September

Picture of the Month - September 2020

Here you see current insights into the research of the LaMa groups. A collection of the former pictures can be found in the Gallery.

Direct Exploitation of the Ethynyl Moiety in Calcium Carbide Through Sealed Ball Milling

Utilizing simple calcium carbide (CaC₂) directly for the synthesis of valuable organic building blocks is made possible through mechanical force excerted through high-power ball milling. Hence, reactions such as the one shown can be carried out in the absence of additives or even solvent. Various ketones including those bearing α-hydrogens were ethynylated in good yields at short reaction times. Aryl halides are also amenable substrates for this protocol as they furnish aryl ethynes through a benzyne intermediate. This method offers a practical and cheap alternative to the established procedures for introducing of ethynyl functionalities. The original publication can be found here: A. Hosseini, P. R. Schreiner, Eur. J. Org. Chem. 2020, 4339. (doi.org/10.1002/ejoc.202000612).

This picture was submitted by Prof. Dr. Peter R. Schreiner.