Inhaltspezifische Aktionen

AG Kilchert

Research

The 3’ to 5’ exonucleolytic RNA exosome complex is a major regulator of RNA stability in the cell and degrades many types of RNA substrates. The complex is essential in all eukaryotes and exosome dysfunction has been linked to cancer and disease. While the molecular function and the structure of the complex are very well understood, the factors that determine substrate selectivity and allow regulation of its activity remain largely obscure. We ask: What factors are involved in exosome targeting? How is substrate selection regulated ins response to external cues? How does targeted RNA decay contribute to resilience towards stress? Using the fission yeast Schizosaccharomyces pombe as a model organism, we aim to identify RNA-binding proteins that direct RNA substrates towards the exosome, to discover their mode of substrate recognition, and analyse their exosome targeting capacity in vivo and in vitro.

 

Contact /Adresse:

 

 Dr. Cornelia Kilchert

 

Institut für Biochemie, B050
 Heinrich-Buff-Ring 17
 35392 Giessen                         

 

- Emmy Noether Research Group Leader -

 

Tel.: +49-(0)641-9935420

FAX: +49-(0)641-9935409

Email:

 

 

 

Lab Members

 

Ebru Aydin

Doktorandin /

doctoral student

Tel.: +49-(0)641-9935418

FAX: +49-(0)641-9935409

Email: Ebru.Aydin
 

Jacqueline Böhme

Doktorandin /

doctoral student

Tel.: +49-(0)641-9935418

FAX: +49-(0)641-9935409

Email: Jacqueline.Boehme

 

Silke Schreiner

Technische Assistentin / technician

Tel.: +49-(0)641-9935418

FAX: +49-(0)641-9935409

Email: Silke.Schreiner

 

Jan Weber

Doktorand /

doctoral student

 

Tel.: +49-(0)641-9935418

FAX: +49-(0)641-9935409

Email: Jan.Weber

 

 

Open positions

We explore mechanisms of post-transcriptional gene regulation and use molecular biology and biochemical methods to study the regulation of RNA decay in the cell nucleus, with a particular focus on the cellular response to DNA damage. Among others, we employ RNA-protein crosslinking and high-throughput sequencing techniques. We welcome applications from Master students, PhD students, and postdocs with a keen interest in RNA biology, and offer a highly motivated environment with excellent conditions for scientific training. For further information or applications please contact Dr. Cornelia Kilchert.