) did participate in a long-awaited retreat together. This year we traveled to Frankfurt and visited the beautiful palm garden (Pamengarten), had delicious Burgers for lunch and ended the visit high up in the sky on the Main-Tower. The sun was shining and we enjoyed every minute of the day together!
September 2022
6 th SFB/TRR81 Symposium
The last international SFB/TRR81 Symposium “ Chromatin Changes in Differentiation and Malignancies ” took place in Egmond aan Zee, The Netherlands. The PhD students Lena Paasche, Andreas Herchenröther and Tim-Marius Wunderlich from the Hake team successfully presented their work on interaction partners of the histone variant H2A.Z on posters and in talks (Lena & Sandra). We all learned a lot, found new collaboration partners, discussed many things, had lots of fun and will miss our meetings, when the SFB/TRR81 finishes end of 2022.
September 2022
Good-bye Lena!
After four years at the Institute for Genetics in the Hake group, our technical assistant Lena Vogel, who always helped us with lab organisation duties, is leaving us! Thank you for your help, Lena! Lena starts a completely new stage in her life outside of Giessen. We wish Lena all the best for her new tasks and challenges.
September 2022
SFB/TRR81 Seminar of Prof. Dr. David Tremethick
Fantastic lecture on H2A.Z and H2A.B in genome organization and transcription regulation by David Tremethick - one of THE key leaders in the field of histone variants. Thank you, David, for visiting us here in Giessen as invited speaker from the SFB/TRR81 consortium.
August 2022
Summer-BBQ of the Institute for Genetics
We had to wait a long time, but finally it happened: we again had a summer BBQ with all members of the Institute for Genetics. What do you want more: sunshine, temperatures above 30 0 C, lots of delicious food as well as lots of laughter and fun!
July 2022
Review “H2A.Z’s social network: functional partners of an enigmatic histone variant” from Carlotta Kreienbaum and Lena Paasche published
Beautiful and insightful review by Carlotta Kreienbaum and Lena Paasche, PhD students in the Hake group, about interacting proteins of the histone variant H2A.Z has been published in Trends Biochem Sci . Great read for everyone interested in histone variants and beyond!
See also:
https://www.sciencedirect.com/science/article/abs/pii/S0968000422001141?via%3Dihub
July 2022
SFB/TRR81 Seminar of Dr. Marcus Buschbeck
Dr. Marcus Buschbeck from the ‘Josep Carreras Leukaemia Research Institute’ in Badalona, Spain, has given a ‘Hybrid-Talk’ in the framework of the SFB/TRR81 Seminar at Institute for Genetics. Everyone in the audience was thrilled by his newest insights about histone variants and epigenetic mechanisms in leukaemias. Marcus spent his day in Giessen talking to members of the Institute, where many ideas were discussed and possible collaborations started (also over a ‘Pizza-Lunch’).
June 2022
„Team-Building Activities“ of the Braun & Hake groups
After more than two enduring years of the Corona pandemic, it was finally possible again: We all could get together! With so many new members at the Institute, we decided to have a “Team-Building” Day to strengthen the team spirit. With lots of fun, ideas and creativity, many challenges were collectively solved:
“Egg Roll”: how to fastest move one egg from one floor to the next without touching and cracking it (see movie)?
“Newspaper Tower”: how to build the highest but still stable newspaper tower?
“Research Term Presentation”: how to present a research term without talking (see “Mitosis Dance” video)?
And, of course, many, many other challenges (see picture). This successful day was completed with a joint dinner and lots of laughter at the river ‘Lahn’.
| Egg-Roll-Video: | Mitosis-Video: |
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May 2022
Good-bye Julia and Welcome Joline!
Everyone at the Institute for Genetics is sad that our secretary Julie Paul (right) is leaving us. We thank her for her commitment, her help, great spirit and happiness. We will miss her and wish her all the best for her new job!
Yet, there are also good news to celebrate: Joline Bergel (left) is Julia’s successor. We are very excited and are looking forward to our cooperation with Joline and are sure that we are going to become a great team. Welcome to the Institute, Joline!
April 2022
Review “Spotlight on histone H2A variants: From B to X to Z” from Andreas Herchenröther, Tim Wunderlich and Jie Lan published
Highly informative review about the recent discoveries on the function of histone H2A variants H2A.B, H2A.X and H2A.Z has been published in Semin Cell Dev Biol . Andreas Herchenröther, Tim Marius Wunderlich and Jie Lan, members of the Hake group, have put together this great work! A must read for all chromatin and H2A variant fans.
See also:
https://www.sciencedirect.com/science/article/abs/pii/S1084952122000970?via%3Dihub
December 2021
Farewell Anna & Christmas-Party
It is the end of an era: Anna Hergott, who reliably and vigorously supported us and our predecessors over many years, is now retiring. We thank you, Anna, for your tireless commitment for the Institute for Genetics and wish you a wonderful and calmer time.
Additionally, we got together for our X-Mas party. Even though we had to celebrate in the cold, with masks and under Corona-rules (all vaccinated and tested), we had lots of fun and joy. Finally, a collective adventure that united us with games and music and generated a fantastic atmosphere. Many thanks to the main organizers Carlotta and Lena!
November 2021
Welcome Julia Paul: our new secretary at the Institute for Genetics
All members of the Institute for Genetics are thrilled to welcome Julia Paul as new secretary! She is going to be trained by our current secretary Anna Hergott, who will, unfortunately, retire and leave us in Mid-December. Welcome, Julia! We are looking forward to a great teamwork!
Corona-related start in freezy outdoors.
October 2021
Congratulations Tara to a successful Thesis Defense!
Tara Procida, from the Hake group, did successfully defend her Thesis at the JLU Giessen. She is the first PhD student from the Hake team that graduated at the JLU. After her defense, Tara was celebrated from the whole Genetic Institute and many friends. We are all extremely proud of you, Tara!
September 2021
Welcome Lena!
The Hake group welcomes Lena Weber cordially as new PhD student. Lena, we appreciate it very much that you decided to conduct your doctoral thesis with us. We are super excited: we already know that you are a valuable part of your team and wish you a successful and happy time in the lab.
Lena Weber
April - May 2021
Welcome Carlotta & Jie!
A shared path ends, others are starting. We are saying farewell to Sandy (Sandra Stullgys), who we will miss very much! All the best for your new career! But there are also great news: Carlotta Kreienbaum, who successfully prepared her Master Thesis within the Hake group and thrilled us with her singing talent, startet her PhD thesis; and Jie Lan, a highly experienced chromatin researcher, began his PostDoc work in the Hake group. We are welcoming both of them and are looking forward to exciting discoveries. Best of luck!
February 2021
ZAP-70, involved in B cell receptor signalling, regulates gene expression, cellular fitness and protein synthesis in chronic lymphocytic leukemia (CLL) cells
The Hake group is happy to have contributed to the story headed by Ingo Ringshausen, University of Cambridge, UK, demonstrating how constitutive levels of ZAP-70 increase the aggressiveness of CLL. This study showed that ZAP-70 promotes cell survival and protein synthesis, thereby improving cellular fitness of CLL cells and driving disease progression. The study is now published in Blood.
See also:
January 2021
Farewell of Konstantin Kletenkov
Konstantin Kletenkov, PostDoc in the Hake group, found a new position and leaves the team end of January. We will miss a great colleague and very good friend and congratulate him to this fantastic next step in his career. With his knowledge and constant team support he was always a great help and estimated member of the Hake team. With a little “Corona-conform” celebration we gave him a hearty farewell and wish him all the best for his future.
JAZF1 is a novel p400-complex member involved in H2A.Z acetylation at regulatory regions (enhancers)
Great work from TARA PROCIDA, a PhD student in the Hake group, was just published in IJMS. In collaboration with the groups of Marek Bartkuhn, Thorsten Stiewe, Tilman Borggrefe and Matthias Mann and help from former (Jack, Peritore & Bönisch) and current (Daus & Kletenkov) Hake group members, Tara identified JAZF1 as novel member of the H2A.Z-specific p400/TIP60/NuA4 chaperone complex and demonstrated its role in the regulation of H2A.Z acetylation levels at more than 1.000 regulatory regions (enhancers) and its involvement in ribosome biogenesis.
See also:
https://www.mdpi.com/1422-0067/22/2/678
Chromatin remodelling processes during urinary tract infections identified
The Hake group is happy to have contributed to the story headed by the JLU researchers Sudhanshu Bushan and Andreas Meinhardt demonstrating decreased acetyl-CoA levels upon uropathic E. coli infections leading to reduced H3K9 acetylation at promoters and changes in gene expression pattern. Hence, upon infection, the bacteria rearrange host cell metabolism to induce chromatin remodeling processes that subvert expression of host innate immune response genes. The study is now published in J. Infect.Dis.
See also:
December 2020
Virtual Christmas-Party
Everything was different this year. SARS-CoV-2 had not respect for our desire to celebrate, and so the Hake lab got together with Marek’s new team and organized a virtual Christmas party. Many thanks to the “newcomers”, who were responsible for planning and preparation of this unusual event. Due to their effort, in the end we all had a wonderful party with gifts, games and lots of fun. Even with distance, what a fantastic team! Merry X-mas, happy New Year 2021 and, most of all, stay safe and healthy!
Architecture of the NuRD complex solved
Congratulations to Sandra Hake, who contributed to the latest discoveries on the architecture of the nucleosome remodeling and deacetylase (NuRD) complex by the Joel Mackay group (Sydney, Australia). They define the stoichiometry of the complex and demonstrate that PWWP2A competes with MBD3 to sequester the Deacetylase module from NuRD. The study is now published in Cell Reports.
See also:
https://www.cell.com/cell-reports/pdf/S2211-1247(20)31439-X.pdf
Graphical abstract of Low et al, Cell Reports, 2020
November 2020
„ Decoration-Competition“ between the Hake Labs
To have some fun and joy in these dull and contact-less days, a decoration competition between the Hake labs was organized. The challenge was to decorate the labs according to the theme “Fall-Winter-Halloween”. An independent and competent jury consisting of the former lab members Marek and David determined the winners: Lab 306 with Nadine, Sandy and Tara. Congratulations! It was a tight result; everyone was extremely creative and imaginative and all participants had lots of fun. Such an event will certainly be repeated in the next year… And, of course, everything was executed strictly according to Corona guidelines.
July 2020
Nature publication on the role of H3.3 Serine 31 phosphorylation in transcription induction
In collaboration with the groups of Steven Z. Josefowicz, Haitao Li and C. David Allis did members of the Hake team help to discover new functions of the histone variant H3.3. Phosphorylation of the H3.3-unique serine at position 31 (H3.3S31ph), which was first identified by Sandra Hake to be mitosis-specific (Hake SB et al., PNAS, 2005), leads to a stimulus-dependent rapid induction of transcription due to recruitment and ejection of chromatin regulators in post-mitotic cells. Details can be found in the original article published in Nature :
https://www.nature.com/articles/s41586-020-2533-0
April 2020
Congratulations to Prof. Dr. Marek Bartkuhn
An era is ending: Marek Bartkuhn, long-standing research assistant, bioinformatics-guru, chromatin-specialist, “smart cookie” and fantastic friend accepted the W2 professorship for Bioinformatics and Systems Biology at the FB11 (Medicine) of the JLU and is leaving the Institute for Genetics. We are all extremely happy about Marek’s success and are, at the same time, very sad to lose him as direct colleague. All the best, Marek! We will miss you!
Prof. Dr. Marek Bartkuhn
Due to the Corona-Pandemie, we had to give a virtual fare-well to Marek.
March 2020
Corona Pandemic
End of March, we had to drastically reduce our experimental work due to the ongoing Corona Pandemic. Empty floors, deserted labs and virtual meetings are evidences of this difficult time. But clearly, health comes first! We all hope that everyone at the Institute and their family and friends will get through the crisis unharmed.
December 2019
Christmas Party of the Institute for Genetics
With lots of fun, gifts, entertaining games and good food the members of the Institute for Genetics celebrated an advanced Christmas party. All PIs had to give ad hoc presentations to imaginative scientific discoveries. “Dirty-Santa” gifts and many games enriched the amazing atmosphere even more and a delicious meal at a restaurant with a memorable poem by Tim completed the event exquisitely.
November 2019
Histone variants H3.X and H3.Y and their functional role in DUX4 expression
Congratulations to Sandra Hake who contributed to the latest discoveries in H3.X and H3.Y histone variant biology made by the Stephen Tapscott group (Seattle, USA). The authors discovered a feedback loop between the transcription factor DUX4, involved in facioscapulohumeral dystrophy (FSHD), and the primate-specific histone variants H3.Y and H3.X, identified in 2010 by the Hake group. Their findings provide a model for how the brief expression of DUX4 can establish via H3.X/Y a memory of its transcriptional network. The study is now published in Cell Reports.
See also:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31325-7
Graphical abstract of Resnick R. et al., Cell Reports, 2019
October 2019
Team-Forming Activities of the Hake group
This year’s Hake lab retreat took place at the Institute to strengthen the team spirit with many different challenges. With lots of fun, creativity, trust and cleverness all members of the group solved several different problems, such as:
“Egg-Drop”: how to wrap/secure a raw egg with some selected lab consumables to prevent breakage after falling from the third story of the building?
“Towel-Turn”: how to turn a towel while the whole team stands on it?
„Spaghetti-Marshmallow-Tower“: how to build the highest but still stable spaghetti tower with a marshmallow on top, when only tape, rubber band and rope are allowed to be used?
“Minefield”: how to travers through an area with many obstacles while having the eyes tied and only the partner is allowed to shout directions from a distance?
And besides many other challenges, four teams had to generate a logo that best represents the Hake team and its scientific focus. It was a fantastic day with lots of fun, laughter and new insights, where everyone got closer with each other.
September 2019
5 th International Symposium of the TRR81
The 5 th international Symposium of the TRR81, organized by U. Bauer, A. Brehm, T. Borggrefe, F. Grosveld, S. Hake, M. Kracht, S. Philipsen and X. Yuan, took place at the MPI in Bad Nauheim from September 9 th till 11 th . Fantastic talks and amazing poster presentations featured new discoveries that are in the scientific focus of the TRR81 “Chromatin changes in differentiation and malignancies”. We are extremely happy and proud that Sandra Stullgys and Tim Wunderlich from the Hake team won the 3 rd price for their poster presentation and flash talk.
July 2019
Congratulations to Stephanie Link for her fantastic PhD Defense!
Stephanie Link, who is a member of the Hake group and continued working at the LMU Munich, has successfully defended her PhD Thesis.
Marek Bartkuhn: Two Papers Published
Congratulations to Marek Bartkuhn from the Hake team and Tobias Zimmermann, whose bioinformatic analyses contributed to TWO collaborative papers published now in Cancers & Nature Communications .
See also:
https://www.ncbi.nlm.nih.gov/pubmed/31242600
https://www.ncbi.nlm.nih.gov/pubmed/31249304
Paper-Party and “Paper-Hanging” tradition to celebrate Marek’s and Tobias’s recent achievements.
Summer-BBQ Party of the Institute of Genetics
Although the summer made a short break and temperatures dropped, we all had a fantastic time at this year’s Summer-BBQ-Party and table tennis game, with almost all members of the Institute participating. The tables almost collapsed under the weight of the self-made and delicious food. In addition, several past birthdays were celebrated with lots of presents. It was, as always, a wonderful and happy day, we will remember for a long time.
June 2019
Welcome to our new Bachelor Students
We are happy to welcome our new Bachelor Students at the Institute of Genetics!!! Valentina Birne, Niklas Papenkordt, Max Pommert, Inga Stellmacher and Lena Weber are joining the Hake team, and Annika Dohmen, Yannic Noe and Nico Schlaudraff are working in the group of Reinhard Dammann. We are sure, we will all have a great and productive time together!
Review on H2A.Z’s role in Gene Regulation
Congratulations to Andreas Herchenröther from the Hake team, who contributed to a review from the Tilman Borggrefe group on “H2A.Z in Gene Regulation”, published now in Epigenetics & Chromatin . See also:
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-019-0274-9
Andreas starting the new tradition of displaying papers from the Hake team published at the JLU Giessen
25 years of employment, congratulations to Jörg Leers!
This June, Jörg Leers’ 25 th year job anniversary took place. Congratulations to his long and exciting scientific career! We are happy and lucky to have such a fantastic, funny and experienced colleague in our team!
Jörg Leers
May 2019
Welcome Tim!
The Hake lab welcomes Tim Marius Wunderlich as new PhD student! We are thrilled that Tim is joining us and continues the highly successful work of Stephanie Link, who will graduate in Munich soon. Good luck for your studies, Tim!
Tim Wunderlich (in the middle)
May 2019
Institute for Genetics "takes off"!
This year’s Institute retreat took us to Darmstadt. We had a fantastic, “high-orbiting” time at the ESA (ESOC). Cosmology meets Biology: we all can learn a lot from each other. The day was concluded at the zoo with more exciting discoveries in the reptile, butterflies, bird and ape houses made.
April 2019
Sonja Sahner officially honored!
Although her 25 th year job anniversary happened already last year, the president of the JLU Giessen, Prof. Dr. Mukherjee, presented Sonja with her certificate at an official ceremony. Music, sparkling wine, speeches and great food made it an amazing day to remember. (see also https://www.uni-giessen.de/ueber-uns/pressestelle/pm/pm65-19)
March 2019
Girls-Day Rocks!
Today, 5 th grade school girls visited our lab and successfully performed many experiments under the guidance of Marek Bartkuhn. We had lots of fun and were quite impressed by these motivated future scientists. Look at what they did with red cabbage juice: a big color spectacle in early spring time!
February 2019
Welcome Konstantin, a new PostDoc in the Hake group!
We are thrilled to welcome Konstantin Kletenkov, the new PostDoc in the Hake group!
December 2018
Christmas Party
The groups of Reinhard Dammann and Sandra Hake have jointly celebrated Christmas with many games, gifts, fun, laughter and delicious food. It was an unforgettable party; 1000 thanks to all participants! Together, we are recapitulating a successful year 2018 and are looking forward to mastering all challenges in 2019!
Job-Anniversary of Sonja Sahner
Sonja Sahner, the lab manager of the group of Sandra Hake, celebrated 25 th job anniversary. We all thank Sonja for her tireless commitment, her organization talent, her dedication of the team, and that she cheers us up with her optimism and laughter. We are looking forward to many, many more years with Sonja at our side!
Reinhard Dammann pays tribute to Sonja at an internal celebration party.
October 2018
Welcome Sandra, Lena and Tobias
The Hake team welcomes three new members in Fall 2018. Sandra Stullgys complements the group as new PhD student, Lena Vogel strengthens the technical assistants’ staff and Tobias Friedrich performs practical work and will prepare his Master Thesis. We are all extremely happy about the reinforcement of our team!
From left to right: Lena Vogel, Tobias Friedrich and Sandra Stullgys
The story on PWWP2A-H2A.Z continues…
Together with research groups from Marburg, Munich, Cambridge (UK) and Sydney (Australia), members of the Hake group in collaboration with Marek Bartkuhn investigated in detail the chromatin binding abilities of PWWP2A and its role in gene regulation. This work, headed by Stephanie Link and Ramona Spitzer, opens new insights into the intricate mechanisms of how H2A.Z, via recruitment of PWWP2A and a histone deacetylase complex, influences histone modifications at regulatory genomic elements leading to the modulation of target gene transcription. Details are found within the original article published in Nature Communication :
https://www.nature.com/articles/s41467-018-06665-5
September 2018
Congratulations to Ramona Spitzer to her successful PhD Defense
Ramona Spitzer, who is a member of the Hake group and continued working at the LMU Munich, has successfully defended her PhD Thesis.
Ramona after her successful and fantastic PhD defence.
August 2018
Institute Retreat: Sportive challenges
This year, all members of the Genetic Institute participated together in a sportive retreat. Tree climbing in the morning and table tennis as well as tabel football in the afternoon guaranteed a day of fun.
Members of the Hake and Dammann teams at the "Klettergarten"
The winners of the table tennis tournament
August 2018
Welcome Rashed
We all welcome Mohammad Rashedul Alam as a new member of the Hake team!
Rashed celebrated the start of his PhD with delicious, self-cooked Bangladeshi food.
Rashed (on the left) together with members of the Hake and Dammann teams and his wife celebrating the start of his PhD work in the seminar room with exquisite Bangladeshi food.
July 2018
Inaugural Lecture of Sandra Hake
On July 5 th 2018, the President of the JLU Giessen and the Dean of the Faculty 08 invited the public to the Inaugural Lecture “Beyond the DNA double helix: Why the same genes do not implicate same fate” of Sandra Hake.
Job-Anniversary of Anna Hergott
Anna Hergott, secretary and soul of the Institute of Genetics, celebrates her 25th job anniversary. All members of the Institute thank Anna for her continous commitment and help, the organisation of the Institute would not be possible without her. Thank you and congratulations, Anna!
Anna Hergott
DFG-funding of Collaborative Chromatin Research in Gießen/Marburg/Bad Nauheim and Rotterdam (TRR81) continues for four years!
The German Research Foundation (DFG) provides funding for the third and last funding period of the Collaborative Research Center, the TransRegio TRR81 “Chromatin Changes in Differentiation and Malignancies” between Gießen/Marburg/Bad Nauheim and Rotterdam. The TRR81 coordinates research of 22 groups, an integrated research training network and two special core facilities homed in the faculties of the Justus-Liebig-University Gießen, Philipps-University Marburg, Max-Planck-Institute Bad Nauheim, and Erasmus University Rotterdam, The Netherlands, as well as two external Universities (Cologne and Heidelberg/Mannheim). Spokesperson and coordinator of the TRR81 is Prof. Alexander Brehm (Marburg), Vice-coordinator is Prof. Sandra Hake (Gießen) and Coordinator in Rotterdam is Prof. Sjaak Philipsen.
The TRR81 focuses on chromatin structure changes occurring during cell differentiation and malignancies. For more information see https://www.uni-giessen.de/fbz/fb08/trr81
June 2018
Summer-BBQ of the Institute of Genetics
With best weather, all members of the Institute of Genetics got together for the yearly BBQ on the JLU Campus. Sunshine, hot sausages, salads, BBQ-sauces and delicious desserts warranted a stimulating and cheerful atmosphere!
Masters of BBQ
Collective meal of both scientific groups
End of an Era
On June 30th, 2018, after almost 50!!! years of service for the Institute of Genetics at the JLU, Leni (Helen) Schäfer-Pfeiffer has laid aside her pipette and started her well-deserved retirement.
We wish her all the best for the new path-of-life and thank her for her outstanding commitment over the last decades!
Leni together with her husband at the farewell party
April 2018
Tara Procida is awarded with JLU Graduate Stipend!
Congratulations to Tara Procida, who was awarded with the prestigious Graduate Stipend from the JLU!
Tara Procida
January 2018
Sandra Hake was elected member of the advisory board of the German Genetics Society (Gesellschaft für Genetik, GfG)
https://www.gfgenetik.de and http://www.biospektrum.de/blatt/d_bs_pdf&_id=1539845
October 2017
Gone with the win…
Stormy fall weather sets the Genetic Institute into motion…
Retreat of the Genetics Institute to Friedberg
This year, all members of Reinhard Damman’s and Sandra Hake’s groups traveled to Friedberg. After sightseeing of the old city and castle and lunch, we demonstrated our sportiveness by playing “black-light” minigolf.
Welcome Tara and Andreas!
Tara Procida and Andreas Herchenröther are new PhD students in the group of Sandra Hake. We are all excited about Tara’s and Andreas’ start in our team!
Tara Procida and Andreas Herchenröt her
Congratulations to Lisa-Maria Zink’s excellent thesis defense!
Lisa-Maria Zink, from the group of Sandra Hake, did an amazing job in her thesis defense.
Lisa-Maria Zink (left) celebrating her excellent thesis defense at the LMU Munich.
September 2017
PWWP2A and Mitosis
Stephanie Link and Sandra Hake have written a feature article on PWWP2A’s role in mitotic processes. The review that was published in the Journal “Cell Cycle” can be viewed under http://www.tandfonline.com/doi/full/10.1080/15384101.2017.1372523 .
September 2017
3 rd International EMBO Workshop on Histone Variants
Sandra Hake, together with her co-organizers Marcus Buschbeck and Patrick Heun and with administrative support of Anna Hergott and Carolin Brieger, did organize the 3 rd international EMBO Workshop “Histone Variants: Molecular functions in health and disease”, September 6 th – 8 th , 2017 in Planegg-Martinsried ( http://meetings.embo.org/event/17-histone-variants ). With participants from all over the world (e.g. Australia, Japan, Korea, Europe), excellent talks and posters and many stimulating discussion sessions, the meeting turned out to be a great success.
Marcus Buschbeck, Sandra Hake und Patrick Heun
Sandra Hake as moderator and chair of the final panel discussion session.
June 2017
PWWP2A: a new partner of H2A.Z nucleosomes
An international science team headed by Sandra Hake identified PWWP2A, a so-far
uncharacterized protein, as interactor of the histone variant H2A.Z. PWWP2A
binds to chromatin in a multivalent manner and has important functions in gene
regulation, mitosis and cranial-facial development in frogs. Details can be found
in the original publication in The EMBO Journal
( http://emboj.embopress.org/content/early/2017/06/23/embj.201695757.long ).
At the time M.Sc. Tara Procida is on training in our institute
Tara Procida coached by Leni......
March 2017
Masters of the Table
Getting together: the AG Dammann and AG Hake celebrated the start of their newly installed
yearly sportive tournament (at the table tennis plate). The picture shows all participants and
the winner, our "Genetics Timo Boll" Jörg Leers (right)!
(Only Adriana, Nadine, Sonja and Tobias are missing.)
February 2017
Deposition requirements of H3.Y and H3.3 revealed
The graduate student Lisa-Maria Zink (AG Hake, LMU Team) in close collaboration with the
groups of Matthias Mann (MPI Munich), Philippe Collas (University of Oslo, Norway) and Marek
Bartkuhn (JLU Giessen) succeeded in identifying the chaperone complex of the primate specific
histone variant H3.Y allowing further insights into the deposition mechanisms of another closely
related and in cancer frequently mutated histone variant H3.3.
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkx131
February 2017
All you want (and need) to know about histone variants….
Marcus Buschbeck (Josep Carreras Leukemia Research Institute, Badalona, Spain) and Sandra
Hake have published a seminal review article on histone variants and their roles in cell fate
decisions and cancer in Nature Reviews Molecular Cell Biology
(see also http://www.nature.com/nrm/journal/v18/n5/full/nrm.2016.166.html )
November 2016
Farewell LMU, Welcome JLU
After ten fantastic, successful and fun years at the LMU, the “molecular biology family” says
“good-buy” to Sandra Hake (alias crazy professor). Mandatory: costumes, cocktails, music,
performances and lots of fun!
Thanks to all former colleagues, alumni and group members (see picture) for organizing such wonderful party!
And thanks to the JLU Giessen for such a warm welcome (see also JLU Uniforum February 2017 issue
http://geb.uni-giessen.de/geb/volltexte/2017/12493/
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