Inhaltspezifische Aktionen


Bernstein E., Dent S., Dou Y., Duncan E.M., Hake S.B., Strahl B.D. and Wysocka J. (2023). C. David Allis (1951-2023). Cell, 186(4): 663 and Mol Cell, 83(4): 497


Herchenröther A., Gossen S., Friedrich T., Reim A., Daus N., Diegmüller F., Leers J., Sani H.M., Gerstner S., Schwarz L., Stellmacher I., Szymkowiak L.V., Nist A., Stiewe T., Borggrefe T., Mann M., Mackay J.P., Bartkuhn M., Borchers A., Lan J. and Hake S.B. (2023). The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. Nature Commun., 14(1): 472


Kreienbaum C., Paasche L.W. and Hake S.B. (2022). H2A.Z's 'social' network: functional partners of an enigmatic histone variant. Trends Biochem Sci, 47(11): 909


Herchenröther A., Wunderlich T.M., Lan J. and Hake S.B. (2022). Spotlight in histone H2A variants: Fram B to X to Z. Semin Cell Dev Biol, 15(135):3


Chen J., Sathiaseelan V., Moore A.D., Tan S., Chilamakuri C.S., Roamio Franklin V.N., Shahsavari A., Jakwerth C.A., Hake S.B., Warren A.J., Mohorianu I., D’Santos C.S. and Ringshausen I. (2021). ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia. Blood, DOI: 10.1182/blood.2020009960


Procida T., Friedrich T., Jack A.P.M., Peritore M., Bönisch C., Eberl H.C., Daus N., Kletenkov K., Nist A., Stiewe T., Borggrefe T., Mann M., Bartkuhn M. and Hake S.B. (2021). JAZF1, a novel p400/TIP60/NuA4 complex member, regulates H2A.Z acetylation at regulatory regions. IJMS, 12(22): E678; DOI: 10.3390/ijms22020678


Zhang Z., Wang M., Zhang Y., Zhang Y., Bartkuhn M., Markmann M., Hossain H., Chakraborty T., Hake S.B., Jia Z., Meinhardt A. and Bhushan S. (2021). Uropathogenic Escherichia coli virulence factor a hemolysin reduces histone acetylation to inhibit expression of pro-inflammatory cytokine genes. J Infect Dis., DOI: 10.1093/infdis/jiab018


Low J.K.K., Silva A.P.G., Sharifi Tabar M., Torrado M., Webb S.R., Parker B.L., Sana M., Smits C., Schmidberger J.W., Brillault L., Jackman M.J., Wolliams D.C. Jr., Blobel G.A., Hake S.B., Shepherd N.E., Landsberg M.J., and Mackay J.P. (2020). The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture. Cell Reports, 33(9): 108450; DOI: 10.1016/j.celrep.2020.108450


Armache A., Yang S., Martinez de Paz A., Robbins L.E., Durmaz C., Cheong J.Q., Ravishankar A., Daman A.W., Ahimovic D.J., Klevorn T., Yue Y., Arslan T., Lin S., Panchenko T., Hrit J., Wang M., Thudium S., Garcia B.A., Korb E., Armache K.J., Rothbart S.B., Hake S.B., Allis C.D., Li H., and Josefowicz S.Z. (2020) Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature, DOI: 10.1038/s41586-020-2533-0


Resnick R., Wong C.J., Hamm D.C., Bennett S.R., Skene P.J., Hake S.B., Henikoff S., van der Maarel S.M. and Tapscott S.J. (2019). DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression. Cell Reports, 29(7): 1812-1820


Riedlinger T., Bartkuhn M., Zimmermann T., Hake S.B., Nist A., Stiewe T., Kracht M. and Schmitz M.L. (2019). Chemotherapeutic drugs inhibiting Topoisomerase 1 activity impede cytokine-induced and NF-kB p65-regulated gene expression. Cancers, DOI: 10.3390/cancers11060883


Giaimo B.D., Ferrante F., Herchenröther A., Hake S.B. and Borggrefe T.. (2019). The histone variant H2A.Z in gene regulation. Epigenetics & Chromatin, DOI:10.1186/s13072-019-0274-9


Link S., Spitzer R.M.M., Sana M., Torrado M., Völker-Albert M.C., Keilhauer E.C., Burgold T., Pünzeler S., Low J.K.K., Lindström I., Nist A., Regnard C., Stiewe T., Hendrich B., Imhof A., Mann M., Mackay J.P., Bartkuhn M.* and Hake S.B.* (2018). PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Nature Commun., DOI: 10.1038/s41467-018-06665-5


Link, S. and Hake S.B. (2017). PWWP2A: A novel mitosis link? Cell Cycle, 16(29): 1849-1850


Pünzeler S., Link S., Wagner G., Keilhauer E.C., Kronbeck N., Spitzer R.M.M., Leidescher S., Markaki Y., Menthele E., Regnard C., Schneider K., Takahashi D., Kusakabe M., Vardabasso C., Zink L.M., Straub T., Bernstein E., Harata M., Leonhardt H., Mann M., Rupp R. and Hake S.B. (2017) Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. The EMBO Journal, 36(15): 2263-2279


Zink L.M., Delbarre E., Eberl H.C., Keilhauer E.C., Bönisch C., Pünzeler S., Bartkuhn, M., Collas P., Mann M. and Hake S.B. (2017). H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3-H4 binding and deposition. Nucleic Acids Research, 45(10): 5691-5706


Buschbeck M. and Hake S.B. (2017). Variants of core histones and their roles in cell fate decisions, development and cancer. Nature Rev Mol Cell Biol, 18(5): 299-314


Zink L.M. and Hake S.B. (2016). Histone variants: Nuclear function and disease. Curr Opin Genet Dev, 37: 82-89


Vardabasso C., Hake S.B. and Bernstein E. (2015). Histone variant H2A.Z.2: a novel driver of melanoma progression. Molecular & Cellular Oncology, 3(2): e1073417


Vardabasso C., Gaspar-Maia A., Hasson D., Pünzeler S., Valle-Garcia D., Straub T., Keilhauer E.C., Strub T., Panda T., Chung C.Y., Segura M.F., Fontanals-Cirera B., Verma A., Mann M., Hernando E., Hake S.B.* and Bernstein E.* (2015). Histone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma. Mol. Cell, 59(1): 75-88 (*: co-corresponding authors)


Abendroth C., Hofmeister A., Hake S.B., Kamweru P.K., Miess E., Dornblut C., Küffner I., Deng W., Leonhardt H., Orthaus S., Hoischen C. and Diekmann S. (2015). The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3. Int. J. Mol. Sci., 16(3): 5839-5863


Leonhardt H. and Hake S.B. (2014). Histone glutamine methylation afFACTing rDNA transcription. Cell Res., 24(3): 261-262


Dindar G., Anger A.M., Mehlhorn C., Hake S.B. and Janzen C.J. (2014). Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes. Nature Commun., DOI: 10.1038/ncomms6313


Jack A.P. and Hake S.B. (2014). Getting down to the core of histone modifications. Chromosoma, 124(4): 335-371


Sansoni V., Casas-Delucchi C.S., Rajan M., Schmidt A., Bönisch C., Thomae A.W., Staege M.S., Hake S.B., Cardoso M.C. and Imhof A. (2014). The histone variant H2A.Bbd is enriched at sites of DNA damage. Nucleic Acids Research, 42(19): 6405-6420


Garcia-Gimenez J.L., Olaso G., Hake S.B., Bönisch C., Wiedemann S.M., Markovic J., Dasi F., Gimeno A., Perez-Quilis C., Palacios O., Capdevila M., Vina J. and Pallardo F.V. (2013). Histone H3 glutathionylation in proliferating mammalian cells destabilizes nucleosomal structure. Antioxid. Redox. Signal, 19(12): 1305-1320


Jack A.P., Bussemer S., Hahn M., Pünzeler S., Snyder M., Wells M., Csankovszki G., Solovei I., Schotta G., and Hake S.B. (2013). H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. PLoS ONE, 8(2): e51765


Talbert P.B., Ahmad K., Almouzni G., Ausio J., Berger F., Bhalla P.L., Bonner W.M., Cande W.Z., Chadwick B.P., Chan S.W.L., Cross G.A.M., Cui L., Dimitrov S.I., Doenecke D., Eirin-Lopez J.M., Gorovsky M.A., Hake S.B., Hamkalo B.A., Holec S., Jacobsen S.E., Khochbin S., Ladurner A.G., Landsman D., Latham J.A., Loppin B., Malik H.S., Marzluff W.F., Pehrson J.R., Postberg J., Singh M.B., Schneider R., Smith M.M., Thompson E., Torres-Padilla M.E., Tremethick D.J., Turner B.M., Waterborg J.H., Wollmann H., Yelagandula R., Zhu B. and Henikoff S. (2012). A unified phylogeny-based nomenclature for histone variants. Epigenetics & Chromatin, 5: 7


Pichler G., Jack A., Wolf P. and Hake S.B. (2012). Versatile Toolbox for High Throughput Biochemical and Functional Studies with Fluorescent Fusion Proteins. PLoS ONE, 7(5): e36967


Bönisch C. and Hake S.B. (2012). Histone H2A variants in nucleosomes and chromatin: more or less stable? Nucleic Acids Research, 40(21): 10719-10741


Bönisch C., Schneider K., Pünzeler S., Wiedemann S.M., Bielmeier C., Bocola M., Eberl H.C., Kügel W., Neumann, J., Kremmer E., Leonhardt H., Mann M., Michaelis J., Schermelleh L. and Hake S.B. (2012). H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Research, 40(13): 5951-5964


Ratnakumar K., Duarte L.F., LeRoy G., Hasson, D., Smeets D., Vardabasso C., Bönisch C., Zheng T., Xiang, B., Zhang D.Y., Li H., Wang X., Hake S.B., Schermelleh L., Garcia B.A. and Bernstein E. (2012). ATRX-mediated chromatin association of histone variant macroH2A1 regulates alpha globin expression. Genes & Development, 26(5): 433-438


Torrente M.P., Zee B.M., Young N.L., Baliban R.C., Leroy G., Floudas C.A., Hake S.B. and Garcia B.A. 2011. Comprehensive proteomic interrogation of human chromatin. PLoS ONE, 6(9): e24747


Müller-Taubenberger A., Bönisch C., Fürbringer M, Wittek F. and Hake S.B. (2011). The histone methyltransferase Dot1 is required for DNA damage repair and proper development in Dictyostelium. Biochem. Biophys. Res. Commun., 404(4): 1016-1022


Wiedemann S.M., Mildner S.N., Bönisch C., Israel L., Maiser A., Matheisl S., Straub T., Merk R., Leonhardt H., Kremmer E., Schermelleh L., and Hake S.B. (2010). Identification and characterization of novel primate-specific histone H3 variants H3.X and H3.Y. Journal of Cell Biology, 190(5): 777-791 (Cover-Story mit Highlight Artikel)


Basu A., Rose K.L., Zhang J., Beavis R.C., Ueberheide B., Garcia B.A., Chait B., Zhao Y., Hunt D.F., Segal E., Allis C.D. and Hake S.B. (2009). Proteome-wide prediction of acetylation substrates. PNAS, 106(33): 13785-13790


Bönisch C., Nieratschker S.M., Orfanos N.K. and Hake S.B. (2008). Chromatin proteomics and epigenetic regulatory circuits. Expert Rev. Proteomics, 5(1): 105-119


Shechter D., Dormann H.L., Allis C.D. and Hake S.B. (2007). Extraction, purification and analysis of histones. Nature Prot., 2(6): 1445-1457


Mandava V., Fernandez J.P., Deng H., Janzen C.J., Hake S.B. and Cross G.A. (2007). Histone modifications in Trypanosoma brucei. Mol. Biochem. Parasitol., 156(1): 41-50


Garcia B.A.*, Hake S.B.*, Diaz R.L., Kauer M., Morris S.A., Recht J., Shabanowitz J., Mishra, N., Strahl B.D., Allis C.D. and Hunt D.F. (2007). Organismal differences in post-translational modifications in histones H3 and H4. J. Biol. Chem., 282(19): 7641-7655 (*: geteilte Erstautorenschaft)


Morris S.A., Rao B., Garcia B.A., Hake S.B., Diaz R.L., Shabanowitz J., Hunt D.F., Allis C.D., Lieb J.D. and Strahl B.D. (2007). Identification of histone H3 lysine 36 acetylation as a highly conserved modification. J. Bio. Chem., 282(19): 7632-7640


Bernstein E. and Hake S.B. (2006). The nucleosome: a little variation goes a long way. Biochem. Cell Biol., 84(4): 495-507


Janzen C.J., Hake S.B., Lowell J.E. and Cross G.A.M. (2006). Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei. Mol. Cell, 23(4): 497-507


Janzen C.J., Fernandez J.P., Deng H., Diaz R., Hake S.B., and Cross G.A.M. (2006). Unusual histone modifications in Trypanosoma brucei. FEBS Lett., 580(9): 2306-2310


Hake S.B. and Allis C.D. (2006). Histone H3 variants and their potential role in indexing mammalian genomes: The “H3 barcode hypothesis”. PNAS, 103(17): 6428-6435 (Inaugural Artikel zu Ehren von C. David Allis’ Aufnahme in die National Academy of Science.)


Hake S.B., Garcia B.A., Duncan E.M., Kauer M., Dellaire G., Shabanowitz J., Bazett-Jones D.P., Allis C.D. and Hunt D.F. (2006). Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J. Biol. Chem., 281(1): 559-568


Taverna S.D., Allis C.D. and Hake S.B. (2006). “Hunt”-ing for post-translational modifications that underlie the histone code. Int. J. Mass. Spec., 259(1-3): 40-45


Kim J., Hake S.B. and Roeder R.G. (2005). The human homologue of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. Mol. Cell, 20(5): 759-770


Garcia B.A., Barber C.M., Hake S.B., Ptak C., Turner F.B., Busby S.A., Shabanowitz J., Moran R.G., Allis C.D. and Hunt D.F. (2005). Modifications of human histone H3 variants during mitosis. Biochemistry, 4(44): 13202-13213


Hake S.B., Garcia B.A., Kauer M., Baker S.P., Shabanowitz J., Hunt D.F. and Allis C.D. (2005). Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. PNAS, 102(18): 6344-6349


Hake S.B., Xiao A. and Allis C.D. (2004). Linking the epigenetic “language” of covalent histone modifications to cancer. Br. J. Cancer, 90(4): 761-769


Camacho-Carvajal M.M., Klinger S., Schnappauf F., Hake S.B. and Steimle V. (2004). Importance of class II transactivator leucine-rich repeats for dominant negative function and nucleo-cytoplasmic transport. Int. Immunology, 16(1): 65-75


Hake S.B., Tobin H.M., Steimle V. and Denzin L.K. (2003). Comparison of the transcriptional regulation of classical and non-classical MHC class II genes. Eur. J. Immunology, 33(9): 2361-2371


Schnappauf F., Hake S.B., Camacho-Carvajal M.M., Bontron S., Lisowska-Grospierre B. and Steimle V. (2003). N-terminal destruction signals lead to rapid degradation of the major histocompatibility complex class II transactivator CIITA. Eur. J. Immunology, 33(8): 2337-2347


Glazier K.S., Hake S.B., Tobin H.M., Chadburn A., Schattner E.J. and Denzin L.K. (2002). Germinal center B cells regulate their capability to present antigen by modulation of HLA-DO. J. Exp. Med., 195(8): 1063-1069


Hake S.B., Masternak K., Kammerbauer C., Janzen C., Reith W. and Steimle V. (2000). CIITA leucine rich repeats control nuclear localization and in vitro recruitment of the MHC class II enhanceosome. Mol. Cell. Biol., 20(20): 7716-7725





Book chapter entitled “Chromatin modifications” in “Nutrition in Epigenetics”. Wiley-Blackwell, 2011.


Co-Editor together with Janzen C.J. of the book “Protein Acetylation” in the book series “Methods in Molecular Biology”. HUMANA Press, Springer, 2013