Unlocking Pain
Content
Pain, particularly in chronic manifestations, arises from a multifactorial etiology and presents a complex clinical and molecular phenotype. To enhance the efficacy of chronic pain management, a comprehensive understanding of the intricate interplay between clinical and molecular phenotypes, alongside underlying mechanisms, is essential. In our research unit, we employ an interdisciplinary biopsychosocial approach, integrating fields such as neurology, neuroscience, psychosomatics, psychoneuroimmunology, (clinical) psychology, veterinary medicine, molecular biology, and epigenetics. Through the utilization of state-of-the-art methodologies and in vitro models, we aim to investigate and decode the complexities of pain pathology.
Projects in process
- Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Linking Molecular and Clinical Phenotypes to Neuro-Immune-Dysregulation (PI: Schagdarsurengin; Cooperation partners from AZB TNNG: Krämer-Best, Leisengang, Rummel, Peters)
- The chronic pelvic pain syndrome (CPPS) in men: epigenetic decoding of a complex disease regarding etiopathogenesis, comorbidities and consequential diseases (PI: Schagdarsurengin; Cooperation partners from AZB TNNG: Krämer-Best, Peters, Kruse, Rummel, Leisengang)
- Neuro-inflammatory paths and consequences in CPPS in men: from neurological pain-phenotype to molecular mechanisms and epi-genotype (PI: Krämer-Best and Schagdarsurengin; Cooperation partners from AZB TNNG: Peters, Kruse, Rummel, Leisengang)
- Predictors of therapy efficacy and treatment expectations in chronic pain patients (PI: Hermann and Krämer-Best)
- In vitro models to study neuroinflammatory processes in structures of the nociceptive system (Leisengang, Cooperation partners from AZB TNNG: Rummel, Schagdarsurengin)
- Influence of extracellular vesicles from adipose tissue derived mesenchymal stromal cells (AdMSCs) on inflammatory processes in structures of the nociceptive system (PI: Leisengang; In collaboration with Prof. S. Arnhold, Institute for Veterinary Anatomy, Histology and Embryology, Veterinary Faculty, JLU Gießen)
- Role of the TRPM3 channel in LPS-induced sickness behavior in mice (PI: Leisengang; In collaboration with Prof. J. Oberwinkler, Institute of Physiology and Pathophysiology, Philipps-University Marburg); Funded by the Forschungscampus Mittelhessen (FCMH) “Experimentierräume”
- Adipokines and adipocytokines in canine lumbosacral stenosis (PI: Leisengang; In collaboration with Prof. M. Schmidt, Department of Veterinary Clinical Sciences, Small Animal Clinic – Neurosurgery, Neuroradiology and Clinical Neurology, JLU Gießen)
Active participants
FB06 Psychology and Sports Science
- Prof. Dr. Christiane Hermann
FB 10 Veterinary Medicine
- Dr. Stephan Leisengang
- Prof. Dr. Martin Schmidt
FB 11 Medicine
- Prof. Dr. Heidrun Krämer-Best
- Prof. Dr. Eva Peters
- Prof. Dr. Undraga Schagdarsurengin
- Dr. Katrin Richter
Contact person
Undraga Schagdarsurengin (undraga.schagdarsurengin@chiru.med.uni-giessen.de)
Heidrun Krämer-Best (Heidrun.Kraemer)