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Dr. Martin Gand

Dr. Martin Gand

Postdoc

 

Phone: +49 641 / 99 34912

Fax: +49 641 / 99 34909

Office: B 239

 

 

As a part of my current work I investigate the use of enzymes in food production. Examples are the usage of lipases in the cheese production for generating piquant aromas or the usage of peptidases for breaking down proteins that cause celiac disease, which are to be mentioned.

 

Work Priorities

  • Homologous and heterologous expression of enzymes, as well as the identification of new enzymes form fungi and insects
  • Purification and stabilization of enzyme preparations
  • Usage of side streams and renewabla resources for cost-effecient preparation of enzymes
  • Production of aromatic substances by (chemical) enzymatical methods
  • Structure determination of transformation products

 

Curriculum Vitae

  • since 2018 Postdoc at the Justus Liebig University Giessen in the working group for food chemistry and food biotechnology of Prof. Dr. Holger Zorn
  • 2016-2018 Postdoc at the University of Hamburg in the working group for molecular phytopathology of Prof. Dr. Wilhelm Schäfer, BMBF project: New Enzymes and Metabolites
  • 2012-2016 Doctorate at the University of Greifswald in the working group for protein biochemistry of Jun. Prof. Dr. Matthias Höhne; Topic: "Identification and characterization of imine reductases"
  • 2007-2012 Study of biochemistry at the University of Greifswals, thesis in the working group for biotechnology and enzyme catalysis of Prof. Dr. Uwe Bornscheuer

 

Publications: Peer reviewed journals

[8]

Aspergillus sydowii: Genome Analysis and Characterization of Two Heterologous Expressed, Non-redundant Xylanases

S. Brandt, B. Ellinger, T. van Nguyen, S. Harder, H. Schlüter, R. L. Hahnke, M. Rühl, W. SChäfer, M. Gand, Front. Microbiol., 2020, 11, 573482.

DOI: 10.3389/fmicb.2020.573482

[7]

Promoter activation in Δhfq mutants as an efficient tool for specialized metabolite production enabling direct bioactivity testing

E. Bode, A. K. Heinrich, M. Hirschmann, D. Abebew, N. Y. Shi, T. D. Vo, F. Wesche, Y. M. Shi, P. Grün, S. Simonyi, N. Keller, Y. Engel, S. Wenski, R. Bennet, S. Beyer, I. Bischoff, A. Buaya, S. C. Brandt, I. Cakmak, H. Çimen, S. Eckstein, D. Frank, R. Fürst, M. Gand, G. Geisslinger, S. Hazir, M. Henke, R. Heermann, V. Lecaudey, W. Schäfer, S. Schiffmann, A. Schüffler, R. Schwenk, M. Skaljac, E. Thines, M. Thines, T. Ulshöfer, A. Vilcinskas, T. A. Wichelhaus, H. B. Bode, Angew. Chem. Int. Ed., 2019, 58(52), 18957-18963.

DOI: 10.1002/anie.201910563

[6]

A unique fungal strain collection from Vietnam characterized for high performance degraders of bioecological important biopolymers and lipids

S. C. Brandt, B. Ellinger, T. van Nguyen, Q. D. Thi, G. van Nguyen, C. Baschien, A. Yurkov, R. L. Hahnke, W. Schäfer, M. Gand, PLoS One, 2018, 13(8), e0202695.

DOI: 10.1371/journal.pone.0202695

[5]

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

P. Matzel P, M. Gand, M. Höhne, Green Chem., 2017, 19(2), 385-389.

DOI: 10.1039/C6GC03023H

[4]

A NADH- accepting imine reductase variant: Immobilization and cofactor regeneration by oxidative deamination

M. Gand, C. Thöle, H. Müller, H, Brundiek, G. Bashiri, M. Höhne, J. Biotechnol., 2016, 230, 11-18.

DOI: 10.1016/j.jbiotec.2016.05.006

[3]

Asymmetric reductive amination of ketones catalyzed by imine reductases

D. Wetzl, M. Gand, A. Ross, H. Müller, P. Matzel, S. P. Hanlon, M. Müller, B. Wirz, M. Höhne, H. Iding, ChemCatChem, 2016, 8(12), 2023-2026.

DOI: 10.1002/cctc.201600384

[2]

Enhancement of promiscuous amidase activity of a Bacillus subtilis esterase by formation of a Pi-Pi network

S. Hackenschmidt, E. Moldenhauer, G. Behrens, M. Gand, I. Pavlidis, U. Bornscheuer, ChemCatChem, 2014, 6(4), 1015-1020.

DOI: 10.1002/cctc.201300837

[1]

Characterization of three novel enzymes with imine reductase activity

M. Gand M, H. Müller, R. Wardenga, M. Höhne, J. Mol. Catal. B. Enzym., 2014, 110, 126-132.

DOI: 10.1016/j.molcatb.2014.09.017

 

 

Publications: Books and book chapters

[1]

Asymmetric Reduction of C=N Bonds by Imine Reductases and Reductive Aminases

M. Höhne, P. Matzel, M. Gand, in Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients, (Ed: P. Grunwald), 2019, Jenny Stanford Publishing, Singapore.