CoroPan Research Projects
The 9 subprojects of the research consortium pursue the scientific goal in their respective research fields of providing comparative studies on the molecular basis of replication and pathogenesis of coronaviruses as a foundation for new therapeutic approaches. 8 of the 9 subprojects (P1, P2, P4 to P8, and Z1) are represented by equal subproject leaders from research groups of two of the three partner universities each.
The RNA Environment in Coronavirus-Infected Cells
Principal Investigators:
- Prof. Dr. Friedemann Weber (JLU)
- Dr. Marek Widera (GUF)
LOEWE funded team members:
- Christian Sauer (JLU)
- Stefanie Hess (GUF)
Antiviral Activity and Differential Activation of Interferon-Stimulated Genes in Respiratory Infections with Low- versus High-Pathogenic Coronaviruses
Principal Investigators:
- Prof. Dr. Stephan Becker (UMR), Dr. Lucie Sauerhering (UMR)
- Prof. Dr. Susanne Herold (JLU)
LOEWE funded team members:
- Ida Kuhl (UMR)
- N.N. (JLU)
Coronavirus Replication in the Interplay of ER-Phagy and ER-Associated Degradation and Translation
Principal Investigators:
- Prof. Dr. Michael Kracht (JLU)
- Prof. Dr. Verena Krähling (UMR)
LOEWE funded team members:
- Sara Baumgart (UMR)
- Dr. Samer Shaban (JLU)
Functions and Interactions of Coronavirus Ion Channel Proteins
Principal Investigators:
- Dr. Aparna Renigunta (UMR), Dr. Vijay Renigunta (UMR)
- Prof. Dr. John Ziebuhr (JLU)
LOEWE funded team members:
- Usman Ghani (JLU)
- Chinmayi Venkatesh Bhat (UMR)
The Role of Phosphorylation of Coronavirus Nucleocapsid Proteins in the Viral Life Cycle
Principal Investigators:
- Dr. Nadine Biedenkopf (UMR)
- Dr. Tuna Toptan Grabmair (GUF)
LOEWE funded team members:
- Dr. Srinivas Pallerla (GUF)
- Maren Wieja (UMR)
Activation of Coronaviruses by Host Proteases: Studies on Resistance Development, Tissue Tropism, and Host Adaptation
Principal Investigators:
LOEWE funded team members:
- Dr. Miriam Heindl (UMR)
- Emma Torbica (GUF)
Structural and Functional Characeterization of Conserved Cis-Acting RNA Elements in the 5´- and 3´-UTRs of Various Coronavirus Genomes
Principal Investigators:
- Prof. Dr. Arnold Grünweller (UMR)
- Dr. Ramakanth Madhugiri (JLU)
LOEWE funded team members:
- Dr. Stefan Merkl (UMR)
- Mohamed Darwish (JLU)
Virus Bank
Principal Investigators:
- Prof. Dr. Sandra Ciesek (GUF)
- Prof. Dr. John Ziebuhr (JLU)
LOEWE funded team members:
- Dr. Arne Auste (GUF)
Proteomics Platform
Principal Investigators:
LOEWE funded team members:
- N.N. (GUF)