Selected Publications
- Hussain, A. F., Grimm, A., Sheng, W., Zhang, C., Al-Rawe, M., Bräutigam, K., Abu Mraheil, M., Zeppernick, F., Meinholld-Heerlein, I. Toward Homogenous Antibody Drug Conjugates Using Enzyme-Based Conjugation Approaches (2021). Pharmaceuticals. doi: 10.3390/ph14040343.
- Bräutigam, K., Kabore-Wolff, E., Hussain, A. F., Polack, S., Rody, A., Hanker, L., Köster, F. Inhibitors of PD-1/PD-L1 and ERK1/2 impede the proliferation of receptor positive and triple-negative breast cancer cell lines (2021). Journal of Cancer Research and Clinical Oncology. doi: 10.1007/s00432-021-03694-4.
- Hussain, A. F., Heppenstall, P. A., Kampmeier, F., Meinhold-Heerlein, I., Barth, S. One-step site-specific antibody fragment conjugation using SNAP-tag technology. Nature Protocols (2019). doi: 10.1038/s41596-019-0214-y.
- Maennling, A. M., Tur, M. K., Niebert, M., Klockenbring, T., Zeppernick, F., Gattenlöhner, S., Meinhold-Heerlein, I., Hussain, A. H. Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials. Cancers (2019). doi: 10.3390/cancers11121826.
- Nachreiner, I.,* Hussain, A. F.,* Wullner, U., Machuy, N., Meyer, T. T., Fischer, R., Gattenlöhner, S., Meinhold-Heerlein, I., Barth, S., Tur, M. K. Elimination of HER3-expressing breast cancer cells using aptamer-siRNA chimeras. Accepted for publication in Experimental and Therapeutic Medicine (2019). doi: 10.3892/etm.2019.7753.
- Wollschlaeger, C., Meinhold-Heerlein, I., Cong, X., Bräutigam, K., Di Fiore, S., Zeppernick, F., Klockenbring, T., Stickeler, E., Barth, S. and Hussain, A. F. Simultaneous and Independent Dual Site-Specific Self-Labeling of Recombinant Antibodies. Bioconjugate Chemistry (2018). doi: 10.1021/acs.bioconjchem.8b00545.
- Dhandapani, R., Arokiaraj, C., Taberner, F., Pacifico, P., Raja, S., Nocchi, L., Portulano, C., Franciosa, F., Maffei, M., Hussain, A. F., de Castro Reis, F., Reymond, L., Perlas, E., Garcovich, S., Barth, S., Johnsson, K., Lechner, S. and Heppenstall. P., Control of mechanical pain hypersensitivity through ligand-targeted photoablation of TrkB positive sensory neurons. Nature Communications (2018). doi: 10.1038/s41467-018-04049-3.
- Bauerschlag, D., Meinhold-Heerlein, I., Maass, N., Bleilevens, A., Bräutigam, K., Al Rawashdeh, W., Di Fiore, S., Haugg, A. M., Gremse, F., Steitz, J., Fischer, R., Stickeler, E., Barth, S. and Hussain, A. F. Detection and specific elimination of EGFR+ ovarian cancer cells using near infrared photoimmunotheranostics approach. Pharmaceutical Research (2017). doi: 10.1007/s11095-017-2096-4.
- Chouman, K., Woitok, M., Kessler, C., Mladenov, R., Weinhold, E., Hanz, G., Fischer, R., Meinhold-Heerlein, I., Bleilevens, A., Haugg, A. M., Stickeler, E., Kolberg, K. and Hussain, A. F. Fine tuning antibody conjugation methods using snap tag technology, Anti-Cancer Agents in Medicinal Chemistry (2017). doi: 10.2174/1871520617666170213123737.
- Amoury, M., Bauerschlag, D., Zeppernick, F., von Felbert, V., Berges, N., Di Fiore, S., Mintert, I., Bleilevens, B., Maass, N., Bräutigam, K., Meinhold-Heerlein, I., Stickeler, E., Barth, S., Fischer, R. and Hussain, A. F. Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand, Oncotarget (2016).
- Amoury, M., Kolberg, K., Pham, A. T., Hristodorov, D., Mladenov, R., Di Fiore, A. T., Helfrich, W., Kiessling, F., Fischer, R., Pardo, A., Thepen, T., Hussain, A. F., Nachreiner, T. and Barth, S. Granzyme b-based cytolytic fusion protein targeting Epcam specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model, Cancer Lett (2016). doi: 10.18632/oncotarget.10705.
- Von Felbert, V., Bauerschlag, D., Maass, N., Brautigam, K., Meinhold-Heerlein, I., Woitok, M., Barth, S. and Hussain A. F. A specific photoimmunotheranostics agent to detect and eliminate skin cancer cells expressing EGFR, J Cancer Res Clin Oncol (2016). doi: 10.1007/s00432-016-2122-7.
- Amoury, M., Mladenov, R., Nachreiner, T., Pham, A. T., Hristodorov, D., Di Fiore, S., Helfrich, W., Pardo, A., Fey, G., Schwenkert, M., Thepen, T., Kiessling, F., Hussain, A. F., Fischer, R., Kolberg, K. and Barth, S. A novel approach for targeted elimination of cspg4-positive triple-negative breast cancer cells using a map tau-based fusion protein, Int J Cancer (2016). doi: 10.1002/ijc.30119.
- Hussain, A. F., Krüger, H.R., Kampmeier, F., Weissbach, T., Licha, K., Kratz, F., Haag, R., Calderón, M., Barth, S. Targeted delivery of dendritic polyglycerol-doxorubicin conjugates by scFv-SNAP fusion protein suppresses EGFR+ cancer cell growth. Biomacromolecules (2013). doi: 10.1021/bm400410e.
- Hussain, A. F., Tur, M. T and Barth, S. An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in αvβ3 integrin expressing cancers. Nucleic Acid Therapeutics (2013). doi: 10.1089/nat.2012.0408.
- Hussain, A. F., Amoury, M. and Barth, S. SNAP-tag technology: a powerful tool for site specific conjugation of therapeutic and imaging agents. Current Pharmaceutical Design (2013). DOI:10.2174/1381612811319300014
- Hussain, A. F., Wullner, U., Neef, I., Tur, M.K. and Barth, S. Targeted delivery of short interfering RNAs - strategies for in vivo delivery. Book chapter in Topics in anti-cancer research book. (2012). DOI: 10.2174/9781608054787112010011.
- Hussain, A. F., Kampmeier, F., von Felbert, V., Merk, H., Tur, M. T and Barth, S. SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells. Bioconjug. Chem. (2011). doi: 10.1021/bc200304k.