AG Kilchert
Research
The 3’ to 5’ exonucleolytic RNA exosome complex is a major regulator of RNA stability in the cell and degrades many types of RNA substrates. The complex is essential in all eukaryotes and exosome dysfunction has been linked to cancer and disease. While the molecular function and the structure of the complex are very well understood, the factors that determine substrate selectivity and allow regulation of its activity remain largely obscure. We ask: What factors are involved in exosome targeting? How is substrate selection regulated ins response to external cues? How does targeted RNA decay contribute to resilience towards stress? Using the fission yeast Schizosaccharomyces pombe as a model organism, we aim to identify RNA-binding proteins that direct RNA substrates towards the exosome, to discover their mode of substrate recognition, and analyse their exosome targeting capacity in vivo and in vitro.
Contact /Adresse:
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Dr. Cornelia Kilchert Institut für Biochemie, B050 |
- Emmy Noether Research Group Leader -
Tel.: +49-(0)641-9935420 FAX: +49-(0)641-9935409 Email:Cornelia.Kilchert@chemie.bio.uni-giessen.de
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Lab Members
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Ebru Aydin Doktorandin / doctoral student |
Tel.: +49-(0)641-9935418 FAX: +49-(0)641-9935409 Email: Ebru.Aydin@chemie.bio.uni-giessen.de |
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Jacqueline Böhme Doktorandin / doctoral student |
Tel.: +49-(0)641-9935418 FAX: +49-(0)641-9935409 Email: Jacqueline.Boehme@chemie.bio.uni-giessen.de |
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Silke Schreiner Technische Assistentin / technician |
Tel.: +49-(0)641-9935423 FAX: +49-(0)641-9935409 Email: Silke.Schreiner@chemie.bio.uni-giessen.de |
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Jan Weber Doktorand / doctoral student
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Tel.: +49-(0)641-9935418 FAX: +49-(0)641-9935409 Email: Jan.Weber@bio.uni-giessen.de |
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Open positions
We explore mechanisms of post-transcriptional gene regulation and use molecular biology and biochemical methods to study the regulation of RNA decay in the cell nucleus, with a particular focus on the cellular response to DNA damage. Among others, we employ RNA-protein crosslinking and high-throughput sequencing techniques. We welcome applications from Master students, PhD students, and postdocs with a keen interest in RNA biology, and offer a highly motivated environment with excellent conditions for scientific training. For further information or applications please contact Dr. Cornelia Kilchert.