Inhaltspezifische Aktionen

Ausgewählte Publikationen

 

Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli
N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI,
Scheibe S, Fysikopoulos A, Wu CY, Klepetko W, Jaksch P, Eichstaedt C, Grünig E,
Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M,
Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A,
Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K,
Grimminger F, Brandes RP, Weissmann N. NADPH oxidase subunit NOXO1 is a target
for emphysema treatment in COPD. Nat Metab. 2020 Jun;2(6):532-546. doi:
10.1038/s42255-020-0215-8. Epub 2020 Jun 8. Erratum in: Nat Metab. 2020
Jul;2(7):648. PMID: 32694733.

Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S,
Dufour E, Andjelković A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M,
Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun
T, Jacobs HT, Weissmann N, Szibor M. Bypassing mitochondrial complex III using
alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv. 2020 Apr
15;6(16):eaba0694. doi: 10.1126/sciadv.aba0694. PMID: 32426457; PMCID:
PMC7159913.

Fysikopoulos A, Seimetz M, Hadzic S, Knoepp F, Wu CY, Malkmus K, Wilhelm J,
Pichl A, Bednorz M, Tadele Roxlau E, Ghofrani HA, Sommer N, Gierhardt M,
Schermuly RT, Seeger W, Grimminger F, Weissmann N, Kraut S. Amelioration of
elastase-induced lung emphysema and reversal of pulmonary hypertension by
pharmacological iNOS inhibition in mice. Br J Pharmacol. 2020 Mar 22. doi:
10.1111/bph.15057. Epub ahead of print. PMID: 32201936.

Gredic M, Blanco I, Kovacs G, Helyes Z, Ferdinandy P, Olschewski H, Barberà
JA, Weissmann N. Pulmonary hypertension in chronic obstructive pulmonary
disease. Br J Pharmacol. 2020 Jan 23. doi: 10.1111/bph.14979. Epub ahead of
print. PMID: 31976545.

5: Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P,
Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N,
López-Barneo J. Acute O<sub>2</sub> sensing through HIF2α-dependent expression
of atypical cytochrome oxidase subunits in arterial chemoreceptors. Sci Signal.
2020 Jan 21;13(615):eaay9452. doi: 10.1126/scisignal.aay9452. PMID: 31848220.

Weiss A, Neubauer MC, Yerabolu D, Kojonazarov B, Schlueter BC, Neubert L,
Jonigk D, Baal N, Ruppert C, Dorfmuller P, Pullamsetti SS, Weissmann N, Ghofrani
HA, Grimminger F, Seeger W, Schermuly RT. Targeting cyclin-dependent kinases for
the treatment of pulmonary arterial hypertension. Nat Commun. 2019 May
17;10(1):2204. doi: 10.1038/s41467-019-10135-x. PMID: 31101827; PMCID:
PMC6525202.

Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL,
Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F,
Seeger W, Savai R, Pullamsetti SS. A RASSF1A-HIF1α loop drives Warburg effect in
cancer and pulmonary hypertension. Nat Commun. 2019 May 13;10(1):2130. doi:
10.1038/s41467-019-10044-z. PMID: 31086178; PMCID: PMC6513860.

Pichl A, Sommer N, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau
ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O,
Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA,
Weissmann N. Riociguat for treatment of pulmonary hypertension in COPD: a
translational study. Eur Respir J. 2019 Jun 27;53(6):1802445. doi:
10.1183/13993003.02445-2018. PMID: 30956210.

Kojonazarov B, Hadzic S, Ghofrani HA, Grimminger F, Seeger W, Weissmann N,
Schermuly RT. Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary
Hypertension. Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi:
10.1164/rccm.201902-0390LE. PMID: 31034778.

Esfandiary A, Kutsche HS, Schreckenberg R, Weber M, Pak O, Kojonazarov B,
Sydykov A, Hirschhäuser C, Wolf A, Haag D, Hecker M, Fink L, Seeger W, Ghofrani
HA, Schermuly RT, Weißmann N, Schulz R, Rohrbach S, Li L, Sommer N, Schlüter KD.
Protection against pressure overload-induced right heart failure by uncoupling
protein 2 silencing. Cardiovasc Res. 2019 Jun 1;115(7):1217-1227. doi:
10.1093/cvr/cvz049. PMID: 30850841; PMCID: PMC6529920.

Weissmann N. Chronic Obstructive Pulmonary Disease and Pulmonary Vascular
Disease. A Comorbidity? Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S278-S281. doi:
10.1513/AnnalsATS.201808-532MG. PMID: 30759003; PMCID: PMC6944394.

Novoyatleva T, Kojonazarov B, Owczarek A, Veeroju S, Rai N, Henneke I, Böhm
M, Grimminger F, Ghofrani HA, Seeger W, Weissmann N, Schermuly RT. Evidence for
the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced
Pulmonary Hypertension. Am J Respir Crit Care Med. 2019 Jun 1;199(11):1407-1420.
doi: 10.1164/rccm.201806-1170OC. PMID: 30557519.

Nathan SD, Barbera JA, Gaine SP, Harari S, Martinez FJ, Olschewski H, Olsson
KM, Peacock AJ, Pepke-Zaba J, Provencher S, Weissmann N, Seeger W. Pulmonary
hypertension in chronic lung disease and hypoxia. Eur Respir J. 2019 Jan
24;53(1):1801914. doi: 10.1183/13993003.01914-2018. PMID: 30545980; PMCID:
PMC6351338.

Strielkov I, Krause NC, Sommer N, Schermuly RT, Ghofrani HA, Grimminger F,
Gudermann T, Dietrich A, Weissmann N. Hypoxic pulmonary vasoconstriction in
isolated mouse pulmonary arterial vessels. Exp Physiol. 2018
Sep;103(9):1185-1191. doi: 10.1113/EP087117. Epub 2018 Jul 6. PMID: 29917290.

Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A,
Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K,
Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger
W, Murphy MP, Weissmann N, Sommer N. Impact of the mitochondria-targeted
antioxidant MitoQ on hypoxia-induced pulmonary hypertension. Eur Respir J. 2018
Feb 1:1701024. doi: 10.1183/13993003.01024-2017. Epub ahead of print. PMID:
29419444.

Pak O, Sydykov A, Kosanovic D, Schermuly RT, Dietrich A, Schröder K, Brandes
RP, Gudermann T, Sommer N, Weissmann N. Lung Ischaemia-Reperfusion Injury: The
Role of Reactive Oxygen Species. Adv Exp Med Biol. 2017;967:195-225. doi:
10.1007/978-3-319-63245-2_12. PMID: 29047088.

Budas GR, Boehm M, Kojonazarov B, Viswanathan G, Tian X, Veeroju S,
Novoyatleva T, Grimminger F, Hinojosa-Kirschenbaum F, Ghofrani HA, Weissmann N,
Seeger W, Liles JT, Schermuly RT. ASK1 Inhibition Halts Disease Progression in
Preclinical Models of Pulmonary Arterial Hypertension. Am J Respir Crit Care
Med. 2018 Feb 1;197(3):373-385. doi: 10.1164/rccm.201703-0502OC. PMID: 28910144.

Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M,
Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A,
Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F,
Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Mitochondrial Complex IV
Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circ Res.
2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482. Epub 2017 Jun 15.
PMID: 28620066; PMCID: PMC5544581.

Schröder K, Weissmann N, Brandes RP. Organizers and activators: Cytosolic
Nox proteins impacting on vascular function. Free Radic Biol Med. 2017
Aug;109:22-32. doi: 10.1016/j.freeradbiomed.2017.03.017. Epub 2017 Mar 21. PMID:
28336130.

Veith C, Kraut S, Wilhelm J, Sommer N, Quanz K, Seeger W, Brandes RP,
Weissmann N, Schröder K. NADPH oxidase 4 is not involved in hypoxia-induced
pulmonary hypertension. Pulm Circ. 2016 Sep;6(3):397-400. doi: 10.1086/687756.
PMID: 27683617; PMCID: PMC5019094.

Grimminger J, Ghofrani HA, Weissmann N, Klose H, Grimminger F. COPD-
associated pulmonary hypertension: clinical implications and current methods for
treatment. Expert Rev Respir Med. 2016 Jul;10(7):755-66. doi:
10.1080/17476348.2016.1190275. Epub 2016 Jun 7. PMID: 27212458.

Sommer N, Strielkov I, Pak O, Weissmann N. Oxygen sensing and signal
transduction in hypoxic pulmonary vasoconstriction. Eur Respir J. 2016
Jan;47(1):288-303. doi: 10.1183/13993003.00945-2015. Epub 2015 Oct 22. PMID:
26493804.

Veith C, Schermuly RT, Brandes RP, Weissmann N. Molecular mechanisms of
hypoxia-inducible factor-induced pulmonary arterial smooth muscle cell
alterations in pulmonary hypertension. J Physiol. 2016 Mar 1;594(5):1167-77.
doi: 10.1113/JP270689. Epub 2015 Sep 30. PMID: 26228924; PMCID: PMC4771790.

Seimetz M, Parajuli N, Pichl A, Bednorz M, Ghofrani HA, Schermuly RT, Seeger
W, Grimminger F, Weissmann N. Cigarette Smoke-Induced Emphysema and Pulmonary
Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.
PLoS One. 2015 Jun 9;10(6):e0129327. doi: 10.1371/journal.pone.0129327. PMID:
26058042; PMCID: PMC4461257.

Wilkins MR, Ghofrani HA, Weissmann N, Aldashev A, Zhao L. Pathophysiology
and treatment of high-altitude pulmonary vascular disease. Circulation. 2015 Feb
10;131(6):582-90. doi: 10.1161/CIRCULATIONAHA.114.006977. PMID: 25666980.

Veit F, Pak O, Brandes RP, Weissmann N. Hypoxia-dependent reactive oxygen
species signaling in the pulmonary circulation: focus on ion channels. Antioxid
Redox Signal. 2015 Feb 20;22(6):537-52. doi: 10.1089/ars.2014.6234. PMID:
25545236; PMCID: PMC4322788.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi
MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS. Pro-
proliferative and inflammatory signaling converge on FoxO1 transcription factor
in pulmonary hypertension. Nat Med. 2014 Nov;20(11):1289-300. doi:
10.1038/nm.3695. Epub 2014 Oct 26. PMID: 25344740.

Weissmann N, Lobo B, Pichl A, Parajuli N, Seimetz M, Puig-Pey R, Ferrer E,
Peinado VI, Domínguez-Fandos D, Fysikopoulos A, Stasch JP, Ghofrani HA, Coll-
Bonfill N, Frey R, Schermuly RT, García-Lucio J, Blanco I, Bednorz M, Tura-Ceide
O, Tadele E, Brandes RP, Grimminger J, Klepetko W, Jaksch P, Rodriguez-Roisin R,
Seeger W, Grimminger F, Barberà JA. Stimulation of soluble guanylate cyclase
prevents cigarette smoke-induced pulmonary hypertension and emphysema. Am J
Respir Crit Care Med. 2014 Jun 1;189(11):1359-73. doi:
10.1164/rccm.201311-2037OC. PMID: 24738736.

Weissmann N, Peters DM, Klöpping C, Krüger K, Pilat C, Katta S, Seimetz M,
Ghofrani HA, Schermuly RT, Witzenrath M, Seeger W, Grimminger F, Mooren FC.
Structural and functional prevention of hypoxia-induced pulmonary hypertension
by individualized exercise training in mice. Am J Physiol Lung Cell Mol Physiol.
2014 Jun 1;306(11):L986-95. doi: 10.1152/ajplung.00275.2013. Epub 2014 Apr 4.
PMID: 24705723.

Schulz R, Murzabekova G, Egemnazarov B, Kraut S, Eisele HJ, Dumitrascu R,
Heitmann J, Seimetz M, Witzenrath M, Ghofrani HA, Schermuly RT, Grimminger F,
Seeger W, Weissmann N. Arterial hypertension in a murine model of sleep apnea:
role of NADPH oxidase 2. J Hypertens. 2014 Feb;32(2):300-5. doi:
10.1097/HJH.0000000000000016. PMID: 24270180.

Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath
M, Ahlbrecht K, Fecher-Trost C, Flockerzi V, Ghofrani HA, Grimminger F, Seeger
W, Gudermann T, Dietrich A, Weissmann N. Classical transient receptor potential
channel 1 in hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med.
2013 Dec 15;188(12):1451-9. doi: 10.1164/rccm.201307-1252OC. PMID: 24251695.

Veit F, Pak O, Egemnazarov B, Roth M, Kosanovic D, Seimetz M, Sommer N,
Ghofrani HA, Seeger W, Grimminger F, Brandes RP, Schermuly RT, Weissmann N.
Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after
monocrotaline-induced pulmonary vascular remodeling. Antioxid Redox Signal. 2013
Dec 20;19(18):2213-31. doi: 10.1089/ars.2012.4904. Epub 2013 Jul 20. PMID:
23706097.

Pak O, Sommer N, Hoeres T, Bakr A, Waisbrod S, Sydykov A, Haag D, Esfandiary
A, Kojonazarov B, Veit F, Fuchs B, Weisel FC, Hecker M, Schermuly RT, Grimminger
F, Ghofrani HA, Seeger W, Weissmann N. Mitochondrial hyperpolarization in
pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as
disease model. Am J Respir Cell Mol Biol. 2013 Sep;49(3):358-67. doi:
10.1165/rcmb.2012-0361OC. PMID: 23590303.

Dumitrascu R, Heitmann J, Seeger W, Weissmann N, Schulz R. Obstructive sleep
apnea, oxidative stress and cardiovascular disease: lessons from animal studies.
Oxid Med Cell Longev. 2013;2013:234631. doi: 10.1155/2013/234631. Epub 2013 Mar
3. PMID: 23533685; PMCID: PMC3603718.

Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M,
Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O,
Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T,
Ghofrani HA, Dietrich A. Activation of TRPC6 channels is essential for lung
ischaemia-reperfusion induced oedema in mice. Nat Commun. 2012 Jan 31;3:649.
doi: 10.1038/ncomms1660. PMID: 22337127; PMCID: PMC3272568.

Mittal M, Gu XQ, Pak O, Pamenter ME, Haag D, Fuchs DB, Schermuly RT,
Ghofrani HA, Brandes RP, Seeger W, Grimminger F, Haddad GG, Weissmann N. Hypoxia
induces Kv channel current inhibition by increased NADPH oxidase-derived
reactive oxygen species. Free Radic Biol Med. 2012 Mar 15;52(6):1033-42. doi:
10.1016/j.freeradbiomed.2011.12.004. Epub 2011 Dec 16. PMID: 22222468.

Seimetz M, Parajuli N, Pichl A, Veit F, Kwapiszewska G, Weisel FC, Milger K,
Egemnazarov B, Turowska A, Fuchs B, Nikam S, Roth M, Sydykov A, Medebach T,
Klepetko W, Jaksch P, Dumitrascu R, Garn H, Voswinckel R, Kostin S, Seeger W,
Schermuly RT, Grimminger F, Ghofrani HA, Weissmann N. Inducible NOS inhibition
reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice.
Cell. 2011 Oct 14;147(2):293-305. doi: 10.1016/j.cell.2011.08.035. PMID:
22000010.

Fuchs B, Rupp M, Ghofrani HA, Schermuly RT, Seeger W, Grimminger F,
Gudermann T, Dietrich A, Weissmann N. Diacylglycerol regulates acute hypoxic
pulmonary vasoconstriction via TRPC6. Respir Res. 2011 Feb 4;12(1):20. doi:
10.1186/1465-9921-12-20. PMID: 21294865; PMCID: PMC3042943.

Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA,
Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N. Mitochondrial
cytochrome redox states and respiration in acute pulmonary oxygen sensing. Eur
Respir J. 2010 Nov;36(5):1056-66. doi: 10.1183/09031936.00013809. Epub 2010 Jun
1. PMID: 20516051.

Fuchs B, Dietrich A, Gudermann T, Kalwa H, Grimminger F, Weissmann N. The
role of classical transient receptor potential channels in the regulation of
hypoxic pulmonary vasoconstriction. Adv Exp Med Biol. 2010;661:187-200. doi:
10.1007/978-1-60761-500-2_12. PMID: 20204731.

Weissmann N, Hackemack S, Dahal BK, Pullamsetti SS, Savai R, Mittal M, Fuchs
B, Medebach T, Dumitrascu R, Eickels Mv, Ghofrani HA, Seeger W, Grimminger F,
Schermuly RT. The soluble guanylate cyclase activator HMR1766 reverses hypoxia-
induced experimental pulmonary hypertension in mice. Am J Physiol Lung Cell Mol
Physiol. 2009 Oct;297(4):L658-65. doi: 10.1152/ajplung.00189.2009. Epub 2009 Jul
17. PMID: 19617308.

Roth M, Rupp M, Hofmann S, Mittal M, Fuchs B, Sommer N, Parajuli N, Quanz K,
Schubert D, Dony E, Schermuly RT, Ghofrani HA, Sausbier U, Rutschmann K, Wilhelm
S, Seeger W, Ruth P, Grimminger F, Sausbier M, Weissmann N. Heme oxygenase-2 and
large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.
Am J Respir Crit Care Med. 2009 Aug 15;180(4):353-64. doi:
10.1164/rccm.200806-848OC. Epub 2009 Jun 4. PMID: 19498059.

Kwapiszewska G, Wygrecka M, Marsh LM, Schmitt S, Trösser R, Wilhelm J,
Helmus K, Eul B, Zakrzewicz A, Ghofrani HA, Schermuly RT, Bohle RM, Grimminger
F, Seeger W, Eickelberg O, Fink L, Weissmann N. Fhl-1, a new key protein in
pulmonary hypertension. Circulation. 2008 Sep 9;118(11):1183-94. doi:
10.1161/CIRCULATIONAHA.107.761916. Epub 2008 Aug 25. PMID: 18725486.

Mittal M, Roth M, König P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly
RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hänze J,
Seeger W, Grimminger F, Schmidt HH, Weissmann N. Hypoxia-dependent regulation of
nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res.
2007 Aug 3;101(3):258-67. doi: 10.1161/CIRCRESAHA.107.148015. Epub 2007 Jun 21.
PMID: 17585072.

Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, Olschewski A,
Storch U, Mederos y Schnitzler M, Ghofrani HA, Schermuly RT, Pinkenburg O,
Seeger W, Grimminger F, Gudermann T. Classical transient receptor potential
channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and
alveolar gas exchange. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19093-8.
doi: 10.1073/pnas.0606728103. Epub 2006 Dec 1. PMID: 17142322; PMCID:
PMC1748182.