Project T2
Stimulation of bone defect and fracture healing in systemically impaired bone by biomaterials and metallic implants
T2 is essential to test materials developed in M and pretested in B-projects in small and large animals. In a first step, we will use or clinically relevant metaphyseal fracture defect model in osteoporotic rats established within the first funding period, allowing already to show a positive effect of osteoanabolic composite materials on bone healing. In a next step, qualified materials will be characterized in a fracture defect model in sheep. Feedback of these results to M- and B-projects ensures continuous material improvement.
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Micro-CT with fixed T-shaped plate. Fracture zone with bone substitute material. Contrast enhanced vessels are present surrounding the material. |
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A, B: Nano-CT after removal of bone showing the bone substitute material and vessels (white arrows). C, D: New formed vessels marked by CD31 (PECAM-1 staining). E: Contrast enhanced vessels surrounding the material. |
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| A-D: Transverse nano-CT at different voxel sizes 5-10-20 and 40 mikrometer. a-d: Bone substitute material (green) surrounding newly formed vessels. Quelle: Alt V et al. Assessment of angiogenesis in osseointegration of a silica-collagen biomaterial using three-dimensional nano-computed tomography. Acta Biomater 2011 Oct; 7(10): 3773-9. |
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Principal Investigators (PI) | |
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University Hospital Giessen and Marburg GmbH Campus Giessen Experimental Trauma Surgery Justus-Liebig-University of Giessen Contact: Rudolf-Buchheim-Straße 7 35385 Gießen Phone: +49 (0)641 / 985 44667 Fax: +49 (0)641 / 985 44609 Email: volker.alt@chiru.med.uni-giessen.de |
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Department of Trauma, Hand and Reconstructive Surgery |
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Co-Workers
- Dr. Seemun Ray
Email: Seemun.Ray@med.uni-giessen.de