Reconstruction of Genome-scale Model (GEM)
Reconstruction of Genome-scale Model (GEM)
Microbiological studies are increasingly relying on in silico methods to perform exploration and rapid analysis of genomic data, and functional genomics studies are supplemented by the new perspectives that genome-scale metabolic models offer. The metabolic reconstruction can help identify potential targets for novel antibiotics or alternative therapeutic approaches. This necessitates a focus on a GEM, which can efficiently identify and characterize the constructed based on genome sequence annotation and physiological data, encompassing all the metabolic reactions within an organism and the genes encoding each enzyme. High-quality GEMs provide deeper insights into the species itself, its interactions with other species, and offer more personalized treatment options for diseases caused by these species. High-quality reconstructions of GEMs require extensive manual curation, which is often time-consuming
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