March
Picture of the Month - March 2019
Here you see current insights into the research of the LaMa groups. A collection of the former pictures can be found in the Gallery.
Artificial DNA-Scissors
Compounds which alkylate and split DNA are common reagents in cancer therapy as well as antibiotics. In our group we developed an efficient synthetic approach to bis-3-chloropiperidines as such artificial DNA-alkylants. In cooperation with the groups of Barbara Gatto (pharmacy in Padova/Italy) and Daniele Fabris (mass-spectrometry in Albany) we analyse the reactivity and selectivity of these compounds.
Literature:
- I. Zuravka, A. Sosic, B. Gatto, R. Göttlich, Synthesis and evaluation of a bis-3-chloropiperidine derivative incorporating an anthraquinone pharmacophore, Bioorg. Med. Chem.Lett. 2015, 25, 4606-4609, doi: 10.1016/j.bmcl.2015.08.042
- A. Sosic, I. Zuravka, N.-K. Schmitt, A. Miola, R. Göttlich, D. Fabris, B. Gatto, Direct and Topoisomerase II mediated DNA damage by Bis-3-chloropiperidines: the importance of being an earnest G, ChemMedChem 2017, 12, 1471 – 1479, doi: 10.1002/cmdc.201700368
- C. Carraro, A. Francke, A. Sosic, F. Kohl, T. Helbing, M. De Franco, D. Fabris, R. Göttlich B. Gatto, Behind the mirror: chirality tunes the reactivity and cytotoxicity of chloropiperidines as potential anticancer agents, Med.Chem.Lett. 2019, 10, doi: 10.1021/acsmedchemlett.8b00580
This picture was submitted by Tim Helbing, group of Prof. Dr. Richard Göttlich.