Professur für klinische Versorgungsforschung - AG Herzinsuffizienz
Research Focus
Heart failure (HF) is a rapidly growing cardiovascular condition globally. In Western societies, about 50% of all HF patients suffer from HF with preserved ejection fraction (HFpEF). HFpEF is considered to be a clinical syndrome rather than a specific disease, with various underlying aetiologies including vascular stiffening, microvascular disease, inflammation, and fibrosis, all of which are frequently linked to a high comorbidity burden (e.g. 40% diabetes, 95% hypertension). Once patients develop clinical symptoms, the prognosis is poor (about 25% mortality within the first year).
The causative mechanisms underlying HFpEF are multifactorial, yet, HFpEF is frequently complicated by the development of pulmonary hypertension (PH), assumed to be caused mainly by left ventricular (LV) diastolic dysfunction with impairment of pulmonary venous outflow (pulmonary venous congestion). Therefore, haemodynamic telemonitoring using implantable pulmonary artery pressure (PAP) sensors like the CardioMEMs system provides the possibility to study the effects of novel drugs, devices, and physical activity on PAP characteristics in patients with HFpEF.
Contact
Prof. Dr. med. Birgit Aßmus
Medizinische Klinik I
Innere Medizin / Kardiologie
Klinikstr. 33
35392 Gießen
Leitende Oberärztin, Leitung Herzinsuffizienz
Tel.: 0641-985 42212
Fax: 0641-985 42219
birgit.assmus@innere.med.uni-giessen.de
Team
Publications
- Herrmann EJ, Raghavan B, Tekeste M, Mantzsch K, Meybohm P, Assmus B. Randomized Pilot Trial of Pre- and Postoperative Heart Failure Nurse-Supported Care in Heart Failure Patients Requiring Noncardiac Surgery – Feasibility and Results. Clin Cardiol. 2024 Jun;47(6):e24304. doi:10.1002/clc.24304.
- Schmidt G, Frieling N, Schneck E, Habicher M, Koch C, Aßmus B*, Sander M.* Comparison of preoperative NT-proBNP and simple cardiac risk scores for predicting postoperative morbidity after non-cardiac surgery with intermediate or high surgical risk. Perioper Med (Lond). 2024 May 17;13(1):44. doi:10.1186/s13741-024-00400-z. *equally contributed.
- Schmidt G, Frieling N, Schneck E, Habicher M, Koch C, Rubarth K, Balzer F, Aßmus B*, Sander M.* Preoperative routine measurement of NT-proBNP predicts postoperative morbidity... BMC Anesthesiol. 2024 Mar 23;24(1):113. doi:10.1186/s12871-024-02488-8.
- Mullens W, Rosenkranz S, Sharif F, Aßmus B, Mahon NG, Kempf T, Stevenson LW, Bartunek J. Feasibility of Continuous Noninvasive Pulmonary Artery Pressure Monitoring... JACC Heart Fail. 2024 Apr;12(4):785-788. doi:10.1016/j.jchf.2023.12.016.
- Assmus B, Angermann CE, Alkhlout B, Asselbergs FW, et al. Effects of remote haemodynamic-guided heart failure management... Eur J Heart Fail. 2022;24(12):2320–2330. doi:10.1002/ejhf.2656.
- Sharif F, Rosenkranz S, Bartunek J, Kempf T, Assmus B, Mahon NG, Mullens W. Safety and efficacy of a wireless pulmonary artery pressure sensor... ESC Heart Fail. 2022 Oct;9(5):2862–2872. doi:10.1002/ehf2.14006.
- Herrmann EJ, Raghavan B, Eissing N, Fichtlscherer S, Hamm CW, Assmus B. Pulmonary Artery Pressure-Guided Telemonitoring... Life (Basel) 2022;12(5):766. doi:10.3390/life12050766.
- Störk S, Bernhardt A, Böhm M, et al., Aßmus B. PASSPORT-HF: rationale and design of the PASSPORT-HF trial. Clin Res Cardiol. 2022;111(11):1245–1255. doi:10.1007/s00392-022-01987-3.