Publikationen
2023
Moescheid MF, Puckelwaldt O, Beutler M, Haeberlein S, Grevelding CG. Defining an optimal control for RNAi experiments with adult Schistosoma mansoni. Sci Rep (2023) 13(1):9766
Li X, Weth O, Haeberlein S, Grevelding CG. Molecular characterization of Smtdc-1 and Smddc-1 discloses roles as male-competence factors for the sexual maturation of Schistosoma mansoni females. Front Cell Infect Microbiol (2023) 13:1173557
Obermann W, Azri MFD, Konopka L, Schmidt N, Magari F, Sherman J, Silva LMR, Hermosilla C, Ludewig AH, Houhou H, Haeberlein S, Luo MY, Häcker I, Schetelig MF, Grevelding CG, Schroeder FC, Lau GSK, Taubert A, Rodriguez A, Heine A, Yeo TC, Grünweller A, Taroncher-Oldenburg G. Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates. Sci Rep (2023) 13(1):9297
Beutler M, Harnischfeger J, Weber MHW, Hahnel SR, Quack T, Blohm A, Ueberall ME, Timm T, Lochnit G, Rennar GA, Gallinger TL, Houhou H, Rahlfs S, Falcone FH, Becker K, Schlitzer M, Haeberlein S, Czermak P, Salzig D, Grevelding CG. Identification and characterisation of the tegument-expressed aldehyde dehydrogenase SmALDH_312 of Schistosoma mansoni, a target of disulfiram. Eur J Med Chem (2023) 251:11517
von Bülow V, Gindner S, Baier A, Hehr L, Buss N, Russ L, Wrobel S, Wirth V, Tabatabai K, Quack T, Haeberlein S, Kadesch P, Gerbig S, Wiedemann KJ, Spengler B, Mehl A, Morlock G, Schramm G, Pons-Kühnemann J, Falcone FH, Wilson RA, Bankov K, Wild P, Grevelding CG, Roeb E, Roderfeld M. Metabolic reprogramming of hepatocytes by Schistosoma mansoni eggs. JHEP Reports (2023) 5(2):100625
2022
Gallinger TL, Aboagye SY, Obermann W, Weiss M, Grünweller A, Unverzagt C, Williams DL, Schlitzer M, Haeberlein S. First in silico screening of insect molecules for identification of novel anti-parasitic compounds. Pharmaceuticals (2022) 15(2):119
Morawietz CM, Peter Ventura AM, Grevelding CG, Haeberlein S*, Spengler B*. Spatial visualization of drug uptake and distribution in Fasciola hepatica using high-resolution AP-SMALDI mass spectrometry imaging. Parasitol Res (2022) 121(4):1145-1153
Mughal MN, Grevelding CG, Haeberlein S. The anticancer drug imatinib induces autophagy in Schistosoma mansoni. Int J Parasitol (2022) 52(4):211-215
Gallinger TL, Obermann W, Lange-Grünweller K, Schmidt N, Haeberlein S, Grünweller A, Grevelding CG, Schlitzer M. From dithiocarbamates to branched dithiocarbazates: Compounds with potent antischistosomal activity. Arch Pharm (Weinheim) (2022):e2200491
Rennar GA, Gallinger TL, Mäder P, Lange-Grünweller K, Haeberlein S, Grünweller A, Grevelding CG, Schlitzer M. Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects. Eur J Med Chem (2022); 242:114641
2021
Mokosch A, Gerbig S, Grevelding CG, Haeberlein S*, Spengler B*. High-resolution AP-SMALDI MSI as a new tool for drug imaging in Schistosoma mansoni. Anal Bioanal Chem (2021) 413:2755-2766
Mughal MN, Grevelding CG, Haeberlein S. First characterization of autophagy-related genes in Schistosoma mansoni. Int J Parasitol (2021) S0020-7519:00092-8
Peter Ventura AM, Haeberlein S, Konopka L, Obermann W, Grünweller A, Grevelding CG, Schlitzer M. Synthesis and antischistosomal activity of linker- and thiophene-modified biaryl alkyl carboxylic acid derivatives. Arch Pharm (2021) 15:e2100259
2020
*Morawietz CM, Houhou H, Puckelwaldt O, Hehr L, Dreisbach D, Mokosch A, Roeb E, Roderfeld M, Spengler B*, Haeberlein S*. Targeting kinases in Fasciola hepatica: anthelminthic effects and tissue distribution of selected kinase inhibitors. Front Vet Science (2020). 7:611270
Tonk M, Vilcinskas A, Grevelding, CG, Haeberlein S. Anthelminthic activity of assassin bug venom against the blood fluke Schistosoma mansoni. Antibiotics (2020). 9: 664
Weth O, Haeberlein S, Haimann M, Zhang Y, Grevelding CG. Towards deorphanizing G protein-coupled receptors of Schistosoma mansoni using the MALAR yeast two-hybrid system. Parasitology (2020) 147:865-872
2019
Houhou H, Puckelwaldt O, Strube C, Haeberlein S. Reference gene analysis and its use for kinase expression profiling in Fasciola hepatica. Sci Rep (2019) 9:15867
Peter Ventura AM, Haeberlein S, Lange-Grünweller K, Grünweller A, Hartmann RK, Grevelding CG, Schlitzer M. Development of biarylalkyl carboxylic acid amides with improved anti-schistosomal activity. ChemMedChem (2019) 14:1856-1862
Kellershohn J, Thomas L, Grünweller A, Hartmann RK, Hardt M, Vilcinskas A, Grevelding CG, Haeberlein S. Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni. PLoS Negl Trop Dis (2019) 13: e0007240
Haeberlein S, Angrisano A, Quack T, Lu Z, Kellershohn J, Blohm A, Grevelding CG, Hahnel SR. Identification of a new panel of reference genes to study pairing-dependent gene expression in Schistosoma mansoni. Int J Parasitol. (2019) 49: 615-624
Li X, Haeberlein S, Zhao L, Mughal MN, Zhu T, Liu L, Fang R, Zhou Y, Zhao J, Grevelding CG, Hu M. The ABL kinase inhibitor Imatinib causes phenotypic changes and lethality in adult Schistosoma japonicum. Parasitol Res (2019) 118: 881-890
Bis 2018
Schleicher U, Liese J, Justies N, Mischke T, Haeberlein S, Sebald H, Kalinke U, Weiss S, Bogdan C. Type I interferon signaling is required for CpG-oligodesoxy-nucleotide-induced control of Leishmania major, but not for spontaneous cure of subcutaneous primary or secondary L. major infection. Front Immunol (2018) 9: 79
Haeberlein S, Chevalley-Maurel S, Ozir-Fazalalikhan A, Koppejan H, Winkel BMF, Ramesar J, Khan SM, Sauerwein RW, Roestenberg M, Janse CJ, Smits HH,Franke-Fayard B. Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load. Sci Rep (2017) 7: 10372
Haeberlein S, Obieglo K, Ozir-Fazalalikhan A, Chayé MAM, Veninga H, van der Vlugt LEPM, Voskamp A, Boon L, den Haan JM, Westerhof LB, Wilbers RHP, Schots A, Schramm G, Hokke CH, Smits HH. Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells. PLoS Pathog (2017) 13: e1006539
van der Vlugt LEPM, Obieglo K, Ozir-Fazalalikhan A, Sparwasser T, Haeberlein S, Smits HH. Schistosome-induced pulmonary B cells inhibit allergic airway inflamma-tion and display a reduced Th2-driving function. Int J Parasitol. (2017) 47: 545-554
Hussaarts L, García-Tardón N, van Beek L, Heemskerk MM, Haeberlein S, van der Zon GC, Ozir-Fazalalikhan A, Berbée JF, Willems van Dijk K, van Harmelen V, Yazdanbakhsh M, Guigas B. Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice. FASEB J (2015) 29: 3027-3029
Haeberlein S, Fischer D, Thomas SM, Schleicher U, Beierkuhnlein C, Bogdan C. Risk assessment of autochthonous leishmaniasis in Southern Germany by combined distribution modelling and field surveys. PLoS ONE (2013) 8: e81088
Prajeeth CK, Haeberlein S, Sebald H, Schleicher U, Bogdan C. Leishmania-infected macrophages are targets of NK cell-derived cytokines, but not of NK cell cytotoxicity. Infect Immun (2011) 79: 2699-2708
Haeberlein S, Sebald H, Bogdan C, Schleicher U. IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK cell effector functions by Leishmania infantum in vivo. Eur Journal Immunol (2010) 40: 1708-1717
Haas W, Haeberlein S. Penetration of cercariae into the living human skin: Schistosoma mansoni vs. Trichobilharzia szidati. Parasitol Res (2009) 105:1061-1066
Haas W, Haeberlein S, Behring S, Schönamsgruber E, Zopelli E. Schistosoma mansoni: human skin ceramides are a chemical cue for host recognition of cercariae. Exp Parasitol (2008) 120: 94-97
Haeberlein S and Haas W. Chemical attractants of human skin for swimming Schistosoma mansoni cercariae. Parasitol Res (2008) 102: 657-662
Wulff C, Haeberlein S, Haas W. Cream formulations protecting against cercarial dermatitis by Trichobilharzia. Parasitol Res (2007) 101: 91-97
Haas W, Wulff C, Grabe K, Meyer V, Haeberlein S. Navigation within host tissues: cues for orientation of Diplostomum spathaceum (Trematoda) in fish towards veins, head and eye. Parasitology (2007) 134: 1013-1023
Reviews and Book chapters
Pereira Moreira B, Weber MHW, Haeberlein S, Mokosch AS, Spengler B, Grevelding CG, Falcone FH. Drug repurposing and de novo drug discovery of protein kinase inhibitors as new drugs against schistosomiasis. Molecules (2022) 27(4): 1414
van der Vlugt LE, Haeberlein S, de Graaf W, Martha TE, Smits HH. Toll-like receptor ligation for the induction of regulatory B cells. MethodsMolBiol (2014) 1190: 127-141