Benutzerspezifische Werkzeuge

Information zum Seitenaufbau und Sprungmarken fuer Screenreader-Benutzer: Ganz oben links auf jeder Seite befindet sich das Logo der JLU, verlinkt mit der Startseite. Neben dem Logo kann sich rechts daneben das Bannerbild anschließen. Rechts daneben kann sich ein weiteres Bild/Schriftzug befinden. Es folgt die Suche. Unterhalb dieser oberen Leiste schliesst sich die Hauptnavigation an. Unterhalb der Hauptnavigation befindet sich der Inhaltsbereich. Die Feinnavigation findet sich - sofern vorhanden - in der linken Spalte. In der rechten Spalte finden Sie ueblicherweise Kontaktdaten. Als Abschluss der Seite findet sich die Brotkrumennavigation und im Fussbereich Links zu Barrierefreiheit, Impressum, Hilfe und das Login fuer Redakteure. Barrierefreiheit JLU - Logo, Link zur Startseite der JLU-Gießen Direkt zur Navigation vertikale linke Navigationsleiste vor Sie sind hier Direkt zum Inhalt vor rechter Kolumne mit zusaetzlichen Informationen vor Suche vor Fußbereich mit Impressum


Artikelaktionen

Veröffentlichungen

2019

Riedlinger T., Bartkuhn M., Zimmermann T., Hake S.B., Nist A., Stiewe T., Kracht M. and Schmitz M.L. (2019). Chemotherapeutic drugs inhibiting Topoisomerase 1 activity impede cytokine-induced and NF-kB p65-regulated gene expression. Cancers, DOI: 10.3390/cancers11060883

 

2018

Bergmaier, P., Weth, O., Dienstbach, S., Boettger, T., Galjart, N., Mernberger, M., Bartkuhn, M., and Renkawitz, R. (2018). Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference. Nucleic Acids Res 46, 7097-7107.

 

Bouchard, C., Sahu, P., Meixner, M., Notzold, R.R., Rust, M.B., Kremmer, E., Feederle, R., Hart-Smith, G., Finkernagel, F., Bartkuhn, M., Savai Pullamsetti, S., Nist, A., Stiewe, T., Philipsen, S., and Bauer, U.M. (2018). Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes. Cell Rep 24, 3339-3352.

 

Giaimo, B.D., Ferrante, F., Vallejo, D.M., Hein, K., Gutierrez-Perez, I., Nist, A., Stiewe, T., Mittler, G., Herold, S., Zimmermann, T., Bartkuhn, M., Schwarz, P., Oswald, F., Dominguez, M., and Borggrefe, T. (2018). Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids Res 46, 8197-8215.

 

Link, S., Spitzer, R.M.M., Sana, M., Torrado, M., Volker-Albert, M.C., Keilhauer, E.C., Burgold, T., Punzeler, S., Low, J.K.K., Lindstrom, I., Nist, A., Regnard, C., Stiewe, T., Hendrich, B., Imhof, A., Mann, M., Mackay, J.P., Bartkuhn, M., and Hake, S.B. (2018). PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Nat Commun 9, 4300.

 

Siegler, B.H., Uhle, F., Lichtenstern, C., Arens, C., Bartkuhn, M., Weigand, M.A., and Weiterer, S. (2018). Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components. PLoS One 13, e0204168.

 

2017

Ali, T., Kruger, M., Bhuju, S., Jarek, M., Bartkuhn, M., and Renkawitz, R. (2017). Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190. Nucleic Acids Res 45, 2384-2395.

 

Jox, T., Buxa, M.K., Bohla, D., Ullah, I., Macinkovic, I., Brehm, A., Bartkuhn, M., and Renkawitz, R. (2017). Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Epigenetics Chromatin 10, 32.

 

Kiehl, S., Zimmermann, T., Savai, R., Pullamsetti, S.S., Seeger, W., Bartkuhn, M., and Dammann, R.H. (2017). Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer. Sci Rep 7, 3896.

 

Poppe, M., Wittig, S., Jurida, L., Bartkuhn, M., Wilhelm, J., Muller, H., Beuerlein, K., Karl, N., Bhuju, S., Ziebuhr, J., Schmitz, M.L., and Kracht, M. (2017). The NF-kappaB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog 13, e1006286.

 

Theofel, I., Bartkuhn, M., Boettger, T., Gartner, S.M.K., Kreher, J., Brehm, A., and Rathke, C. (2017). tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation. Biol Open 6, 439-448.

 

Thiel, V.N., Giaimo, B.D., Schwarz, P., Soller, K., Vas, V., Bartkuhn, M., Blatte, T.J., Dohner, K., Bullinger, L., Borggrefe, T., Geiger, H., and Oswald, F. (2017). Heterodimerization of AML1/ETO with CBFbeta is required for leukemogenesis but not for myeloproliferation. Leukemia 31, 2491-2502.

 

Xu, T., Park, S.S., Giaimo, B.D., Hall, D., Ferrante, F., Ho, D.M., Hori, K., Anhezini, L., Ertl, I., Bartkuhn, M., Zhang, H., Milon, E., Ha, K., Conlon, K.P., Kuick, R., Govindarajoo, B., Zhang, Y., Sun, Y., Dou, Y., Basrur, V., Elenitoba-Johnson, K.S., Nesvizhskii, A.I., Ceron, J., Lee, C.Y., Borggrefe, T., Kovall, R.A., and Rual, J.F. (2017). RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. EMBO J 36, 3232-3249.

 

Zink, L.M., Delbarre, E., Eberl, H.C., Keilhauer, E.C., Bonisch, C., Punzeler, S., Bartkuhn, M., Collas, P., Mann, M., and Hake, S.B. (2017). H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. Nucleic Acids Res 45, 5691-5706.

 

2016

 

Ali, T., Renkawitz, R., and Bartkuhn, M. (2016). Insulators and domains of gene expression. Curr Opin Genet Dev 37, 17-26.

 

Klaus, E.S., Gonzalez, N.H., Bergmann, M., Bartkuhn, M., Weidner, W., Kliesch, S., and Rathke, C. (2016). Murine and Human Spermatids Are Characterized by Numerous, Newly Synthesized and Differentially Expressed Transcription Factors and Bromodomain-Containing Proteins. Biol Reprod 95, 4.

 

2015

 

Jurida, L., Soelch, J., Bartkuhn, M., Handschick, K., Muller, H., Newel, D., Weber, A., Dittrich-Breiholz, O., Schneider, H., Bhuju, S., Saul, V.V., Schmitz, M.L., and Kracht, M. (2015). The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-kappaB p65. Cell Rep.

 

Maksimenko, O., Bartkuhn, M., Stakhov, V., Herold, M., Zolotarev, N., Jox, T., Buxa, M.K., Kirsch, R., Bonchuk, A., Fedotova, A., Kyrchanova, O., Renkawitz, R., and Georgiev, P. (2015). Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin. Genome Res 25, 89-99.

 

Weiterer, S., Uhle, F., Lichtenstern, C., Siegler, B.H., Bhuju, S., Jarek, M., Bartkuhn, M., and Weigand, M.A. (2015a). Sepsis induces specific changes in histone modification patterns in human monocytes. PLoS One 10, e0121748.

 

Weiterer, S., Uhle, F., Siegler, B.H., Lichtenstern, C., Bartkuhn, M., and Weigand, M.A. (2015b). [Epigenetic regulation in sepsis : current state of knowledge]. Anaesthesist 64, 42-55.

 

2014

 

Ahanger, S.H., Gunther, K., Weth, O., Bartkuhn, M., Bhonde, R.R., Shouche, Y.S., and Renkawitz, R. (2014). Ectopically tethered CP190 induces large-scale chromatin decondensation. Sci Rep 4, 3917.

 

Baumgart, S., Chen, N.M., Siveke, J.T., Konig, A., Zhang, J.S., Singh, S.K., Wolf, E., Bartkuhn, M., Esposito, I., Hessmann, E., Reinecke, J., Nikorowitsch, J., Brunner, M., Singh, G., Fernandez-Zapico, M.E., Smyrk, T., Bamlet, W.R., Eilers, M., Neesse, A., Gress, T.M., Billadeau, D.D., Tuveson, D., Urrutia, R., and Ellenrieder, V. (2014). Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. Cancer Discov 4, 688-701.

 

Bohla, D., Herold, M., Panzer, I., Buxa, M.K., Ali, T., Demmers, J., Kruger, M., Scharfe, M., Jarek, M., Bartkuhn, M., and Renkawitz, R. (2014). A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking. PLoS One 9, e107765.

 

Dottermusch-Heidel, C., Gartner, S.M., Tegeder, I., Rathke, C., Barckmann, B., Bartkuhn, M., Bhushan, S., Steger, K., Meinhardt, A., and Renkawitz-Pohl, R. (2014). H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat. Biol Open 3, 444-452.

 

Handschick, K., Beuerlein, K., Jurida, L., Bartkuhn, M., Muller, H., Soelch, J., Weber, A., Dittrich-Breiholz, O., Schneider, H., Scharfe, M., Jarek, M., Stellzig, J., Schmitz, M.L., and Kracht, M. (2014). Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-kappaB-dependent gene expression. Mol Cell 53, 193-208.

 

Theofel, I., Bartkuhn, M., Hundertmark, T., Boettger, T., Gartner, S.M., Leser, K., Awe, S., Schipper, M., Renkawitz-Pohl, R., and Rathke, C. (2014). tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS One 9, e108267.

 

Walz, S., Lorenzin, F., Morton, J., Wiese, K.E., von Eyss, B., Herold, S., Rycak, L., Dumay-Odelot, H., Karim, S., Bartkuhn, M., Roels, F., Wustefeld, T., Fischer, M., Teichmann, M., Zender, L., Wei, C.L., Sansom, O., Wolf, E., and Eilers, M. (2014). Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature 511, 483-487.

 

Weiterer, S., Uhle, F., Bhuju, S., Jarek, M., Weigand, M.A., and Bartkuhn, M. (2014). From human monocytes to genome-wide binding sites--a protocol for small amounts of blood: monocyte isolation/ChIP-protocol/library amplification/genome wide computational data analysis. PLoS One 9, e94164.

 

2013

 

Gunther, K., Rust, M., Leers, J., Boettger, T., Scharfe, M., Jarek, M., Bartkuhn, M., and Renkawitz, R. (2013). Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences. Nucleic Acids Res 41, 3010-3021.

 

Teschler, S., Bartkuhn, M., Kunzel, N., Schmidt, C., Kiehl, S., Dammann, G., and Dammann, R. (2013). Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder. PLoS One 8, e84180.

 

2012

 

Heger, P., Marin, B., Bartkuhn, M., Schierenberg, E., and Wiehe, T. (2012). The chromatin insulator CTCF and the emergence of metazoan diversity. Proc Natl Acad Sci U S A 109, 17507-17512.

 

Herold, M., Bartkuhn, M., and Renkawitz, R. (2012). CTCF: insights into insulator function during development. Development 139, 1045-1057.

 

Paradowska, A.S., Miller, D., Spiess, A.N., Vieweg, M., Cerna, M., Dvorakova-Hortova, K., Bartkuhn, M., Schuppe, H.C., Weidner, W., and Steger, K. (2012). Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development. Epigenetics 7, 1057-1070.

 

Sleutels, F., Soochit, W., Bartkuhn, M., Heath, H., Dienstbach, S., Bergmaier, P., Franke, V., Rosa-Garrido, M., van de Nobelen, S., Caesar, L., van der Reijden, M., Bryne, J.C., van Ijcken, W., Grootegoed, J.A., Delgado, M.D., Lenhard, B., Renkawitz, R., Grosveld, F., and Galjart, N. (2012). The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner. Epigenetics Chromatin 5, 8.

 

2011

 

Steilmann, C., Paradowska, A., Bartkuhn, M., Vieweg, M., Schuppe, H.C., Bergmann, M., Kliesch, S., Weidner, W., and Steger, K. (2011). Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa. Reprod Fertil Dev 23, 997-1011.

 

Ohlsson, R., Bartkuhn, M., and Renkawitz, R. (2010). CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin. Chromosoma 119, 351-360.

 

2010 and before

 

Steilmann, C., Cavalcanti, M.C., Bartkuhn, M., Pons-Kuhnemann, J., Schuppe, H.C., Weidner, W., Steger, K., and Paradowska, A. (2010). The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men. Reproduction 140, 435-443.

 

Weth, O., Weth, C., Bartkuhn, M., Leers, J., Uhle, F., and Renkawitz, R. (2010). Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites. PLoS One 5, e10119.

 

Bartkuhn, M., Straub, T., Herold, M., Herrmann, M., Rathke, C., Saumweber, H., Gilfillan, G.D., Becker, P.B., and Renkawitz, R. (2009). Active promoters and insulators are marked by the centrosomal protein 190. EMBO J 28, 877-888.

 

Bartkuhn, M., and Renkawitz, R. (2008). Long range chromatin interactions involved in gene regulation. Biochim Biophys Acta 1783, 2161-2166.

 

Holohan, E.E., Kwong, C., Adryan, B., Bartkuhn, M., Herold, M., Renkawitz, R., Russell, S., and White, R. (2007). CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex. PLoS Genet 3, e112.

 

Mohan, M., Bartkuhn, M., Herold, M., Philippen, A., Heinl, N., Bardenhagen, I., Leers, J., White, R.A., Renkawitz-Pohl, R., Saumweber, H., and Renkawitz, R. (2007). The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. EMBO J 26, 4203-4214.

 

Popichenko, D., Sellin, J., Bartkuhn, M., and Paululat, A. (2007). Hand is a direct target of the forkhead transcription factor Biniou during Drosophila visceral mesoderm differentiation. BMC Dev Biol 7, 49.

 

Rathke, C., Baarends, W.M., Jayaramaiah-Raja, S., Bartkuhn, M., Renkawitz, R., and Renkawitz-Pohl, R. (2007). Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila. J Cell Sci 120, 1689-1700.

 

Burke, L.J., Zhang, R., Bartkuhn, M., Tiwari, V.K., Tavoosidana, G., Kurukuti, S., Weth, C., Leers, J., Galjart, N., Ohlsson, R., and Renkawitz, R. (2005). CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J 24, 3291-3300.

 

Moon, H., Filippova, G., Loukinov, D., Pugacheva, E., Chen, Q., Smith, S.T., Munhall, A., Grewe, B., Bartkuhn, M., Arnold, R., Burke, L.J., Renkawitz-Pohl, R., Ohlsson, R., Zhou, J., Renkawitz, R., and Lobanenkov, V. (2005). CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep 6, 165-170.