Prof. Dr. Richard Göttlich's group
Welcome to the website of the research group of Prof. Dr. Richard Göttlich!
In the Göttlich group, we combine various topics all revolving around nitrogen chemistry.
The first subject area is united by the modification of bile acids. The use of the natural transport systems of bile acids prompts research into conjugates with fluorescent tags to understand transport processes and the substrate specificity of the different transporters. In addition, the formation of carrier-drug conjugates with 3‑chloropiperidines, which have been investigated in the working group for some time, show the application of bile acids for a liver-specific transport of the DNA alkylating agents. Here, structure-activity relationships with regard to transport and cytotoxic properties of the active substance are particularly relevant. (Figure a)
Another research area is the investigation of N-heteroaromatic cycles fused with imidazole and their possible integration as emitter materials in OLEDs, due to their strong blue emission. As we have already described imidazo[1,5-a]pyridines (IPs), and -quinolines (IQs) in detail, our focus has shifted to imidazo[1,5-a]isoquinolines (IiQs) and connected imidazo[1,5-a]pyridines as well as the investigation of their photoluminescence properties. The main objective is to investigate the effect of molecular structure on the emission spectrum of this class of molecules. (Figure b)
Another project in cooperation with the Schindler group deals with the synthesis of nitrogenous ligands and their respective copper complexes. The ability to form different copper-oxygen adducts allows research on selective oxidation of organic substrates like toluene to benzaldehyde. (Figure c)
|
|
|
|